Pituitary-specific positive transcription factor 1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)''', also known as '''POU1F1''', is a [[transcription factor]] for [[growth hormone]].<ref name="ncbi">{{cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_POU1F1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1au7.
| PDB = {{PDB2|1au7}}
| Name = POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
| HGNCid = 9210
| Symbol = POU1F1
| AltSymbols =; GHF-1; PIT1; Pit-1; Pit-1 beta
| OMIM = 173110
| ECnumber = 
| Homologene = 259
| MGIid = 97588
| GeneAtlas_image1 = PBB_GE_POU1F1_207846_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5449
    | Hs_Ensembl = ENSG00000064835
    | Hs_RefseqProtein = NP_000297
    | Hs_RefseqmRNA = NM_000306
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 87391473
    | Hs_GenLoc_end = 87408427
    | Hs_Uniprot = P28069
    | Mm_EntrezGene = 18736
    | Mm_Ensembl = ENSMUSG00000004842
    | Mm_RefseqmRNA = NM_008849
    | Mm_RefseqProtein = NP_032875
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 65438862
    | Mm_GenLoc_end = 65453881
    | Mm_Uniprot = Q62089
  }}
}}
'''POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)''', also known as '''POU1F1''', is a [[transcription factor]] for [[growth hormone]].<ref>{{cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding [[growth hormone]] (GH; MIM 139250) and [[prolactin]] (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and [[thyroid-stimulating hormone]] beta subunit (TSHB; MIM 188540) by [[thyrotropin-releasing hormone]] (TRH; MIM 257120) and [[cyclic AMP]].[supplied by OMIM]<ref name="ncbi" />
{{PBB_Summary
| section_title =
| summary_text = PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5449| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Pituitary-specific positive transcription factor 1 has been shown to [[Protein-protein interaction|interact]] with [[GATA2]]<ref name=pmid10367888>{{cite journal | vauthors = Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG | title = Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types | language =  | journal = Cell | volume = 97 | issue = 5 | pages = 587–98 | date = May 1999 | pmid = 10367888 | doi = 10.1016/S0092-8674(00)80770-9 }}</ref> and [[PITX1]].<ref name=pmid8755540>{{cite journal | vauthors = Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG | title = P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development | language =  | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 93 | issue = 15 | pages = 7706–10 | date = July 1996 | pmid = 8755540 | pmc = 38811 | doi = 10.1073/pnas.93.15.7706  }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Parks JS, Brown MR | title = Transcription factors regulating pituitary development | journal = Growth Horm. IGF Res. | volume = 9 Suppl B | issue =  | pages = 2–8; discussion 8–11 | year = 1999 | pmid = 10549299 | doi = 10.1016/S1096-6374(99)80074-4 }}
| citations =
* {{cite journal | vauthors = Rodriguez R, Andersen B | title = Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency | journal = Minerva Endocrinol. | volume = 28 | issue = 2 | pages = 123–33 | year = 2003 | pmid = 12717343 | doi =  }}
*{{cite journal | author=Parks JS, Brown MR |title=Transcription factors regulating pituitary development. |journal=Growth Horm. IGF Res. |volume=9 Suppl B |issue=  |pages= 2-8; discussion 8-11 |year= 1999 |pmid= 10549299 |doi= }}
* {{cite journal | vauthors = Quentien MH, Barlier A, Franc JL, Pellegrini I, Brue T, Enjalbert A | title = Pituitary transcription factors: from congenital deficiencies to gene therapy | journal = J. Neuroendocrinol. | volume = 18 | issue = 9 | pages = 633–42 | year = 2006 | pmid = 16879162 | doi = 10.1111/j.1365-2826.2006.01461.x }}
*{{cite journal | author=Rodriguez R, Andersen B |title=Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency. |journal=Minerva Endocrinol. |volume=28 |issue= 2 |pages= 123-33 |year= 2003 |pmid= 12717343 |doi=  }}
* {{cite journal | vauthors = Cattini PA, Yang X, Jin Y, Detillieux KA | title = Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression | journal = Neuroendocrinology | volume = 83 | issue = 3–4 | pages = 145–53 | year = 2006 | pmid = 17047377 | doi = 10.1159/000095522 }}
*{{cite journal | author=Quentien MH, Barlier A, Franc JL, ''et al.'' |title=Pituitary transcription factors: from congenital deficiencies to gene therapy. |journal=J. Neuroendocrinol. |volume=18 |issue= 9 |pages= 633-42 |year= 2006 |pmid= 16879162 |doi= 10.1111/j.1365-2826.2006.01461.x }}
