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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Krueppel-like factor 5''' is a [[protein]] that in humans is encoded by the ''KLF5'' [[gene]].<ref name="pmid8479902">{{cite journal | vauthors = Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y | title = cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2 | journal = Nucleic Acids Research | volume = 21 | issue = 7 | pages = 1527–32 | date = Apr 1993 | pmid = 8479902 | pmc = 309358 | doi = 10.1093/nar/21.7.1527 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kruppel-like factor 5 (intestinal)
| HGNCid = 6349
| Symbol = KLF5
| AltSymbols =; BTEB2; CKLF; IKLF
| OMIM = 602903
| ECnumber = 
| Homologene = 37520
| MGIid = 1338056
| GeneAtlas_image1 = PBB_GE_KLF5_209211_at_tn.png
| GeneAtlas_image2 = PBB_GE_KLF5_209212_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030033 |text = microvillus biogenesis}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 688
    | Hs_Ensembl = ENSG00000102554
    | Hs_RefseqProtein = NP_001721
    | Hs_RefseqmRNA = NM_001730
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 72530931
    | Hs_GenLoc_end = 72549677
    | Hs_Uniprot = Q13887
    | Mm_EntrezGene = 12224
    | Mm_Ensembl = ENSMUSG00000005148
    | Mm_RefseqmRNA = NM_009769
    | Mm_RefseqProtein = NP_033899
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 98181825
    | Mm_GenLoc_end = 98196556
    | Mm_Uniprot = Q923C0
  }}
}}
'''Kruppel-like factor 5 (intestinal)''', also known as '''KLF5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a [[transcription factor]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.<ref name="entrez">{{cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
KLF5 has been shown to [[Protein-protein interaction|interact]] with [[Protein SET]].<ref name=pmid14612398>{{cite journal | vauthors = Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R | title = Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain | journal = Molecular and Cellular Biology | volume = 23 | issue = 23 | pages = 8528–41 | date = Dec 2003 | pmid = 14612398 | pmc = 262669 | doi = 10.1128/MCB.23.23.8528-8541.2003 }}</ref>
 
