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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Class E basic helix-loop-helix protein 40''' is a [[protein]] that in humans is encoded by the ''BHLHE40'' [[gene]].<ref name="pmid9240428">{{cite journal | vauthors = Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y | title = Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 2 | pages = 294–8 | date = Jul 1997 | pmid = 9240428 | pmc =  | doi = 10.1006/bbrc.1997.6960 }}</ref><ref name="pmid10449910">{{cite journal | vauthors = Antonevich T, Taneja R | title = Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 85 | issue = 3-4 | pages = 254–5 | date = Oct 1999 | pmid = 10449910 | pmc =  | doi = 10.1159/000015305 }}</ref><ref name="pmid18557763">{{cite journal | vauthors = Stevens JD, Roalson EH, Skinner MK | title = Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation | journal = Differentiation; Research in Biological Diversity | volume = 76 | issue = 9 | pages = 1006–22 | date = Nov 2008 | pmid = 18557763 | pmc =  | doi = 10.1111/j.1432-0436.2008.00285.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Basic helix-loop-helix domain containing, class B, 2
| HGNCid = 1046
| Symbol = BHLHB2
| AltSymbols =; DEC1; SHARP-2; STRA13; Stra14
| OMIM = 604256
| ECnumber = 
| Homologene = 2722
| MGIid = 1097714
| GeneAtlas_image1 = PBB_GE_BHLHB2_201170_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BHLHB2_201169_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8553
    | Hs_Ensembl = ENSG00000134107
    | Hs_RefseqProtein = NP_003661
    | Hs_RefseqmRNA = NM_003670
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 4996208
    | Hs_GenLoc_end = 5001861
    | Hs_Uniprot = O14503
    | Mm_EntrezGene = 20893
    | Mm_Ensembl = ENSMUSG00000030103
    | Mm_RefseqmRNA = NM_011498
    | Mm_RefseqProtein = NP_035628
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 108626406
    | Mm_GenLoc_end = 108632702
    | Mm_Uniprot = Q52L58
  }}
}}
'''Basic helix-loop-helix domain containing, class B, 2''', also known as '''BHLHB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DEC1 encodes a basic helix-loop-helix protein expressed in various tissues.  Expression in the chondrocytes is responsive to the addition of Bt2cAMP.  Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = DEC1 encodes a basic helix-loop-helix protein expressed in various tissues.  Expression in the chondrocytes is responsive to the addition of Bt2cAMP.  Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y | title = Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2 | journal = Journal of Biochemistry | volume = 129 | issue = 3 | pages = 391–6 | date = Mar 2001 | pmid = 11226878 | doi = 10.1093/oxfordjournals.jbchem.a002869 }}
| citations =
* {{cite journal | vauthors = Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI | title = Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 18 | pages = 15306–15 | date = May 2001 | pmid = 11278694 | doi = 10.1074/jbc.M010516200 }}
*{{cite journal | author=Shen M, Kawamoto T, Yan W, ''et al.'' |title=Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 294-8 |year= 1997 |pmid= 9240428 |doi= 10.1006/bbrc.1997.6960 }}
* {{cite journal | vauthors = Sun H, Lu B, Li RQ, Flavell RA, Taneja R | title = Defective T cell activation and autoimmune disorder in Stra13-deficient mice | journal = Nature Immunology | volume = 2 | issue = 11 | pages = 1040–7 | date = Nov 2001 | pmid = 11668339 | doi = 10.1038/ni721 }}
*{{cite journal  | author=Antonevich T, Taneja R |title=Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=85 |issue= 3-4 |pages= 254-5 |year= 1999 |pmid= 10449910 |doi=  }}
* {{cite journal | vauthors = Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O | title = Identification of genes differentially induced by hypoxia in pancreatic cancer cells | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 4 | pages = 882–6 | date = Nov 2001 | pmid = 11688991 | doi = 10.1006/bbrc.2001.5867 }}
*{{cite journal  | author=Teramoto M, Nakamasu K, Noshiro M, ''et al.'' |title=Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2. |journal=J. Biochem. |volume=129 |issue= 3 |pages= 391-6 |year= 2001 |pmid= 11226878 |doi= }}
* {{cite journal | vauthors = Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B | title = Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation | journal = The Biochemical Journal | volume = 367 | issue = Pt 2 | pages = 413–22 | date = Oct 2002 | pmid = 12119049 | pmc = 1222902 | doi = 10.1042/BJ20020514 }}
*{{cite journal | author=Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI |title=Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15306-15 |year= 2001 |pmid= 11278694 |doi= 10.1074/jbc.M010516200 }}
* {{cite journal | vauthors = St-Pierre B, Flock G, Zacksenhaus E, Egan SE | title = Stra13 homodimers repress transcription through class B E-box elements | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46544–51 | date = Nov 2002 | pmid = 12297495 | doi = 10.1074/jbc.M111652200 }}
*{{cite journal | author=Sun H, Lu B, Li RQ, ''et al.'' |title=Defective T cell activation and autoimmune disorder in Stra13-deficient mice. |journal=Nat. Immunol. |volume=2 |issue= 11 |pages= 1040-7 |year= 2001 |pmid= 11668339 |doi= 10.1038/ni721 }}
* {{cite journal | vauthors = Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y | title = Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 49 | pages = 47014–21 | date = Dec 2002 | pmid = 12354771 | doi = 10.1074/jbc.M204938200 }}
