FOSL2: Difference between revisions

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Revision as of 04:53, 31 August 2017

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.^[1]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: FOSL2 FOS-like antigen 2".

Matsui M, Tokuhara M, Konuma Y, et al. (1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490.
Molven A, Houge G, Berger R (1997). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23". Genomics. 38 (1): 72–5. doi:10.1006/geno.1996.0593. PMID 8954781.
Outinen PA, Sood SK, Pfeifer SI, et al. (1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood. 94 (3): 959–67. PMID 10419887.
Miyamoto NG, Medberry PS, Hesselgesser J, et al. (2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors". J. Neuroimmunol. 105 (1): 78–90. doi:10.1016/S0165-5728(00)00195-8. PMID 10713367.
Ng DC, Shafaee S, Lee D, Bikle DD (2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter". J. Biol. Chem. 275 (31): 24080–8. doi:10.1074/jbc.M002508200. PMID 10816578.
Bamberger AM, Milde-Langosch K, Rössing E, et al. (2001). "Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators". J. Cancer Res. Clin. Oncol. 127 (9): 545–50. doi:10.1007/s004320100255. PMID 11570575.
Udalova IA, Kwiatkowski D (2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region". Biochem. Biophys. Res. Commun. 289 (1): 25–33. doi:10.1006/bbrc.2001.5929. PMID 11708771.
Benkoussa M, Brand C, Delmotte MH, et al. (2002). "Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter". Mol. Cell. Biol. 22 (13): 4522–34. doi:10.1128/MCB.22.13.4522-4534.2002. PMC 133906. PMID 12052862.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Santalucía T, Christmann M, Yacoub MH, Brand NJ (2004). "Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1". Cardiovasc. Res. 59 (3): 639–48. doi:10.1016/S0008-6363(03)00472-3. PMID 14499865.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

FOSL2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
FactorBook FOSL2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: FOSL2 FOS-like antigen 2".

[1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Fos-related antigen 2''' (FRA2) is a [[protein]] that in humans is encoded by the ''FOSL2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = FOS-like antigen 2
- | HGNCid = 3798
- | Symbol = FOSL2
- | AltSymbols =; FLJ23306; FRA2
- | OMIM = 601575
- | ECnumber =
- | Homologene = 3845
- | MGIid = 102858
- | GeneAtlas_image1 = PBB_GE_FOSL2_205409_at_tn.png
- | GeneAtlas_image2 = PBB_GE_FOSL2_218880_at_tn.png
- | GeneAtlas_image3 = PBB_GE_FOSL2_218881_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008219 |text = cell death}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2355
-    | Hs_Ensembl = ENSG00000075426
-    | Hs_RefseqProtein = NP_005244
-    | Hs_RefseqmRNA = NM_005253
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 28469173
-    | Hs_GenLoc_end = 28493683
-    | Hs_Uniprot = P15408
-    | Mm_EntrezGene = 14284
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = NM_008037
-    | Mm_RefseqProtein = NP_032063
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''FOS-like antigen 2''', also known as '''FOSL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+==Function==
-{{PBB_Summary
+The Fos gene family consists of 4 members: [[c-Fos]], [[FOSB]], [[FOSL1]], and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
-| section_title =
-| summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.<ref name="entrez">{{cite web | title = Entrez Gene: FOSL2 FOS-like antigen 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2355| accessdate = }}</ref>
-}}
 ==See also==
@@ Line 60: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 66: / Line 15: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Matsui M, Tokuhara M, Konuma Y, ''et al.'' |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249-55 |year= 1990 |pmid= 2107490 |doi=  }}
+*{{cite journal  |vauthors=Matsui M, Tokuhara M, Konuma Y |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249–55 |year= 1990 |pmid= 2107490 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72-5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593 }}
+*{{cite journal  |vauthors=Molven A, Houge G, Berger R |title=Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23. |journal=Genomics |volume=38 |issue= 1 |pages= 72–5 |year= 1997 |pmid= 8954781 |doi= 10.1006/geno.1996.0593 }}
-*{{cite journal  | author=Outinen PA, Sood SK, Pfeifer SI, ''et al.'' |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959-67 |year= 1999 |pmid= 10419887 |doi=  }}
+*{{cite journal  |vauthors=Outinen PA, Sood SK, Pfeifer SI |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Miyamoto NG, Medberry PS, Hesselgesser J, ''et al.'' |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78-90 |year= 2000 |pmid= 10713367 |doi=  }}
+*{{cite journal  |vauthors=Miyamoto NG, Medberry PS, Hesselgesser J |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78–90 |year= 2000 |pmid= 10713367 |doi=10.1016/S0165-5728(00)00195-8  |display-authors=etal}}
-*{{cite journal  | author=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080-8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200 }}
+*{{cite journal  |vauthors=Ng DC, Shafaee S, Lee D, Bikle DD |title=Requirement of an AP-1 site in the calcium response region of the involucrin promoter. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24080–8 |year= 2000 |pmid= 10816578 |doi= 10.1074/jbc.M002508200 }}
-*{{cite journal  | author=Bamberger AM, Milde-Langosch K, Rössing E, ''et al.'' |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545-50 |year= 2001 |pmid= 11570575 |doi=  }}
+*{{cite journal  |vauthors=Bamberger AM, Milde-Langosch K, Rössing E |title=Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators. |journal=J. Cancer Res. Clin. Oncol. |volume=127 |issue= 9 |pages= 545–50 |year= 2001 |pmid= 11570575 |doi=10.1007/s004320100255  |display-authors=etal}}
-*{{cite journal  | author=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25-33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
+*{{cite journal  |vauthors=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25–33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929 }}
-*{{cite journal  | author=Benkoussa M, Brand C, Delmotte MH, ''et al.'' |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522-34 |year= 2002 |pmid= 12052862 |doi=  }}
+*{{cite journal  |vauthors=Benkoussa M, Brand C, Delmotte MH |title=Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter. |journal=Mol. Cell. Biol. |volume=22 |issue= 13 |pages= 4522–34 |year= 2002 |pmid= 12052862 |doi=10.1128/MCB.22.13.4522-4534.2002  | pmc=133906  |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639-48 |year= 2004 |pmid= 14499865 |doi=  }}
+*{{cite journal  |vauthors=Santalucía T, Christmann M, Yacoub MH, Brand NJ |title=Hypertrophic agonists induce the binding of c-Fos to an AP-1 site in cardiac myocytes: implications for the expression of GLUT1. |journal=Cardiovasc. Res. |volume=59 |issue= 3 |pages= 639–48 |year= 2004 |pmid= 14499865 |doi=10.1016/S0008-6363(03)00472-3  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
+*{{cite journal  |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal  |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
 }}
 {{refend}}
@@ Line 86: / Line 35: @@
 == External links ==
 * {{MeshName|FOSL2+protein,+human}}
+* {{FactorBook|FOSL2}}
+{{NLM content}}
+{{Transcription factors|g1}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{NLM content}}
-{{protein-stub}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-2-stub}}

FOSL2: Difference between revisions

Revision as of 04:53, 31 August 2017

Contents

Function

See also

References

Further reading

External links

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