== See also ==
* [[Kruppel-like factors]]
* [[Kruppel-like factors]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ghaleb AM, Nandan MO, Chanchevalap S, Dalton WB, Hisamuddin IM, Yang VW | title = Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation | journal = Cell Research | volume = 15 | issue = 2 | pages = 92–6 | date = Feb 2005 | pmid = 15740636 | pmc = 1317089 | doi = 10.1038/sj.cr.7290271 }}
| citations =
* {{cite journal | vauthors = Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I | title = Significance of the transcription factor KLF5 in cardiovascular remodeling | journal = Journal of Thrombosis and Haemostasis | volume = 3 | issue = 8 | pages = 1569–76 | date = Aug 2005 | pmid = 16102021 | doi = 10.1111/j.1538-7836.2005.01366.x }}
*{{cite journal | author=Ghaleb AM, Nandan MO, Chanchevalap S, ''et al.'' |title=Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. |journal=Cell Res. |volume=15 |issue= 2 |pages= 92-6 |year= 2005 |pmid= 15740636 |doi= 10.1038/sj.cr.7290271 }}
* {{cite journal | vauthors = McConnell BB, Ghaleb AM, Nandan MO, Yang VW | title = The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology | journal = BioEssays | volume = 29 | issue = 6 | pages = 549–57 | date = Jun 2007 | pmid = 17508399 | pmc = 2211634 | doi = 10.1002/bies.20581 }}
*{{cite journal | author=Nagai R, Suzuki T, Aizawa K, ''et al.'' |title=Significance of the transcription factor KLF5 in cardiovascular remodeling. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1569-76 |year= 2005 |pmid= 16102021 |doi= 10.1111/j.1538-7836.2005.01366.x }}
* {{cite journal | vauthors = Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K | title = Transcriptional activation domain of human BTEB2, a GC box-binding factor | journal = Journal of Biochemistry | volume = 121 | issue = 2 | pages = 389–96 | date = Feb 1997 | pmid = 9089417 | doi = 10.1093/oxfordjournals.jbchem.a021600 }}
*{{cite journal | author=McConnell BB, Ghaleb AM, Nandan MO, Yang VW |title=The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. |journal=Bioessays |volume=29 |issue= 6 |pages= 549-57 |year= 2007 |pmid= 17508399 |doi= 10.1002/bies.20581 }}
* {{cite journal | vauthors = Conkright MD, Wani MA, Anderson KP, Lingrel JB | title = A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells | journal = Nucleic Acids Research | volume = 27 | issue = 5 | pages = 1263–70 | date = Mar 1999 | pmid = 9973612 | pmc = 148310 | doi = 10.1093/nar/27.5.1263 }}
*{{cite journal | author=Sogawa K, Imataka H, Yamasaki Y, ''et al.'' |title=cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. |journal=Nucleic Acids Res. |volume=21 |issue= 7 |pages= 1527-32 |year= 1993 |pmid= 8479902 |doi= }}
* {{cite journal | vauthors = Shi H, Zhang Z, Wang X, Liu S, Teng CT | title = Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter | journal = Nucleic Acids Research | volume = 27 | issue = 24 | pages = 4807–15 | date = Dec 1999 | pmid = 10572182 | pmc = 148782 | doi = 10.1093/nar/27.24.4807 }}
*{{cite journal | author=Kojima S, Kobayashi A, Gotoh O, ''et al.'' |title=Transcriptional activation domain of human BTEB2, a GC box-binding factor. |journal=J. Biochem. |volume=121 |issue= 2 |pages= 389-96 |year= 1997 |pmid= 9089417 |doi= }}
* {{cite journal | vauthors = Hoshino Y, Kurabayashi M, Kanda T, Hasegawa A, Sakamoto H, Okamoto E, Kowase K, Watanabe N, Manabe I, Suzuki T, Nakano A, Takase S, Wilcox JN, Nagai R | title = Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis | journal = Circulation | volume = 102 | issue = 20 | pages = 2528–34 | date = Nov 2000 | pmid = 11076828 | doi = 10.1161/01.cir.102.20.2528 }}
*{{cite journal | author=Conkright MD, Wani MA, Anderson KP, Lingrel JB |title=A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. |journal=Nucleic Acids Res. |volume=27 |issue= 5 |pages= 1263-70 |year= 1999 |pmid= 9973612 |doi= }}
* {{cite journal | vauthors = Sun R, Chen X, Yang VW | title = Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 10 | pages = 6897–900 | date = Mar 2001 | pmid = 11152667 | pmc = 2268089 | doi = 10.1074/jbc.C000870200 }}
*{{cite journal | author=Shi H, Zhang Z, Wang X, ''et al.'' |title=Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. |journal=Nucleic Acids Res. |volume=27 |issue= 24 |pages= 4807-15 |year= 2000 |pmid= 10572182 |doi= }}
* {{cite journal | vauthors = Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW | title = Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene | journal = Nucleic Acids Research | volume = 30 | issue = 13 | pages = 2736–41 | date = Jul 2002 | pmid = 12087155 | pmc = 117055 | doi = 10.1093/nar/gkf400 }}
*{{cite journal | author=Hoshino Y, Kurabayashi M, Kanda T, ''et al.'' |title=Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis. |journal=Circulation |volume=102 |issue= 20 |pages= 2528-34 |year= 2000 |pmid= 11076828 |doi= }}
* {{cite journal | vauthors = Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R | title = Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling | journal = Nature Medicine | volume = 8 | issue = 8 | pages = 856–63 | date = Aug 2002 | pmid = 12101409 | doi = 10.1038/nm738 }}
*{{cite journal | author=Sun R, Chen X, Yang VW |title=Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 6897-900 |year= 2001 |pmid= 11152667 |doi= 10.1074/jbc.C000870200 }}
