DNA damage-inducible transcript 3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''DNA damage-inducible transcript 3''', also known as '''C/EBP homologous protein (CHOP)''', is a pro-[[apoptosis|apoptotic]] [[transcription factor]] that is encoded by the ''DDIT3'' [[gene]].<ref name="pmid1990262">{{cite journal | vauthors = Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, ((Alamo I Jr)), Barrett SF, Hickson ID, ((Fornace AJ Jr)) | title = Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C | journal = Mol Cell Biol | volume = 11 | issue = 2 | pages = 1009–16 |date=March 1991 | pmid = 1990262 | pmc = 359769 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDIT3 DNA-damage-inducible transcript 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = DNA-damage-inducible transcript 3
| HGNCid = 2726
| Symbol = DDIT3
| AltSymbols =; CEBPZ; CHOP; CHOP10; GADD153; MGC4154
| OMIM = 126337
| ECnumber = 
| Homologene = 3012
| MGIid = 109247
| GeneAtlas_image1 = PBB_GE_DDIT3_209383_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0006983 |text = ER overload response}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0030503 |text = regulation of cell redox homeostasis}} {{GNF_GO|id=GO:0030968 |text = unfolded protein response}} {{GNF_GO|id=GO:0042789 |text = mRNA transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1649
    | Hs_Ensembl = ENSG00000175197
    | Hs_RefseqProtein = NP_004074
    | Hs_RefseqmRNA = NM_004083
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 56196640
    | Hs_GenLoc_end = 56200567
    | Hs_Uniprot = P35638
    | Mm_EntrezGene = 13198
    | Mm_Ensembl = ENSMUSG00000025408
    | Mm_RefseqmRNA = NM_007837
    | Mm_RefseqProtein = NP_031863
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 126693757
    | Mm_GenLoc_end = 126699237
    | Mm_Uniprot = Q3V405
  }}
}}
'''DNA-damage-inducible transcript 3''', also known as '''DDIT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDIT3 DNA-damage-inducible transcript 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DNA damage-inducible transcript 3 has been shown to [[Protein-protein interaction|interact]] with [proteins]:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[ATF3]],<ref name = pmid8622660>{{cite journal | date = March 1996 | vauthors = Chen BP, Wolfgang CD, Hai T | title = Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10 | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1157–68 | pmid = 8622660 | pmc = 231098 | doi = 10.1128/MCB.16.3.1157}}</ref>
| summary_text =  
* [[C-Fos]],<ref name = pmid10523647/>
}}
* [[C-jun]]<ref name = pmid10523647/> and
* [[CEBPB]],<ref name = pmid12706815>{{cite journal | date = April 2003 | vauthors = Hattori T, Ohoka N, Hayashi H, Onozaki K | title = C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform | journal = FEBS Lett. | volume = 541 | issue = 1-3 | pages = 33–9 | pmid = 12706815 | doi = 10.1016/s0014-5793(03)00283-7}}</ref><ref name = pmid8662954>{{cite journal | date = June 1996 | vauthors = Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ | title = Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14285–9 | pmid = 8662954 | doi = 10.1074/jbc.271.24.14285}}</ref>
* [[Casein kinase 2, alpha 1|CSNK2A1]],<ref name = pmid12876286>{{cite journal | date = October 2003 | vauthors = Ubeda M, Habener JF | title = CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation | journal = J. Biol. Chem. | volume = 278 | issue = 42 | pages = 40514–20 | pmid = 12876286 | doi = 10.1074/jbc.M306404200}}</ref>
* [[JunD]],<ref name = pmid10523647>{{cite journal | date = November 1999 | vauthors = Ubeda M, Vallejo M, Habener JF | title = CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7589–99 | pmid = 10523647 | pmc = 84780 | doi = }}</ref> and
* [[RPS3A]].<ref name = pmid10713066>{{cite journal | date = March 2000 | vauthors = Cui K, Coutts M, Stahl J, Sytkowski AJ | title = Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis | journal = J. Biol. Chem. | volume = 275 | issue = 11 | pages = 7591–6 | pmid = 10713066 | doi = 10.1074/jbc.275.11.7591}}</ref>
{{Div col end}}
 
