ZEB1: Difference between revisions

Jump to navigation Jump to search
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger E-box-binding homeobox 1''' is a [[protein]] that in humans is encoded by the ''ZEB1'' [[gene]].<ref name="pmid1427828">{{cite journal | vauthors = Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB | title = The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2 | journal = Genomics | volume = 14 | issue = 1 | pages = 194–6 | date = September 1992 | pmid = 1427828 | pmc =  | doi = 10.1016/S0888-7543(05)80307-6 }}</ref><ref name="pmid1840704">{{cite journal | vauthors = Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA | title = Identification of a zinc finger protein that inhibits IL-2 gene expression | journal = Science | volume = 254 | issue = 5039 | pages = 1791–4 | date = December 1991 | pmid = 1840704 | pmc = | doi = 10.1126/science.1840704 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ZEB1 (previously known as TCF8) encodes a [[zinc finger]] and [[homeodomain]] [[transcription factor]] that represses T-lymphocyte-specific [[interleukin 2|IL2]] gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 [[transcription start site]].<ref name="entrez" /><ref name=autogenerated1>{{cite journal | vauthors = Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA | title = Identification of a zinc finger protein that inhibits IL-2 gene expression | journal = Science | volume = 254 | issue = 5039 | pages = 1791–4 | date = December 1991 | pmid = 1840704 | doi = 10.1126/science.1840704 }}</ref> ZEB1 and its mammalian paralog [[ZEB2]] belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.<ref name="pmid26464018">{{cite journal | vauthors = Bürglin TR, Affolter M | title = Homeodomain proteins: an update | journal = Chromosoma | volume = 125 | issue = 3 | pages = 497–521 | date = July 2016 | pmid = 26464018 | pmc = 4901127 | doi = 10.1007/s00412-015-0543-8 }}</ref> The structure of the homeodomain shown on the right.
{{GNF_Protein_box
| image = PBB_Protein_ZEB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e19.
| PDB = {{PDB2|2e19}}
| Name = Zinc finger E-box binding homeobox 1
| HGNCid = 11642
| Symbol = ZEB1
| AltSymbols =; AREB6; BZP; MGC133261; NIL-2-A; NIL-2A; TCF8; ZEB; ZFHEP; ZFHX1A
| OMIM = 189909
| ECnumber =
| Homologene = 31779
| MGIid = 1344313
| GeneAtlas_image1 = PBB_GE_ZEB1_210875_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZEB1_212758_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ZEB1_212764_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0048598 |text = embryonic morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6935
    | Hs_Ensembl = ENSG00000148516
    | Hs_RefseqProtein = NP_110378
    | Hs_RefseqmRNA = NM_030751
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 31647430
    | Hs_GenLoc_end = 31858748
    | Hs_Uniprot = P37275
    | Mm_EntrezGene = 21417
    | Mm_Ensembl = ENSMUSG00000024238
    | Mm_RefseqmRNA = NM_011546
    | Mm_RefseqProtein = NP_035676
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 5591872
    | Mm_GenLoc_end = 5774908
    | Mm_Uniprot = Q3URK4
  }}
}}
'''Zinc finger E-box binding homeobox 1''', also known as '''ZEB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{PBB_Summary
Mutations of the gene are linked to [[posterior polymorphous corneal dystrophy 3]]. A recent study suggested its contributing role in [[lung cancer]] invasiveness and metastasis development.<ref name="pmid24468793">{{cite journal | vauthors = Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL | title = Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1 | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 94 | issue = 4 | pages = 362–70 | date = April 2014 | pmid = 24468793 | doi = 10.1038/labinvest.2013.153 }}</ref>
| section_title =  
| summary_text = TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Franklin AJ, Jetton TL, Shelton KD, Magnuson MA | title = BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription | journal = Molecular and Cellular Biology | volume = 14 | issue = 10 | pages = 6773–88 | date = October 1994 | pmid = 7935395 | pmc = 359208 | doi =  }}