*{{cite journal | author=Yoon DY, Buchler P, Saarikoski ST, ''et al.'' |title=Identification of genes differentially induced by hypoxia in pancreatic cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 882-6 |year= 2001 |pmid= 11688991 |doi= 10.1006/bbrc.2001.5867 }}
* {{cite journal | vauthors = Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y | title = Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages | journal = The Journal of Biological Chemistry | volume = 277 | issue = 51 | pages = 50112–20 | date = Dec 2002 | pmid = 12384505 | doi = 10.1074/jbc.M206771200 }}
*{{cite journal | author=Li Y, Zhang H, Xie M, ''et al.'' |title=Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 413-22 |year= 2002 |pmid= 12119049 |doi= 10.1042/BJ20020514 }}
* {{cite journal | vauthors = Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K | title = Dec1 and Dec2 are regulators of the mammalian molecular clock | journal = Nature | volume = 419 | issue = 6909 | pages = 841–4 | date = Oct 2002 | pmid = 12397359 | doi = 10.1038/nature01123 }}
*{{cite journal | author=St-Pierre B, Flock G, Zacksenhaus E, Egan SE |title=Stra13 homodimers repress transcription through class B E-box elements. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46544-51 |year= 2003 |pmid= 12297495 |doi= 10.1074/jbc.M111652200 }}
* {{cite journal | vauthors = Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B | title = DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 19 | pages = 16899–907 | date = May 2003 | pmid = 12624110 | doi = 10.1074/jbc.M300596200 }}
*{{cite journal | author=Miyazaki K, Kawamoto T, Tanimoto K, ''et al.'' |title=Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47014-21 |year= 2003 |pmid= 12354771 |doi= 10.1074/jbc.M204938200 }}
* {{cite journal | vauthors = Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL | title = DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer | journal = The Journal of Pathology | volume = 200 | issue = 2 | pages = 222–8 | date = Jun 2003 | pmid = 12754744 | doi = 10.1002/path.1330 }}
*{{cite journal | author=Shen M, Yoshida E, Yan W, ''et al.'' |title=Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50112-20 |year= 2003 |pmid= 12384505 |doi= 10.1074/jbc.M206771200 }}
* {{cite journal | vauthors = Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI | title = STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets | journal = Journal of Molecular Biology | volume = 340 | issue = 4 | pages = 641–53 | date = Jul 2004 | pmid = 15223310 | doi = 10.1016/j.jmb.2004.05.025 }}
*{{cite journal | author=Honma S, Kawamoto T, Takagi Y, ''et al.'' |title=Dec1 and Dec2 are regulators of the mammalian molecular clock. |journal=Nature |volume=419 |issue= 6909 |pages= 841-4 |year= 2002 |pmid= 12397359 |doi= 10.1038/nature01123 }}
* {{cite journal | vauthors = Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y | title = Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1 | journal = European Journal of Biochemistry / FEBS | volume = 271 | issue = 22 | pages = 4409–19 | date = Nov 2004 | pmid = 15560782 | doi = 10.1111/j.1432-1033.2004.04379.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ivanova AV, Ivanov SV, Lerman ML | title = Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins | journal = Cellular and Molecular Life Sciences | volume = 62 | issue = 4 | pages = 471–84 | date = Feb 2005 | pmid = 15719173 | doi = 10.1007/s00018-004-4423-2 }}
*{{cite journal  | author=Li Y, Xie M, Song X, ''et al.'' |title=DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16899-907 |year= 2003 |pmid= 12624110 |doi= 10.1074/jbc.M300596200 }}
* {{cite journal | vauthors = Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ | title = STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker | journal = Journal of Medical Genetics | volume = 42 | issue = 7 | pages = 565–76 | date = Jul 2005 | pmid = 15994878 | pmc = 1736099 | doi = 10.1136/jmg.2004.029835 }}
*{{cite journal | author=Giatromanolaki A, Koukourakis MI, Sivridis E, ''et al.'' |title=DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. |journal=J. Pathol. |volume=200 |issue= 2 |pages= 222-8 |year= 2003 |pmid= 12754744 |doi= 10.1002/path.1330 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Ivanova AV, Ivanov SV, Zhang X, ''et al.'' |title=STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. |journal=J. Mol. Biol. |volume=340 |issue= 4 |pages= 641-53 |year= 2004 |pmid= 15223310 |doi= 10.1016/j.jmb.2004.05.025 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Sato F, Kawamoto T, Fujimoto K, ''et al.'' |title=Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. |journal=Eur. J. Biochem. |volume=271 |issue= 22 |pages= 4409-19 |year= 2005 |pmid= 15560782 |doi= 10.1111/j.1432-1033.2004.04379.x }}
*{{cite journal | author=Ivanova AV, Ivanov SV, Lerman ML |title=Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 4 |pages= 471-84 |year= 2005 |pmid= 15719173 |doi= 10.1007/s00018-004-4423-2 }}
*{{cite journal | author=Ivanova A, Liao SY, Lerman MI, ''et al.'' |title=STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker. |journal=J. Med. Genet. |volume=42 |issue= 7 |pages= 565-76 |year= 2006 |pmid= 15994878 |doi= 10.1136/jmg.2004.029835 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|BHLHB2+protein,+human}}
* {{MeshName|BHLHB2+protein,+human}}
* {{FactorBook|BHLHE40}}
* {{UCSC gene info|BHLHE40}}
* {{UCSC gene info|DEC1}}
* {{UCSC gene info|STRA13}}