* {{cite journal | vauthors = Li X, Giachelli CM | title = Sodium-dependent phosphate cotransporters and vascular calcification | journal = Curr. Opin. Nephrol. Hypertens. | volume = 16 | issue = 4 | pages = 325–8 | year = 2007 | pmid = 17565274 | doi = 10.1097/MNH.0b013e3281c55ef1 }}
*{{cite journal | author=Cattini PA, Yang X, Jin Y, Detillieux KA |title=Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 145-53 |year= 2006 |pmid= 17047377 |doi= 10.1159/000095522 }}
* {{cite journal | vauthors = Tatsumi K, Miyai K, Notomi T, Kaibe K, Amino N, Mizuno Y, Kohno H | title = Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene | journal = Nat. Genet. | volume = 1 | issue = 1 | pages = 56–8 | year = 1993 | pmid = 1302000 | doi = 10.1038/ng0492-56 }}
*{{cite journal | author=Li X, Giachelli CM |title=Sodium-dependent phosphate cotransporters and vascular calcification. |journal=Curr. Opin. Nephrol. Hypertens. |volume=16 |issue= 4 |pages= 325-8 |year= 2007 |pmid= 17565274 |doi= 10.1097/MNH.0b013e3281c55ef1 }}
* {{cite journal | vauthors = Tatsumi K, Notomi T, Amino N, Miyai K | title = Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1 | journal = Biochim. Biophys. Acta | volume = 1129 | issue = 2 | pages = 231–4 | year = 1992 | pmid = 1370379 | doi = 10.1016/0167-4781(92)90494-k }}
*{{cite journal | author=Tatsumi K, Miyai K, Notomi T, ''et al.'' |title=Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene. |journal=Nat. Genet. |volume=1 |issue= 1 |pages= 56-8 |year= 1993 |pmid= 1302000 |doi= 10.1038/ng0492-56 }}
* {{cite journal | vauthors = Ohta K, Nobukuni Y, Mitsubuchi H, Fujimoto S, Matsuo N, Inagaki H, Endo F, Matsuda I | title = Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency | journal = Biochem. Biophys. Res. Commun. | volume = 189 | issue = 2 | pages = 851–5 | year = 1993 | pmid = 1472057 | doi = 10.1016/0006-291X(92)92281-2 }}
*{{cite journal | author=Tatsumi K, Notomi T, Amino N, Miyai K |title=Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1. |journal=Biochim. Biophys. Acta |volume=1129 |issue= 2 |pages= 231-4 |year= 1992 |pmid= 1370379 |doi= }}
* {{cite journal | vauthors = Ohta K, Nobukuni Y, Mitsubuchi H, Ohta T, Tohma T, Jinno Y, Endo F, Matsuda I | title = Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1 | journal = Gene | volume = 122 | issue = 2 | pages = 387–8 | year = 1993 | pmid = 1487156 | doi = 10.1016/0378-1119(92)90234-G }}
*{{cite journal | author=Ohta K, Nobukuni Y, Mitsubuchi H, ''et al.'' |title=Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 2 |pages= 851-5 |year= 1993 |pmid= 1472057 |doi= }}
* {{cite journal | vauthors = Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE | title = A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency | journal = Science | volume = 257 | issue = 5073 | pages = 1115–8 | year = 1992 | pmid = 1509262 | doi = 10.1126/science.257.5073.1115 }}
*{{cite journal | author=Ohta K, Nobukuni Y, Mitsubuchi H, ''et al.'' |title=Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1. |journal=Gene |volume=122 |issue= 2 |pages= 387-8 |year= 1993 |pmid= 1487156 |doi= }}
* {{cite journal | vauthors = Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA | title = Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia | journal = Science | volume = 257 | issue = 5073 | pages = 1118–21 | year = 1992 | pmid = 1509263 | doi = 10.1126/science.257.5073.1118 }}
*{{cite journal | author=Radovick S, Nations M, Du Y, ''et al.'' |title=A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency. |journal=Science |volume=257 |issue= 5073 |pages= 1115-8 |year= 1992 |pmid= 1509262 |doi= }}
* {{cite journal | vauthors = Lew AM, Elsholtz HP | title = Cloning of the human cDNA for transcription factor Pit-1 | journal = Nucleic Acids Res. | volume = 19 | issue = 22 | pages = 6329 | year = 1991 | pmid = 1956794 | pmc = 329149 | doi = 10.1093/nar/19.22.6329 }}
*{{cite journal | author=Pfäffle RW, DiMattia GE, Parks JS, ''et al.'' |title=Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. |journal=Science |volume=257 |issue= 5073 |pages= 1118-21 |year= 1992 |pmid= 1509263 |doi= }}
* {{cite journal | vauthors = He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG | title = Expression of a large family of POU-domain regulatory genes in mammalian brain development | journal = Nature | volume = 340 | issue = 6228 | pages = 35–41 | year = 1989 | pmid = 2739723 | doi = 10.1038/340035a0 }}
