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{{Infobox_gene}}
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'''GA-binding protein subunit beta-1''' is a [[protein]] that in humans is encoded by the ''GABPB1'' [[gene]].<ref name="pmid7958862">{{cite journal |vauthors=de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL | title = Molecular and genetic characterization of GABP beta | journal = Genes Dev | volume = 8 | issue = 15 | pages = 1853–65 |date=Nov 1994 | pmid = 7958862 | pmc =  | doi =10.1101/gad.8.15.1853 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2553| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GABPB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1awc.
| PDB = {{PDB2|1awc}}
| Name = GA binding protein transcription factor, beta subunit 2
| HGNCid = 4074
| Symbol = GABPB2
| AltSymbols =; BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GABPB; GABPB1; NRF2B1; NRF2B2
| OMIM = 600610
| ECnumber =
| Homologene = 7723
| MGIid = 95611
  | GeneAtlas_image1 = PBB_GE_GABPB2_204618_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GABPB2_206173_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2553
    | Hs_Ensembl = ENSG00000104064
    | Hs_RefseqProtein = NP_002032
    | Hs_RefseqmRNA = NM_002041
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 48356681
    | Hs_GenLoc_end = 48434687
    | Hs_Uniprot = Q06547
    | Mm_EntrezGene = 14391
    | Mm_Ensembl = ENSMUSG00000027361
    | Mm_RefseqmRNA = XM_985484
    | Mm_RefseqProtein = XP_990578
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 126318883
    | Mm_GenLoc_end = 126367009
    | Mm_Uniprot = Q3UJN3
  }}
}}
'''GA binding protein transcription factor, beta subunit 2''', also known as '''GABPB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2553| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2553| accessdate = }}</ref>
| summary_text = This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2553| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sawada J, Goto M, Watanabe H, ''et al.'' |title=Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. |journal=Jpn. J. Cancer Res. |volume=86 |issue= 1 |pages= 10-2 |year= 1995 |pmid= 7737900 |doi=  }}
*{{cite journal  |vauthors=Sawada J, Goto M, Watanabe H |title=Regional mapping of two subunits of transcription factor E4TF1 to human chromosome. |journal=Jpn. J. Cancer Res. |volume=86 |issue= 1 |pages= 10–2 |year= 1995 |pmid= 7737900 |doi=  10.1111/j.1349-7006.1995.tb02981.x|display-authors=etal}}
*{{cite journal  | author=Gugneja S, Virbasius JV, Scarpulla RC |title=Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 102-11 |year= 1995 |pmid= 7799916 |doi=  }}
*{{cite journal  |vauthors=Gugneja S, Virbasius JV, Scarpulla RC |title=Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. |journal=Mol. Cell. Biol. |volume=15 |issue= 1 |pages= 102–11 |year= 1995 |pmid= 7799916 |doi=  | pmc=231915 }}
*{{cite journal  | author=de la Brousse FC, Birkenmeier EH, King DS, ''et al.'' |title=Molecular and genetic characterization of GABP beta. |journal=Genes Dev. |volume=8 |issue= 15 |pages= 1853-65 |year= 1994 |pmid= 7958862 |doi=  }}
*{{cite journal  |vauthors=Virbasius JV, Virbasius CA, Scarpulla RC |title=Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 380–92 |year= 1993 |pmid= 8383622 |doi=10.1101/gad.7.3.380 }}
*{{cite journal  | author=Virbasius JV, Virbasius CA, Scarpulla RC |title=Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 380-92 |year= 1993 |pmid= 8383622 |doi=  }}
*{{cite journal  |vauthors=Watanabe H, Sawada J, Yano K |title=cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1385–91 |year= 1993 |pmid= 8441384 |doi=  | pmc=359448  |display-authors=etal}}
*{{cite journal  | author=Watanabe H, Sawada J, Yano K, ''et al.'' |title=cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1385-91 |year= 1993 |pmid= 8441384 |doi=  }}
*{{cite journal  |vauthors=Gugneja S, Virbasius CM, Scarpulla RC |title=Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5708–16 |year= 1996 |pmid= 8816484 |doi= | pmc=231571 }}
*{{cite journal  | author=Gugneja S, Virbasius CM, Scarpulla RC |title=Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5708-16 |year= 1996 |pmid= 8816484 |doi=  }}
*{{cite journal  |vauthors=Sawa C, Goto M, Suzuki F |title=Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation. |journal=Nucleic Acids Res. |volume=24 |issue= 24 |pages= 4954–61 |year= 1997 |pmid= 9016666 |doi=10.1093/nar/24.24.4954 | pmc=146336  |display-authors=etal}}
