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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''AT rich interactive domain 4A (RBP1-like)''', also known as '''ARID4A''', is a [[protein]] which in humans is encoded by the ''ARID4A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5926| accessdate = }}</ref><ref name="pmid1857421">{{cite journal | vauthors = Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A | title = Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product | journal = Nature | volume = 352 | issue = 6332 | pages = 251–4 | date = Jul 1991 | pmid = 1857421 | doi = 10.1038/352251a0 }}</ref><ref name="pmid8455946">{{cite journal | vauthors = Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ | title = Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites | journal = Oncogene | volume = 8 | issue = 4 | pages = 949–57 | date = Apr 1993 | pmid = 8455946 | doi = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
The protein encoded by this gene is a ubiquitously expressed [[cell nucleus|nuclear]] protein. It binds directly, with several other proteins, to [[retinoblastoma protein]] (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit [[histone deacetylase|HDAC]]s and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.<ref name="entrez"/>
| image =
| image_source =
| PDB =  
| Name = AT rich interactive domain 4A (RBP1-like)
| HGNCid = 9885
| Symbol = ARID4A
| AltSymbols =; RBBP1; RBP-1; RBP1
| OMIM = 180201
| ECnumber = 
| Homologene = 11303
| MGIid = 2444354
| GeneAtlas_image1 = PBB_GE_ARID4A_205062_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0017053 |text = transcriptional repressor complex}}
| Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5926
    | Hs_Ensembl = ENSG00000032219
    | Hs_RefseqProtein = NP_002883
    | Hs_RefseqmRNA = NM_002892
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 57835116
    | Hs_GenLoc_end = 57909391
    | Hs_Uniprot = P29374
    | Mm_EntrezGene = 238247
    | Mm_Ensembl = ENSMUSG00000048118
    | Mm_RefseqmRNA = XM_354675
    | Mm_RefseqProtein = XP_354675
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 71934435
    | Mm_GenLoc_end = 72016206
    | Mm_Uniprot = 
  }}
}}
'''AT rich interactive domain 4A (RBP1-like)''', also known as '''ARID4A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5926| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Model organisms ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.<ref name="entrez">{{cite web | title = Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5926| accessdate = }}</ref>
}}


==References==
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
{{reflist|2}}
|+ ''Arid4a'' knockout mouse phenotype
==Further reading==
|-
{{refbegin | 2}}
! Characteristic!! Phenotype
{{PBB_Further_reading
 
| citations =
|-
*{{cite journal  | author=Defeo-Jones D, Huang PS, Jones RE, ''et al.'' |title=Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. |journal=Nature |volume=352 |issue= 6332 |pages= 251-4 |year= 1991 |pmid= 1857421 |doi= 10.1038/352251a0 }}
| [[Homozygote]] viability || bgcolor="#C40000"|Abnormal
*{{cite journal  | author=Fattaey AR, Helin K, Dembski MS, ''et al.'' |title=Characterization of the retinoblastoma binding proteins RBP1 and RBP2. |journal=Oncogene |volume=8 |issue= 11 |pages= 3149-56 |year= 1993 |pmid= 8414517 |doi= }}
|-
*{{cite journal  | author=Otterson GA, Kratzke RA, Lin AY, ''et al.'' |title=Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. |journal=Oncogene |volume=8 |issue= 4 |pages= 949-57 |year= 1993 |pmid= 8455946 |doi=  }}
| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
*{{cite journal  | author=Margottin F, Bour SP, Durand H, ''et al.'' |title=A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. |journal=Mol. Cell |volume=1 |issue= 4 |pages= 565-74 |year= 1998 |pmid= 9660940 |doi= }}
|-
*{{cite journal  | author=Lai A, Marcellus RC, Corbeil HB, Branton PE |title=RBP1 induces growth arrest by repression of E2F-dependent transcription. |journal=Oncogene |volume=18 |issue= 12 |pages= 2091-100 |year= 1999 |pmid= 10321733 |doi= 10.1038/sj.onc.1202520 }}
| Fertility || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Cao J, Gao T, Giuliano AE, Irie RF |title=Recognition of an epitope of a breast cancer antigen by human antibody. |journal=Breast Cancer Res. Treat. |volume=53 |issue= 3 |pages= 279-90 |year= 1999 |pmid= 10369074 |doi= }}
|-
*{{cite journal  | author=Lai A, Lee JM, Yang WM, ''et al.'' |title=RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6632-41 |year= 2000 |pmid= 10490602 |doi= }}
| Body weight || bgcolor="#C40000"|Abnormal<ref name="Body weight">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/weight-curves/ |title=Body weight data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
*{{cite journal  | author=Lai A, Kennedy BK, Barbie DA, ''et al.'' |title=RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. |journal=Mol. Cell. Biol. |volume=21 |issue= 8 |pages= 2918-32 |year= 2001 |pmid= 11283269 |doi= 10.1128/MCB.21.8.2918-2932.2001 }}
|-
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Fleischer TC, Yun UJ, Ayer DE |title=Identification and characterization of three new components of the mSin3A corepressor complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 10 |pages= 3456-67 |year= 2003 |pmid= 12724404 |doi= }}
|-
*{{cite journal | author=Meehan WJ, Samant RS, Hopper JE, ''et al.'' |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1562-9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200 }}
| Neurological assessment || bgcolor="#488ED3"|Normal
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
|-
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
| Grip strength || bgcolor="#C40000"|Abnormal<ref name="Grip strength">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/grip-strength/ |title=Grip strength data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
*{{cite journal  | author=Monroe DG, Secreto FJ, Hawse JR, ''et al.'' |title=Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28596-604 |year= 2006 |pmid= 16873370 |doi= 10.1074/jbc.M605226200 }}
|-
}}
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal<ref name="DEXA">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/body-composition-dexa/ |title=DEXA data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Radiography]] || bgcolor="#C40000"|Abnormal<ref name="Radiography">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/x-ray-imaging/ |title=Radiography data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| Body temperature || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#C40000"|Abnormal<ref name="Clinical chemistry">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/plasma-chemistry/ |title=Clinical chemistry data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Haematology]] || bgcolor="#C40000"|Abnormal<ref name="Haematology">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/haematology-cbc/ |title=Haematology data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Peripheral blood lymphocyte]]s || bgcolor="#C40000"|Abnormal
|-
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Skin Histopathology || bgcolor="#488ED3"|Normal
|-
| Eye Histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/salmonella-challenge/ |title=''Salmonella'' infection data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAJ/citrobacter-challenge/ |title=''Citrobacter'' infection data for Arid4a |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of ARID4A function. A conditional [[knockout mouse]] line, called ''Arid4a<sup>tm1a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Arid4a |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432398 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the [[Wellcome Trust Sanger Institute]].<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref> Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}</ref>
 