*{{cite journal |author=Lew AM, Elsholtz HP |title=Cloning of the human cDNA for transcription factor Pit-1. |journal=Nucleic Acids Res. |volume=19 |issue= 22 |pages= 6329 |year= 1991 |pmid= 1956794 |doi= }}
* {{cite journal | vauthors = Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M | title = The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein | journal = Cell | volume = 55 | issue = 3 | pages = 505–18 | year = 1988 | pmid = 2902927 | doi = 10.1016/0092-8674(88)90037-2 }}
*{{cite journal | author=He X, Treacy MN, Simmons DM, ''et al.'' |title=Expression of a large family of POU-domain regulatory genes in mammalian brain development. |journal=Nature |volume=340 |issue= 6228 |pages= 35-41 |year= 1989 |pmid= 2739723 |doi= 10.1038/340035a0 }}
* {{cite journal | vauthors = Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G | title = The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products | journal = Genes Dev. | volume = 2 | issue = 12A | pages = 1513–6 | year = 1989 | pmid = 3215510 | doi = 10.1101/gad.2.12a.1513 }}
*{{cite journal | author=Bodner M, Castrillo JL, Theill LE, ''et al.'' |title=The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. |journal=Cell |volume=55 |issue= 3 |pages= 505-18 |year= 1988 |pmid= 2902927 |doi= }}
* {{cite journal | vauthors = de Zegher F, Pernasetti F, Vanhole C, Devlieger H, Van den Berghe G, Martial JA | title = The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency | journal = J. Clin. Endocrinol. Metab. | volume = 80 | issue = 11 | pages = 3127–30 | year = 1995 | pmid = 7593413 | doi = 10.1210/jc.80.11.3127 }}
*{{cite journal | author=Herr W, Sturm RA, Clerc RG, ''et al.'' |title=The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. |journal=Genes Dev. |volume=2 |issue= 12A |pages= 1513-6 |year= 1989 |pmid= 3215510 |doi= }}
* {{cite journal | vauthors = Bamberger AM, Bamberger CM, Pu LP, Puy LA, Loh YP, Asa SL | title = Expression of pit-1 messenger ribonucleic acid and protein in the human placenta | journal = J. Clin. Endocrinol. Metab. | volume = 80 | issue = 7 | pages = 2021–6 | year = 1995 | pmid = 7608249 | doi = 10.1210/jc.80.7.2021 }}
*{{cite journal | author=de Zegher F, Pernasetti F, Vanhole C, ''et al.'' |title=The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 11 |pages= 3127-30 |year= 1995 |pmid= 7593413 |doi= }}
* {{cite journal | vauthors = Irie Y, Tatsumi K, Ogawa M, Kamijo T, Preeyasombat C, Suprasongsin C, Amino N | title = A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency | journal = Endocr. J. | volume = 42 | issue = 3 | pages = 351–4 | year = 1995 | pmid = 7670563 | doi = 10.1507/endocrj.42.351 }}
*{{cite journal | author=Bamberger AM, Bamberger CM, Pu LP, ''et al.'' |title=Expression of pit-1 messenger ribonucleic acid and protein in the human placenta. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 7 |pages= 2021-6 |year= 1995 |pmid= 7608249 |doi= }}
* {{cite journal | vauthors = Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL | title = A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene | journal = Gene | volume = 155 | issue = 2 | pages = 273–5 | year = 1995 | pmid = 7721104 | doi = 10.1016/0378-1119(94)00757-J }}
*{{cite journal | author=Irie Y, Tatsumi K, Ogawa M, ''et al.'' |title=A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency. |journal=Endocr. J. |volume=42 |issue= 3 |pages= 351-4 |year= 1995 |pmid= 7670563 |doi= }}
* {{cite journal | vauthors = Okamoto N, Wada Y, Ida S, Koga R, Ozono K, Chiyo H, Hayashi A, Tatsumi K | title = Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype | journal = Hum. Mol. Genet. | volume = 3 | issue = 9 | pages = 1565–8 | year = 1995 | pmid = 7833912 | doi = 10.1093/hmg/3.9.1565 }}
*{{cite journal | author=Delhase M, Vila V, Hooghe-Peters EL, Castrillo JL |title=A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1/PIT-1 gene. |journal=Gene |volume=155 |issue= 2 |pages= 273-5 |year= 1995 |pmid= 7721104 |doi= }}
*{{cite journal | author=Okamoto N, Wada Y, Ida S, ''et al.'' |title=Monoallelic expression of normal mRNA in the PIT1 mutation heterozygotes with normal phenotype and biallelic expression in the abnormal phenotype. |journal=Hum. Mol. Genet. |volume=3 |issue= 9 |pages= 1565-8 |year= 1995 |pmid= 7833912 |doi= }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|PIT1+protein,+human}}
* {{MeshName|PIT1+protein,+human}}
* {{MeshName|Transcription+Factor+Pit-1}}
* {{MeshName|Transcription+Factor+Pit-1}}


