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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''GATA2''' is a human [[gene]] which makes a [[protein]] called '''GATA binding protein 2''' - a [[transcription factor]].<ref name="pmid1714909">{{cite journal | vauthors = Lee ME, Temizer DH, Clifford JA, Quertermous T | title = Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells | journal = J. Biol. Chem. | volume = 266 | issue = 24 | pages = 16188–92 | date = 25 August 1991 | pmid = 1714909 | url = http://www.jbc.org/cgi/content/abstract/266/24/16188 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GATA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gnf.
| PDB = {{PDB2|1gnf}}, {{PDB2|1y0j}}
| Name = GATA binding protein 2
| HGNCid = 4171
| Symbol = GATA2
| AltSymbols =; MGC2306; NFE1B
| OMIM = 137295
| ECnumber = 
| Homologene = 32030
| MGIid = 95662
| GeneAtlas_image1 = PBB_GE_GATA2_209710_at_tn.png
| GeneAtlas_image2 = PBB_GE_GATA2_210358_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006909 |text = phagocytosis}} {{GNF_GO|id=GO:0021983 |text = pituitary gland development}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0048469 |text = cell maturation}} {{GNF_GO|id=GO:0050766 |text = positive regulation of phagocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2624
    | Hs_Ensembl = ENSG00000179348
    | Hs_RefseqProtein = NP_116027
    | Hs_RefseqmRNA = NM_032638
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 129680962
    | Hs_GenLoc_end = 129694718
    | Hs_Uniprot = P23769
    | Mm_EntrezGene = 14461
    | Mm_Ensembl = ENSMUSG00000015053
    | Mm_RefseqmRNA = NM_008090
    | Mm_RefseqProtein = NP_032116
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 88159532
    | Mm_GenLoc_end = 88172671
    | Mm_Uniprot = Q3B845
  }}
}}
'''GATA binding protein 2''', also known as '''GATA2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[GATA transcription factor|GATA family of transcription factors]], which contain [[zinc finger]]s in their [[DNA binding domain]], have emerged as candidate regulators of [[gene expression]] in [[haematopoiesis|hematopoietic]] cells.<ref name="pmid8078582">{{cite journal | vauthors = Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH | title = An early haematopoietic defect in mice lacking the transcription factor GATA-2 | journal = Nature | volume = 371 | issue = 6494 | pages = 221–6 | date = September 1994 | pmid = 8078582 | doi = 10.1038/371221a0 | url =  }}</ref> [[GATA1]] is essential for normal primitive and definitive [[erythropoiesis]] and is expressed at high levels in [[red blood cell|erythroid cell]]s, [[mast cell]]s, and [[megakaryocyte]]s. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic [[stem cell]]s. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation.<ref name="pmid8504932">{{cite journal | vauthors = Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M | title = Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner | journal = Genes Dev. | volume = 7 | issue = 6 | pages = 1097–109 | date = June 1993 | pmid = 8504932 | doi = 10.1101/gad.7.6.1097 | url =  }}</ref> GATA2 also plays an essential role in the negative regulation of type 2 [[deiodinase]] gene ([[DIO2]]).<ref>{{cite journal|last1=Matsunaga|first1=H|last2=Sasaki|first2=S|last3=Suzuki|first3=S|last4=Matsushita|first4=A|last5=Nakamura|first5=H|last6=Nakamura|first6=HM|last7=Hirahara|first7=N|last8=Kuroda|first8=G|last9=Iwaki|first9=H|last10=Ohba|first10=K|last11=Morita|first11=H|last12=Oki|first12=Y|last13=Suda|first13=T|title=Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph.|journal=PLOS ONE|date=2015|volume=10|issue=11|pages=e0142400|doi=10.1371/journal.pone.0142400|pmid=26571013|pmc=4646574}}</ref> [[GATA3]] expression is restricted to [[T cell|T-lymphocyte cell]]s and some nonhematopoietic cell types, including embryonic stem cells.<ref name="entrez">{{cite web | title = Entrez Gene: GATA2 GATA binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2624| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells (Tsai et al., 1994). GATA1 (MIM 305371) is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation (Briegel et al., 1993). GATA3 (MIM 131320) expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GATA2 GATA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2624| accessdate = }}</ref>
 
