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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''B-cell lymphoma/leukemia 11B''' is a [[protein]] that in humans is encoded by the ''BCL11B'' [[gene]].<ref name="pmid11719382">{{cite journal | vauthors = Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ | title = The BCL11 gene family: involvement of BCL11A in lymphoid malignancies | journal = Blood | volume = 98 | issue = 12 | pages = 3413–20  | date = Nov 2001 | pmid = 11719382 | pmc =  | doi = 10.1182/blood.V98.12.3413 }}</ref><ref name="pmid16950772">{{cite journal | vauthors = Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, Filtz TM, Leid M | title = CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene | journal = J. Biol. Chem. | volume = 281 | issue = 43 | pages = 32272–83  | date = Oct 2006 | pmid = 16950772 | pmc = 2547407 | doi = 10.1074/jbc.M602776200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==  Function ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = B-cell CLL/lymphoma 11B (zinc finger protein)
| HGNCid = 13222
| Symbol = BCL11B
| AltSymbols =; RIT1; CTIP-2; CTIP2; hRIT1-alpha
| OMIM = 606558
| ECnumber = 
| Homologene = 10974
| MGIid = 1929913
| GeneAtlas_image1 = PBB_GE_BCL11B_219528_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64919
    | Hs_Ensembl = ENSG00000127152
    | Hs_RefseqProtein = NP_075049
    | Hs_RefseqmRNA = NM_022898
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 98705377
    | Hs_GenLoc_end = 98807575
    | Hs_Uniprot = Q9C0K0
    | Mm_EntrezGene = 58208
    | Mm_Ensembl = ENSMUSG00000048251
    | Mm_RefseqmRNA = NM_001079883
    | Mm_RefseqProtein = NP_001073352
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 108361448
    | Mm_GenLoc_end = 108451221
    | Mm_Uniprot = Q3TEG9
  }}
}}
'''B-cell CLL/lymphoma 11B (zinc finger protein)''', also known as '''BCL11B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a C2H2-type [[zinc finger]] protein and is closely related to [[BCL11A]], a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919| accessdate = }}</ref>
}}


