TEAD3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transcriptional enhancer factor TEF-5''' is a [[protein]] that in humans is encoded by the ''TEAD3'' [[gene]].<ref name="pmid9889009">{{cite journal | vauthors = Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I | title = Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis | journal = Genomics | volume = 55 | issue = 1 | pages = 127–9 | date = Jan 1999 | pmid = 9889009 | pmc =  | doi = 10.1006/geno.1998.5628 }}</ref><ref name="pmid9148898">{{cite journal | vauthors = Jacquemin P, Martial JA, Davidson I | title = Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer | journal = The Journal of Biological Chemistry | volume = 272 | issue = 20 | pages = 12928–37 | date = May 1997 | pmid = 9148898 | pmc =  | doi = 10.1074/jbc.272.20.12928 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TEAD3 TEA domain family member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TEAD3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hzd.
| PDB = {{PDB2|2hzd}}
| Name = TEA domain family member 3
| HGNCid = 11716
| Symbol = TEAD3
| AltSymbols =; DTEF-1; ETFR-1; TEAD5; TEF-5; TEF5
| OMIM = 603170
| ECnumber = 
| Homologene = 81821
| MGIid = 109241
| GeneAtlas_image1 = PBB_GE_TEAD3_209454_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7005
    | Hs_Ensembl = ENSG00000007866
    | Hs_RefseqProtein = NP_003205
    | Hs_RefseqmRNA = NM_003214
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 35549354
    | Hs_GenLoc_end = 35572763
    | Hs_Uniprot = Q99594
    | Mm_EntrezGene = 21678
    | Mm_Ensembl = ENSMUSG00000002249
    | Mm_RefseqmRNA = NM_011566
    | Mm_RefseqProtein = NP_035696
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 28059264
    | Mm_GenLoc_end = 28078189
    | Mm_Uniprot = Q80V67
  }}
}}
'''TEA domain family member 3''', also known as '''TEAD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TEAD3 TEA domain family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product is a member of the transcriptional enhancer factor (TEF) family of [[transcription factor]]s, which contain the TEA/ATTS DNA-binding domain.<ref name="pmid2070413">{{cite journal | vauthors = Bürglin, TR | title = The TEA domain: a novel, highly conserved DNA-binding motif | journal = Cell | volume = 66 | issue = 1 | pages = 11–12 | date = Jul 1991 | pmid = 2070413 | pmc =  | doi = 10.1016/0092-8674(91)90132-I }}</ref> Members of the family in mammals are [[TEAD1]], [[TEAD2]], TEAD3, [[TEAD4]]. TEAD3 is predominantly expressed in the [[placenta]] and is involved in the [[transactivation]] of the [[Chorionic somatomammotropin|chorionic somatomammotropin-B]] gene enhancer. It is expressed in nervous system and muscle in fish embryos.<ref name = "Mann_2007">{{cite journal | vauthors = Mann CJ, Osborn DP, Hughes SM | title = Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord | journal = Gene Expression Patterns | volume = 7 | issue = 8 | pages = 827–36 | date = Oct 2007 | pmid = 17916448 | pmc = 3360971 | doi = 10.1016/j.modgep.2007.08.001 }}</ref> Translation of this protein is initiated at a non-AUG (AUA) [[start codon]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.<ref name="entrez">{{cite web | title = Entrez Gene: TEAD3 TEA domain family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7005| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Jiang SW, Wu K, Eberhardt NL | title = Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer | journal = Molecular Endocrinology | volume = 13 | issue = 6 | pages = 879–89 | date = Jun 1999 | pmid = 10379887 | doi = 10.1210/me.13.6.879 }}
| citations =
* {{cite journal | vauthors = Vaudin P, Delanoue R, Davidson I, Silber J, Zider A | title = TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation | journal = Development | volume = 126 | issue = 21 | pages = 4807–16 | date = Nov 1999 | pmid = 10518497 | doi =  }}
*{{cite journal  | author=Jacquemin P, Martial JA, Davidson I |title=Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |journal=J. Biol. Chem. |volume=272 |issue= 20 |pages= 12928-37 |year= 1997 |pmid= 9148898 |doi=  }}
* {{cite journal | vauthors = Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML | title = TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm | journal = Genes & Development | volume = 15 | issue = 10 | pages = 1229–41 | date = May 2001 | pmid = 11358867 | pmc = 313800 | doi = 10.1101/gad.888601 }}
*{{cite journal | author=Jacquemin P, Depetris D, Mattei MG, ''et al.'' |title=Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. |journal=Genomics |volume=55 |issue= 1 |pages= 127-9 |year= 1999 |pmid= 9889009 |doi= 10.1006/geno.1998.5628 }}
* {{cite journal | vauthors = Maeda T, Mazzulli JR, Farrance IK, Stewart AF | title = Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 27 | pages = 24346–52 | date = Jul 2002 | pmid = 11986313 | doi = 10.1074/jbc.M201171200 }}
*{{cite journal  | author=Jiang SW, Wu K, Eberhardt NL |title=Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 879-89 |year= 1999 |pmid= 10379887 |doi= }}
* {{cite journal | vauthors = Peng L, Huang Y, Jin F, Jiang SW, Payne AH | title = Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1 | journal = Molecular Endocrinology | volume = 18 | issue = 8 | pages = 2049–60 | date = Aug 2004 | pmid = 15131259 | pmc = 3273420 | doi = 10.1210/me.2004-0028 }}
*{{cite journal | author=Vaudin P, Delanoue R, Davidson I, ''et al.'' |title=TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation. |journal=Development |volume=126 |issue= 21 |pages= 4807-16 |year= 1999 |pmid= 10518497 |doi=  }}
*{{cite journal | author=Vassilev A, Kaneko KJ, Shu H, ''et al.'' |title=TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. |journal=Genes Dev. |volume=15 |issue= 10 |pages= 1229-41 |year= 2001 |pmid= 11358867 |doi= 10.1101/gad.888601 }}
*{{cite journal | author=Maeda T, Mazzulli JR, Farrance IK, Stewart AF |title=Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24346-52 |year= 2002 |pmid= 11986313 |doi= 10.1074/jbc.M201171200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Peng L, Huang Y, Jin F, ''et al.'' |title=Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2049-60 |year= 2005 |pmid= 15131259 |doi= 10.1210/me.2004-0028 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|TEAD3+protein,+human}}
 
{{PDB Gallery|geneid=7005}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
 
 
{{gene-6-stub}}

Latest revision as of 03:19, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[1][2][3]

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[5] Translation of this protein is initiated at a non-AUG (AUA) start codon.[3]

References

  1. ↑ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
  2. ↑ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
  3. ↑ 3.0 3.1 "Entrez Gene: TEAD3 TEA domain family member 3".
  4. ↑ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413.
  5. ↑ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

Further reading

External links


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