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{{DISPLAYTITLE:''MLX'' (gene)}}
{{PBB_Controls
{{Infobox_gene}}
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'''Max-like protein X''' is a [[protein]] that in humans is encoded by the ''MLX'' [[gene]].<ref name="pmid8973301">{{cite journal |vauthors=Bjerknes M, Cheng H | title = TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor | journal = Gene | volume = 181 | issue = 1–2 | pages = 7–11 |date=January 1997 | pmid = 8973301 | pmc =  | doi =10.1016/S0378-1119(96)00376-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = MAX-like protein X
| HGNCid = 11645
| Symbol = MLX
| AltSymbols =; MAD7; MXD7; TCFL4
| OMIM = 602976
| ECnumber = 
| Homologene = 7969
| MGIid = 108398
| GeneAtlas_image1 = PBB_GE_MLX_213708_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MLX_210752_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MLX_217909_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6945
    | Hs_Ensembl = ENSG00000108788
    | Hs_RefseqProtein = NP_733752
    | Hs_RefseqmRNA = NM_170607
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 37972616
    | Hs_GenLoc_end = 37978783
    | Hs_Uniprot = Q9UH92
    | Mm_EntrezGene = 21428
    | Mm_Ensembl = ENSMUSG00000017801
    | Mm_RefseqmRNA = NM_011550
    | Mm_RefseqProtein = NP_035680
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 100903400
    | Mm_GenLoc_end = 100908297
    | Mm_Uniprot = Q3UQB4
  }}
}}
'''MAX-like protein X''', also known as '''MLX''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of [[basic helix-loop-helix]] [[leucine zipper]] (bHLH-Zip) [[transcription factors]]. These factors form [[heterodimer]]s with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely [[Mad1]] and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
}}
}}
==Interactions==
MLX (gene) has been shown to [[Protein-protein interaction|interact]] with [[MNT (gene)|MNT]],<ref name=pmid11230181>{{cite journal |last=Cairo |first=S |authorlink= |author2=Merla G |author3=Urbinati F |author4=Ballabio A |author5=Reymond A  |date=March 2001  |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue=6 |pages=617–27 |publisher= |location = England| issn = 0964-6906| pmid = 11230181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal |last=Meroni |first=G |authorlink= |author2=Cairo S |author3=Merla G |author4=Messali S |author5=Brent R |author6=Ballabio A |author7=Reymond A  |date=July 2000  |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue=29 |pages=3266–77 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10918583 |doi = 10.1038/sj.onc.1203634 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MXD1]]<ref name=pmid11230181/><ref name=pmid10918583/> and [[MLXIPL]].<ref name=pmid11230181/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Rommens JM, Durocher F, McArthur J, ''et al.'' |title=Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. |journal=Genomics |volume=28 |issue= 3 |pages= 530-42 |year= 1996 |pmid= 7490091 |doi=  }}
* {{cite journal  | author=Rommens JM |title=Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21 |journal=Genomics |volume=28 |issue= 3 |pages= 530–42 |year= 1996 |pmid= 7490091 |doi=10.1006/geno.1995.1185  |name-list-format=vanc| author2=Durocher F  | author3=McArthur J  | display-authors=3  | last4=Tonin  | first4=Patricia  | last5=Leblanc  | first5=Jean-François  | last6=Allen  | first6=Todd  | last7=Samson  | first7=Carolle  | last8=Ferri  | first8=Lorenzo  | last9=Narod  | first9=Steven }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
* {{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal  | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3 | last4=Bonaldo | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=S  | last7=Dietrich  | first7=N  | last8=Dubuque  | first8=T  | last9=Favello  | first9=A }}
*{{cite journal | author=Bjerknes M, Cheng H |title=TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor. |journal=Gene |volume=181 |issue= 1-2 |pages= 7-11 |year= 1997 |pmid= 8973301 |doi=  }}
* {{cite journal  |vauthors=Billin AN, Eilers AL, Queva C, Ayer DE |title=Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36344–50 |year= 2000 |pmid= 10593926 |doi=10.1074/jbc.274.51.36344 }}
*{{cite journal  | author=Billin AN, Eilers AL, Queva C, Ayer DE |title=Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36344-50 |year= 2000 |pmid= 10593926 |doi=  }}
