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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{For|the failed Formula One team|US F1 Team}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Upstream stimulatory factor 1''' is a [[protein]] that in humans is encoded by the ''USF1'' [[gene]].<ref name="pmid8486371">{{cite journal | vauthors = Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ | title = Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23 | journal = Genomics | volume = 16 | issue = 1 | pages = 266–8 | date = Apr 1993 | pmid = 8486371 | pmc =  | doi = 10.1006/geno.1993.1174 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USF1 upstream transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7391| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_USF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1an4.
| PDB = {{PDB2|1an4}}
| Name = Upstream transcription factor 1
| HGNCid = 12593
| Symbol = USF1
| AltSymbols =; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF
| OMIM = 191523
| ECnumber = 
| Homologene = 31426
| MGIid = 99542
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7391
    | Hs_Ensembl = ENSG00000158773
    | Hs_RefseqProtein = NP_009053
    | Hs_RefseqmRNA = NM_007122
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159275665
    | Hs_GenLoc_end = 159282391
    | Hs_Uniprot = P22415
    | Mm_EntrezGene = 22278
    | Mm_Ensembl = ENSMUSG00000026641
    | Mm_RefseqmRNA = NM_009480
    | Mm_RefseqProtein = NP_033506
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 173248059
    | Mm_GenLoc_end = 173254796
    | Mm_Uniprot = O09135
  }}
}}
'''Upstream transcription factor 1''', also known as '''USF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: USF1 upstream transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7391| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[basic helix-loop-helix]] [[leucine zipper]] family and can function as a cellular [[transcription factor]]. The encoded protein can activate transcription through pyrimidine-rich [[initiator element|initiator]] (Inr) elements and [[E-box]] motifs. This gene has been linked to [[combined hyperlipidemia|familial combined hyperlipidemia (FCHL)]]. Two transcript variants encoding distinct [[Protein isoform|isoforms]] have been identified for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: USF1 upstream transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7391| accessdate = }}</ref>
}}