* {{cite journal | vauthors = Sur I, Undén AB, Toftgård R | title = Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles | journal = European Journal of Cell Biology | volume = 81 | issue = 6 | pages = 323–34 | date = Jun 2002 | pmid = 12113473 | doi = 10.1078/0171-9335-00257 }}
*{{cite journal | author=Dang DT, Zhao W, Mahatan CS, ''et al.'' |title=Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. |journal=Nucleic Acids Res. |volume=30 |issue= 13 |pages= 2736-41 |year= 2002 |pmid= 12087155 |doi= }}
* {{cite journal | vauthors = Chen C, Bhalala HV, Qiao H, Dong JT | title = A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer | journal = Oncogene | volume = 21 | issue = 43 | pages = 6567–72 | date = Sep 2002 | pmid = 12242654 | doi = 10.1038/sj.onc.1205817 }}
*{{cite journal | author=Shindo T, Manabe I, Fukushima Y, ''et al.'' |title=Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. |journal=Nat. Med. |volume=8 |issue= 8 |pages= 856-63 |year= 2002 |pmid= 12101409 |doi= 10.1038/nm738 }}
* {{cite journal | vauthors = Yang XO, Doty RT, Hicks JS, Willerford DM | title = Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs | journal = Blood | volume = 101 | issue = 11 | pages = 4492–9 | date = Jun 2003 | pmid = 12576331 | doi = 10.1182/blood-2002-08-2579 }}
*{{cite journal | author=Sur I, Undén AB, Toftgård R |title=Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. |journal=Eur. J. Cell Biol. |volume=81 |issue= 6 |pages= 323-34 |year= 2003 |pmid= 12113473 |doi= }}
* {{cite journal | vauthors = Chen C, Bhalala HV, Vessella RL, Dong JT | title = KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer | journal = The Prostate | volume = 55 | issue = 2 | pages = 81–8 | date = May 2003 | pmid = 12661032 | doi = 10.1002/pros.10205 }}
*{{cite journal | author=Chen C, Bhalala HV, Qiao H, Dong JT |title=A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. |journal=Oncogene |volume=21 |issue= 43 |pages= 6567-72 |year= 2002 |pmid= 12242654 |doi= 10.1038/sj.onc.1205817 }}
* {{cite journal | vauthors = Zhang Z, Teng CT | title = Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function | journal = Nucleic Acids Research | volume = 31 | issue = 8 | pages = 2196–208 | date = Apr 2003 | pmid = 12682370 | pmc = 153738 | doi = 10.1093/nar/gkg310 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T | title = Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 2 | pages = 251–6 | date = Aug 2003 | pmid = 12901861 | doi = 10.1016/S0006-291X(03)01356-1 }}
*{{cite journal | author=Yang XO, Doty RT, Hicks JS, Willerford DM |title=Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. |journal=Blood |volume=101 |issue= 11 |pages= 4492-9 |year= 2003 |pmid= 12576331 |doi= 10.1182/blood-2002-08-2579 }}
* {{cite journal | vauthors = Aizawa K, Suzuki T, Kada N, Ishihara A, Kawai-Kowase K, Matsumura T, Sasaki K, Munemasa Y, Manabe I, Kurabayashi M, Collins T, Nagai R | title = Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB | journal = The Journal of Biological Chemistry | volume = 279 | issue = 1 | pages = 70–6 | date = Jan 2004 | pmid = 14573617 | doi = 10.1074/jbc.M306621200 }}
*{{cite journal | author=Chen C, Bhalala HV, Vessella RL, Dong JT |title=KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. |journal=Prostate |volume=55 |issue= 2 |pages= 81-8 |year= 2003 |pmid= 12661032 |doi= 10.1002/pros.10205 }}
* {{cite journal | vauthors = Sato T, Kanda T, Iida T, Takahashi T, Kishi S, Hoshino Y | title = Immunohistochemical study of surgically excised choroidal neovascular membranes | journal = The Journal of International Medical Research | volume = 31 | issue = 5 | pages = 402–6 | year = 2004 | pmid = 14587307 | doi = 10.1177/147323000303100507 }}
*{{cite journal | author=Zhang Z, Teng CT |title=Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. |journal=Nucleic Acids Res. |volume=31 |issue= 8 |pages= 2196-208 |year= 2003 |pmid= 12682370 |doi= }}
*{{cite journal | author=Ohnishi S, Ohnami S, Laub F, ''et al.'' |title=Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 251-6 |year= 2003 |pmid= 12901861 |doi= }}
*{{cite journal  | author=Aizawa K, Suzuki T, Kada N, ''et al.'' |title=Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 70-6 |year= 2004 |pmid= 14573617 |doi= 10.1074/jbc.M306621200 }}
*{{cite journal  | author=Sato T, Kanda T, Iida T, ''et al.'' |title=Immunohistochemical study of surgically excised choroidal neovascular membranes. |journal=J. Int. Med. Res. |volume=31 |issue= 5 |pages= 402-6 |year= 2004 |pmid= 14587307 |doi=  }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|KLF5+protein,+human}}
* {{MeshName|KLF5+protein,+human}}
{{Transcription factors|g2}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-13-stub}}

Latest revision as of 06:31, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.[1][2]

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.[2]

Interactions

KLF5 has been shown to interact with Protein SET.[3]

See also

References

  1. ↑ Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC 309358. PMID 8479902.
  2. ↑ 2.0 2.1 "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
  3. ↑ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC 262669. PMID 14612398.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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