}}
GATA2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[HDAC3]],<ref name = pmid11567998>{{cite journal | vauthors = Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H | title = Histone deacetylase 3 associates with and represses the transcription factor GATA-2 | journal = Blood | volume = 98 | issue = 7 | pages = 2116–23 | date = October 2001 | pmid = 11567998 | doi =  10.1182/blood.v98.7.2116}}</ref>
* [[LMO2]],<ref name = pmid7568177>{{cite journal | vauthors = Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH | title = Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 21 | pages = 9585–9 | date = October 1995 | pmid = 7568177 | pmc = 40846 | doi =  10.1073/pnas.92.21.9585}}</ref>
* [[Pituitary-specific positive transcription factor 1|POU1F1]],<ref name = pmid10367888>{{cite journal | vauthors = Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG | title = Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types | journal = Cell | volume = 97 | issue = 5 | pages = 587–98 | date = May 1999 | pmid = 10367888 | doi =  10.1016/s0092-8674(00)80770-9}}</ref>
* [[OCT4|POU5F1]],<ref name = pmid28953884>{{cite journal | vauthors = Fogarty NM, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JM, Niakan KK | title = Genome editing reveals a role for OCT4 in human embryogenesis | journal = Nature | issue = 550 | pages = 67–73 | date = Oct 2017 | pmid = 28953884 | doi =  10.1038/nature24033}}</ref>
* [[Promyelocytic leukemia protein|PML]]<ref name = pmid10938104>{{cite journal | vauthors = Tsuzuki S, Towatari M, Saito H, Enver T | title = Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6276–86 | date = September 2000 | pmid = 10938104 | pmc = 86102 | doi =  10.1128/mcb.20.17.6276-6286.2000}}</ref>
* [[SPI1]],<ref name = pmid10411939>{{cite journal | vauthors = Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z | title = Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 15 | pages = 8705–10 | date = July 1999 | pmid = 10411939 | pmc = 17580 | doi =  10.1073/pnas.96.15.8705}}</ref> and
* [[Zinc finger and BTB domain-containing protein 16|ZBTB16]].<ref name = pmid11964310>{{cite journal | vauthors = Tsuzuki S, Enver T | title = Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein | journal = Blood | volume = 99 | issue = 9 | pages = 3404–10 | date = May 2002 | pmid = 11964310 | doi =  10.1182/blood.v99.9.3404}}</ref>
{{Div col end}}
 
== Genetic disorders ==
 
Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with [[MonoMAC]] Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia.<ref name="pmid21765025">{{cite journal | vauthors = Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M | title = Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency | journal = Blood | volume = 118 | issue = 10 | pages = 2656–8 | date = September 2011 | pmid = 21765025 | doi = 10.1182/blood-2011-06-360313 }}</ref> Mutations in this gene have also been associated with  familial myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) and lymphedema, deafness and myelodysplasia ([[Emberger syndrome]]).<ref name="Lübking2015">{{cite journal | vauthors = Lübking A, Vosberg S, Konstandin NP, Dufour A, Graf A, Krebs S, Blum H, Weber A, Lenhoff S, Ehinger M, Spiekermann K, Greif PA, Cammenga J | year = 2015 | title = Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation | url = | journal = Leuk Res Rep | volume = 4 | issue = 2| pages = 72–5 | doi = 10.1016/j.lrr.2015.10.001 }}</ref>
 