| citations =
* {{cite journal | vauthors = Watanabe Y, Kawakami K, Hirayama Y, Nagano K | title = Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene | journal = Journal of Biochemistry | volume = 114 | issue = 6 | pages = 849–55 | date = December 1993 | pmid = 8138542 | doi =  }}
*{{cite journal | author=Williams TM, Montoya G, Wu Y, ''et al.'' |title=The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. |journal=Genomics |volume=14 |issue= 1 |pages= 194-6 |year= 1992 |pmid= 1427828 |doi=  }}
* {{cite journal | vauthors = Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K | title = Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6 | journal = Molecular and Cellular Biology | volume = 18 | issue = 1 | pages = 10–8 | date = January 1998 | pmid = 9418848 | pmc = 121442 | doi = 10.1128/mcb.18.1.10 }}
*{{cite journal  | author=Williams TM, Moolten D, Burlein J, ''et al.'' |title=Identification of a zinc finger protein that inhibits IL-2 gene expression. |journal=Science |volume=254 |issue= 5039 |pages= 1791-4 |year= 1992 |pmid= 1840704 |doi=  }}
* {{cite journal | vauthors = Turner J, Crossley M | title = Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators | journal = The EMBO Journal | volume = 17 | issue = 17 | pages = 5129–40 | date = September 1998 | pmid = 9724649 | pmc = 1170841 | doi = 10.1093/emboj/17.17.5129 }}
*{{cite journal  | author=Franklin AJ, Jetton TL, Shelton KD, Magnuson MA |title=BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 10 |pages= 6773-88 |year= 1994 |pmid= 7935395 |doi=  }}
* {{cite journal | vauthors = Postigo AA, Dean DC | title = ZEB represses transcription through interaction with the corepressor CtBP | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 12 | pages = 6683–8 | date = June 1999 | pmid = 10359772 | pmc = 21975 | doi = 10.1073/pnas.96.12.6683 }}
*{{cite journal | author=Watanabe Y, Kawakami K, Hirayama Y, Nagano K |title=Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. |journal=J. Biochem. |volume=114 |issue= 6 |pages= 849-55 |year= 1994 |pmid= 8138542 |doi=  }}
* {{cite journal | vauthors = Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T | title = Tip60 is a cell-type-specific transcriptional regulator | journal = Journal of Biochemistry | volume = 129 | issue = 4 | pages = 635–41 | date = April 2001 | pmid = 11275565 | doi = 10.1093/oxfordjournals.jbchem.a002901 }}
*{{cite journal | author=Ikeda K, Halle JP, Stelzer G, ''et al.'' |title=Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 10-8 |year= 1998 |pmid= 9418848 |doi= }}
* {{cite journal | vauthors = Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S | title = Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology | journal = Journal of Bone and Mineral Research | volume = 16 | issue = 12 | pages = 2192–204 | date = December 2001 | pmid = 11760832 | doi = 10.1359/jbmr.2001.16.12.2192 }}
*{{cite journal | author=Turner J, Crossley M |title=Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. |journal=EMBO J. |volume=17 |issue= 17 |pages= 5129-40 |year= 1998 |pmid= 9724649 |doi= 10.1093/emboj/17.17.5129 }}
* {{cite journal | vauthors = Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S | title = Effects of HIV-1 Nef on cellular gene expression profiles | journal = Journal of Biomedical Science | volume = 9 | issue = 1 | pages = 82–96 | year = 2002 | pmid = 11810028 | doi = 10.1007/BF02256581 }}
*{{cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683-8 |year= 1999 |pmid= 10359772 |doi= }}
* {{cite journal | vauthors = Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J | title = Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39209–16 | date = October 2002 | pmid = 12161443 | doi = 10.1074/jbc.M206400200 }}
*{{cite journal | author=Hlubek F, Löhberg C, Meiler J, ''et al.'' |title=Tip60 is a cell-type-specific transcriptional regulator. |journal=J. Biochem. |volume=129 |issue= 4 |pages= 635-41 |year= 2001 |pmid= 11275565 |doi= }}
* {{cite journal | vauthors = Costantino ME, Stearman RP, Smith GE, Darling DS | title = Cell-specific phosphorylation of Zfhep transcription factor | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 368–73 | date = August 2002 | pmid = 12163027 | doi = 10.1016/S0006-291X(02)00880-X }}
