CEBPE: Difference between revisions

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Latest revision as of 01:57, 27 October 2017

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene^[1]^[2] and is pro-apoptotic.^[3]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".
↑ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
↑ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
Gombart AF, Koeffler HP (Jan 2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Current Opinion in Hematology. 9 (1): 36–42. doi:10.1097/00062752-200201000-00007. PMID 11753076.
Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP (Mar 1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor". Molecular and Cellular Biology. 17 (3): 1375–86. doi:10.1128/mcb.17.3.1375. PMC 231862. PMID 9032264.
Yamanaka R, Kim GD, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P, Tenen DG, Xanthopoulos KG (Jun 1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6462–7. doi:10.1073/pnas.94.12.6462. PMC 21072. PMID 9177240.
Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP (May 1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters". Blood. 93 (10): 3327–37. PMID 10233885.
Lekstrom-Himes JA, Dorman SE, Kopar P, Holland SM, Gallin JI (Jun 1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon". The Journal of Experimental Medicine. 189 (11): 1847–52. doi:10.1084/jem.189.11.1847. PMC 2193089. PMID 10359588.
Tavor S, Vuong PT, Park DJ, Gombart AF, Cohen AH, Koeffler HP (Mar 2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice". Blood. 99 (5): 1794–801. doi:10.1182/blood.V99.5.1794. PMID 11861297.
Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG (Jun 2002). "Induction of granulocytic differentiation by 2 pathways". Blood. 99 (12): 4406–12. doi:10.1182/blood.V99.12.4406. PMID 12036869.
Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC (Oct 2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation". The Journal of Biological Chemistry. 277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID 12161447.
Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE, Lekstrom-Himes JA, Ackerman SJ (Nov 2002). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of Biological Chemistry. 277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID 12202480.
Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC (Feb 2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia". Blood. 101 (3): 1141–8. doi:10.1182/blood-2002-05-1374. PMID 12393450.
Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP (Apr 2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1". Blood. 101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID 12515729.
Khanna-Gupta A, Zibello T, Sun H, Gaines P, Berliner N (May 2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression". Blood. 101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID 12522000.
Gery S, Gombart AF, Fung YK, Koeffler HP (Feb 2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis". Blood. 103 (3): 828–35. doi:10.1182/blood-2003-01-0159. PMID 12947005.
Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP (Dec 2004). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes". Blood. 104 (13): 3911–7. doi:10.1182/blood-2003-10-3688. PMID 15308577.

External links

CEBPE protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CEBPE genome location and CEBPE gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".

[pmid8661101-2] Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.