==Lung cancer==
 
GATA2 has recently been implicated in [[non-small-cell lung cancer]] - specifically those tumours that are driven by a faulty [[Ras subfamily|Ras]] protein. Targeting processes that occur downstream of GATA2 signalling with clinically approved drugs had a significant effect in mouse models of the disease.<ref>{{cite journal | vauthors = Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N, Nye E, Stamp G, Behrens A, Downward J | title = The GATA2 Transcriptional Network is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer | journal = Cell | volume = 149 | issue = 3 | pages = 642–655 | year = 2012 | pmid = 22541434 | pmc =  | doi = 10.1016/j.cell.2012.02.059 }}</ref>


==See also==
==See also==
* [[GATA transcription factor]]
* [[GATA transcription factor]]
* [[MonoMAC]]


==References==
==References==
{{reflist|2}}
{{Reflist|2}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Minegishi N | title = [Transcription factors regulating hematopoiesis: researches spanning from molecule to whole body] | journal = Seikagaku | volume = 74 | issue = 5 | pages = 398–402 | year = 2002 | pmid = 12073612 | doi =  }}
| citations =
* {{cite journal | vauthors = Ohneda K, Yamamoto M | title = Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage | journal = Acta Haematol. | volume = 108 | issue = 4 | pages = 237–45 | year = 2003 | pmid = 12432220 | doi = 10.1159/000065660 }}
*{{cite journal | author=Minegishi N |title=[Transcription factors regulating hematopoiesis: researches spanning from molecule to whole body] |journal=Seikagaku |volume=74 |issue= 5 |pages= 398-402 |year= 2002 |pmid= 12073612 |doi=  }}
* {{cite journal | vauthors = Dorfman DM, Wilson DB, Bruns GA, Orkin SH | title = Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells | journal = J. Biol. Chem. | volume = 267 | issue = 2 | pages = 1279–85 | year = 1992 | pmid = 1370462 | doi =  }}
*{{cite journal | author=Ohneda K, Yamamoto M |title=Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. |journal=Acta Haematol. |volume=108 |issue= 4 |pages= 237-45 |year= 2003 |pmid= 12432220 |doi= }}
* {{cite journal | vauthors = Page RL, Wharton JM, Wilkinson WE, Friedman IM, Claypool WD, Karim A, Kowalski KG, McDonald SJ, Gardiner P, Pritchett EL | title = Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics | journal = Clin. Pharmacol. Ther. | volume = 51 | issue = 4 | pages = 371–8 | year = 1992 | pmid = 1563207 | doi = 10.1038/clpt.1992.36 }}
*{{cite journal | author=Dorfman DM, Wilson DB, Bruns GA, Orkin SH |title=Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 1279-85 |year= 1992 |pmid= 1370462 |doi=  }}
* {{cite journal | vauthors = Lee ME, Temizer DH, Clifford JA, Quertermous T | title = Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells | journal = J. Biol. Chem. | volume = 266 | issue = 24 | pages = 16188–92 | year = 1991 | pmid = 1714909 | doi =  }}
*{{cite journal | author=Page RL, Wharton JM, Wilkinson WE, ''et al.'' |title=Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics. |journal=Clin. Pharmacol. Ther. |volume=51 |issue= 4 |pages= 371-8 |year= 1992 |pmid= 1563207 |doi= }}
* {{cite journal | vauthors = Zhang R, Min W, Sessa WC | title = Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells | journal = J. Biol. Chem. | volume = 270 | issue = 25 | pages = 15320–6 | year = 1995 | pmid = 7541039 | doi = 10.1074/jbc.270.25.15320 }}
*{{cite journal | author=Lee ME, Temizer DH, Clifford JA, Quertermous T |title=Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. |journal=J. Biol. Chem. |volume=266 |issue= 24 |pages= 16188-92 |year= 1991 |pmid= 1714909 |doi=  }}