*{{cite journal | author=Locklin RM, Riggs BL, Hicok KC, ''et al.'' |title=Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. |journal=J. Bone Miner. Res. |volume=16 |issue= 12 |pages= 2192-204 |year= 2002 |pmid= 11760832 |doi= }}
* {{cite journal | vauthors = Postigo AA | title = Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2443–52 | date = May 2003 | pmid = 12743038 | pmc = 155983 | doi = 10.1093/emboj/cdg225 }}
*{{cite journal | author=Shaheduzzaman S, Krishnan V, Petrovic A, ''et al.'' |title=Effects of HIV-1 Nef on cellular gene expression profiles. |journal=J. Biomed. Sci. |volume=9 |issue= 1 |pages= 82-96 |year= 2002 |pmid= 11810028 |doi= }}
* {{cite journal | vauthors = Postigo AA, Depp JL, Taylor JJ, Kroll KL | title = Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2453–62 | date = May 2003 | pmid = 12743039 | pmc = 155984 | doi = 10.1093/emboj/cdg226 }}
*{{cite journal | author=Guaita S, Puig I, Franci C, ''et al.'' |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209-16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200 }}
* {{cite journal | vauthors = Dillner NB, Sanders MM | title = Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades | journal = DNA and Cell Biology | volume = 23 | issue = 1 | pages = 25–34 | date = January 2004 | pmid = 14965470 | doi = 10.1089/104454904322745907 }}
*{{cite journal | author=Costantino ME, Stearman RP, Smith GE, Darling DS |title=Cell-specific phosphorylation of Zfhep transcription factor. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 368-73 |year= 2002 |pmid= 12163027 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE | title = A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10 | journal = American Journal of Medical Genetics. Part A | volume = 130A | issue = 4 | pages = 372–7 | date = November 2004 | pmid = 15384081 | pmc = 1249494 | doi = 10.1002/ajmg.a.30267 }}
*{{cite journal | author=Postigo AA |title=Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2443-52 |year= 2003 |pmid= 12743038 |doi= 10.1093/emboj/cdg225 }}
* {{cite journal | vauthors = Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R | title = DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells | journal = Oncogene | volume = 24 | issue = 14 | pages = 2375–85 | date = March 2005 | pmid = 15674322 | doi = 10.1038/sj.onc.1208429 }}
*{{cite journal | author=Postigo AA, Depp JL, Taylor JJ, Kroll KL |title=Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2453-62 |year= 2003 |pmid= 12743039 |doi= 10.1093/emboj/cdg226 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Dillner NB, Sanders MM |title=Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades. |journal=DNA Cell Biol. |volume=23 |issue= 1 |pages= 25-34 |year= 2004 |pmid= 14965470 |doi= 10.1089/104454904322745907 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Shimizu S, Krafchak C, Fuse N, ''et al.'' |title=A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. |journal=Am. J. Med. Genet. A |volume=130 |issue= 4 |pages= 372-7 |year= 2005 |pmid= 15384081 |doi= 10.1002/ajmg.a.30267 }}
*{{cite journal | author=Eger A, Aigner K, Sonderegger S, ''et al.'' |title=DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. |journal=Oncogene |volume=24 |issue= 14 |pages= 2375-85 |year= 2005 |pmid= 15674322 |doi= 10.1038/sj.onc.1208429 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{FactorBook|ZEB1}}
 
{{PDB Gallery|geneid=6935}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
 
{{Gene-10-stub}}

Revision as of 01:06, 19 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[5] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6]

References

  1. Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  2. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  3. 3.0 3.1 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  4. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  5. Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  6. Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

External links