==Clinical significance==
During [[endoplasmic reticulum]] stress (such as [[Endoplasmic reticulum stress in beta cells|occurs in beta cells of the pancreas]] or in [[macrophage]]s causing [[atherosclerosis]]), CHOP can induce activation of [[ER oxidoreductin|Ero1]], causing calcium release from the endoplasmic reticulum into the [[cytoplasm]], resulting in [[apoptosis]].<ref name="pmid19752026">{{cite journal | vauthors=Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I | title=Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis | journal= [[Journal of Cell Biology]] | volume=186 | issue=6 | pages=783-792 | year=2009 | url=http://jcb.rupress.org/content/186/6/783.long | DOI=10.1083/jcb.200904060 | PMC=2753154 | PMID = 19752026 }}</ref>  CHOP also induces apoptosis during endoplasmic reticulum stress by activating [[PPP1R15A|growth arrest and DNA damage-inducible protein GADD34]].<ref name="pmid15601821">{{cite journal | vauthors=Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D | title=CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | journal= [[Genes & Development]] | volume=18 | issue=24 | pages=3066-3077 | year=2004 | url=http://genesdev.cshlp.org/content/18/24/3066.long | DOI=10.1101/gad.1250704 | PMC=535917 | PMID = 15601821 }}</ref>  
 
Mutations or fusions of CHOP (e.g. with [[FUS (gene)|FUS]] to form '''[[FUS-CHOP]]''') can cause [[Myxoid liposarcoma]].<ref name=Panag1996>{{cite journal  | author=Panagopoulos I |title=Fusion of the EWS and CHOP genes in myxoid liposarcoma |journal=Oncogene |volume=12 |issue= 3 |pages= 489–94 |year= 1996 |pmid= 8637704 |doi=  |name-list-format=vanc| author2=Höglund M  | author3=Mertens F  | display-authors=3  | last4=Mandahl  | first4=N  | last5=Mitelman  | first5=F  | last6=Aman  | first6=P  }}</ref>
 
