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{{DISPLAYTITLE:''BATF'' (gene)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Basic leucine zipper transcription factor, ATF-like''', also known as '''BATF''', is a [[protein]] which in humans is encoded by the ''BATF'' [[gene]].<ref name="pmid8570175">{{cite journal | vauthors = Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ | title = B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family | journal = Oncogene | volume = 11 | issue = 11 | pages = 2255–65 | date = December 1995 | pmid = 8570175 | doi =  }}</ref><ref name="pmid8630063">{{cite journal | vauthors = Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S | title = SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes | journal = Biochem. Biophys. Res. Commun. | volume = 222 | issue = 1 | pages = 164–70 | date = May 1996 | pmid = 8630063 | doi = 10.1006/bbrc.1996.0700 }}</ref><ref name="entrez"/>
| require_manual_inspection = no
 
| update_protein_box = yes
== Function ==
| update_summary = yes
 
| update_citations = yes
The protein encoded by this gene is a nuclear basic leucine zipper ([[bZIP domain|bZIP]]) protein that belongs to the [[AP-1 transcription factor|AP-1]]/[[activating transcription factor|ATF]] superfamily of [[transcription factor]]s. The leucine zipper of this protein mediates dimerization with members of the [[C-jun|Jun]] family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.<ref name="entrez">{{cite web | title = Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10538| accessdate = }}</ref>
}}
 
Mice without the BATF gene (BATF [[knockout mouse|knockout mice]]) lacked a type of inflammatory immune cell ([[T helper 17 cell|Th17]]) and were resistant to conditions that normally induces an autoimmune condition similar to [[multiple sclerosis]].<ref name="pmid19578362">{{cite journal | vauthors = Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM | title = The AP-1 transcription factor Batf controls TH17 differentiation | journal = Nature | volume = 460 | issue = 7253 | pages = 405–9 | date = July 2009 | pmid = 19578362 | pmc = 2716014 | doi = 10.1038/nature08114 | laysummary = http://www.eurekalert.org/pub_releases/2009-07/wuso-gri071609.php | laydate = 2009-07-16 | laysource = eurekalert.org }}</ref>
 
