ZNF217: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS (v470))
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 217''', also known as '''ZNF217''', is a [[protein]] which in humans is encoded by the ''ZNF217'' [[gene]].<ref name="pmid9671742">{{cite journal | vauthors = Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW | title = Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8703–8 | date = Jul 1998 | pmid = 9671742 | pmc = 21140 | doi = 10.1073/pnas.95.15.8703 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF217 zinc finger protein 217| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7764| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Zinc finger protein 217
| HGNCid = 13009
| Symbol = ZNF217
| AltSymbols =; ZABC1
| OMIM = 602967
| ECnumber = 
| Homologene = 4757
| MGIid = 2685408
| GeneAtlas_image1 = PBB_GE_ZNF217_203739_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7764
    | Hs_Ensembl = ENSG00000171940
    | Hs_RefseqProtein = NP_006517
    | Hs_RefseqmRNA = NM_006526
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 51617011
    | Hs_GenLoc_end = 51633043
    | Hs_Uniprot = O75362
    | Mm_EntrezGene = 228913
    | Mm_Ensembl = ENSMUSG00000052056
    | Mm_RefseqmRNA = XM_985378
    | Mm_RefseqProtein = XP_990472
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 169801284
    | Mm_GenLoc_end = 169822425
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 217''', also known as '''ZNF217''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF217 zinc finger protein 217| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7764| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ZNF217 can attenuate [[apoptosis|apoptotic]] signals resulting from [[telomere]] dysfunction and may promote neoplastic transformation and later stages of malignancy.<ref name="pmid16203743">{{cite journal | vauthors = Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C | title = ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction | journal = Human Molecular Genetics | volume = 14 | issue = 21 | pages = 3219–25 | date = Nov 2005 | pmid = 16203743 | doi = 10.1093/hmg/ddi352 }}</ref> Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.<ref>{{cite journal | vauthors = Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z | title = The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression | journal = Cancer Discovery | volume = 2 | issue = 7 | pages = 638–51 | date = Jul 2012 | pmid = 22728437 | pmc = 3546490 | doi = 10.1158/2159-8290.CD-12-0093 | url = http://cancerdiscovery.aacrjournals.org/content/2/7/638.long }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
== See also ==
* [[Zinc finger]]
* [[Zinc finger]]