*{{cite journal  | author=Sawa C, Goto M, Suzuki F, ''et al.'' |title=Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation. |journal=Nucleic Acids Res. |volume=24 |issue= 24 |pages= 4954-61 |year= 1997 |pmid= 9016666 |doi=  }}
*{{cite journal  |vauthors=Sowa Y, Shiio Y, Fujita T |title=Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. |journal=Cancer Res. |volume=57 |issue= 15 |pages= 3145–8 |year= 1997 |pmid= 9242441 |doi=  |display-authors=etal}}
*{{cite journal  | author=Sowa Y, Shiio Y, Fujita T, ''et al.'' |title=Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1. |journal=Cancer Res. |volume=57 |issue= 15 |pages= 3145-8 |year= 1997 |pmid= 9242441 |doi=  }}
*{{cite journal  |vauthors=Batchelor AH, Piper DE, de la Brousse FC |title=The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. |journal=Science |volume=279 |issue= 5353 |pages= 1037–41 |year= 1998 |pmid= 9461436 |doi=10.1126/science.279.5353.1037 |display-authors=etal}}
*{{cite journal  | author=Batchelor AH, Piper DE, de la Brousse FC, ''et al.'' |title=The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. |journal=Science |volume=279 |issue= 5353 |pages= 1037-41 |year= 1998 |pmid= 9461436 |doi=  }}
*{{cite journal  |vauthors=Suzuki F, Goto M, Sawa C |title=Functional interactions of transcription factor human GA-binding protein subunits. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29302–8 |year= 1998 |pmid= 9792629 |doi=10.1074/jbc.273.45.29302 |display-authors=etal}}
*{{cite journal  | author=Suzuki F, Goto M, Sawa C, ''et al.'' |title=Functional interactions of transcription factor human GA-binding protein subunits. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29302-8 |year= 1998 |pmid= 9792629 |doi=  }}
*{{cite journal  |vauthors=Sawada J, Simizu N, Suzuki F |title=Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35475–82 |year= 2000 |pmid= 10585419 |doi=10.1074/jbc.274.50.35475 |display-authors=etal}}
*{{cite journal  | author=Sawada J, Simizu N, Suzuki F, ''et al.'' |title=Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35475-82 |year= 2000 |pmid= 10585419 |doi=  }}
*{{cite journal  |vauthors=Vogel JL, Kristie TM |title=The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. |journal=EMBO J. |volume=19 |issue= 4 |pages= 683–90 |year= 2000 |pmid= 10675337 |doi= 10.1093/emboj/19.4.683 | pmc=305606 }}
*{{cite journal  | author=Vogel JL, Kristie TM |title=The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. |journal=EMBO J. |volume=19 |issue= 4 |pages= 683-90 |year= 2000 |pmid= 10675337 |doi= 10.1093/emboj/19.4.683 }}
*{{cite journal  |vauthors=Sawa C, Yoshikawa T, Matsuda-Suzuki F |title=YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22484–90 |year= 2002 |pmid= 11953439 |doi= 10.1074/jbc.M203060200 |display-authors=etal}}
*{{cite journal  | author=Sawa C, Yoshikawa T, Matsuda-Suzuki F, ''et al.'' |title=YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22484-90 |year= 2002 |pmid= 11953439 |doi= 10.1074/jbc.M203060200 }}
*{{cite journal  |vauthors=Marie S, Race V, Nassogne MC |title=Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. |journal=Am. J. Hum. Genet. |volume=71 |issue= 1 |pages= 14–21 |year= 2002 |pmid= 12016589 |doi=10.1086/341036 | pmc=384970  |display-authors=etal}}
*{{cite journal  | author=Marie S, Race V, Nassogne MC, ''et al.'' |title=Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency. |journal=Am. J. Hum. Genet. |volume=71 |issue= 1 |pages= 14-21 |year= 2002 |pmid= 12016589 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Jeong BC, Kim MY, Lee JH |title=Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. |journal=FEBS Lett. |volume=580 |issue= 2 |pages= 669–76 |year= 2006 |pmid= 16412436 |doi= 10.1016/j.febslet.2005.12.086 |display-authors=etal}}
*{{cite journal  | author=Jeong BC, Kim MY, Lee JH, ''et al.'' |title=Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. |journal=FEBS Lett. |volume=580 |issue= 2 |pages= 669-76 |year= 2006 |pmid= 16412436 |doi= 10.1016/j.febslet.2005.12.086 }}
*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2553}}


== External links ==
== External links ==
* {{MeshName|GABPB2+protein,+human}}
* {{MeshName|GABPB2+protein,+human}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-15-stub}}

Latest revision as of 08:35, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene.[1][2]

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

References

  1. ↑ de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994). "Molecular and genetic characterization of GABP beta". Genes Dev. 8 (15): 1853–65. doi:10.1101/gad.8.15.1853. PMID 7958862.
  2. ↑ 2.0 2.1 "Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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