ATF6: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Activating transcription factor 6''', also known as '''ATF6''', is a [[protein]] that, in humans, is encoded by the ''ATF6''  [[gene]]<ref name="pmid2516827">{{cite journal | vauthors = Hai TW, Liu F, Coukos WJ, Green MR | title = Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers | journal = Genes Dev. | volume = 3 | issue = 12B | pages = 2083–90 | date = December 1989 | pmid = 2516827 | doi = 10.1101/gad.3.12b.2083 }}</ref><ref name="pmid9271374">{{cite journal | vauthors = Zhu C, Johansen FE, Prywes R | title = Interaction of ATF6 and serum response factor | journal = Mol. Cell. Biol. | volume = 17 | issue = 9 | pages = 4957–66 | date = September 1997 | pmid = 9271374 | pmc = 232347 | doi =  | url = http://mcb.asm.org/cgi/content/abstract/17/9/4957 }}</ref><ref name="pmid17440018">{{cite journal | vauthors = Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW | title = Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians | journal = J. Clin. Endocrinol. Metab. | volume = 92 | issue = 7 | pages = 2720–5 | date = July 2007 | pmid = 17440018 | doi = 10.1210/jc.2006-2280 }}</ref> and is involved in the [[unfolded protein response]].
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Activating transcription factor 6
| HGNCid = 791
| Symbol = ATF6
| AltSymbols =;
| OMIM = 605537
| ECnumber = 
| Homologene = 32015
| MGIid = 1926157
| GeneAtlas_image1 = PBB_GE_ATF6_203952_at_tn.png
| GeneAtlas_image2 = PBB_GE_ATF6_217550_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0006990 |text = unfolded protein response, positive regulation of target gene transcription}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22926
    | Hs_Ensembl = ENSG00000118217
    | Hs_RefseqProtein = NP_031374
    | Hs_RefseqmRNA = NM_007348
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 160002708
    | Hs_GenLoc_end = 160200484
    | Hs_Uniprot = P18850
    | Mm_EntrezGene = 226641
    | Mm_Ensembl = ENSMUSG00000026663
    | Mm_RefseqmRNA = XM_001001518
    | Mm_RefseqProtein = XP_001001518
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 172543889
    | Mm_GenLoc_end = 172704443
    | Mm_Uniprot =
  }}
}}
'''Activating transcription factor 6''', also known as '''ATF6''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ATF6 is an [[endoplasmic reticulum]] (ER) stress-regulated transmembrane [[transcription factor]] that activates the transcription of ER molecules.<ref name="entrez">{{cite web | title = Entrez Gene: ATF6 activating transcription factor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22926| accessdate = }}</ref> Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6.  The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.
{{PBB_Summary
| section_title =
| summary_text = ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ATF6 activating transcription factor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22926| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Activating transcription factor]]
* [[Activating transcription factor]]


==References==
== Interactions ==
{{reflist|2}}
ATF6 has been shown to [[Protein-protein interaction|interact]] with [[YY1]]<ref name="pmid10866666">{{cite journal | vauthors = Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS | title = ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1 | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5096–106 | year = 2000 | pmid = 10866666 | pmc = 85959 | doi = 10.1128/MCB.20.14.5096-5106.2000 }}</ref> and [[Serum response factor]].<ref name="pmid9271374" />


