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{{Infobox_gene}}
{{PBB_Controls
'''Recombining binding protein suppressor of hairless''' is a [[protein]] that in humans is encoded by the ''RBPJ'' [[gene]].<ref name="pmid8406481">{{cite journal | vauthors = Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T | title = Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue | journal = Genomics | volume = 17 | issue = 2 | pages = 306–15 | date = Aug 1993 | pmid = 8406481 | pmc =  | doi = 10.1006/geno.1993.1326 }}</ref><ref name="pmid9290259">{{cite journal | vauthors = Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK | title = Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization | journal = The Japanese Journal of Human Genetics | volume = 42 | issue = 2 | pages = 337–41 | date = Jun 1997 | pmid = 9290259 | pmc =  | doi = 10.1007/BF02766956 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3516| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RBPJ<ref name="Hugo">{{cite web | title = Human Genome Organization: RBPJ Report | url = http://www.genenames.org/data/hgnc_data.php?hgnc_id=5724 | accessdate = }}</ref> also known as CBF1, is the human homolog for the [[Drosophila]] gene [[Su(H)|Suppressor of Hairless]]. Its [[promoter region]] is classically used to demonstrate [[Notch signaling pathway|Notch1]] signaling.<ref name="MCB">{{cite journal | vauthors = Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD | title = Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2 | journal = Molecular and Cellular Biology | volume = 16 | issue = 3 | pages = 952–9 | date = Mar 1996 | pmid = 8622698 | pmc = 231077 | doi=10.1128/mcb.16.3.952}}</ref>
{{GNF_Protein_box
| image = PBB_Protein_RBPJ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2f8x.
| PDB = {{PDB2|2f8x}}
| Name = Recombination signal binding protein for immunoglobulin kappa J region
| HGNCid = 5724
| Symbol = RBPJ
| AltSymbols =; CBF1; IGKJRB; IGKJRB1; KBF2; MGC61669; RBP-J; RBPJK; RBPSUH; SUH; csl
| OMIM = 147183
| ECnumber = 
| Homologene = 7511
| MGIid = 96522
| GeneAtlas_image1 = PBB_GE_RBPJ_211974_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000150 |text = recombinase activity}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001837 |text = epithelial to mesenchymal transition}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3516
    | Hs_Ensembl = ENSG00000168214
    | Hs_RefseqProtein = NP_005340
    | Hs_RefseqmRNA = NM_005349
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 25930430
    | Hs_GenLoc_end = 26045851
    | Hs_Uniprot = Q06330
    | Mm_EntrezGene = 19664
    | Mm_Ensembl = ENSMUSG00000039191
    | Mm_RefseqmRNA = NM_001080927
    | Mm_RefseqProtein = NP_001074396
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 53878598
    | Mm_GenLoc_end = 53944383
    | Mm_Uniprot = A0N920
  }}
}}
'''Recombination signal binding protein for immunoglobulin kappa J region''', also known as '''RBPJ''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3516| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
RBPJ has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[NOTCH1]]<ref name = pmid12644465>{{cite journal | vauthors = Nam Y, Weng AP, Aster JC, Blacklow SC | title = Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 23 | pages = 21232–9 | date = Jun 2003 | pmid = 12644465 | doi = 10.1074/jbc.M301567200 }}</ref><ref name = pmid9111040>{{cite journal | vauthors = Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J | title = Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription | journal = The Journal of Biological Chemistry | volume = 272 | issue = 17 | pages = 11336–43 | date = Apr 1997 | pmid = 9111040 | doi = 10.1074/jbc.272.17.11336 }}</ref>
==Further reading==
* [[Nuclear receptor co-repressor 2|NCOR2]],<ref name = pmid11404076>{{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1-2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi = 10.1016/s0925-4773(01)00373-2 }}</ref><ref name = pmid11509665>{{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = Sep 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/mcb.21.18.6222-6232.2001 }}</ref>
{{refbegin | 2}}
* [[PCAF]],<ref name = pmid10747963>{{cite journal | vauthors = Kurooka H, Honjo T | title = Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17211–20 | date = Jun 2000 | pmid = 10747963 | doi = 10.1074/jbc.M000909200 }}</ref>
{{PBB_Further_reading
* [[SND1]],<ref name = pmid10644367/><ref name = pmid9874765>{{cite journal | vauthors = Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD | title = CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 1 | pages = 23–8 | date = Jan 1999 | pmid = 9874765 | pmc = 15086 | doi = 10.1073/pnas.96.1.23 }}</ref> and
| citations =  
* [[SNW1]].<ref name = pmid10644367>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/jvi.74.4.1939-1947.2000 }}</ref><ref name = pmid10713164>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/mcb.20.7.2400-2410.2000 }}</ref>
*{{cite journal  | author=Oka C, Kawaichi M |title=V(D)J recombination of immunoglobulin genes. |journal=Adv. Biophys. |volume=31 |issue= |pages= 163-80 |year= 1995 |pmid= 7625272 |doi= }}
 