Twenty five tests were carried out and nine [[phenotypes]] were reported. Fewer [[homozygous]] [[mutant]] embryos were identified during gestation than expected, and in a separate study less than the predicted [[Mendelian ratio]] survived until [[weaning]]. Homozygous mutant male adults has a reduced body weight curve and a decreased grip strength. Homozygous mutant adults of both sexes had a decreased body weight as determined by [[DEXA]], displayed [[vertebral fusion]] and had clinical chemistry abnormalities including [[hypoalbuminemia]] and decreased circulating [[fructosamine]] levels. They also had haematological defects and an increased [[NK cell]] number.<ref name="mgp_reference" />
 
== Interactions ==
ARID4A has been shown to [[Protein-protein interaction|interact]] with [[Retinoblastoma protein]].<ref name=pmid10490602>{{cite journal | vauthors = Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE | title = RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6632–41 | date = Oct 1999 | pmid = 10490602 | pmc = 84642 | doi=10.1128/mcb.19.10.6632}}</ref>
{{clear}}
== References ==
{{reflist|33em}}
 
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A | title = Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product | journal = Nature | volume = 352 | issue = 6332 | pages = 251–4 | date = Jul 1991 | pmid = 1857421 | doi = 10.1038/352251a0 }}
* {{cite journal | vauthors = Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D | title = Characterization of the retinoblastoma binding proteins RBP1 and RBP2 | journal = Oncogene | volume = 8 | issue = 11 | pages = 3149–56 | date = Nov 1993 | pmid = 8414517 | doi =  }}
* {{cite journal | vauthors = Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ | title = Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites | journal = Oncogene | volume = 8 | issue = 4 | pages = 949–57 | date = Apr 1993 | pmid = 8455946 | doi =  }}
* {{cite journal | vauthors = Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R | title = A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif | journal = Molecular Cell | volume = 1 | issue = 4 | pages = 565–74 | date = Mar 1998 | pmid = 9660940 | doi = 10.1016/S1097-2765(00)80056-8 }}
* {{cite journal | vauthors = Lai A, Marcellus RC, Corbeil HB, Branton PE | title = RBP1 induces growth arrest by repression of E2F-dependent transcription | journal = Oncogene | volume = 18 | issue = 12 | pages = 2091–100 | date = Mar 1999 | pmid = 10321733 | doi = 10.1038/sj.onc.1202520 }}
* {{cite journal | vauthors = Cao J, Gao T, Giuliano AE, Irie RF | title = Recognition of an epitope of a breast cancer antigen by human antibody | journal = Breast Cancer Research and Treatment | volume = 53 | issue = 3 | pages = 279–90 | date = Feb 1999 | pmid = 10369074 | doi = 10.1023/A:1006115922401 }}
* {{cite journal | vauthors = Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE | title = RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6632–41 | date = Oct 1999 | pmid = 10490602 | pmc = 84642 | doi =  10.1128/mcb.19.10.6632}}
* {{cite journal | vauthors = Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE | title = RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest | journal = Molecular and Cellular Biology | volume = 21 | issue = 8 | pages = 2918–32 | date = Apr 2001 | pmid = 11283269 | pmc = 86920 | doi = 10.1128/MCB.21.8.2918-2932.2001 }}
* {{cite journal | vauthors = Fleischer TC, Yun UJ, Ayer DE | title = Identification and characterization of three new components of the mSin3A corepressor complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 10 | pages = 3456–67 | date = May 2003 | pmid = 12724404 | pmc = 164750 | doi = 10.1128/MCB.23.10.3456-3467.2003 }}