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hai T, Hartman MG | title = The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis | journal = Gene | volume = 273 | issue = 1 | pages = 1–11 | year = 2001 | pmid = 11483355 | doi = 10.1016/S0378-1119(01)00551-0 }}
| citations =
* {{cite journal | vauthors = Hai TW, Liu F, Coukos WJ, Green MR | title = Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers | journal = Genes Dev. | volume = 3 | issue = 12B | pages = 2083–90 | year = 1990 | pmid = 2516827 | doi = 10.1101/gad.3.12b.2083 }}
*{{cite journal | author=Hai T, Hartman MG |title=The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. |journal=Gene |volume=273 |issue= 1 |pages= 1-11 |year= 2001 |pmid= 11483355 |doi= }}
* {{cite journal | vauthors = Zhu C, Johansen FE, Prywes R | title = Interaction of ATF6 and serum response factor | journal = Mol. Cell. Biol. | volume = 17 | issue = 9 | pages = 4957–66 | year = 1997 | pmid = 9271374 | pmc = 232347 | doi =  }}
*{{cite journal | author=Hai TW, Liu F, Coukos WJ, Green MR |title=Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. |journal=Genes Dev. |volume=3 |issue= 12B |pages= 2083-90 |year= 1990 |pmid= 2516827 |doi= }}
* {{cite journal | vauthors = Yoshida H, Haze K, Yanagi H, Yura T, Mori K | title = Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 50 | pages = 33741–9 | year = 1999 | pmid = 9837962 | doi = 10.1074/jbc.273.50.33741 }}
*{{cite journal | author=Zhu C, Johansen FE, Prywes R |title=Interaction of ATF6 and serum response factor. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 4957-66 |year= 1997 |pmid= 9271374 |doi=  }}
* {{cite journal | vauthors = Haze K, Yoshida H, Yanagi H, Yura T, Mori K | title = Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress | journal = Mol. Biol. Cell | volume = 10 | issue = 11 | pages = 3787–99 | year = 1999 | pmid = 10564271 | pmc = 25679 | doi = 10.1091/mbc.10.11.3787 }}
*{{cite journal | author=Yoshida H, Haze K, Yanagi H, ''et al.'' |title=Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33741-9 |year= 1999 |pmid= 9837962 |doi= }}
* {{cite journal | vauthors = Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS | title = ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1 | journal = Mol. Cell. Biol. | volume = 20 | issue = 14 | pages = 5096–106 | year = 2000 | pmid = 10866666 | pmc = 85959 | doi = 10.1128/MCB.20.14.5096-5106.2000 }}
*{{cite journal | author=Haze K, Yoshida H, Yanagi H, ''et al.'' |title=Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3787-99 |year= 1999 |pmid= 10564271 |doi= }}
* {{cite journal | vauthors = Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K | title = Endoplasmic Reticulum Stress-Induced Formation of Transcription Factor Complex ERSF Including NF-Y (CBF) and Activating Transcription Factors 6α and 6β That Activates the Mammalian Unfolded Protein Response | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1239–48 | year = 2001 | pmid = 11158310 | pmc = 99577 | doi = 10.1128/MCB.21.4.1239-1248.2001 }}
*{{cite journal | author=Li M, Baumeister P, Roy B, ''et al.'' |title=ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5096-106 |year= 2000 |pmid= 10866666 |doi= }}
* {{cite journal | vauthors = Ye J, Rawson RB, Komuro R, Chen X, Davé UP, Prywes R, Brown MS, Goldstein JL | title = ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs | journal = Mol. Cell | volume = 6 | issue = 6 | pages = 1355–64 | year = 2001 | pmid = 11163209 | doi = 10.1016/S1097-2765(00)00133-7 }}
*{{cite journal  | author=Yoshida H, Okada T, Haze K, ''et al.'' |title=Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1239-48 |year= 2001 |pmid= 11158310 |doi= 10.1128/MCB.21.4.1239-1248.2001 }}
* {{cite journal | vauthors = Parker R, Phan T, Baumeister P, Roy B, Cheriyath V, Roy AL, Lee AS | title = Identification of TFII-I as the Endoplasmic Reticulum Stress Response Element Binding Factor ERSF: Its Autoregulation by Stress and Interaction with ATF6 | journal = Mol. Cell. Biol. | volume = 21 | issue = 9 | pages = 3220–33 | year = 2001 | pmid = 11287625 | pmc = 86961 | doi = 10.1128/MCB.21.9.3220-3233.2001 }}
*{{cite journal | author=Ye J, Rawson RB, Komuro R, ''et al.'' |title=ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1355-64 |year= 2001 |pmid= 11163209 |doi= }}
* {{cite journal | vauthors = Gotoh T, Oyadomari S, Mori K, Mori M | title = Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 12343–50 | year = 2002 | pmid = 11805088 | doi = 10.1074/jbc.M107988200 }}
*{{cite journal | author=Parker R, Phan T, Baumeister P, ''et al.'' |title=Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 3220-33 |year= 2001 |pmid= 11287625 |doi= 10.1128/MCB.21.9.3220-3233.2001 }}
* {{cite journal | vauthors = Chen X, Shen J, Prywes R | title = The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 13045–52 | year = 2002 | pmid = 11821395 | doi = 10.1074/jbc.M110636200 }}
*{{cite journal | author=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343-50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200 }}
* {{cite journal | vauthors = Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC | title = Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16 | journal = J. Biol. Chem. | volume = 277 | issue = 23 | pages = 20734–9 | year = 2002 | pmid = 11909875 | doi = 10.1074/jbc.M201749200 }}
*{{cite journal | author=Chen X, Shen J, Prywes R |title=The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13045-52 |year= 2002 |pmid= 11821395 |doi= 10.1074/jbc.M110636200 }}
* {{cite journal | vauthors = Okada T, Yoshida H, Akazawa R, Negishi M, Mori K | title = Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response | journal = Biochem. J. | volume = 366 | issue = Pt 2 | pages = 585–94 | year = 2002 | pmid = 12014989 | pmc = 1222788 | doi = 10.1042/BJ20020391 }}
*{{cite journal | author=Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC |title=Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20734-9 |year= 2002 |pmid= 11909875 |doi= 10.1074/jbc.M201749200 }}
* {{cite journal | vauthors = Luo S, Lee AS | title = Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation | journal = Biochem. J. | volume = 366 | issue = Pt 3 | pages = 787–95 | year = 2002 | pmid = 12076252 | pmc = 1222838 | doi = 10.1042/BJ20011802 }}
*{{cite journal | author=Okada T, Yoshida H, Akazawa R, ''et al.'' |title=Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. |journal=Biochem. J. |volume=366 |issue= Pt 2 |pages= 585-94 |year= 2002 |pmid= 12014989 |doi= 10.1042/BJ20020391 }}
* {{cite journal | vauthors = Tardif KD, Mori K, Siddiqui A | title = Hepatitis C Virus Subgenomic Replicons Induce Endoplasmic Reticulum Stress Activating an Intracellular Signaling Pathway | journal = J. Virol. | volume = 76 | issue = 15 | pages = 7453–9 | year = 2002 | pmid = 12097557 | pmc = 136367 | doi = 10.1128/JVI.76.15.7453-7459.2002 }}
*{{cite journal | author=Luo S, Lee AS |title=Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 787-95 |year= 2002 |pmid= 12076252 |doi= 10.1042/BJ20011802 }}
* {{cite journal | vauthors = Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M | title = Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis | journal = J. Hepatol. | volume = 38 | issue = 5 | pages = 605–14 | year = 2004 | pmid = 12713871 | doi = 10.1016/S0168-8278(03)00029-1 }}
*{{cite journal | author=Tardif KD, Mori K, Siddiqui A |title=Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. |journal=J. Virol. |volume=76 |issue= 15 |pages= 7453-9 |year= 2002 |pmid= 12097557 |doi= }}
* {{cite journal | vauthors = Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K | title = A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6 | journal = J. Biol. Chem. | volume = 278 | issue = 33 | pages = 31024–32 | year = 2003 | pmid = 12782636 | doi = 10.1074/jbc.M300923200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Newman JR, Keating AE | title = Comprehensive identification of human bZIP interactions with coiled-coil arrays | journal = Science | volume = 300 | issue = 5628 | pages = 2097–101 | year = 2003 | pmid = 12805554 | doi = 10.1126/science.1084648 }}
*{{cite journal | author=Shuda M, Kondoh N, Imazeki N, ''et al.'' |title=Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. |journal=J. Hepatol. |volume=38 |issue= 5 |pages= 605-14 |year= 2004 |pmid= 12713871 |doi=  }}
*{{cite journal  | author=Okada T, Haze K, Nadanaka S, ''et al.'' |title=A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31024-32 |year= 2003 |pmid= 12782636 |doi= 10.1074/jbc.M300923200 }}
*{{cite journal | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097-101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ATF6+protein,+human}}
* {{MeshName|ATF6+protein,+human}}
* {{UCSC gene info|ATF6}}


