ELK4: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ETS domain-containing protein Elk-4''' is a [[protein]] that in humans is encoded by the ''ELK4'' [[gene]].<ref name="pmid7851904">{{cite journal | vauthors = Shipley J, Sheer D, Dalton S, Treisman R, Patel K | title = Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively | journal = Genomics | volume = 23 | issue = 3 | pages = 710–1 | date = Mar 1995 | pmid = 7851904 | pmc =  | doi = 10.1006/geno.1994.1564 }}</ref><ref name="pmid8575773">{{cite journal | vauthors = Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B | title = Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes | journal = Genomics | volume = 29 | issue = 3 | pages = 769–72 | date = Mar 1996 | pmid = 8575773 | pmc = | doi = 10.1006/geno.1995.9938 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ELK4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bc7.
| PDB = {{PDB2|1bc7}}, {{PDB2|1bc8}}, {{PDB2|1hbx}}, {{PDB2|1k6o}}
| Name = ELK4, ETS-domain protein (SRF accessory protein 1)
| HGNCid = 3326
| Symbol = ELK4
| AltSymbols =; SAP1
| OMIM = 600246
| ECnumber = 
| Homologene = 1492
| MGIid = 102853
| GeneAtlas_image1 = PBB_GE_ELK4_206919_at_tn.png
| GeneAtlas_image2 = PBB_GE_ELK4_205994_at_tn.png
| GeneAtlas_image3 = PBB_GE_ELK4_214831_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2005
    | Hs_Ensembl = ENSG00000158711
    | Hs_RefseqProtein = NP_001964
    | Hs_RefseqmRNA = NM_001973
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 203833330
    | Hs_GenLoc_end = 203868623
    | Hs_Uniprot = P28324
    | Mm_EntrezGene = 13714
    | Mm_Ensembl = ENSMUSG00000026436
    | Mm_RefseqmRNA = NM_007923
    | Mm_RefseqProtein = NP_031949
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 133835422
    | Mm_GenLoc_end = 133860151
    | Mm_Uniprot = Q8C6Q0
  }}
}}
'''ELK4, ETS-domain protein (SRF accessory protein 1)''', also known as '''ELK4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[ETS transcription factor family|Ets family of transcription factors]] and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2005| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ELK4 has been shown to [[Protein-protein interaction|interact]] with:
* [[BRCA1]],<ref name = pmid11313879>{{cite journal | vauthors = Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN | title = c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells | journal = Oncogene | volume = 20 | issue = 11 | pages = 1357–67 | date = Mar 2001 | pmid = 11313879 | doi = 10.1038/sj.onc.1204256 }}</ref> and
* [[Serum response factor]]<ref name = pmid11406578>{{cite journal | vauthors = Hassler M, Richmond TJ | title = The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex | journal = EMBO J. | volume = 20 | issue = 12 | pages = 3018–28 | date = Jun 2001 | pmid = 11406578 | pmc = 150215 | doi = 10.1093/emboj/20.12.3018 }}</ref><ref name = pmid9271374>{{cite journal | vauthors = Zhu C, Johansen FE, Prywes R | title = Interaction of ATF6 and serum response factor | journal = Mol. Cell. Biol. | volume = 17 | issue = 9 | pages = 4957–66 | date = Sep 1997 | pmid = 9271374 | pmc = 232347 | doi =  }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sharrocks AD, Brown AL, Ling Y, Yates PR | title = The ETS-domain transcription factor family | journal = Int. J. Biochem. Cell Biol. | volume = 29 | issue = 12 | pages = 1371–87 | year = 1998 | pmid = 9570133 | doi = 10.1016/S1357-2725(97)00086-1 }}
| citations =
* {{cite journal | vauthors = Wasylyk B, Hagman J, Gutierrez-Hartmann A | title = Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway | journal = Trends Biochem. Sci. | volume = 23 | issue = 6 | pages = 213–6 | year = 1998 | pmid = 9644975 | doi = 10.1016/S0968-0004(98)01211-0 }}
*{{cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371-87 |year= 1998 |pmid= 9570133 |doi= }}
* {{cite journal | vauthors = Dalton S, Treisman R | title = Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element | journal = Cell | volume = 68 | issue = 3 | pages = 597–612 | year = 1992 | pmid = 1339307 | doi = 10.1016/0092-8674(92)90194-H }}