* {{cite journal | vauthors = Meehan WJ, Samant RS, Hopper JE, Carrozza MJ, Shevde LA, Workman JL, Eckert KA, Verderame MF, Welch DR | title = Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription | journal = The Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1562–9 | date = Jan 2004 | pmid = 14581478 | doi = 10.1074/jbc.M307969200 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Monroe DG, Secreto FJ, Hawse JR, Subramaniam M, Khosla S, Spelsberg TC | title = Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements | journal = The Journal of Biological Chemistry | volume = 281 | issue = 39 | pages = 28596–604 | date = Sep 2006 | pmid = 16873370 | doi = 10.1074/jbc.M605226200 }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ARID4A+protein,+human}}
* {{MeshName|ARID4A+protein,+human}}
* {{UCSC gene info|ARID4A}}
* {{UCSC gene info|RBP1}}


{{NLM content}}
{{Transcription factors|g0}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Genes mutated in mice]]

Latest revision as of 18:14, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AT rich interactive domain 4A (RBP1-like), also known as ARID4A, is a protein which in humans is encoded by the ARID4A gene.[1][2][3]

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.[1]

Model organisms

Model organisms have been used in the study of ARID4A function. A conditional knockout mouse line, called Arid4atm1a(EUCOMM)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[16][17][18] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19]

Twenty five tests were carried out and nine phenotypes were reported. Fewer homozygous mutant embryos were identified during gestation than expected, and in a separate study less than the predicted Mendelian ratio survived until weaning. Homozygous mutant male adults has a reduced body weight curve and a decreased grip strength. Homozygous mutant adults of both sexes had a decreased body weight as determined by DEXA, displayed vertebral fusion and had clinical chemistry abnormalities including hypoalbuminemia and decreased circulating fructosamine levels. They also had haematological defects and an increased NK cell number.[12]

Interactions

ARID4A has been shown to interact with Retinoblastoma protein.[20]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ARID4A AT rich interactive domain 4A (RBP1-like)".
  2. ↑ Defeo-Jones D, Huang PS, Jones RE, Haskell KM, Vuocolo GA, Hanobik MG, Huber HE, Oliff A (Jul 1991). "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product". Nature. 352 (6332): 251–4. doi:10.1038/352251a0. PMID 1857421.
  3. ↑ Otterson GA, Kratzke RA, Lin AY, Johnston PG, Kaye FJ (Apr 1993). "Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites". Oncogene. 8 (4): 949–57. PMID 8455946.
  4. ↑ "Body weight data for Arid4a". Wellcome Trust Sanger Institute.
  5. ↑ "Grip strength data for Arid4a". Wellcome Trust Sanger Institute.
  6. ↑ "DEXA data for Arid4a". Wellcome Trust Sanger Institute.
  7. ↑ "Radiography data for Arid4a". Wellcome Trust Sanger Institute.
  8. ↑ "Clinical chemistry data for Arid4a". Wellcome Trust Sanger Institute.
  9. ↑ "Haematology data for Arid4a". Wellcome Trust Sanger Institute.
  10. ↑ "Salmonella infection data for Arid4a". Wellcome Trust Sanger Institute.
  11. ↑ "Citrobacter infection data for Arid4a". Wellcome Trust Sanger Institute.
  12. ↑ 12.0 12.1 12.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  13. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  14. ↑ "International Knockout Mouse Consortium".
  15. ↑ "Mouse Genome Informatics".
  16. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  19. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  20. ↑ Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE (Oct 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Molecular and Cellular Biology. 19 (10): 6632–41. doi:10.1128/mcb.19.10.6632. PMC 84642. PMID 10490602.

Further reading

External links

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