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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''AT-rich interactive domain-containing protein 3B''' is a [[protein]] that in humans is encoded by the ''ARID3B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10620| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = AT rich interactive domain 3B (BRIGHT-like)
| HGNCid = 14350
| Symbol = ARID3B
| AltSymbols =; BDP; DRIL2
| OMIM = 
| ECnumber = 
| Homologene = 4721
| MGIid = 1930768
| GeneAtlas_image1 = PBB_GE_ARID3B_218964_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10620
    | Hs_Ensembl = ENSG00000179361
    | Hs_RefseqProtein = NP_006456
    | Hs_RefseqmRNA = NM_006465
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 72620600
    | Hs_GenLoc_end = 72677521
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56380
    | Mm_Ensembl = ENSMUSG00000004661
    | Mm_RefseqmRNA = NM_019689
    | Mm_RefseqProtein = NP_062663
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 57588491
    | Mm_GenLoc_end = 57634843
    | Mm_Uniprot = 
  }}
}}
'''AT rich interactive domain 3B (BRIGHT-like)''', also known as '''ARID3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10620| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[ARID domain|ARID]] (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.<ref name="entrez">{{cite web | title = Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10620| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kortschak RD, Tucker PW, Saint R | title = ARID proteins come in from the desert | journal = Trends in Biochemical Sciences | volume = 25 | issue = 6 | pages = 294–9 | date = Jun 2000 | pmid = 10838570 | doi = 10.1016/S0968-0004(00)01597-8 }}
| citations =
* {{cite journal | vauthors = Numata S, Claudio PP, Dean C, Giordano A, Croce CM | title = Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product | journal = Cancer Research | volume = 59 | issue = 15 | pages = 3741–7 | date = Aug 1999 | pmid = 10446990 | doi =  }}
*{{cite journal | author=Kortschak RD, Tucker PW, Saint R |title=ARID proteins come in from the desert. |journal=Trends Biochem. Sci. |volume=25 |issue= 6 |pages= 294-9 |year= 2000 |pmid= 10838570 |doi= }}
* {{cite journal | vauthors = Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH | title = let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex | journal = Cell Reports | volume = 14 | issue = 3 | pages = 520–33 | year = 2016 | pmid = 26776511 | doi = 10.1016/j.celrep.2015.12.064 }}
*{{cite journal | author=Numata S, Claudio PP, Dean C, ''et al.'' |title=Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product. |journal=Cancer Res. |volume=59 |issue= 15 |pages= 3741-7 |year= 1999 |pmid= 10446990 |doi=  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ARID3B+protein,+human}}
* {{MeshName|ARID3B+protein,+human}}
* {{UCSC gene info|ARID3B}}


{{NLM content}}
{{Transcription factors|g0}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-15-stub}}

Latest revision as of 02:14, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.[1]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)".

Further reading

  • Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570.
  • Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID 10446990.
  • Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. doi:10.1016/j.celrep.2015.12.064. PMID 26776511.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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