*{{cite journal | author=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213-6 |year= 1998 |pmid= 9644975 |doi= }}
* {{cite journal | vauthors = Price MA, Rogers AE, Treisman R | title = Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET) | journal = EMBO J. | volume = 14 | issue = 11 | pages = 2589–601 | year = 1995 | pmid = 7540136 | pmc = 398373 | doi =  }}
*{{cite journal | author=Dalton S, Treisman R |title=Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. |journal=Cell |volume=68 |issue= 3 |pages= 597-612 |year= 1992 |pmid= 1339307 |doi= }}
* {{cite journal | vauthors = Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O | title = Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence | journal = Nature | volume = 377 | issue = 6547 Suppl | pages = 3–174 | year = 1995 | pmid = 7566098 | doi = <!-- none available --> | url = http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format = PDF }}
*{{cite journal | author=Price MA, Rogers AE, Treisman R |title=Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). |journal=EMBO J. |volume=14 |issue= 11 |pages= 2589-601 |year= 1995 |pmid= 7540136 |doi=  }}
* {{cite journal | vauthors = Dalton S, Treisman R | title = Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element | journal = Cell | volume = 76 | issue = 2 | pages = 411 | year = 1994 | pmid = 8293474 | doi = <!--none--> | url = http://download.cell.com/pdf/PII0092867494903476.pdf | format = PDF }}
*{{cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi= }}
* {{cite journal | vauthors = Janknecht R, Hunter T | title = Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase | journal = J. Biol. Chem. | volume = 272 | issue = 7 | pages = 4219–24 | year = 1997 | pmid = 9020136 | doi = 10.1074/jbc.272.7.4219 }}
*{{cite journal  | author=Shipley J, Sheer D, Dalton S, ''et al.'' |title=Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. |journal=Genomics |volume=23 |issue= 3 |pages= 710-1 |year= 1995 |pmid= 7851904 |doi= 10.1006/geno.1994.1564 }}
* {{cite journal | vauthors = Janknecht R, Hunter T | title = Convergence of MAP kinase pathways on the ternary complex factor Sap-1a | journal = EMBO J. | volume = 16 | issue = 7 | pages = 1620–7 | year = 1997 | pmid = 9130707 | pmc = 1169766 | doi = 10.1093/emboj/16.7.1620 }}
*{{cite journal | author=Dalton S, Treisman R |title=Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. |journal=Cell |volume=76 |issue= 2 |pages= 411 |year= 1994 |pmid= 8293474 |doi= }}
* {{cite journal | vauthors = Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS | title = p38-2, a novel mitogen-activated protein kinase with distinct properties | journal = J. Biol. Chem. | volume = 272 | issue = 31 | pages = 19509–17 | year = 1997 | pmid = 9235954 | doi = 10.1074/jbc.272.31.19509 }}
*{{cite journal  | author=Giovane A, Sobieszczuk P, Mignon C, ''et al.'' |title=Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. |journal=Genomics |volume=29 |issue= 3 |pages= 769-72 |year= 1996 |pmid= 8575773 |doi= 10.1006/geno.1995.9938 }}
* {{cite journal | vauthors = Mo Y, Vaessen B, Johnston K, Marmorstein R | title = Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins | journal = Mol. Cell | volume = 2 | issue = 2 | pages = 201–12 | year = 1998 | pmid = 9734357 | doi = 10.1016/S1097-2765(00)80130-6 }}
*{{cite journal | author=Janknecht R, Hunter T |title=Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4219-24 |year= 1997 |pmid= 9020136 |doi= }}
* {{cite journal | vauthors = Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD | title = Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors | journal = EMBO J. | volume = 18 | issue = 4 | pages = 968–76 | year = 1999 | pmid = 10022839 | pmc = 1171189 | doi = 10.1093/emboj/18.4.968 }}
*{{cite journal | author=Janknecht R, Hunter T |title=Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. |journal=EMBO J. |volume=16 |issue= 7 |pages= 1620-7 |year= 1997 |pmid= 9130707 |doi= 10.1093/emboj/16.7.1620 }}