==References==
== References ==
{{reflist|2}}
{{reflist|30em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin |30em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Quinlan KG, Verger A, Yaswen P, Crossley M | title = Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad | journal = Biochimica et Biophysica Acta | volume = 1775 | issue = 2 | pages = 333–40 | date = Jun 2007 | pmid = 17572303 | doi = 10.1016/j.bbcan.2007.05.001 }}
| citations =
* {{cite journal | vauthors = Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM | title = Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 6 | pages = 2156–60 | date = Mar 1994 | pmid = 8134364 | pmc = 43329 | doi = 10.1073/pnas.91.6.2156 }}
*{{cite journal | author=Quinlan KG, Verger A, Yaswen P, Crossley M |title=Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad. |journal=Biochim. Biophys. Acta |volume=1775 |issue= 2 |pages= 333-40 |year= 2007 |pmid= 17572303 |doi= 10.1016/j.bbcan.2007.05.001 }}
* {{cite journal | vauthors = Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW | title = Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8703–8 | date = Jul 1998 | pmid = 9671742 | pmc = 21140 | doi = 10.1073/pnas.95.15.8703 }}
*{{cite journal | author=Kallioniemi A, Kallioniemi OP, Piper J, ''et al.'' |title=Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 6 |pages= 2156-60 |year= 1994 |pmid= 8134364 |doi= }}
* {{cite journal | vauthors = Nonet GH, Stampfer MR, Chin K, Gray JW, Collins CC, Yaswen P | title = The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells | journal = Cancer Research | volume = 61 | issue = 4 | pages = 1250–4 | date = Feb 2001 | pmid = 11245413 | doi =  }}
*{{cite journal | author=Collins C, Rommens JM, Kowbel D, ''et al.'' |title=Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8703-8 |year= 1998 |pmid= 9671742 |doi= }}
* {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
*{{cite journal | author=Nonet GH, Stampfer MR, Chin K, ''et al.'' |title=The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells. |journal=Cancer Res. |volume=61 |issue= 4 |pages= 1250-4 |year= 2001 |pmid= 11245413 |doi=  }}
* {{cite journal | vauthors = Weiss MM, Snijders AM, Kuipers EJ, Ylstra B, Pinkel D, Meuwissen SG, van Diest PJ, Albertson DG, Meijer GA | title = Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization | journal = The Journal of Pathology | volume = 200 | issue = 3 | pages = 320–6 | date = Jul 2003 | pmid = 12845628 | doi = 10.1002/path.1359 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Shimada M, Imura J, Kozaki T, Fujimori T, Asakawa S, Shimizu N, Kawaguchi R | title = Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization | journal = Oncology Reports | volume = 13 | issue = 4 | pages = 633–41 | date = Apr 2005 | pmid = 15756435 | doi = 10.3892/or.13.4.633 }}
*{{cite journal  | author=Hakimi MA, Dong Y, Lane WS, ''et al.'' |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234-9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200 }}
* {{cite journal | vauthors = Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C | title = ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction | journal = Human Molecular Genetics | volume = 14 | issue = 21 | pages = 3219–25 | date = Nov 2005 | pmid = 16203743 | doi = 10.1093/hmg/ddi352 }}
*{{cite journal | author=Weiss MM, Snijders AM, Kuipers EJ, ''et al.'' |title=Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization. |journal=J. Pathol. |volume=200 |issue= 3 |pages= 320-6 |year= 2003 |pmid= 12845628 |doi= 10.1002/path.1359 }}
* {{cite journal | vauthors = Quinlan KG, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, Bolognesi M, Crossley M | title = Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins | journal = Molecular and Cellular Biology | volume = 26 | issue = 21 | pages = 8159–72 | date = Nov 2006 | pmid = 16940172 | pmc = 1636751 | doi = 10.1128/MCB.00680-06 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Cowger JJ, Zhao Q, Isovic M, Torchia J | title = Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence | journal = Oncogene | volume = 26 | issue = 23 | pages = 3378–86 | date = May 2007 | pmid = 17130829 | doi = 10.1038/sj.onc.1210126 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Shimada M, Imura J, Kozaki T, ''et al.'' |title=Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization. |journal=Oncol. Rep. |volume=13 |issue= 4 |pages= 633-41 |year= 2005 |pmid= 15756435 |doi= }}
*{{cite journal | author=Huang G, Krig S, Kowbel D, ''et al.'' |title=ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. |journal=Hum. Mol. Genet. |volume=14 |issue= 21 |pages= 3219-25 |year= 2006 |pmid= 16203743 |doi= 10.1093/hmg/ddi352 }}
*{{cite journal | author=Quinlan KG, Nardini M, Verger A, ''et al.'' |title=Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. |journal=Mol. Cell. Biol. |volume=26 |issue= 21 |pages= 8159-72 |year= 2007 |pmid= 16940172 |doi= 10.1128/MCB.00680-06 }}
*{{cite journal | author=Cowger JJ, Zhao Q, Isovic M, Torchia J |title=Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. |journal=Oncogene |volume=26 |issue= 23 |pages= 3378-86 |year= 2007 |pmid= 17130829 |doi= 10.1038/sj.onc.1210126 }}
}}
{{refend}}
{{refend}}


Line 84: Line 30:
* {{MeshName|ZNF217+protein,+human}}
* {{MeshName|ZNF217+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
{{protein-stub}}
 
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-20-stub}}

Revision as of 02:43, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.[1][2]

Function

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[3] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[4]

See also

References

  1. ↑ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Jul 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
  2. ↑ "Entrez Gene: ZNF217 zinc finger protein 217".
  3. ↑ Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics. 14 (21): 3219–25. doi:10.1093/hmg/ddi352. PMID 16203743.
  4. ↑ Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z (Jul 2012). "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression". Cancer Discovery. 2 (7): 638–51. doi:10.1158/2159-8290.CD-12-0093. PMC 3546490. PMID 22728437.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=ZNF217&oldid=1419627"