==References==
A study of mice suggested reduced USF1 levels increases metabolism in [[brown fat]].<ref name="pmid26819196">{{cite journal | vauthors = Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M | display-authors = 6 | title = USF1 deficiency activates brown adipose tissue and improves cardiometabolic health | journal = Science Translational Medicine | volume = 8 | issue = 323 | pages = 323ra13 | year = 2016 | pmid = 26819196 | doi = 10.1126/scitranslmed.aad0015 }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
USF1 (human gene) has been shown to [[Protein-protein interaction|interact]] with [[USF2]],<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid8576131>{{cite journal | vauthors = Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A | title = Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms | journal = The Journal of Biological Chemistry | volume = 271 | issue = 3 | pages = 1405–15 | date = Jan 1996 | pmid = 8576131 | doi = 10.1074/jbc.271.3.1405 }}</ref> [[FOSL1]]<ref name=pmid9160889>{{cite journal | vauthors = Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H | title = Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity | journal = Oncogene | volume = 14 | issue = 17 | pages = 2091–8 | date = May 1997 | pmid = 9160889 | doi = 10.1038/sj.onc.1201046 }}</ref> and [[GTF2I]].<ref name=pmid9384587>{{cite journal | vauthors = Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG | title = Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1 | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 7091–104 | date = Dec 1997 | pmid = 9384587 | pmc = 1170311 | doi = 10.1093/emboj/16.23.7091 }}</ref><ref name=pmid1961251>{{cite journal | vauthors = Roy AL, Meisterernst M, Pognonec P, Roeder RG | title = Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF | journal = Nature | volume = 354 | issue = 6350 | pages = 245–8 | date = Nov 1991 | pmid = 1961251 | doi = 10.1038/354245a0 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Corre S, Galibert MD | title = [USF as a key regulatory element of gene expression] | journal = Médecine Sciences | volume = 22 | issue = 1 | pages = 62–7 | date = Jan 2006 | pmid = 16386222 | doi = 10.1051/medsci/200622162 }}
| citations =
* {{cite journal | vauthors = Lee JC, Lusis AJ, Pajukanta P | title = Familial combined hyperlipidemia: upstream transcription factor 1 and beyond | journal = Current Opinion in Lipidology | volume = 17 | issue = 2 | pages = 101–9 | date = Apr 2006 | pmid = 16531745 | doi = 10.1097/01.mol.0000217890.54875.13 }}
*{{cite journal | author=Corre S, Galibert MD |title=[USF as a key regulatory element of gene expression] |journal=Med Sci (Paris) |volume=22 |issue= 1 |pages= 62-7 |year= 2006 |pmid= 16386222 |doi= }}
* {{cite journal | vauthors = Roy AL, Meisterernst M, Pognonec P, Roeder RG | title = Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF | journal = Nature | volume = 354 | issue = 6350 | pages = 245–8 | date = Nov 1991 | pmid = 1961251 | doi = 10.1038/354245a0 }}
*{{cite journal | author=Lee JC, Lusis AJ, Pajukanta P |title=Familial combined hyperlipidemia: upstream transcription factor 1 and beyond. |journal=Curr. Opin. Lipidol. |volume=17 |issue= 2 |pages= 101-9 |year= 2007 |pmid= 16531745 |doi= 10.1097/01.mol.0000217890.54875.13 }}
* {{cite journal | vauthors = Gregor PD, Sawadogo M, Roeder RG | title = The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer | journal = Genes & Development | volume = 4 | issue = 10 | pages = 1730–40 | date = Oct 1990 | pmid = 2249772 | doi = 10.1101/gad.4.10.1730 }}
*{{cite journal | author=Roy AL, Meisterernst M, Pognonec P, Roeder RG |title=Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF. |journal=Nature |volume=354 |issue= 6350 |pages= 245-8 |year= 1992 |pmid= 1961251 |doi= 10.1038/354245a0 }}
* {{cite journal | vauthors = Henrion AA, Martinez A, Mattei MG, Kahn A, Raymondjean M | title = Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse | journal = Genomics | volume = 25 | issue = 1 | pages = 36–43 | date = Jan 1995 | pmid = 7774954 | doi = 10.1016/0888-7543(95)80107-W }}
*{{cite journal | author=Gregor PD, Sawadogo M, Roeder RG |title=The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. |journal=Genes Dev. |volume=4 |issue= 10 |pages= 1730-40 |year= 1991 |pmid= 2249772 |doi= }}
* {{cite journal | vauthors = Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK | title = Structure and function of the b/HLH/Z domain of USF | journal = The EMBO Journal | volume = 13 | issue = 1 | pages = 180–9 | date = Jan 1994 | pmid = 8306960 | pmc = 394791 | doi =  }}
*{{cite journal | author=Henrion AA, Martinez A, Mattei MG, ''et al.'' |title=Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse. |journal=Genomics |volume=25 |issue= 1 |pages= 36-43 |year= 1995 |pmid= 7774954 |doi= }}
* {{cite journal | vauthors = Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A | title = Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms | journal = The Journal of Biological Chemistry | volume = 271 | issue = 3 | pages = 1405–15 | date = Jan 1996 | pmid = 8576131 | doi = 10.1074/jbc.271.3.1405 }}
*{{cite journal | author=Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK |title=Structure and function of the b/HLH/Z domain of USF. |journal=EMBO J. |volume=13 |issue= 1 |pages= 180-9 |year= 1994 |pmid= 8306960 |doi=  }}
* {{cite journal | vauthors = Ghosh AK, Datta PK, Jacob ST | title = The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo | journal = Oncogene | volume = 14 | issue = 5 | pages = 589–94 | date = Feb 1997 | pmid = 9053857 | doi = 10.1038/sj.onc.1200866 }}
*{{cite journal | author=Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ |title=Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23. |journal=Genomics |volume=16 |issue= 1 |pages= 266-8 |year= 1993 |pmid= 8486371 |doi= 10.1006/geno.1993.1174 }}
* {{cite journal | vauthors = Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H | title = Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity | journal = Oncogene | volume = 14 | issue = 17 | pages = 2091–8 | date = May 1997 | pmid = 9160889 | doi = 10.1038/sj.onc.1201046 }}
*{{cite journal | author=Viollet B, Lefrançois-Martinez AM, Henrion A, ''et al.'' |title=Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1405-15 |year= 1996 |pmid= 8576131 |doi= }}
* {{cite journal | vauthors = Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG | title = Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1 | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 7091–104 | date = Dec 1997 | pmid = 9384587 | pmc = 1170311 | doi = 10.1093/emboj/16.23.7091 }}
*{{cite journal | author=Ghosh AK, Datta PK, Jacob ST |title=The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo. |journal=Oncogene |volume=14 |issue= 5 |pages= 589-94 |year= 1997 |pmid= 9053857 |doi= 10.1038/sj.onc.1200866 }}
* {{cite journal | vauthors = Pajukanta P, Nuotio I, Terwilliger JD, Porkka KV, Ylitalo K, Pihlajamäki J, Suomalainen AJ, Syvänen AC, Lehtimäki T, Viikari JS, Laakso M, Taskinen MR, Ehnholm C, Peltonen L | title = Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23 | journal = Nature Genetics | volume = 18 | issue = 4 | pages = 369–73 | date = Apr 1998 | pmid = 9537421 | doi = 10.1038/ng0498-369 }}
*{{cite journal | author=Pognonec P, Boulukos KE, Aperlo C, ''et al.'' |title=Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. |journal=Oncogene |volume=14 |issue= 17 |pages= 2091-8 |year= 1997 |pmid= 9160889 |doi= 10.1038/sj.onc.1201046 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Roy AL, Du H, Gregor PD, ''et al.'' |title=Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1. |journal=EMBO J. |volume=16 |issue= 23 |pages= 7091-104 |year= 1998 |pmid= 9384587 |doi= 10.1093/emboj/16.23.7091 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Pajukanta P, Nuotio I, Terwilliger JD, ''et al.'' |title=Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. |journal=Nat. Genet. |volume=18 |issue= 4 |pages= 369-73 |year= 1998 |pmid= 9537421 |doi= 10.1038/ng0498-369 }}
* {{cite journal | vauthors = Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G | title = Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2 | journal = The Biochemical Journal | volume = 365 | issue = Pt 2 | pages = 481–8 | date = Jul 2002 | pmid = 11945176 | pmc = 1222691 | doi = 10.1042/BJ20020223 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Villavicencio EH, Yoon JW, Frank DJ, Füchtbauer EM, Walterhouse DO, Iannaccone PM | title = Cooperative E-box regulation of human GLI1 by TWIST and USF | journal = Genesis | volume = 32 | issue = 4 | pages = 247–58 | date = Apr 2002 | pmid = 11948912 | doi = 10.1002/gene.10078 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Coulson JM, Edgson JL, Marshall-Jones ZV, Mulgrew R, Quinn JP, Woll PJ | title = Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 549–61 | date = Feb 2003 | pmid = 12403649 | pmc = 1223122 | doi = 10.1042/BJ20021176 }}
*{{cite journal | author=Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G |title=Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2. |journal=Biochem. J. |volume=365 |issue= Pt 2 |pages= 481-8 |year= 2002 |pmid= 11945176 |doi= 10.1042/BJ20020223 }}
* {{cite journal | vauthors = Salero E, Giménez C, Zafra F | title = Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene | journal = The Biochemical Journal | volume = 370 | issue = Pt 3 | pages = 979–86 | date = Mar 2003 | pmid = 12444925 | pmc = 1223214 | doi = 10.1042/BJ20021142 }}
*{{cite journal | author=Villavicencio EH, Yoon JW, Frank DJ, ''et al.'' |title=Cooperative E-box regulation of human GLI1 by TWIST and USF. |journal=Genesis |volume=32 |issue= 4 |pages= 247-58 |year= 2002 |pmid= 11948912 |doi= }}
* {{cite journal | vauthors = Pickwell GV, Shih H, Quattrochi LC | title = Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation | journal = Biochemical Pharmacology | volume = 65 | issue = 7 | pages = 1087–96 | date = Apr 2003 | pmid = 12663044 | doi = 10.1016/S0006-2952(03)00037-6 }}
*{{cite journal | author=Coulson JM, Edgson JL, Marshall-Jones ZV, ''et al.'' |title=Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 549-61 |year= 2003 |pmid= 12403649 |doi= 10.1042/BJ20021176 }}
*{{cite journal | author=Salero E, Giménez C, Zafra F |title=Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene. |journal=Biochem. J. |volume=370 |issue= Pt 3 |pages= 979-86 |year= 2003 |pmid= 12444925 |doi= 10.1042/BJ20021142 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Pickwell GV, Shih H, Quattrochi LC |title=Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation. |journal=Biochem. Pharmacol. |volume=65 |issue= 7 |pages= 1087-96 |year= 2003 |pmid= 12663044 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{Transcription factors}}
* {{FactorBook|USF1}}
{{PDB Gallery|geneid=7391}}
 