* {{cite journal | vauthors = Kamakura S, Moriguchi T, Nishida E | title = Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus | journal = J. Biol. Chem. | volume = 274 | issue = 37 | pages = 26563–71 | year = 1999 | pmid = 10473620 | doi = 10.1074/jbc.274.37.26563 }}
*{{cite journal | author=Stein B, Yang MX, Young DB, ''et al.'' |title=p38-2, a novel mitogen-activated protein kinase with distinct properties. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19509-17 |year= 1997 |pmid= 9235954 |doi= }}
* {{cite journal | vauthors = Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN | title = c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells | journal = Oncogene | volume = 20 | issue = 11 | pages = 1357–67 | year = 2001 | pmid = 11313879 | doi = 10.1038/sj.onc.1204256 }}
*{{cite journal | author=Mo Y, Vaessen B, Johnston K, Marmorstein R |title=Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins. |journal=Mol. Cell |volume=2 |issue= 2 |pages= 201-12 |year= 1998 |pmid= 9734357 |doi= }}
* {{cite journal | vauthors = Hassler M, Richmond TJ | title = The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex | journal = EMBO J. | volume = 20 | issue = 12 | pages = 3018–28 | year = 2001 | pmid = 11406578 | pmc = 150215 | doi = 10.1093/emboj/20.12.3018 }}
*{{cite journal | author=Yates PR, Atherton GT, Deed RW, ''et al.'' |title=Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. |journal=EMBO J. |volume=18 |issue= 4 |pages= 968-76 |year= 1999 |pmid= 10022839 |doi= 10.1093/emboj/18.4.968 }}
* {{cite journal | vauthors = Mo Y, Ho W, Johnston K, Marmorstein R | title = Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex | journal = J. Mol. Biol. | volume = 314 | issue = 3 | pages = 495–506 | year = 2002 | pmid = 11846562 | doi = 10.1006/jmbi.2001.5138 }}
*{{cite journal | author=Kamakura S, Moriguchi T, Nishida E |title=Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26563-71 |year= 1999 |pmid= 10473620 |doi= }}
*{{cite journal | author=Chai Y, Chipitsyna G, Cui J, ''et al.'' |title=c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. |journal=Oncogene |volume=20 |issue= 11 |pages= 1357-67 |year= 2001 |pmid= 11313879 |doi= 10.1038/sj.onc.1204256 }}
*{{cite journal | author=Hassler M, Richmond TJ |title=The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3018-28 |year= 2001 |pmid= 11406578 |doi= 10.1093/emboj/20.12.3018 }}
*{{cite journal | author=Mo Y, Ho W, Johnston K, Marmorstein R |title=Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. |journal=J. Mol. Biol. |volume=314 |issue= 3 |pages= 495-506 |year= 2002 |pmid= 11846562 |doi= 10.1006/jmbi.2001.5138 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ELK4+protein,+human}}
* {{MeshName|ELK4+protein,+human}}
* {{FactorBook|ELK4}}


{{PDB Gallery|geneid=2005}}
{{Transcription factors|g3}}
{{NLM content}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 00:27, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.[1][2][3]

Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.[3]

Interactions

ELK4 has been shown to interact with:

References

  1. ↑ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
  2. ↑ Giovane A, Sobieszczuk P, Mignon C, Mattei MG, Wasylyk B (Mar 1996). "Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes". Genomics. 29 (3): 769–72. doi:10.1006/geno.1995.9938. PMID 8575773.
  3. ↑ 3.0 3.1 "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)".
  4. ↑ Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN (Mar 2001). "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene. 20 (11): 1357–67. doi:10.1038/sj.onc.1204256. PMID 11313879.
  5. ↑ Hassler M, Richmond TJ (Jun 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
  6. ↑ Zhu C, Johansen FE, Prywes R (Sep 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. PMC 232347. PMID 9271374.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=ELK4&oldid=1411227"