*{{cite journal | author=Matsunami N, Hamaguchi Y, Yamamoto Y, ''et al.'' |title=A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. |journal=Nature |volume=342 |issue= 6252 |pages= 934-7 |year= 1990 |pmid= 2556644 |doi= 10.1038/342934a0 }}
== References ==
*{{cite journal | author=Tong X, Drapkin R, Yalamanchili R, ''et al.'' |title=The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4735-44 |year= 1995 |pmid= 7651391 |doi= }}
{{Reflist}}
*{{cite journal | author=Amakawa R, Jing W, Ozawa K, ''et al.'' |title=Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue. |journal=Genomics |volume=17 |issue= 2 |pages= 306-15 |year= 1993 |pmid= 8406481 |doi= 10.1006/geno.1993.1326 }}
 
*{{cite journal | author=Zhao B, Marshall DR, Sample CE |title=A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa. |journal=J. Virol. |volume=70 |issue= 7 |pages= 4228-36 |year= 1996 |pmid= 8676443 |doi= }}
== Further reading ==
*{{cite journal | author=Tamura K, Taniguchi Y, Minoguchi S, ''et al.'' |title=Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). |journal=Curr. Biol. |volume=5 |issue= 12 |pages= 1416-23 |year= 1997 |pmid= 8749394 |doi= }}
{{Refbegin | 2}}
*{{cite journal | author=Gress TM, Müller-Pillasch F, Geng M, ''et al.'' |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819-30 |year= 1996 |pmid= 8895530 |doi= }}
* {{cite journal | vauthors = Oka C, Kawaichi M | title = V(D)J recombination of immunoglobulin genes | journal = Advances in Biophysics | volume = 31 | issue = | pages = 163–80 | year = 1995 | pmid = 7625272 | doi = 10.1016/0065-227X(95)99390-B }}
*{{cite journal | author=Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD |title=Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. |journal=J. Virol. |volume=71 |issue= 3 |pages= 1938-45 |year= 1997 |pmid= 9032325 |doi= }}
* {{cite journal | vauthors = Matsunami N, Hamaguchi Y, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, Kawaichi M, Honjo T | title = A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif | journal = Nature | volume = 342 | issue = 6252 | pages = 934–7 | year = 1990 | pmid = 2556644 | doi = 10.1038/342934a0 }}
*{{cite journal  | author=Aster JC, Robertson ES, Hasserjian RP, ''et al.'' |title=Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11336-43 |year= 1997 |pmid= 9111040 |doi= }}
* {{cite journal | vauthors = Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E | title = The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE | journal = Molecular and Cellular Biology | volume = 15 | issue = 9 | pages = 4735–44 | date = Sep 1995 | pmid = 7651391 | pmc = 230717 | doi =  10.1128/mcb.15.9.4735}}
*{{cite journal | author=Tang X, Saito-Ohara F, Song J, ''et al.'' |title=Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization. |journal=Jpn. J. Hum. Genet. |volume=42 |issue= 2 |pages= 337-41 |year= 1997 |pmid= 9290259 |doi= }}
* {{cite journal | vauthors = Zhao B, Marshall DR, Sample CE | title = A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa | journal = Journal of Virology | volume = 70 | issue = 7 | pages = 4228–36 | date = Jul 1996 | pmid = 8676443 | pmc = 190353 | doi =  }}
*{{cite journal | author=Kao HY, Ordentlich P, Koyano-Nakagawa N, ''et al.'' |title=A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2269-77 |year= 1998 |pmid= 9694793 |doi=  }}
* {{cite journal | vauthors = Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T | title = Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H) | journal = Current Biology | volume = 5 | issue = 12 | pages = 1416–23 | date = Dec 1995 | pmid = 8749394 | doi = 10.1016/S0960-9822(95)00279-X }}
*{{cite journal | author=Hsieh JJ, Zhou S, Chen L, ''et al.'' |title=CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 23-8 |year= 1999 |pmid= 9874765 |doi=  }}
* {{cite journal | vauthors = Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H | title = A pancreatic cancer-specific expression profile | journal = Oncogene | volume = 13 | issue = 8 | pages = 1819–30 | date = Oct 1996 | pmid = 8895530 | doi =  }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD | title = Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation | journal = Journal of Virology | volume = 71 | issue = 3 | pages = 1938–45 | date = Mar 1997 | pmid = 9032325 | pmc = 191274 | doi =  }}
*{{cite journal | author=Callahan J, Aster J, Sklar J, ''et al.'' |title=Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells. |journal=Leukemia |volume=14 |issue= 1 |pages= 84-92 |year= 2000 |pmid= 10637481 |doi=  }}
* {{cite journal | vauthors = Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J | title = Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription | journal = The Journal of Biological Chemistry | volume = 272 | issue = 17 | pages = 11336–43 | date = Apr 1997 | pmid = 9111040 | doi = 10.1074/jbc.272.17.11336 }}