* {{cite journal | vauthors = Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH | title = Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 21 | pages = 9585–9 | year = 1995 | pmid = 7568177 | pmc = 40846 | doi = 10.1073/pnas.92.21.9585 }}
*{{cite journal | author=Zhang R, Min W, Sessa WC |title=Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15320-6 |year= 1995 |pmid= 7541039 |doi= }}
* {{cite journal | vauthors = Towatari M, May GE, Marais R, Perkins GR, Marshall CJ, Cowley S, Enver T | title = Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3 | journal = J. Biol. Chem. | volume = 270 | issue = 8 | pages = 4101–7 | year = 1995 | pmid = 7876160 | doi = 10.1074/jbc.270.8.4101 }}
*{{cite journal | author=Osada H, Grutz G, Axelson H, ''et al.'' |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585-9 |year= 1995 |pmid= 7568177 |doi= }}
* {{cite journal | vauthors = Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH | title = An early haematopoietic defect in mice lacking the transcription factor GATA-2 | journal = Nature | volume = 371 | issue = 6494 | pages = 221–6 | year = 1994 | pmid = 8078582 | doi = 10.1038/371221a0 }}
*{{cite journal | author=Towatari M, May GE, Marais R, ''et al.'' |title=Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 4101-7 |year= 1995 |pmid= 7876160 |doi= }}
* {{cite journal | vauthors = Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M | title = Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner | journal = Genes Dev. | volume = 7 | issue = 6 | pages = 1097–109 | year = 1993 | pmid = 8504932 | doi = 10.1101/gad.7.6.1097 }}
*{{cite journal | author=Tsai FY, Keller G, Kuo FC, ''et al.'' |title=An early haematopoietic defect in mice lacking the transcription factor GATA-2. |journal=Nature |volume=371 |issue= 6494 |pages= 221-6 |year= 1994 |pmid= 8078582 |doi= 10.1038/371221a0 }}
* {{cite journal | vauthors = Towatari M, Kanei Y, Saito H, Hamaguchi M | title = Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat | journal = AIDS | volume = 12 | issue = 3 | pages = 253–9 | year = 1998 | pmid = 9517987 | doi = 10.1097/00002030-199803000-00002 }}
*{{cite journal | author=Briegel K, Lim KC, Plank C, ''et al.'' |title=Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. |journal=Genes Dev. |volume=7 |issue= 6 |pages= 1097-109 |year= 1993 |pmid= 8504932 |doi= }}
* {{cite journal | vauthors = Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG | title = Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types | journal = Cell | volume = 97 | issue = 5 | pages = 587–98 | year = 1999 | pmid = 10367888 | doi = 10.1016/S0092-8674(00)80770-9 }}
*{{cite journal | author=Towatari M, Kanei Y, Saito H, Hamaguchi M |title=Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat. |journal=AIDS |volume=12 |issue= 3 |pages= 253-9 |year= 1998 |pmid= 9517987 |doi= }}
* {{cite journal | vauthors = Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z | title = Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 15 | pages = 8705–10 | year = 1999 | pmid = 10411939 | pmc = 17580 | doi = 10.1073/pnas.96.15.8705 }}
*{{cite journal | author=Dasen JS, O'Connell SM, Flynn SE, ''et al.'' |title=Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. |journal=Cell |volume=97 |issue= 5 |pages= 587-98 |year= 1999 |pmid= 10367888 |doi= }}
* {{cite journal | vauthors = Wieser R, Volz A, Vinatzer U, Gardiner K, Jäger U, Mitterbauer M, Ziegler A, Fonatsch C | title = Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia | journal = Biochem. Biophys. Res. Commun. | volume = 273 | issue = 1 | pages = 239–45 | year = 2000 | pmid = 10873593 | doi = 10.1006/bbrc.2000.2947 }}