== References ==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Ramji DP, Foka P |title=CCAAT/enhancer-binding proteins: structure, function and regulation |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 561–75 |year= 2002 |pmid= 12006103 |doi= 10.1042/BJ20020508 | pmc=1222736 }}
| citations =
*{{cite journal  | vauthors=Oyadomari S, Mori M |title=Roles of CHOP/GADD153 in endoplasmic reticulum stress |journal=Cell Death Differ. |volume=11 |issue= 4 |pages= 381–9 |year= 2004 |pmid= 14685163 |doi= 10.1038/sj.cdd.4401373 }}
*{{cite journal  | author=Ramji DP, Foka P |title=CCAAT/enhancer-binding proteins: structure, function and regulation. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 561-75 |year= 2002 |pmid= 12006103 |doi= 10.1042/BJ20020508 }}
*{{cite journal  | author=Aman P |title=Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11) |journal=Genes Chromosomes Cancer |volume=5 |issue= 4 |pages= 278–85 |year= 1993 |pmid= 1283316 |doi=10.1002/gcc.2870050403 |name-list-format=vanc| author2=Ron D | author3=Mandahl N  | display-authors=3  | last4=Fioretos  | first4=Thoas  | last5=Heim  | first5=Sverre  | last6=Arheden  | first6=Kristina  | last7=Willén  | first7=Helena | last8=Rydholm  | first8=Anders  | last9=Mitelman  | first9=Felix  }}
*{{cite journal  | author=Oyadomari S, Mori M |title=Roles of CHOP/GADD153 in endoplasmic reticulum stress. |journal=Cell Death Differ. |volume=11 |issue= 4 |pages= 381-9 |year= 2004 |pmid= 14685163 |doi= 10.1038/sj.cdd.4401373 }}
*{{cite journal  | author=Park JS |title=Isolation, characterization and chromosomal localization of the human GADD153 gene |journal=Gene |volume=116 |issue= 2 |pages= 259–67 |year= 1992 |pmid= 1339368 |doi=10.1016/0378-1119(92)90523-R |name-list-format=vanc| author2=Luethy JD | author3=Wang MG  | display-authors=3  | last4=Fargnoli  | first4=Joseph  | last5=Fornace  | first5=Albert J  | last6=Wesley Mcbride  | first6=O  | last7=Holbrook  | first7=Nikki J }}
*{{cite journal  | author=Aman P, Ron D, Mandahl N, ''et al.'' |title=Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). |journal=Genes Chromosomes Cancer |volume=5 |issue= 4 |pages= 278-85 |year= 1993 |pmid= 1283316 |doi=  }}
*{{cite journal  | vauthors=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439–53 |year= 1992 |pmid= 1547942 |doi=10.1101/gad.6.3.439  }}
*{{cite journal | author=Park JS, Luethy JD, Wang MG, ''et al.'' |title=Isolation, characterization and chromosomal localization of the human GADD153 gene. |journal=Gene |volume=116 |issue= 2 |pages= 259-67 |year= 1992 |pmid= 1339368 |doi=  }}
*{{cite journal  | author=Eneroth M |title=Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2 |journal=Cancer Genet. Cytogenet. |volume=48 |issue= 1 |pages= 101–7 |year= 1990 |pmid= 2372777 |doi=10.1016/0165-4608(90)90222-V |name-list-format=vanc| author2=Mandahl N | author3=Heim S  | display-authors=3  | last4=Willen  | first4=H  | last5=Rydholm  | first5=A  | last6=Alberts  | first6=K  | last7=Mitelman  | first7=F  }}
*{{cite journal  | author=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439-53 |year= 1992 |pmid= 1547942 |doi=  }}
*{{cite journal  | vauthors=Rabbitts TH, Forster A, Larson R, Nathan P |title=Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 175–80 |year= 1993 |pmid= 7503811 |doi= 10.1038/ng0693-175 }}
*{{cite journal | author=Papathanasiou MA, Kerr NC, Robbins JH, ''et al.'' |title=Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. |journal=Mol. Cell. Biol. |volume=11 |issue= 2 |pages= 1009-16 |year= 1991 |pmid= 1990262 |doi=  }}
*{{cite journal  | vauthors=Crozat A, Aman P, Mandahl N, Ron D |title=Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma |journal=Nature |volume=363 |issue= 6430 |pages= 640–4 |year= 1993 |pmid= 8510758 |doi= 10.1038/363640a0 }}
*{{cite journal  | author=Eneroth M, Mandahl N, Heim S, ''et al.'' |title=Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2. |journal=Cancer Genet. Cytogenet. |volume=48 |issue= 1 |pages= 101-7 |year= 1990 |pmid= 2372777 |doi= }}
*{{cite journal  | vauthors=Chen BP, Wolfgang CD, Hai T |title=Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10 |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1157–68 |year= 1996 |pmid= 8622660 |doi= 10.1128/MCB.16.3.1157| pmc=231098 }}
*{{cite journal  | author=Rabbitts TH, Forster A, Larson R, Nathan P |title=Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 175-80 |year= 1993 |pmid= 7503811 |doi= 10.1038/ng0693-175 }}
*{{cite journal  | vauthors=Wang XZ, Ron D |title=Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase |journal=Science |volume=272 |issue= 5266 |pages= 1347–9 |year= 1996 |pmid= 8650547 |doi=10.1126/science.272.5266.1347 }}
*{{cite journal | author=Crozat A, Aman P, Mandahl N, Ron D |title=Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. |journal=Nature |volume=363 |issue= 6430 |pages= 640-4 |year= 1993 |pmid= 8510758 |doi= 10.1038/363640a0 }}
*{{cite journal  | vauthors=Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ |title=Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14285–9 |year= 1996 |pmid= 8662954 |doi=10.1074/jbc.271.24.14285  }}
*{{cite journal  | author=Chen BP, Wolfgang CD, Hai T |title=Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1157-68 |year= 1996 |pmid= 8622660 |doi= }}
*{{cite journal  | vauthors=Ubeda M, Vallejo M, Habener JF |title=CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7589–99 |year= 1999 |pmid= 10523647 |doi= | pmc=84780 }}
*{{cite journal  | author=Panagopoulos I, Höglund M, Mertens F, ''et al.'' |title=Fusion of the EWS and CHOP genes in myxoid liposarcoma. |journal=Oncogene |volume=12 |issue= 3 |pages= 489-94 |year= 1996 |pmid= 8637704 |doi= }}
*{{cite journal  | vauthors=Cui K, Coutts M, Stahl J, Sytkowski AJ |title=Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7591–6 |year= 2000 |pmid= 10713066 |doi=10.1074/jbc.275.11.7591  }}
*{{cite journal  | author=Wang XZ, Ron D |title=Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. |journal=Science |volume=272 |issue= 5266 |pages= 1347-9 |year= 1996 |pmid= 8650547 |doi=  }}
*{{cite journal  | vauthors=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343–50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200 }}
*{{cite journal  | author=Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ |title=Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14285-9 |year= 1996 |pmid= 8662954 |doi=  }}
*{{cite journal  | author=Satoh T |title=Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells |journal=Oncogene |volume=21 |issue= 14 |pages= 2171–80 |year= 2002 |pmid= 11948400 |doi= 10.1038/sj.onc.1205279  |name-list-format=vanc| author2=Toyoda M  | author3=Hoshino H  | display-authors=3  | last4=Monden  | first4=Tsuyoshi  | last5=Yamada  | first5=Masanabu  | last6=Shimizu  | first6=Hiroyuki  | last7=Miyamoto  | first7=Kaoru  | last8=Mori  | first8=Matsumoto }}
*{{cite journal  | author=Ubeda M, Vallejo M, Habener JF |title=CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7589-99 |year= 1999 |pmid= 10523647 |doi= }}
*{{cite journal  | vauthors=Qiao D, Im E, Qi W, Martinez JD |title=Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis |journal=Biochim. Biophys. Acta |volume=1583 |issue= 1 |pages= 108–16 |year= 2002 |pmid= 12069855 |doi=  10.1016/s1388-1981(02)00190-7}}
*{{cite journal  | author=Cui K, Coutts M, Stahl J, Sytkowski AJ |title=Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7591-6 |year= 2000 |pmid= 10713066 |doi=  }}
*{{cite journal  | vauthors=Talukder AH, Wang RA, Kumar R |title=Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells |journal=Oncogene |volume=21 |issue= 27 |pages= 4289–300 |year= 2002 |pmid= 12082616 |doi= 10.1038/sj.onc.1205529 }}
*{{cite journal  | author=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343-50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200 }}
*{{cite journal  | author=Satoh T, Toyoda M, Hoshino H, ''et al.'' |title=Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells. |journal=Oncogene |volume=21 |issue= 14 |pages= 2171-80 |year= 2002 |pmid= 11948400 |doi= 10.1038/sj.onc.1205279 }}
*{{cite journal  | author=Qiao D, Im E, Qi W, Martinez JD |title=Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis. |journal=Biochim. Biophys. Acta |volume=1583 |issue= 1 |pages= 108-16 |year= 2002 |pmid= 12069855 |doi=  }}
*{{cite journal  | author=Talukder AH, Wang RA, Kumar R |title=Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells. |journal=Oncogene |volume=21 |issue= 27 |pages= 4289-300 |year= 2002 |pmid= 12082616 |doi= 10.1038/sj.onc.1205529 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|DDIT3+protein,+human}}
* {{MeshName|DDIT3+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Oncogenes]]

