LHX3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''LIM/homeobox protein Lhx3''' is a [[protein]] that in humans is encoded by the ''LHX3'' [[gene]].<ref name="pmid10598593">{{cite journal |vauthors=Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ | title = Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties | journal = Mol Endocrinol | volume = 13 | issue = 12 | pages = 2212–25 |date=Jan 2000 | pmid = 10598593 | pmc =  | doi =10.1210/me.13.12.2212  }}</ref><ref name="pmid10717474">{{cite journal |vauthors=Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ | title = Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9 | journal = Gene | volume = 245 | issue = 2 | pages = 237–43 |date=May 2000 | pmid = 10717474 | pmc =  | doi =10.1016/S0378-1119(00)00025-1  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8022| accessdate = }}</ref>
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| require_manual_inspection = no
== Function ==
| update_protein_box = yes
 
| update_summary = yes
''LHX3'' encodes a protein of a large protein family, members of which carry the [[LIM domain]], a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for [[pituitary]] development and [[motor neuron]] specification. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez" />
| update_citations = yes
 
}}
== Clinical significance ==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = LIM homeobox 3
| HGNCid = 6595
| Symbol = LHX3
| AltSymbols =; DKFZp762A2013; M2-LHX3
| OMIM = 600577
| ECnumber = 
| Homologene = 7814
| MGIid = 102673
| GeneAtlas_image1 = PBB_GE_LHX3_221670_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8022
    | Hs_Ensembl = ENSG00000107187
    | Hs_RefseqProtein = NP_055379
    | Hs_RefseqmRNA = NM_014564
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 138227917
    | Hs_GenLoc_end = 138236776
    | Hs_Uniprot = Q9UBR4
    | Mm_EntrezGene = 16871
    | Mm_Ensembl = ENSMUSG00000026934
    | Mm_RefseqmRNA = XM_001052045
    | Mm_RefseqProtein = XP_001052045
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 26022956
    | Mm_GenLoc_end = 26030258
    | Mm_Uniprot = Q8C8F2
  }}
}}
'''LIM homeobox 3''', also known as '''LHX3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8022| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
LHX3 has been shown to [[Protein-protein interaction|interact]] with [[Ldb1]].<ref name="pmid9452425">{{cite journal |vauthors=Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3152–7 |date=February 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 }}</ref>
| section_title =  
| summary_text = This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine. Two transcripts variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LHX3 LIM homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8022| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhadanov AB, Bertuzzi S, Taira M, ''et al.'' |title=Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues. |journal=Dev. Dyn. |volume=202 |issue= 4 |pages= 354-64 |year= 1995 |pmid= 7626792 |doi= 10.1002/aja.1002020405 }}
*{{cite journal  | author=Zhadanov AB |title=Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues |journal=Dev. Dyn. |volume=202 |issue= 4 |pages= 354–64 |year= 1995 |pmid= 7626792 |doi= 10.1002/aja.1002020405  |name-list-format=vanc| author2=Bertuzzi S  | author3=Taira M  | display-authors=3  | last4=Dawid  | first4=Igor B.  | last5=Westphal  | first5=Heiner }}
*{{cite journal | author=Zhadanov AB, Copeland NG, Gilbert DJ, ''et al.'' |title=Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3. |journal=Genomics |volume=27 |issue= 1 |pages= 27-32 |year= 1995 |pmid= 7665181 |doi= 10.1006/geno.1995.1004 }}
*{{cite journal  | author=Zhadanov AB |title=Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3 |journal=Genomics |volume=27 |issue= 1 |pages= 27–32 |year= 1995 |pmid= 7665181 |doi= 10.1006/geno.1995.1004  |name-list-format=vanc| author2=Copeland NG  | author3=Gilbert DJ | display-authors=3  | last4=Jenkins  | first4=Nancy A.  | last5=Westphal  | first5=Heiner }}
*{{cite journal  | author=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152-7 |year= 1998 |pmid= 9452425 |doi=  }}
*{{cite journal  |vauthors=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=10.1074/jbc.273.6.3152  }}
*{{cite journal  | author=Bach I, Rodriguez-Esteban C, Carrière C, ''et al.'' |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394-9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 }}
*{{cite journal  | author=Bach I |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970 |name-list-format=vanc| author2=Rodriguez-Esteban C  | author3=Carrière C  | display-authors=3  | last4=Rodriguez-Esteban  | first4=Concepción  | last5=Carrière  | first5=Catherine  | last6=Bhushan  | first6=Anil | last7=Krones  | first7=Anna  | last8=Rose  | first8=David W.  | last9=Glass  | first9=Christopher K. }}
*{{cite journal  | author=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159-67 |year= 2000 |pmid= 10593900 |doi= }}
*{{cite journal  |vauthors=Glenn DJ, Maurer RA |title=MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36159–67 |year= 2000 |pmid= 10593900 |doi=10.1074/jbc.274.51.36159  }}
*{{cite journal | author=Sloop KW, Meier BC, Bridwell JL, ''et al.'' |title=Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2212-25 |year= 2000 |pmid= 10598593 |doi=  }}
*{{cite journal  |vauthors=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336–42 |year= 2000 |pmid= 10788441 |doi=10.1074/jbc.275.18.13336 }}
*{{cite journal  | author=Sloop KW, Showalter AD, Von Kap-Herr C, ''et al.'' |title=Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9. |journal=Gene |volume=245 |issue= 2 |pages= 237-43 |year= 2000 |pmid= 10717474 |doi= }}
*{{cite journal  | author=Parker GE |title=The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23891–8 |year= 2000 |pmid= 10818088 |doi= 10.1074/jbc.M000377200  |name-list-format=vanc| author2=Sandoval RM  | author3=Feister HA  | display-authors=3  | last4=Bidwell  | first4=JP  | last5=Rhodes  | first5=SJ }}