 
{{gene-3-stub}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors|g1}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 02:35, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.[1][2][3][4]

Function

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[4]

References

  1. ↑ Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, Noshiro M, Kato Y (Jul 1997). "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochemical and Biophysical Research Communications. 236 (2): 294–8. doi:10.1006/bbrc.1997.6960. PMID 9240428.
  2. ↑ Antonevich T, Taneja R (Oct 1999). "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 254–5. doi:10.1159/000015305. PMID 10449910.
  3. ↑ Stevens JD, Roalson EH, Skinner MK (Nov 2008). "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity. 76 (9): 1006–22. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763.
  4. ↑ 4.0 4.1 "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2".

Further reading

  • Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y (Mar 2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". Journal of Biochemistry. 129 (3): 391–6. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.
  • Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (May 2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694.
  • Sun H, Lu B, Li RQ, Flavell RA, Taneja R (Nov 2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nature Immunology. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339.
  • Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O (Nov 2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochemical and Biophysical Research Communications. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991.
  • Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B (Oct 2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". The Biochemical Journal. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049.
  • St-Pierre B, Flock G, Zacksenhaus E, Egan SE (Nov 2002). "Stra13 homodimers repress transcription through class B E-box elements". The Journal of Biological Chemistry. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495.
  • Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y (Dec 2002). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". The Journal of Biological Chemistry. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771.
  • Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y (Dec 2002). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". The Journal of Biological Chemistry. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505.
  • Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K (Oct 2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359.
  • Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (May 2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". The Journal of Biological Chemistry. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110.
  • Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL (Jun 2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". The Journal of Pathology. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744.
  • Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI (Jul 2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
  • Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y (Nov 2004). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". European Journal of Biochemistry / FEBS. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
  • Ivanova AV, Ivanov SV, Lerman ML (Feb 2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cellular and Molecular Life Sciences. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173.
  • Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ (Jul 2005). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". Journal of Medical Genetics. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=BHLHB2&oldid=1413084"