[pmid16531405-3] Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

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[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''CCAAT/enhancer binding protein (C/EBP), epsilon''', also known as '''CEBPE''' and '''CRP1''', is a type of [[ccaat-enhancer-binding protein]]. '''CEBPE''' is its human [[gene]]<ref name="entrez">{{cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = }}</ref><ref name="pmid8661101">{{cite journal | vauthors = Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG | title = A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus | journal = Genomics | volume = 35 | issue = 1 | pages = 30–8 | date = Jul 1996 | pmid = 8661101 | doi = 10.1006/geno.1996.0319 }}</ref> and is pro-[[apoptosis|apoptotic]].<ref name="pmid16531405">{{cite journal | vauthors = Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M | title = N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation | journal = The Journal of Biological Chemistry | volume = 281 | issue = 20 | pages = 14494–502 | date = May 2006 | pmid = 16531405 | doi = 10.1074/jbc.M600575200 }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene is a [[bZIP domain|bZIP]] [[transcription factor]] which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein [[CEBPD|CEBP-δ]]. The encoded protein may be essential for terminal differentiation and functional maturation of committed [[granulocyte]] [[progenitor cell]]s. Mutations in this gene have been associated with [[specific granule deficiency]], a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = CCAAT/enhancer binding protein (C/EBP), epsilon
- | HGNCid = 1836
- | Symbol = CEBPE
- | AltSymbols =; C/EBP-epsilon; CRP1
- | OMIM = 600749
- | ECnumber =
- | Homologene = 1367
- | MGIid = 103572
- | GeneAtlas_image1 = PBB_GE_CEBPE_214523_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006909 |text = phagocytosis}} {{GNF_GO|id=GO:0030225 |text = macrophage differentiation}} {{GNF_GO|id=GO:0042089 |text = cytokine biosynthetic process}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1053
-    | Hs_Ensembl = ENSG00000092067
-    | Hs_RefseqProtein = NP_001796
-    | Hs_RefseqmRNA = NM_001805
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 22656387
-    | Hs_GenLoc_end = 22658665
-    | Hs_Uniprot = Q15744
-    | Mm_EntrezGene = 110794
-    | Mm_Ensembl = ENSMUSG00000052435
-    | Mm_RefseqmRNA = XM_989335
-    | Mm_RefseqProtein = XP_994429
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 53664568
-    | Mm_GenLoc_end = 53666379
-    | Mm_Uniprot = Q32MW8
-  }}
-}}
-'''CCAAT/enhancer binding protein (C/EBP), epsilon''', also known as '''CEBPE''' and '''CHOP''', is a type of [[ccaat-enhancer-binding protein]]. '''CEBPE''' is its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = }}</ref>. It is [[proapoptotic]].
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== References ==
-{{PBB_Summary
+{{reflist}}
-| section_title =
-| summary_text = The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = }}</ref>
-}}
-==References==
+== Further reading ==
-{{reflist|2}}
-==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Sladek FM, Darnell JE | title = Mechanisms of liver-specific gene expression | journal = Current Opinion in Genetics & Development | volume = 2 | issue = 2 | pages = 256–9 | date = Apr 1992 | pmid = 1638120 | doi = 10.1016/S0959-437X(05)80282-5 }}
-| citations =
+* {{cite journal | vauthors = Gombart AF, Koeffler HP | title = Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon) | journal = Current Opinion in Hematology | volume = 9 | issue = 1 | pages = 36–42 | date = Jan 2002 | pmid = 11753076 | doi = 10.1097/00062752-200201000-00007 }}
-*{{cite journal  | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256-9 |year= 1992 |pmid= 1638120 |doi=  }}
+* {{cite journal | vauthors = Williams SC, Cantwell CA, Johnson PF | title = A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro | journal = Genes & Development | volume = 5 | issue = 9 | pages = 1553–67 | date = Sep 1991 | pmid = 1884998 | doi = 10.1101/gad.5.9.1553 }}
-*{{cite journal  | author=Gombart AF, Koeffler HP |title=Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon). |journal=Curr. Opin. Hematol. |volume=9 |issue= 1 |pages= 36-42 |year= 2002 |pmid= 11753076 |doi=  }}
+* {{cite journal | vauthors = Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG | title = A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus | journal = Genomics | volume = 35 | issue = 1 | pages = 30–8 | date = Jul 1996 | pmid = 8661101 | doi = 10.1006/geno.1996.0319 }}
-*{{cite journal  | author=Williams SC, Cantwell CA, Johnson PF |title=A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. |journal=Genes Dev. |volume=5 |issue= 9 |pages= 1553-67 |year= 1991 |pmid= 1884998 |doi=  }}
+* {{cite journal | vauthors = Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP | title = Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor | journal = Molecular and Cellular Biology | volume = 17 | issue = 3 | pages = 1375–86 | date = Mar 1997 | pmid = 9032264 | pmc = 231862 | doi =  10.1128/mcb.17.3.1375}}
-*{{cite journal  | author=Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG |title=A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. |journal=Genomics |volume=35 |issue= 1 |pages= 30-8 |year= 1996 |pmid= 8661101 |doi=  }}
+* {{cite journal | vauthors = Yamanaka R, Kim GD, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P, Tenen DG, Xanthopoulos KG | title = CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 12 | pages = 6462–7 | date = Jun 1997 | pmid = 9177240 | pmc = 21072 | doi = 10.1073/pnas.94.12.6462 }}
-*{{cite journal  | author=Chumakov AM, Grillier I, Chumakova E, ''et al.'' |title=Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1375-86 |year= 1997 |pmid= 9032264 |doi=  }}
+* {{cite journal | vauthors = Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP | title = C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters | journal = Blood | volume = 93 | issue = 10 | pages = 3327–37 | date = May 1999 | pmid = 10233885 | doi =  }}