* {{cite journal  | author=Meroni G |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266–77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634 |name-list-format=vanc| author2=Cairo S  | author3=Merla G  | display-authors=3  | last4=Messali  | first4=Silvia  | last5=Brent  | first5=Roger  | last6=Ballabio  | first6=Andrea  | last7=Reymond  | first7=Alexandre }}
*{{cite journal  | author=Meroni G, Cairo S, Merla G, ''et al.'' |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266-77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634 }}
* {{cite journal  | author=Billin AN |title=MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8845–54 |year= 2000 |pmid= 11073985 |doi=10.1128/MCB.20.23.8845-8854.2000  | pmc=86535  |name-list-format=vanc| author2=Eilers AL  | author3=Coulter KL  | display-authors=3  | last4=Logan  | first4=J. S.  | last5=Ayer  | first5=D. E. }}
*{{cite journal  | author=Billin AN, Eilers AL, Coulter KL, ''et al.'' |title=MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8845-54 |year= 2000 |pmid= 11073985 |doi=  }}
* {{cite journal  | author=Cairo S |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617–27 |year= 2001 |pmid= 11230181 |doi=10.1093/hmg/10.6.617  |name-list-format=vanc| author2=Merla G  | author3=Urbinati F  | display-authors=3  | last4=Ballabio  | first4=A  | last5=Reymond  | first5=A }}
*{{cite journal  | author=Cairo S, Merla G, Urbinati F, ''et al.'' |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617-27 |year= 2001 |pmid= 11230181 |doi=  }}
* {{cite journal  | author=Eilers AL |title=A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8514–26 |year= 2003 |pmid= 12446771 |doi=10.1128/MCB.22.24.8514-8526.2002  | pmc=139889  |name-list-format=vanc| author2=Sundwall E  | author3=Lin M  | display-authors=3  | last4=Sullivan  | first4=A. A.  | last5=Ayer  | first5=D. E. }}
*{{cite journal  | author=Eilers AL, Sundwall E, Lin M, ''et al.'' |title=A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8514-26 |year= 2003 |pmid= 12446771 |doi=  }}
* {{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal  |vauthors=Merla G, Howald C, Antonarakis SE, Reymond A |title=The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3 |journal=Hum. Mol. Genet. |volume=13 |issue= 14 |pages= 1505–14 |year= 2005 |pmid= 15163635 |doi= 10.1093/hmg/ddh163 }}
*{{cite journal  | author=Merla G, Howald C, Antonarakis SE, Reymond A |title=The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. |journal=Hum. Mol. Genet. |volume=13 |issue= 14 |pages= 1505-14 |year= 2005 |pmid= 15163635 |doi= 10.1093/hmg/ddh163 }}
* {{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal  |vauthors=Ma L, Tsatsos NG, Towle HC |title=Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 12019–27 |year= 2005 |pmid= 15664996 |doi= 10.1074/jbc.M413063200 }}
*{{cite journal  | author=Ma L, Tsatsos NG, Towle HC |title=Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 12019-27 |year= 2005 |pmid= 15664996 |doi= 10.1074/jbc.M413063200 }}
* {{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal  | author=Sans CL |title=MondoA-Mlx Heterodimers Are Candidate Sensors of Cellular Energy Status: Mitochondrial Localization and Direct Regulation of Glycolysis |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4863–71 |year= 2006 |pmid= 16782875 |doi= 10.1128/MCB.00657-05 | pmc=1489152  |name-list-format=vanc| author2=Satterwhite DJ  | author3=Stoltzman CA  | display-authors=3  | last4=Breen  | first4=K. T.  | last5=Ayer  | first5=D. E. }}
*{{cite journal  | author=Sans CL, Satterwhite DJ, Stoltzman CA, ''et al.'' |title=MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4863-71 |year= 2006 |pmid= 16782875 |doi= 10.1128/MCB.00657-05 }}
}}
}}
{{refend}}
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* {{MeshName|MLX+protein,+human}}
* {{MeshName|MLX+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}
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Revision as of 06:39, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]

Interactions

MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]

References

  1. ↑ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
  2. ↑ 2.0 2.1 "Entrez Gene: MLX MAX-like protein X".
  3. ↑ 3.0 3.1 3.2 Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. England. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181.
  4. ↑ 4.0 4.1 Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. ENGLAND. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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