*{{cite journal | author=Smith PR, de Jesus O, Turner D, ''et al.'' |title=Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus. |journal=J. Virol. |volume=74 |issue= 7 |pages= 3082-92 |year= 2000 |pmid= 10708423 |doi=  }}
* {{cite journal | vauthors = Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T | title = A histone deacetylase corepressor complex regulates the Notch signal transduction pathway | journal = Genes & Development | volume = 12 | issue = 15 | pages = 2269–77 | date = Aug 1998 | pmid = 9694793 | pmc = 317043 | doi = 10.1101/gad.12.15.2269 }}
*{{cite journal | author=Zhou S, Fujimuro M, Hsieh JJ, ''et al.'' |title=SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2400-10 |year= 2000 |pmid= 10713164 |doi= }}
* {{cite journal | vauthors = Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD | title = CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 1 | pages = 23–8 | date = Jan 1999 | pmid = 9874765 | pmc = 15086 | doi = 10.1073/pnas.96.1.23 }}
*{{cite journal | author=Kurooka H, Honjo T |title=Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 17211-20 |year= 2000 |pmid= 10747963 |doi= 10.1074/jbc.M000909200 }}
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Beatus P, Lundkvist J, Oberg C, ''et al.'' |title=The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. |journal=Mech. Dev. |volume=104 |issue= 1-2 |pages= 3-20 |year= 2001 |pmid= 11404076 |doi= }}
* {{cite journal | vauthors = Callahan J, Aster J, Sklar J, Kieff E, Robertson ES | title = Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells | journal = Leukemia | volume = 14 | issue = 1 | pages = 84–92 | date = Jan 2000 | pmid = 10637481 | doi = 10.1038/sj.leu.2401630 }}
*{{cite journal | author=Zhou S, Hayward SD |title=Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6222-32 |year= 2001 |pmid= 11509665 |doi=  }}
* {{cite journal | vauthors = Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ | title = Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus | journal = Journal of Virology | volume = 74 | issue = 7 | pages = 3082–92 | date = Apr 2000 | pmid = 10708423 | pmc = 111807 | doi = 10.1128/JVI.74.7.3082-3092.2000 }}
}}
* {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
{{refend}}
* {{cite journal | vauthors = Kurooka H, Honjo T | title = Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17211–20 | date = Jun 2000 | pmid = 10747963 | doi = 10.1074/jbc.M000909200 }}
* {{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1-2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi = 10.1016/S0925-4773(01)00373-2 }}
* {{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = Sep 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/MCB.21.18.6222-6232.2001 }}
{{Refend}}


== External links ==
== External links ==
* {{MeshName|RBPJ+protein,+human}}
* {{MeshName|RBPJ+protein,+human}}


{{PDB Gallery|geneid=3516}}
{{Transcription factors}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 22:04, 25 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.[1][2][3]

RBPJ[4] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[5]

Interactions

RBPJ has been shown to interact with:

References

  1. ↑ Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (Aug 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–15. doi:10.1006/geno.1993.1326. PMID 8406481.
  2. ↑ Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Jun 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–41. doi:10.1007/BF02766956. PMID 9290259.
  3. ↑ "Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
  4. ↑ "Human Genome Organization: RBPJ Report".
  5. ↑ Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (Mar 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–9. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
  6. ↑ Nam Y, Weng AP, Aster JC, Blacklow SC (Jun 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–9. doi:10.1074/jbc.M301567200. PMID 12644465.
  7. ↑ Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J (Apr 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–43. doi:10.1074/jbc.272.17.11336. PMID 9111040.
  8. ↑ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
  9. ↑ Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
  10. ↑ Kurooka H, Honjo T (Jun 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–20. doi:10.1074/jbc.M000909200. PMID 10747963.
  11. ↑ 11.0 11.1 Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  12. ↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  13. ↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

Further reading

External links

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