{{Transcription factors|g1}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 10:01, 17 September 2017

For the failed Formula One team, see US F1 Team.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Upstream stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene.[1][2]

Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

A study of mice suggested reduced USF1 levels increases metabolism in brown fat.[3]

Interactions

USF1 (human gene) has been shown to interact with USF2,[4][5] FOSL1[6] and GTF2I.[7][8]

References

  1. ↑ Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (Apr 1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.
  2. ↑ 2.0 2.1 "Entrez Gene: USF1 upstream transcription factor 1".
  3. ↑ Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al. (2016). "USF1 deficiency activates brown adipose tissue and improves cardiometabolic health". Science Translational Medicine. 8 (323): 323ra13. doi:10.1126/scitranslmed.aad0015. PMID 26819196.
  4. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Viollet B, Lefrançois-Martinez AM, Henrion A, Kahn A, Raymondjean M, Martinez A (Jan 1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". The Journal of Biological Chemistry. 271 (3): 1405–15. doi:10.1074/jbc.271.3.1405. PMID 8576131.
  6. ↑ Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
  7. ↑ Roy AL, Du H, Gregor PD, Novina CD, Martinez E, Roeder RG (Dec 1997). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". The EMBO Journal. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMC 1170311. PMID 9384587.
  8. ↑ Roy AL, Meisterernst M, Pognonec P, Roeder RG (Nov 1991). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=USF1&oldid=1410978"