Revision as of 17:42, 5 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene.[1][2]

Interactions

DNA damage-inducible transcript 3 has been shown to interact with [proteins]:

Clinical significance

During endoplasmic reticulum stress (such as occurs in beta cells of the pancreas or in macrophages causing atherosclerosis), CHOP can induce activation of Ero1, causing calcium release from the endoplasmic reticulum into the cytoplasm, resulting in apoptosis.[9] CHOP also induces apoptosis during endoplasmic reticulum stress by activating growth arrest and DNA damage-inducible protein GADD34.[10]

Mutations or fusions of CHOP (e.g. with FUS to form FUS-CHOP) can cause Myxoid liposarcoma.[11]

References

  1. ↑ Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo I Jr, Barrett SF, Hickson ID, Fornace AJ Jr (March 1991). "Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol. 11 (2): 1009–16. PMC 359769. PMID 1990262.
  2. ↑ "Entrez Gene: DDIT3 DNA-damage-inducible transcript 3".
  3. ↑ Chen BP, Wolfgang CD, Hai T (March 1996). "Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10". Mol. Cell. Biol. 16 (3): 1157–68. doi:10.1128/MCB.16.3.1157. PMC 231098. PMID 8622660.
  4. ↑ 4.0 4.1 4.2 Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins". Mol. Cell. Biol. 19 (11): 7589–99. PMC 84780. PMID 10523647.
  5. ↑ Hattori T, Ohoka N, Hayashi H, Onozaki K (April 2003). "C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform". FEBS Lett. 541 (1–3): 33–9. doi:10.1016/s0014-5793(03)00283-7. PMID 12706815.
  6. ↑ Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ (June 1996). "Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress". J. Biol. Chem. 271 (24): 14285–9. doi:10.1074/jbc.271.24.14285. PMID 8662954.
  7. ↑ Ubeda M, Habener JF (October 2003). "CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation". J. Biol. Chem. 278 (42): 40514–20. doi:10.1074/jbc.M306404200. PMID 12876286.
  8. ↑ Cui K, Coutts M, Stahl J, Sytkowski AJ (March 2000). "Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis". J. Biol. Chem. 275 (11): 7591–6. doi:10.1074/jbc.275.11.7591. PMID 10713066.
  9. ↑ Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I (2009). "Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis". Journal of Cell Biology. 186 (6): 783–792. doi:10.1083/jcb.200904060. PMC 2753154. PMID 19752026.
  10. ↑ Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D (2004). "CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum". Genes & Development. 18 (24): 3066–3077. doi:10.1101/gad.1250704. PMC 535917. PMID 15601821.
  11. ↑ Panagopoulos I, Höglund M, Mertens F, et al. (1996). "Fusion of the EWS and CHOP genes in myxoid liposarcoma". Oncogene. 12 (3): 489–94. PMID 8637704.

Further reading

External links

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