{{NLM content}}
{{NLM content}}
{{Transcription factors|g1}}
{{Regulome
| activates = [[XBP1]]
| inhibits =
| activated_by = stress
| inhibited_by =
}}
{{DEFAULTSORT:Atf6}}
[[Category:Transcription factors]]
{{gene-1-stub}}
{{gene-1-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 18:21, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in the unfolded protein response.

Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

Interactions

ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]

References

  1. ↑ Hai TW, Liu F, Coukos WJ, Green MR (December 1989). "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers". Genes Dev. 3 (12B): 2083–90. doi:10.1101/gad.3.12b.2083. PMID 2516827.
  2. ↑ 2.0 2.1 Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374.
  3. ↑ Meex SJ, van Greevenbroek MM, Ayoubi TA, Vlietinck R, van Vliet-Ostaptchouk JV, Hofker MH, Vermeulen VM, Schalkwijk CG, Feskens EJ, Boer JM, Stehouwer CD, van der Kallen CJ, de Bruin TW (July 2007). "Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians". J. Clin. Endocrinol. Metab. 92 (7): 2720–5. doi:10.1210/jc.2006-2280. PMID 17440018.
  4. ↑ "Entrez Gene: ATF6 activating transcription factor 6".
  5. ↑ Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (2000). "ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1". Mol. Cell. Biol. 20 (14): 5096–106. doi:10.1128/MCB.20.14.5096-5106.2000. PMC 85959. PMID 10866666.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Retrieved from "https://www.wikidoc.org/index.php?title=ATF6&oldid=1410823"