{{PDB Gallery|geneid=5449}}
{{Transcription factors|g3}}
{{biochemistry-stub}}
{{biochemistry-stub}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:POU-domain proteins]]

Latest revision as of 12:14, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.[1]

Function

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM][1]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2[2] and PITX1.[3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)".
  2. ↑ Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888.
  3. ↑ Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (July 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

Further reading

  • Parks JS, Brown MR (1999). "Transcription factors regulating pituitary development". Growth Horm. IGF Res. 9 Suppl B: 2–8, discussion 8–11. doi:10.1016/S1096-6374(99)80074-4. PMID 10549299.
  • Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. PMID 12717343.
  • Quentien MH, Barlier A, Franc JL, Pellegrini I, Brue T, Enjalbert A (2006). "Pituitary transcription factors: from congenital deficiencies to gene therapy". J. Neuroendocrinol. 18 (9): 633–42. doi:10.1111/j.1365-2826.2006.01461.x. PMID 16879162.
  • Cattini PA, Yang X, Jin Y, Detillieux KA (2006). "Regulation of the human growth hormone gene family: possible role for Pit-1 in early stages of pituitary-specific expression and repression". Neuroendocrinology. 83 (3–4): 145–53. doi:10.1159/000095522. PMID 17047377.
  • Li X, Giachelli CM (2007). "Sodium-dependent phosphate cotransporters and vascular calcification". Curr. Opin. Nephrol. Hypertens. 16 (4): 325–8. doi:10.1097/MNH.0b013e3281c55ef1. PMID 17565274.
  • Tatsumi K, Miyai K, Notomi T, Kaibe K, Amino N, Mizuno Y, Kohno H (1993). "Cretinism with combined hormone deficiency caused by a mutation in the PIT1 gene". Nat. Genet. 1 (1): 56–8. doi:10.1038/ng0492-56. PMID 1302000.
  • Tatsumi K, Notomi T, Amino N, Miyai K (1992). "Nucleotide sequence of the complementary DNA for human Pit-1/GHF-1". Biochim. Biophys. Acta. 1129 (2): 231–4. doi:10.1016/0167-4781(92)90494-k. PMID 1370379.
  • Ohta K, Nobukuni Y, Mitsubuchi H, Fujimoto S, Matsuo N, Inagaki H, Endo F, Matsuda I (1993). "Mutations in the Pit-1 gene in children with combined pituitary hormone deficiency". Biochem. Biophys. Res. Commun. 189 (2): 851–5. doi:10.1016/0006-291X(92)92281-2. PMID 1472057.
  • Ohta K, Nobukuni Y, Mitsubuchi H, Ohta T, Tohma T, Jinno Y, Endo F, Matsuda I (1993). "Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387–8. doi:10.1016/0378-1119(92)90234-G. PMID 1487156.
  • Radovick S, Nations M, Du Y, Berg LA, Weintraub BD, Wondisford FE (1992). "A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency". Science. 257 (5073): 1115–8. doi:10.1126/science.257.5073.1115. PMID 1509262.
  • Pfäffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA (1992). "Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia". Science. 257 (5073): 1118–21. doi:10.1126/science.257.5073.1118. PMID 1509263.
  • Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. doi:10.1093/nar/19.22.6329. PMC 329149. PMID 1956794.
  • He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development". Nature. 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723.
  • Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–18. doi:10.1016/0092-8674(88)90037-2. PMID 2902927.
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External links

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