*{{cite journal  | author=Howard PW, Maurer RA |title=Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13336-42 |year= 2000 |pmid= 10788441 |doi=  }}
*{{cite journal  | author=Netchine I |title=Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 182–6 |year= 2000 |pmid= 10835633 |doi= 10.1038/76041  |name-list-format=vanc| author2=Sobrier ML  | author3=Krude H  | display-authors=3  | last4=Krude  | first4=Heiko  | last5=Schnabel  | first5=Dirk  | last6=Maghnie  | first6=Mohamed  | last7=Marcos  | first7=Elisabeth  | last8=Duriez  | first8=Bénédicte  | last9=Cacheux  | first9=Valère }}
*{{cite journal  | author=Parker GE, Sandoval RM, Feister HA, ''et al.'' |title=The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23891-8 |year= 2000 |pmid= 10818088 |doi= 10.1074/jbc.M000377200 }}
*{{cite journal  |vauthors=Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ |title=Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 49–56 |year= 2000 |pmid= 10903894 |doi= 10.1006/bbrc.2000.3038 }}
*{{cite journal | author=Netchine I, Sobrier ML, Krude H, ''et al.'' |title=Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency. |journal=Nat. Genet. |volume=25 |issue= 2 |pages= 182-6 |year= 2000 |pmid= 10835633 |doi= 10.1038/76041 }}
*{{cite journal  |vauthors=Sloop KW, Dwyer CJ, Rhodes SJ |title=An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36311–9 |year= 2001 |pmid= 11470784 |doi= 10.1074/jbc.M103888200 }}
*{{cite journal  | author=Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ |title=Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 49-56 |year= 2000 |pmid= 10903894 |doi= 10.1006/bbrc.2000.3038 }}
*{{cite journal  | author=Ostendorff HP |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors |journal=Nature |volume=416 |issue= 6876 |pages= 99–103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a |name-list-format=vanc| author2=Peirano RI  | author3=Peters MA  | display-authors=3  | last4=Schlüter  | first4=Anne  | last5=Bossenz  | first5=Michael  | last6=Scheffner  | first6=Martin  | last7=Bach  | first7=Ingolf }}
*{{cite journal  | author=Sloop KW, Dwyer CJ, Rhodes SJ |title=An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36311-9 |year= 2001 |pmid= 11470784 |doi= 10.1074/jbc.M103888200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Ostendorff HP, Peirano RI, Peters MA, ''et al.'' |title=Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. |journal=Nature |volume=416 |issue= 6876 |pages= 99-103 |year= 2002 |pmid= 11882901 |doi= 10.1038/416099a }}
*{{cite journal  |vauthors=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo |journal=Development |volume=130 |issue= 9 |pages= 1915–25 |year= 2003 |pmid= 12642495 |doi=10.1242/dev.00389  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kim SS |title=Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging |journal=Horm. Res. |volume=60 |issue= 6 |pages= 277–83 |year= 2004 |pmid= 14646405 |doi= 10.1159/000074245  |name-list-format=vanc| author2=Kim Y  | author3=Shin YL  | display-authors=3  | last4=Kim  | first4=Gu-Hwan  | last5=Kim  | first5=Tae-Ue  | last6=Yoo  | first6=Han-Wook }}
*{{cite journal  | author=van Meyel DJ, Thomas JB, Agulnick AD |title=Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. |journal=Development |volume=130 |issue= 9 |pages= 1915-25 |year= 2003 |pmid= 12642495 |doi= }}
*{{cite journal  | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207–9 |year= 2004 |pmid= 14714741 |doi=  10.1515/jpem.2003.16.9.1207}}
*{{cite journal | author=Kim SS, Kim Y, Shin YL, ''et al.'' |title=Clinical characteristics and molecular analysis of PIT1, PROP1,LHX3, and HESX1 in combined pituitary hormone deficiency patients with abnormal pituitary MR imaging. |journal=Horm. Res. |volume=60 |issue= 6 |pages= 277-83 |year= 2004 |pmid= 14646405 |doi= 10.1159/000074245 }}
*{{cite journal  | author=West BE |title=Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor |journal=Endocrinology |volume=145 |issue= 11 |pages= 4866–79 |year= 2004 |pmid= 15271874 |doi= 10.1210/en.2004-0598  |name-list-format=vanc| author2=Parker GE  | author3=Savage JJ  | display-authors=3  | last4=Kiratipranon  | first4=P  | last5=Toomey  | first5=KS  | last6=Beach  | first6=LR  | last7=Colvin  | first7=SC  | last8=Sloop  | first8=KW  | last9=Rhodes  | first9=SJ }}
*{{cite journal  | author=Dattani MT |title=Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene. |journal=J. Pediatr. Endocrinol. Metab. |volume=16 |issue= 9 |pages= 1207-9 |year= 2004 |pmid= 14714741 |doi=  }}
*{{cite journal  |vauthors=Parker GE, West BE, Witzmann FA, Rhodes SJ |title=Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 67–80 |year= 2005 |pmid= 15517599 |doi= 10.1002/jcb.20287 }}
*{{cite journal | author=West BE, Parker GE, Savage JJ, ''et al.'' |title=Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor. |journal=Endocrinology |volume=145 |issue= 11 |pages= 4866-79 |year= 2004 |pmid= 15271874 |doi= 10.1210/en.2004-0598 }}
*{{cite journal  | author=Sobrier ML |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279–84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003  |name-list-format=vanc| author2=Attié-Bitach T  | author3=Netchine I  | display-authors=3  | last4=Encha-Razavi  | first4=F.  | last5=Vekemans  | first5=M.  | last6=Amselem  | first6=S. }}
*{{cite journal  | author=Parker GE, West BE, Witzmann FA, Rhodes SJ |title=Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor. |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 67-80 |year= 2005 |pmid= 15517599 |doi= 10.1002/jcb.20287 }}
*{{cite journal  | author=Sobrier ML, Attié-Bitach T, Netchine I, ''et al.'' |title=Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development. |journal=Gene Expr. Patterns |volume=5 |issue= 2 |pages= 279-84 |year= 2006 |pmid= 15567726 |doi= 10.1016/j.modgep.2004.07.003 }}
}}
}}
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* {{MeshName|LHX3+protein,+human}}
* {{MeshName|LHX3+protein,+human}}