-*{{cite journal  | author=Yamanaka R, Kim GD, Radomska HS, ''et al.'' |title=CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6462-7 |year= 1997 |pmid= 9177240 |doi=  }}
+* {{cite journal | vauthors = Lekstrom-Himes JA, Dorman SE, Kopar P, Holland SM, Gallin JI | title = Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon | journal = The Journal of Experimental Medicine | volume = 189 | issue = 11 | pages = 1847–52 | date = Jun 1999 | pmid = 10359588 | pmc = 2193089 | doi = 10.1084/jem.189.11.1847 }}
-*{{cite journal  | author=Verbeek W, Gombart AF, Chumakov AM, ''et al.'' |title=C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. |journal=Blood |volume=93 |issue= 10 |pages= 3327-37 |year= 1999 |pmid= 10233885 |doi=  }}
+* {{cite journal | vauthors = Tavor S, Vuong PT, Park DJ, Gombart AF, Cohen AH, Koeffler HP | title = Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice | journal = Blood | volume = 99 | issue = 5 | pages = 1794–801 | date = Mar 2002 | pmid = 11861297 | doi = 10.1182/blood.V99.5.1794 }}
-*{{cite journal  | author=Lekstrom-Himes JA, Dorman SE, Kopar P, ''et al.'' |title=Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. |journal=J. Exp. Med. |volume=189 |issue= 11 |pages= 1847-52 |year= 1999 |pmid= 10359588 |doi=  }}
+* {{cite journal | vauthors = Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG | title = Induction of granulocytic differentiation by 2 pathways | journal = Blood | volume = 99 | issue = 12 | pages = 4406–12 | date = Jun 2002 | pmid = 12036869 | doi = 10.1182/blood.V99.12.4406 }}
-*{{cite journal  | author=Tavor S, Vuong PT, Park DJ, ''et al.'' |title=Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. |journal=Blood |volume=99 |issue= 5 |pages= 1794-801 |year= 2002 |pmid= 11861297 |doi=  }}
+* {{cite journal | vauthors = Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC | title = Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38037–44 | date = Oct 2002 | pmid = 12161447 | doi = 10.1074/jbc.M207235200 }}
-*{{cite journal  | author=Zhang P, Nelson E, Radomska HS, ''et al.'' |title=Induction of granulocytic differentiation by 2 pathways. |journal=Blood |volume=99 |issue= 12 |pages= 4406-12 |year= 2002 |pmid= 12036869 |doi=  }}
+* {{cite journal | vauthors = Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE, Lekstrom-Himes JA, Ackerman SJ | title = Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 43481–94 | date = Nov 2002 | pmid = 12202480 | doi = 10.1074/jbc.M204777200 }}
-*{{cite journal  | author=Kim J, Cantwell CA, Johnson PF, ''et al.'' |title=Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38037-44 |year= 2002 |pmid= 12161447 |doi= 10.1074/jbc.M207235200 }}
+* {{cite journal | vauthors = Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC | title = CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia | journal = Blood | volume = 101 | issue = 3 | pages = 1141–8 | date = Feb 2003 | pmid = 12393450 | doi = 10.1182/blood-2002-05-1374 }}
-*{{cite journal  | author=Du J, Stankiewicz MJ, Liu Y, ''et al.'' |title=Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43481-94 |year= 2003 |pmid= 12202480 |doi= 10.1074/jbc.M204777200 }}
+* {{cite journal | vauthors = Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP | title = Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1 | journal = Blood | volume = 101 | issue = 8 | pages = 3265–73 | date = Apr 2003 | pmid = 12515729 | doi = 10.1182/blood-2002-04-1039 }}
-*{{cite journal  | author=Truong BT, Lee YJ, Lodie TA, ''et al.'' |title=CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. |journal=Blood |volume=101 |issue= 3 |pages= 1141-8 |year= 2003 |pmid= 12393450 |doi= 10.1182/blood-2002-05-1374 }}
+* {{cite journal | vauthors = Khanna-Gupta A, Zibello T, Sun H, Gaines P, Berliner N | title = Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression | journal = Blood | volume = 101 | issue = 9 | pages = 3460–8 | date = May 2003 | pmid = 12522000 | doi = 10.1182/blood-2002-09-2767 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Gery S, Gombart AF, Fung YK, Koeffler HP | title = C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis | journal = Blood | volume = 103 | issue = 3 | pages = 828–35 | date = Feb 2004 | pmid = 12947005 | doi = 10.1182/blood-2003-01-0159 }}
-*{{cite journal  | author=Gombart AF, Kwok SH, Anderson KL, ''et al.'' |title=Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1. |journal=Blood |volume=101 |issue= 8 |pages= 3265-73 |year= 2003 |pmid= 12515729 |doi= 10.1182/blood-2002-04-1039 }}
+* {{cite journal | vauthors = Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP | title = Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes | journal = Blood | volume = 104 | issue = 13 | pages = 3911–7 | date = Dec 2004 | pmid = 15308577 | doi = 10.1182/blood-2003-10-3688 }}
-*{{cite journal  | author=Khanna-Gupta A, Zibello T, Sun H, ''et al.'' |title=Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression. |journal=Blood |volume=101 |issue= 9 |pages= 3460-8 |year= 2003 |pmid= 12522000 |doi= 10.1182/blood-2002-09-2767 }}
-*{{cite journal  | author=Gery S, Gombart AF, Fung YK, Koeffler HP |title=C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis. |journal=Blood |volume=103 |issue= 3 |pages= 828-35 |year= 2004 |pmid= 12947005 |doi= 10.1182/blood-2003-01-0159 }}
-*{{cite journal  | author=Gery S, Park DJ, Vuong PT, ''et al.'' |title=Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes. |journal=Blood |volume=104 |issue= 13 |pages= 3911-7 |year= 2005 |pmid= 15308577 |doi= 10.1182/blood-2003-10-3688 }}
-}}
 {{refend}}
 == External links ==
-* {{MeshName|CEBPE+protein,+human}}
+* {{MeshName|CEBPE+protein,+human|3=CEBPE protein, human}}
+* {{UCSC gene info|CEBPE}}
 {{NLM content}}
-{{protein-stub}}
+{{gene-14-stub}}
-{{Transcription factors}}
+{{Transcription factors|g1}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}

CEBPE: Difference between revisions

Latest revision as of 01:57, 27 October 2017

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