== Interactions ==


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
BATF (gene) has been shown to [[Protein-protein interaction|interact]] with [[IFI35]].<ref name="pmid8954125">{{cite journal | vauthors = Wang X, Johansen LM, Tae HJ, Taparowsky EJ | title = IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors | journal = Biochem. Biophys. Res. Commun. | volume = 229 | issue = 1 | pages = 316–22 | year = 1996 | pmid = 8954125 | doi = 10.1006/bbrc.1996.1799 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Basic leucine zipper transcription factor, ATF-like
| HGNCid = 958
| Symbol = BATF
| AltSymbols =; B-ATF; BATF1; SFA-2
| OMIM = 
| ECnumber = 
| Homologene = 4666
| MGIid = 1859147
| GeneAtlas_image1 = PBB_GE_BATF_205965_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10538
    | Hs_Ensembl = ENSG00000156127
    | Hs_RefseqProtein = NP_006390
    | Hs_RefseqmRNA = NM_006399
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 75058542
    | Hs_GenLoc_end = 75083086
    | Hs_Uniprot = Q16520
    | Mm_EntrezGene = 53314
    | Mm_Ensembl = ENSMUSG00000034266
    | Mm_RefseqmRNA = NM_016767
    | Mm_RefseqProtein = NP_058047
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 86575781
    | Mm_GenLoc_end = 86598189
    | Mm_Uniprot = O35284
  }}
}}
'''Basic leucine zipper transcription factor, ATF-like''', also known as '''BATF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10538| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.<ref name="entrez">{{cite web | title = Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10538| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
| citations =
* {{cite journal | vauthors = Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ | title = Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation | journal = Biochem. J. | volume = 374 | issue = Pt 2 | pages = 423–31 | year = 2003 | pmid = 12809553 | pmc = 1223616 | doi = 10.1042/BJ20030455 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Johansen LM, Deppmann CD, Erickson KD, Coffin WF, Thornton TM, Humphrey SE, Martin JM, Taparowsky EJ | title = EBNA2 and Activated Notch Induce Expression of BATF | journal = J. Virol. | volume = 77 | issue = 10 | pages = 6029–40 | year = 2003 | pmid = 12719594 | pmc = 154003 | doi = 10.1128/JVI.77.10.6029-6040.2003 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, Vinson C, Taparowsky EJ | title = BATF transgenic mice reveal a role for activator protein-1 in NKT cell development | journal = J. Immunol. | volume = 170 | issue = 5 | pages = 2417–26 | year = 2003 | pmid = 12594265 | doi = 10.4049/jimmunol.170.5.2417 }}
*{{cite journal  | author=Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ |title=Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation. |journal=Biochem. J. |volume=374 |issue= Pt 2 |pages= 423-31 |year= 2003 |pmid= 12809553 |doi= 10.1042/BJ20030455 }}
* {{cite journal | vauthors = Echlin DR, Tae HJ, Mitin N, Taparowsky EJ | title = B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos | journal = Oncogene | volume = 19 | issue = 14 | pages = 1752–63 | year = 2000 | pmid = 10777209 | doi = 10.1038/sj.onc.1203491 }}
*{{cite journal | author=Johansen LM, Deppmann CD, Erickson KD, ''et al.'' |title=EBNA2 and activated Notch induce expression of BATF. |journal=J. Virol. |volume=77 |issue= 10 |pages= 6029-40 |year= 2003 |pmid= 12719594 |doi= }}
* {{cite journal | vauthors = Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ | title = Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1 | journal = Mamm. Genome | volume = 9 | issue = 10 | pages = 849–52 | year = 1998 | pmid = 9745044 | doi = 10.1007/s003359900881 }}
*{{cite journal | author=Williams KL, Zullo AJ, Kaplan MH, ''et al.'' |title=BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. |journal=J. Immunol. |volume=170 |issue= 5 |pages= 2417-26 |year= 2003 |pmid= 12594265 |doi=  }}
* {{cite journal | vauthors = Wang X, Johansen LM, Tae HJ, Taparowsky EJ | title = IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors | journal = Biochem. Biophys. Res. Commun. | volume = 229 | issue = 1 | pages = 316–22 | year = 1997 | pmid = 8954125 | doi = 10.1006/bbrc.1996.1799 }}
*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
* {{cite journal | vauthors = Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S | title = SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes | journal = Biochem. Biophys. Res. Commun. | volume = 222 | issue = 1 | pages = 164–70 | year = 1996 | pmid = 8630063 | doi = 10.1006/bbrc.1996.0700 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ | title = B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family | journal = Oncogene | volume = 11 | issue = 11 | pages = 2255–65 | year = 1996 | pmid = 8570175 | doi =  }}
*{{cite journal | author=Echlin DR, Tae HJ, Mitin N, Taparowsky EJ |title=B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. |journal=Oncogene |volume=19 |issue= 14 |pages= 1752-63 |year= 2000 |pmid= 10777209 |doi= 10.1038/sj.onc.1203491 }}
*{{cite journal | author=Meyer NP, Johansen LM, Tae HJ, ''et al.'' |title=Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1. |journal=Mamm. Genome |volume=9 |issue= 10 |pages= 849-52 |year= 1998 |pmid= 9745044 |doi= }}
*{{cite journal | author=Wang X, Johansen LM, Tae HJ, Taparowsky EJ |title=IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 1 |pages= 316-22 |year= 1997 |pmid= 8954125 |doi= 10.1006/bbrc.1996.1799 }}
*{{cite journal | author=Hasegawa H, Utsunomiya Y, Kishimoto K, ''et al.'' |title=SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 164-70 |year= 1996 |pmid= 8630063 |doi= 10.1006/bbrc.1996.0700 }}
*{{cite journal | author=Dorsey MJ, Tae HJ, Sollenberger KG, ''et al.'' |title=B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. |journal=Oncogene |volume=11 |issue= 11 |pages= 2255-65 |year= 1996 |pmid= 8570175 |doi=  }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|BATF+protein,+human}}
* {{MeshName|BATF+protein,+human}}
* {{FactorBook|BATF}}
* {{UCSC gene info|BATF}}
{{NLM content}}
{{Transcription factors|g1}}


{{Regulome
| activates =
| inhibits = AP-1, BZLF1
| activated_by =
| inhibited_by =
}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-14-stub}}

Latest revision as of 15:35, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[1][2][3]

Function

The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[3]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[4]

Interactions

BATF (gene) has been shown to interact with IFI35.[5]

References

  1. ↑ Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.
  2. ↑ Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
  3. ↑ 3.0 3.1 "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like".
  4. ↑ Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM (July 2009). "The AP-1 transcription factor Batf controls TH17 differentiation". Nature. 460 (7253): 405–9. doi:10.1038/nature08114. PMC 2716014. PMID 19578362. Lay summary – eurekalert.org (2009-07-16).
  5. ↑ Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ (2003). "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation". Biochem. J. 374 (Pt 2): 423–31. doi:10.1042/BJ20030455. PMC 1223616. PMID 12809553.
  • Johansen LM, Deppmann CD, Erickson KD, Coffin WF, Thornton TM, Humphrey SE, Martin JM, Taparowsky EJ (2003). "EBNA2 and Activated Notch Induce Expression of BATF". J. Virol. 77 (10): 6029–40. doi:10.1128/JVI.77.10.6029-6040.2003. PMC 154003. PMID 12719594.
  • Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, Vinson C, Taparowsky EJ (2003). "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development". J. Immunol. 170 (5): 2417–26. doi:10.4049/jimmunol.170.5.2417. PMID 12594265.
  • Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene. 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209.
  • Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1". Mamm. Genome. 9 (10): 849–52. doi:10.1007/s003359900881. PMID 9745044.
  • Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.
  • Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
  • Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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