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{{Underlinked|date=July 2016}}
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{{Infobox_gene}}
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'''Oligodendrocyte transcription factor 1''' is a [[protein]] that in humans is encoded by the ''OLIG1'' [[gene]].<ref name="pmid11526205">{{cite journal | vauthors = Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM | title = Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 19 | pages = 10851–6 | date = Sep 2001 | pmid = 11526205 | pmc = 58563 | doi = 10.1073/pnas.181340798 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OLIG1 oligodendrocyte transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116448| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Oligodendrocyte transcription factor 1
| HGNCid = 16983
| Symbol = OLIG1
| AltSymbols =; BHLHB6
| OMIM = 606385
| ECnumber = 
| Homologene = 9667
| MGIid = 1355334
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0048663 |text = neuron fate commitment}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 116448
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_620450
    | Hs_RefseqmRNA = NM_138983
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 50914
    | Mm_Ensembl = ENSMUSG00000046160
    | Mm_RefseqmRNA = NM_016968
    | Mm_RefseqProtein = NP_058664
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 91158628
    | Mm_GenLoc_end = 91160798
    | Mm_Uniprot = Q3TY96
  }}
}}
'''Oligodendrocyte transcription factor 1''', also known as '''OLIG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OLIG1 oligodendrocyte transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116448| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zhou Q, Wang S, Anderson DJ | title = Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors | journal = Neuron | volume = 25 | issue = 2 | pages = 331–43 | date = Feb 2000 | pmid = 10719889 | doi = 10.1016/S0896-6273(00)80898-3 }}
| citations =
* {{cite journal | vauthors = Takebayashi H, Yoshida S, Sugimori M, Kosako H, Kominami R, Nakafuku M, Nabeshima Y | title = Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3 | journal = Mechanisms of Development | volume = 99 | issue = 1-2 | pages = 143–8 | date = Dec 2000 | pmid = 11091082 | doi = 10.1016/S0925-4773(00)00466-4 }}
*{{cite journal | author=Zhou Q, Wang S, Anderson DJ |title=Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. |journal=Neuron |volume=25 |issue= 2 |pages= 331-43 |year= 2000 |pmid= 10719889 |doi=  }}
* {{cite journal | vauthors = McLellan AS, Langlands K, Kealey T | title = Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening | journal = Gene Expression Patterns | volume = 2 | issue = 3-4 | pages = 329–35 | date = Dec 2002 | pmid = 12617822 | doi = 10.1016/S0925-4773(02)00390-8 }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
* {{cite journal | vauthors = McLellan AS, Langlands K, Kealey T | title = Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening | journal = Mechanisms of Development | volume = 119 Suppl 1 | issue =  | pages = S285-91 | date = Dec 2002 | pmid = 14516699 | doi = 10.1016/S0925-4773(03)00130-8 }}
*{{cite journal | author=Takebayashi H, Yoshida S, Sugimori M, ''et al.'' |title=Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. |journal=Mech. Dev. |volume=99 |issue= 1-2 |pages= 143-8 |year= 2001 |pmid= 11091082 |doi=  }}
* {{cite journal | vauthors = Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD | title = bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS | journal = Science | volume = 306 | issue = 5704 | pages = 2111–5 | date = Dec 2004 | pmid = 15604411 | doi = 10.1126/science.1103709 }}
*{{cite journal  | author=Lu QR, Park JK, Noll E, ''et al.'' |title=Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 19 |pages= 10851-6 |year= 2001 |pmid= 11526205 |doi= 10.1073/pnas.181340798 }}
* {{cite journal | vauthors = Jakovcevski I, Zecevic N | title = Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS | journal = The Journal of Neuroscience | volume = 25 | issue = 44 | pages = 10064–73 | date = Nov 2005 | pmid = 16267213 | doi = 10.1523/JNEUROSCI.2324-05.2005 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S | title = Novel Olig 1-coding variants and susceptibility to multiple sclerosis | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 77 | issue = 11 | pages = 1296–7 | date = Nov 2006 | pmid = 16820418 | pmc = 2077377 | doi = 10.1136/jnnp.2006.090639 }}
*{{cite journal | author=McLellan AS, Langlands K, Kealey T |title=Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. |journal=Gene Expr. Patterns |volume=2 |issue= 3-4 |pages= 329-35 |year= 2003 |pmid= 12617822 |doi= }}
* {{cite journal | vauthors = Ruf N, Martelli M, Weschke B, Uhlenberg B | title = Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy | journal = American Journal of Medical Genetics Part B | volume = 144B | issue = 3 | pages = 365–6 | date = Apr 2007 | pmid = 17171653 | doi = 10.1002/ajmg.b.30434 }}
*{{cite journal | author=McLellan AS, Langlands K, Kealey T |title=Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. |journal=Mech. Dev. |volume=119 Suppl 1 |issue=  |pages= S285-91 |year= |pmid= 14516699 |doi= }}
* {{cite journal | vauthors = Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C | title = Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer | journal = PLoS Medicine | volume = 4 | issue = 3 | pages = e108 | date = Mar 2007 | pmid = 17388669 | pmc = 1831740 | doi = 10.1371/journal.pmed.0040108 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Arnett HA, Fancy SP, Alberta JA, ''et al.'' |title=bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. |journal=Science |volume=306 |issue= 5704 |pages= 2111-5 |year= 2005 |pmid= 15604411 |doi= 10.1126/science.1103709 }}
*{{cite journal | author=Jakovcevski I, Zecevic N |title=Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS. |journal=J. Neurosci. |volume=25 |issue= 44 |pages= 10064-73 |year= 2006 |pmid= 16267213 |doi= 10.1523/JNEUROSCI.2324-05.2005 }}
*{{cite journal | author=Goris A, Yeo TW, Maranian M, ''et al.'' |title=Novel Olig 1-coding variants and susceptibility to multiple sclerosis. |journal=J. Neurol. Neurosurg. Psychiatr. |volume=77 |issue= 11 |pages= 1296-7 |year= 2006 |pmid= 16820418 |doi= 10.1136/jnnp.2006.090639 }}
*{{cite journal | author=Ruf N, Martelli M, Weschke B, Uhlenberg B |title=Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 3 |pages= 365-6 |year= 2007 |pmid= 17171653 |doi= 10.1002/ajmg.b.30434 }}
*{{cite journal | author=Brena RM, Morrison C, Liyanarachchi S, ''et al.'' |title=Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. |journal=PLoS Med. |volume=4 |issue= 3 |pages= e108 |year= 2007 |pmid= 17388669 |doi= 10.1371/journal.pmed.0040108 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|OLIG1+protein,+human}}
* {{MeshName|OLIG1+protein,+human}}
{{NLM content}}
{{Transcription factors|g1}}
[[Category:Transcription factors]]




{{protein-stub}}
{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 02:33, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.[1][2]

References

  1. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM (Sep 2001). "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (19): 10851–6. doi:10.1073/pnas.181340798. PMC 58563. PMID 11526205.
  2. "Entrez Gene: OLIG1 oligodendrocyte transcription factor 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.