==References==
Recent research suggests that BCL11B is crucial for [[ameloblasts]] (the cells that produce [[tooth enamel]]) to form and work properly.<ref name="pmid19251658">{{cite journal | vauthors = Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M | title = Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 11 | pages = 4278–83  | date = March 2009 | pmid = 19251658 | pmc = 2657370 | doi = 10.1073/pnas.0900568106 | laysummary = http://news.bbc.co.uk/2/hi/health/7907192.stm | laysource = BBC News }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
BCL11B has been shown to [[Protein-protein interaction|interact]] with [[COUP-TFI]].<ref name="pmid10744719">{{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22  | date = April 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = J. Biol. Chem. | volume = 275 | issue = 14 | pages = 10315–22 | year = 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}
| citations =
* {{cite journal | vauthors = Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M | title = COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein | journal = Biochem. J. | volume = 368 | issue = Pt 2 | pages = 555–63 | year = 2002 | pmid = 12196208 | pmc = 1223006 | doi = 10.1042/BJ20020496 }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315-22 |year= 2000 |pmid= 10744719 |doi= }}
* {{cite journal | vauthors = Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, Mishima Y, Niwa O, Kominami R | title = Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas | journal = Biochem. Biophys. Res. Commun. | volume = 301 | issue = 2 | pages = 598–603 | year = 2003 | pmid = 12565905 | doi = 10.1016/S0006-291X(02)03069-3 }}
*{{cite journal  | author=Satterwhite E, Sonoki T, Willis TG, ''et al.'' |title=The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. |journal=Blood |volume=98 |issue= 12 |pages= 3413-20 |year= 2001 |pmid= 11719382 |doi=  }}
* {{cite journal | vauthors = Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E | title = Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells | journal = J. Virol. | volume = 77 | issue = 9 | pages = 5415–27 | year = 2003 | pmid = 12692243 | pmc = 153947 | doi = 10.1128/JVI.77.9.5415-5427.2003 }}
*{{cite journal | author=Avram D, Fields A, Senawong T, ''et al.'' |title=COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. |journal=Biochem. J. |volume=368 |issue= Pt 2 |pages= 555-63 |year= 2003 |pmid= 12196208 |doi= 10.1042/BJ20020496 }}
* {{cite journal | vauthors = Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M | title = Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression | journal = J. Biol. Chem. | volume = 278 | issue = 44 | pages = 43041–50 | year = 2003 | pmid = 12930829 | pmc = 2819354 | doi = 10.1074/jbc.M307477200 }}
*{{cite journal | author=Wakabayashi Y, Inoue J, Takahashi Y, ''et al.'' |title=Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 598-603 |year= 2003 |pmid= 12565905 |doi= }}
* {{cite journal | vauthors = Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstock GC, Rosenberg C | title = A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene | journal = Cancer Genet. Cytogenet. | volume = 149 | issue = 1 | pages = 72–6 | year = 2004 | pmid = 15104287 | doi = 10.1016/S0165-4608(03)00302-9 }}
*{{cite journal | author=Rohr O, Lecestre D, Chasserot-Golaz S, ''et al.'' |title=Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. |journal=J. Virol. |volume=77 |issue= 9 |pages= 5415-27 |year= 2003 |pmid= 12692243 |doi= }}
* {{cite journal | vauthors = MacLeod RA, Nagel S, Drexler HG | title = BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia | journal = Cancer Genet. Cytogenet. | volume = 153 | issue = 1 | pages = 88–9 | year = 2004 | pmid = 15325104 | doi = 10.1016/j.cancergencyto.2004.02.020 }}
*{{cite journal | author=Senawong T, Peterson VJ, Avram D, ''et al.'' |title=Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43041-50 |year= 2003 |pmid= 12930829 |doi= 10.1074/jbc.M307477200 }}
* {{cite journal | vauthors = Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, van Dongen JJ, Schmidt CA, Langerak AW | title = Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL | journal = Leukemia | volume = 19 | issue = 2 | pages = 201–8 | year = 2005 | pmid = 15668700 | doi = 10.1038/sj.leu.2403619 }}
*{{cite journal | author=Bezrookove V, van Zelderen-Bhola SL, Brink A, ''et al.'' |title=A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. |journal=Cancer Genet. Cytogenet. |volume=149 |issue= 1 |pages= 72-6 |year= 2004 |pmid= 15104287 |doi= }}
* {{cite journal | vauthors = Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D | title = BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter | journal = Oncogene | volume = 24 | issue = 45 | pages = 6753–64 | year = 2005 | pmid = 16091750 | doi = 10.1038/sj.onc.1208904 }}
*{{cite journal | author=MacLeod RA, Nagel S, Drexler HG |title=BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia. |journal=Cancer Genet. Cytogenet. |volume=153 |issue= 1 |pages= 88-9 |year= 2004 |pmid= 15325104 |doi= 10.1016/j.cancergencyto.2004.02.020 }}
* {{cite journal | vauthors = Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O | title = Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing | journal = EMBO J. | volume = 26 | issue = 2 | pages = 412–23 | year = 2007 | pmid = 17245431 | pmc = 1783449 | doi = 10.1038/sj.emboj.7601516 }}
*{{cite journal | author=Przybylski GK, Dik WA, Wanzeck J, ''et al.'' |title=Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. |journal=Leukemia |volume=19 |issue= 2 |pages= 201-8 |year= 2005 |pmid= 15668700 |doi= 10.1038/sj.leu.2403619 }}
* {{cite journal | vauthors = Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, Meyer C, Drexler HG, MacLeod RA | title = Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1 | journal = Cancer Res. | volume = 67 | issue = 4 | pages = 1461–71 | year = 2007 | pmid = 17308084 | doi = 10.1158/0008-5472.CAN-06-2615 }}
*{{cite journal | author=Cismasiu VB, Adamo K, Gecewicz J, ''et al.'' |title=BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. |journal=Oncogene |volume=24 |issue= 45 |pages= 6753-64 |year= 2005 |pmid= 16091750 |doi= 10.1038/sj.onc.1208904 }}
* {{cite journal | vauthors = Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R | title = Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages | journal = Oncogene | volume = 26 | issue = 40 | pages = 5840–50 | year = 2007 | pmid = 17369851 | doi = 10.1038/sj.onc.1210388 }}
*{{cite journal | author=Topark-Ngarm A, Golonzhka O, Peterson VJ, ''et al.'' |title=CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. |journal=J. Biol. Chem. |volume=281 |issue= 43 |pages= 32272-83 |year= 2006 |pmid= 16950772 |doi= 10.1074/jbc.M602776200 }}
*{{cite journal  | author=Marban C, Suzanne S, Dequiedt F, ''et al.'' |title=Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. |journal=EMBO J. |volume=26 |issue= 2 |pages= 412-23 |year= 2007 |pmid= 17245431 |doi= 10.1038/sj.emboj.7601516 }}
*{{cite journal | author=Nagel S, Scherr M, Kel A, ''et al.'' |title=Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. |journal=Cancer Res. |volume=67 |issue= 4 |pages= 1461-71 |year= 2007 |pmid= 17308084 |doi= 10.1158/0008-5472.CAN-06-2615 }}
*{{cite journal | author=Kamimura K, Mishima Y, Obata M, ''et al.'' |title=Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. |journal=Oncogene |volume=26 |issue= 40 |pages= 5840-50 |year= 2007 |pmid= 17369851 |doi= 10.1038/sj.onc.1210388 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|BCL11B+protein,+human}}
* {{MeshName|BCL11B+protein,+human}}
* {{UCSC gene info|ATL1}}
* {{UCSC gene info|BCL11B}}
* {{UCSC gene info|RIT1}}


{{NLM content}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Latest revision as of 02:31, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[1][2][3]

Function

This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[3]

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly.[4]

Interactions

BCL11B has been shown to interact with COUP-TFI.[5]

References

  1. ↑ Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJ (Nov 2001). "The BCL11 gene family: involvement of BCL11A in lymphoid malignancies". Blood. 98 (12): 3413–20. doi:10.1182/blood.V98.12.3413. PMID 11719382.
  2. ↑ Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B, Martinez B, Crofoot K, Filtz TM, Leid M (Oct 2006). "CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene". J. Biol. Chem. 281 (43): 32272–83. doi:10.1074/jbc.M602776200. PMC 2547407. PMID 16950772.
  3. ↑ 3.0 3.1 "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)".
  4. ↑ Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278–83. doi:10.1073/pnas.0900568106. PMC 2657370. PMID 19251658. Lay summary – BBC News.
  5. ↑ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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