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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-9-stub}}

Latest revision as of 17:55, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.[1][2][3]

Function

LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

Clinical significance

Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.[3]

Interactions

LHX3 has been shown to interact with Ldb1.[4]

References

  1. ↑ Sloop KW, Meier BC, Bridwell JL, Parker GE, Schiller AM, Rhodes SJ (Jan 2000). "Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties". Mol Endocrinol. 13 (12): 2212–25. doi:10.1210/me.13.12.2212. PMID 10598593.
  2. ↑ Sloop KW, Showalter AD, Von Kap-Herr C, Pettenati MJ, Rhodes SJ (May 2000). "Analysis of the human LHX3 neuroendocrine transcription factor gene and mapping to the subtelomeric region of chromosome 9". Gene. 245 (2): 237–43. doi:10.1016/S0378-1119(00)00025-1. PMID 10717474.
  3. ↑ 3.0 3.1 3.2 "Entrez Gene: LHX3 LIM homeobox 3".
  4. ↑ Jurata LW, Pfaff SL, Gill GN (February 1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.

Further reading

  • Zhadanov AB, Bertuzzi S, Taira M, et al. (1995). "Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues". Dev. Dyn. 202 (4): 354–64. doi:10.1002/aja.1002020405. PMID 7626792.
  • Zhadanov AB, Copeland NG, Gilbert DJ, et al. (1995). "Genomic structure and chromosomal localization of the mouse LIM/homeobox gene Lhx3". Genomics. 27 (1): 27–32. doi:10.1006/geno.1995.1004. PMID 7665181.
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. doi:10.1074/jbc.273.6.3152. PMID 9452425.
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
  • Glenn DJ, Maurer RA (2000). "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression". J. Biol. Chem. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
  • Howard PW, Maurer RA (2000). "Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors". J. Biol. Chem. 275 (18): 13336–42. doi:10.1074/jbc.275.18.13336. PMID 10788441.
  • Parker GE, Sandoval RM, Feister HA, et al. (2000). "The homeodomain coordinates nuclear entry of the Lhx3 neuroendocrine transcription factor and association with the nuclear matrix". J. Biol. Chem. 275 (31): 23891–8. doi:10.1074/jbc.M000377200. PMID 10818088.
  • Netchine I, Sobrier ML, Krude H, et al. (2000). "Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency". Nat. Genet. 25 (2): 182–6. doi:10.1038/76041. PMID 10835633.
  • Schmitt S, Biason-Lauber A, Betts D, Schoenle EJ (2000). "Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene". Biochem. Biophys. Res. Commun. 274 (1): 49–56. doi:10.1006/bbrc.2000.3038. PMID 10903894.
  • Sloop KW, Dwyer CJ, Rhodes SJ (2001). "An isoform-specific inhibitory domain regulates the LHX3 LIM homeodomain factor holoprotein and the production of a functional alternate translation form". J. Biol. Chem. 276 (39): 36311–9. doi:10.1074/jbc.M103888200. PMID 11470784.
  • Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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