*{{cite journal | author=Zhang P, Behre G, Pan J, ''et al.'' |title=Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 15 |pages= 8705-10 |year= 1999 |pmid= 10411939 |doi= }}
* {{cite journal | vauthors = Tsuzuki S, Towatari M, Saito H, Enver T | title = Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6276–86 | year = 2000 | pmid = 10938104 | pmc = 86102 | doi = 10.1128/MCB.20.17.6276-6286.2000 }}
*{{cite journal | author=Wieser R, Volz A, Vinatzer U, ''et al.'' |title=Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 239-45 |year= 2000 |pmid= 10873593 |doi= 10.1006/bbrc.2000.2947 }}
* {{cite journal | vauthors = Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA | title = Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12645–53 | year = 2001 | pmid = 11278891 | doi = 10.1074/jbc.M011344200 }}
*{{cite journal | author=Tsuzuki S, Towatari M, Saito H, Enver T |title=Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6276-86 |year= 2000 |pmid= 10938104 |doi= }}
* {{cite journal | vauthors = Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H | title = Histone deacetylase 3 associates with and represses the transcription factor GATA-2 | journal = Blood | volume = 98 | issue = 7 | pages = 2116–23 | year = 2001 | pmid = 11567998 | doi = 10.1182/blood.V98.7.2116 }}
*{{cite journal  | author=Yamashita K, Discher DJ, Hu J, ''et al.'' |title=Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12645-53 |year= 2001 |pmid= 11278891 |doi= 10.1074/jbc.M011344200 }}
* {{cite journal | vauthors = Zhang SB, He QY, Zhao H, Gui CY, Jiang C, Qian RL | title = Function of GATA transcription factors in hydroxyurea-induced HEL cells | journal = Cell Res. | volume = 11 | issue = 4 | pages = 301–10 | year = 2002 | pmid = 11787775 | doi = 10.1038/sj.cr.7290100 }}
*{{cite journal | author=Ozawa Y, Towatari M, Tsuzuki S, ''et al.'' |title=Histone deacetylase 3 associates with and represses the transcription factor GATA-2. |journal=Blood |volume=98 |issue= 7 |pages= 2116-23 |year= 2001 |pmid= 11567998 |doi= }}
* {{cite journal | vauthors = Tsuzuki S, Enver T | title = Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein | journal = Blood | volume = 99 | issue = 9 | pages = 3404–10 | year = 2002 | pmid = 11964310 | doi = 10.1182/blood.V99.9.3404 }}
*{{cite journal | author=Zhang SB, He QY, Zhao H, ''et al.'' |title=Function of GATA transcription factors in hydroxyurea-induced HEL cells. |journal=Cell Res. |volume=11 |issue= 4 |pages= 301-10 |year= 2002 |pmid= 11787775 |doi= 10.1038/sj.cr.7290100 }}
* {{cite journal | vauthors = Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Yamamoto M, Fukao K, Taniguchi H, Nakauchi H, Iwama A | title = Essential and Instructive Roles of GATA Factors in Eosinophil Development | journal = J. Exp. Med. | volume = 195 | issue = 11 | pages = 1379–86 | year = 2002 | pmid = 12045236 | pmc = 2193540 | doi = 10.1084/jem.20020170 }}
*{{cite journal | author=Tsuzuki S, Enver T |title=Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. |journal=Blood |volume=99 |issue= 9 |pages= 3404-10 |year= 2002 |pmid= 11964310 |doi= }}
{{Refend}}
*{{cite journal | author=Hirasawa R, Shimizu R, Takahashi S, ''et al.'' |title=Essential and instructive roles of GATA factors in eosinophil development. |journal=J. Exp. Med. |volume=195 |issue= 11 |pages= 1379-86 |year= 2002 |pmid= 12045236 |doi= }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|GATA2+protein,+human}}
* {{MeshName|GATA2+protein,+human}}
* {{FactorBook|GATA2}}


