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{{Infobox_gene}}
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'''ETS domain-containing protein Elk-3''' is a [[protein]] that in humans is encoded by the ''ELK3'' [[gene]].<ref name="pmid7851904">{{cite journal | vauthors = Shipley J, Sheer D, Dalton S, Treisman R, Patel K | title = Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively | journal = Genomics | volume = 23 | issue = 3 | pages = 710–1 |date=Mar 1995 | pmid = 7851904 | pmc =  | doi = 10.1006/geno.1994.1564 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2004| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ELK3, ETS-domain protein (SRF accessory protein 2)
| HGNCid = 3325
| Symbol = ELK3
| AltSymbols =; ERP; NET; SAP2
| OMIM = 600247
| ECnumber =
| Homologene = 3833
| MGIid = 101762
  | GeneAtlas_image1 = PBB_GE_ELK3_206127_at_tn.png
| GeneAtlas_image2 = PBB_GE_ELK3_221773_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0032422 |text = purine-rich negative regulatory element binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0042060 |text = wound healing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2004
    | Hs_Ensembl = ENSG00000111145
    | Hs_RefseqProtein = NP_005221
    | Hs_RefseqmRNA = NM_005230
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 95112338
    | Hs_GenLoc_end = 95185739
    | Hs_Uniprot = P41970
    | Mm_EntrezGene = 13713
    | Mm_Ensembl = ENSMUSG00000008398
    | Mm_RefseqmRNA = NM_013508
    | Mm_RefseqProtein = NP_038536
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 92678159
    | Mm_GenLoc_end = 92740634
    | Mm_Uniprot = Q3UZH4
  }}
}}
'''ELK3, ETS-domain protein (SRF accessory protein 2)''', also known as '''ELK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2004| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.<ref name="entrez">{{cite web | title = Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2004| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.<ref name="entrez"/>
}}
}}
==Interactions==
ELK3 has been shown to [[Protein-protein interaction|interact]] with [[TCF3]].<ref name=pmid8918463>{{cite journal |last=Maira |first=S M |author2=Wurtz J M |author3=Wasylyk B  |date=Nov 1996 |title=Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif |journal=EMBO J. |volume=15 |issue=21 |pages=5849–65 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 8918463 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=452333 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371-87 |year= 1998 |pmid= 9570133 |doi=  }}
*{{cite journal  | vauthors=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371–87 |year= 1998 |pmid= 9570133 |doi=10.1016/S1357-2725(97)00086-1 }}
*{{cite journal  | author=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213-6 |year= 1998 |pmid= 9644975 |doi=  }}
*{{cite journal  | vauthors=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213–6 |year= 1998 |pmid= 9644975 |doi=10.1016/S0968-0004(98)01211-0 }}
*{{cite journal  | author=Price MA, Rogers AE, Treisman R |title=Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). |journal=EMBO J. |volume=14 |issue= 11 |pages= 2589-601 |year= 1995 |pmid= 7540136 |doi= }}
*{{cite journal  | vauthors=Price MA, Rogers AE, Treisman R |title=Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). |journal=EMBO J. |volume=14 |issue= 11 |pages= 2589–601 |year= 1995 |pmid= 7540136 |doi=  | pmc=398373  }}
*{{cite journal | author=Shipley J, Sheer D, Dalton S, ''et al.'' |title=Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. |journal=Genomics |volume=23 |issue= 3 |pages= 710-1 |year= 1995 |pmid= 7851904 |doi= 10.1006/geno.1994.1564 }}
*{{cite journal  | vauthors=Giovane A, Pintzas A, Maira SM |title=Net, a new ets transcription factor that is activated by Ras. |journal=Genes Dev. |volume=8 |issue= 13 |pages= 1502–13 |year= 1994 |pmid= 7958835 |doi=10.1101/gad.8.13.1502 |display-authors=etal}}
*{{cite journal  | author=Giovane A, Pintzas A, Maira SM, ''et al.'' |title=Net, a new ets transcription factor that is activated by Ras. |journal=Genes Dev. |volume=8 |issue= 13 |pages= 1502-13 |year= 1994 |pmid= 7958835 |doi=  }}
*{{cite journal  | vauthors=Maira SM, Wurtz JM, Wasylyk B |title=Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5849–65 |year= 1997 |pmid= 8918463 |doi= | pmc=452333 }}
*{{cite journal  | author=Maira SM, Wurtz JM, Wasylyk B |title=Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5849-65 |year= 1997 |pmid= 8918463 |doi=  }}
*{{cite journal  | vauthors=Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B |title=Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3392–403 |year= 1999 |pmid= 10369679 |doi= 10.1093/emboj/18.12.3392 | pmc=1171419 }}
*{{cite journal  | author=Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B |title=Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3392-403 |year= 1999 |pmid= 10369679 |doi= 10.1093/emboj/18.12.3392 }}
*{{cite journal  | vauthors=Ducret C, Maira SM, Dierich A, Wasylyk B |title=The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7076–87 |year= 2000 |pmid= 10490644 |doi= | pmc=84702 }}
*{{cite journal  | author=Ducret C, Maira SM, Dierich A, Wasylyk B |title=The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7076-87 |year= 2000 |pmid= 10490644 |doi=  }}
*{{cite journal  | vauthors=Ducret C, Maira SM, Lutz Y, Wasylyk B |title=The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. |journal=Oncogene |volume=19 |issue= 44 |pages= 5063–72 |year= 2000 |pmid= 11042694 |doi= 10.1038/sj.onc.1203892 }}
*{{cite journal  | author=Ducret C, Maira SM, Lutz Y, Wasylyk B |title=The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. |journal=Oncogene |volume=19 |issue= 44 |pages= 5063-72 |year= 2000 |pmid= 11042694 |doi= 10.1038/sj.onc.1203892 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gupta M, Sueblinvong V, Raman J |title=Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44935–48 |year= 2004 |pmid= 12933792 |doi= 10.1074/jbc.M307696200 |display-authors=etal}}
*{{cite journal  | author=Gupta M, Sueblinvong V, Raman J, ''et al.'' |title=Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44935-48 |year= 2004 |pmid= 12933792 |doi= 10.1074/jbc.M307696200 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Wasylyk C, Criqui-Filipe P, Wasylyk B |title=Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net. |journal=Oncogene |volume=24 |issue= 5 |pages= 820–8 |year= 2005 |pmid= 15580297 |doi= 10.1038/sj.onc.1208226 }}
*{{cite journal  | author=Wasylyk C, Criqui-Filipe P, Wasylyk B |title=Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net. |journal=Oncogene |volume=24 |issue= 5 |pages= 820-8 |year= 2005 |pmid= 15580297 |doi= 10.1038/sj.onc.1208226 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
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* {{MeshName|ELK3+protein,+human}}
* {{MeshName|ELK3+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}
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[[Category:Transcription factors]]
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Revision as of 00:27, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[1][2]

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[2]

Interactions

ELK3 has been shown to interact with TCF3.[3]

References

  1. ↑ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
  2. ↑ 2.0 2.1 "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)".
  3. ↑ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. ENGLAND. 15 (21): 5849–65. ISSN 0261-4189. PMC 452333. PMID 8918463.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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