{{PDB Gallery|geneid=2624}}
{{Transcription factors|g2}}
{{NLM content}}
{{NLM content}}
{{gene-3-stub}}
 
{{Transcription factors}}
{{DEFAULTSORT:Gata2}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 00:29, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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View/Edit Human

GATA2 is a human gene which makes a protein called GATA binding protein 2 - a transcription factor.[1]

Function

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells.[2] GATA1 is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation.[3] GATA2 also plays an essential role in the negative regulation of type 2 deiodinase gene (DIO2).[4] GATA3 expression is restricted to T-lymphocyte cells and some nonhematopoietic cell types, including embryonic stem cells.[5]

Interactions

GATA2 has been shown to interact with:

Genetic disorders

Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia.[13] Mutations in this gene have also been associated with familial myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) and lymphedema, deafness and myelodysplasia (Emberger syndrome).[14]

Lung cancer

GATA2 has recently been implicated in non-small-cell lung cancer - specifically those tumours that are driven by a faulty Ras protein. Targeting processes that occur downstream of GATA2 signalling with clinically approved drugs had a significant effect in mouse models of the disease.[15]

See also

References

  1. ↑ Lee ME, Temizer DH, Clifford JA, Quertermous T (25 August 1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24): 16188–92. PMID 1714909.
  2. ↑ Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH (September 1994). "An early haematopoietic defect in mice lacking the transcription factor GATA-2". Nature. 371 (6494): 221–6. doi:10.1038/371221a0. PMID 8078582.
  3. ↑ Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M (June 1993). "Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner". Genes Dev. 7 (6): 1097–109. doi:10.1101/gad.7.6.1097. PMID 8504932.
  4. ↑ Matsunaga, H; Sasaki, S; Suzuki, S; Matsushita, A; Nakamura, H; Nakamura, HM; Hirahara, N; Kuroda, G; Iwaki, H; Ohba, K; Morita, H; Oki, Y; Suda, T (2015). "Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph". PLOS ONE. 10 (11): e0142400. doi:10.1371/journal.pone.0142400. PMC 4646574. PMID 26571013.
  5. ↑ "Entrez Gene: GATA2 GATA binding protein 2".
  6. ↑ Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H (October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23. doi:10.1182/blood.v98.7.2116. PMID 11567998.
  7. ↑ Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
  8. ↑ Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/s0092-8674(00)80770-9. PMID 10367888.
  9. ↑ Fogarty NM, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JM, Niakan KK (Oct 2017). "Genome editing reveals a role for OCT4 in human embryogenesis". Nature (550): 67–73. doi:10.1038/nature24033. PMID 28953884.
  10. ↑ Tsuzuki S, Towatari M, Saito H, Enver T (September 2000). "Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein". Mol. Cell. Biol. 20 (17): 6276–86. doi:10.1128/mcb.20.17.6276-6286.2000. PMC 86102. PMID 10938104.
  11. ↑ Zhang P, Behre G, Pan J, Iwama A, Wara-Aswapati N, Radomska HS, Auron PE, Tenen DG, Sun Z (July 1999). "Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8705–10. doi:10.1073/pnas.96.15.8705. PMC 17580. PMID 10411939.
  12. ↑ Tsuzuki S, Enver T (May 2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood. 99 (9): 3404–10. doi:10.1182/blood.v99.9.3404. PMID 11964310.
  13. ↑ Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M (September 2011). "Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency". Blood. 118 (10): 2656–8. doi:10.1182/blood-2011-06-360313. PMID 21765025.
  14. ↑ Lübking A, Vosberg S, Konstandin NP, Dufour A, Graf A, Krebs S, Blum H, Weber A, Lenhoff S, Ehinger M, Spiekermann K, Greif PA, Cammenga J (2015). "Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell transplantation". Leuk Res Rep. 4 (2): 72–5. doi:10.1016/j.lrr.2015.10.001.
  15. ↑ Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, East P, Diefenbacher M, Armenteros-Monterroso E, Lassailly F, Matthews N, Nye E, Stamp G, Behrens A, Downward J (2012). "The GATA2 Transcriptional Network is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer". Cell. 149 (3): 642–655. doi:10.1016/j.cell.2012.02.059. PMID 22541434.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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