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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nuclear factor of activated T-cells, cytoplasmic 3''' is a [[protein]] that in humans is encoded by the ''NFATC3'' [[gene]].<ref name="pmid7749981">{{cite journal | vauthors = Hoey T, Sun YL, Williamson K, Xu X | title = Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins | journal = Immunity | volume = 2 | issue = 5 | pages = 461–72 | date = May 1995 | pmid = 7749981 | pmc =  | doi = 10.1016/1074-7613(95)90027-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4775| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
| HGNCid = 7777
| Symbol = NFATC3
| AltSymbols =; NFAT4; NFATX
| OMIM = 602698
| ECnumber = 
| Homologene = 27827
| MGIid = 103296
| GeneAtlas_image1 = PBB_GE_NFATC3_210555_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NFATC3_207416_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_NFATC3_210556_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045333 |text = cellular respiration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4775
    | Hs_Ensembl = ENSG00000072736
    | Hs_RefseqProtein = NP_004546
    | Hs_RefseqmRNA = NM_004555
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 66676845
    | Hs_GenLoc_end = 66818301
    | Hs_Uniprot = Q12968
    | Mm_EntrezGene = 18021
    | Mm_Ensembl = ENSMUSG00000031902
    | Mm_RefseqmRNA = NM_010901
    | Mm_RefseqProtein = NP_035031
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 108948972
    | Mm_GenLoc_end = 109017574
    | Mm_Uniprot = Q3TTU5
  }}
}}
'''Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3''', also known as '''NFATC3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4775| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4775| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[NFAT]]
* [[NFAT]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rao A, Luo C, Hogan PG | title = Transcription factors of the NFAT family: regulation and function | journal = Annual Review of Immunology | volume = 15 | issue =  | pages = 707–47 | year = 1997 | pmid = 9143705 | doi = 10.1146/annurev.immunol.15.1.707 }}
| citations =
* {{cite journal | vauthors = Crabtree GR | title = Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT | journal = Cell | volume = 96 | issue = 5 | pages = 611–4 | date = Mar 1999 | pmid = 10089876 | doi = 10.1016/S0092-8674(00)80571-1 }}
*{{cite journal | author=Rao A, Luo C, Hogan PG |title=Transcription factors of the NFAT family: regulation and function. |journal=Annu. Rev. Immunol. |volume=15 |issue=  |pages= 707-47 |year= 1997 |pmid= 9143705 |doi= 10.1146/annurev.immunol.15.1.707 }}
* {{cite journal | vauthors = Horsley V, Pavlath GK | title = NFAT: ubiquitous regulator of cell differentiation and adaptation | journal = The Journal of Cell Biology | volume = 156 | issue = 5 | pages = 771–4 | date = Mar 2002 | pmid = 11877454 | pmc = 2173310 | doi = 10.1083/jcb.200111073 }}
*{{cite journal | author=Crabtree GR |title=Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT. |journal=Cell |volume=96 |issue= 5 |pages= 611-4 |year= 1999 |pmid= 10089876 |doi= }}
* {{cite journal | vauthors = Masuda ES, Naito Y, Tokumitsu H, Campbell D, Saito F, Hannum C, Arai K, Arai N | title = NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus | journal = Molecular and Cellular Biology | volume = 15 | issue = 5 | pages = 2697–706 | date = May 1995 | pmid = 7739550 | pmc = 230500 | doi =  10.1128/mcb.15.5.2697}}
*{{cite journal | author=Horsley V, Pavlath GK |title=NFAT: ubiquitous regulator of cell differentiation and adaptation. |journal=J. Cell Biol. |volume=156 |issue= 5 |pages= 771-4 |year= 2002 |pmid= 11877454 |doi= 10.1083/jcb.200111073 }}
* {{cite journal | vauthors = Jabado N, Le Deist F, Fisher A, Hivroz C | title = Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity | journal = European Journal of Immunology | volume = 24 | issue = 11 | pages = 2646–52 | date = Nov 1994 | pmid = 7957556 | doi = 10.1002/eji.1830241112 }}
*{{cite journal | author=Masuda ES, Naito Y, Tokumitsu H, ''et al.'' |title=NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2697-706 |year= 1995 |pmid= 7739550 |doi=  }}
* {{cite journal | vauthors = Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A | title = Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif | journal = Biochemical and Biophysical Research Communications | volume = 205 | issue = 1 | pages = 467–74 | date = Nov 1994 | pmid = 7999066 | doi = 10.1006/bbrc.1994.2689 }}
*{{cite journal  | author=Hoey T, Sun YL, Williamson K, Xu X |title=Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. |journal=Immunity |volume=2 |issue= 5 |pages= 461-72 |year= 1995 |pmid= 7749981 |doi=  }}
* {{cite journal | vauthors = Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT | title = Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering | journal = European Journal of Immunology | volume = 26 | issue = 9 | pages = 2181–8 | date = Sep 1996 | pmid = 8814265 | doi = 10.1002/eji.1830260933 }}
*{{cite journal | author=Jabado N, Le Deist F, Fisher A, Hivroz C |title=Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity. |journal=Eur. J. Immunol. |volume=24 |issue= 11 |pages= 2646-52 |year= 1994 |pmid= 7957556 |doi= }}
* {{cite journal | vauthors = Masuda ES, Liu J, Imamura R, Imai SI, Arai KI, Arai N | title = Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 2066–75 | date = Apr 1997 | pmid = 9121455 | pmc = 232054 | doi =  10.1128/mcb.17.4.2066}}
*{{cite journal | author=Vacca A, Farina M, Maroder M, ''et al.'' |title=Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 1 |pages= 467-74 |year= 1995 |pmid= 7999066 |doi= 10.1006/bbrc.1994.2689 }}
* {{cite journal | vauthors = Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ | title = Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway | journal = Science | volume = 278 | issue = 5343 | pages = 1638–41 | date = Nov 1997 | pmid = 9374467 | doi = 10.1126/science.278.5343.1638 }}
*{{cite journal | author=Di Somma MM, Majolini MB, Burastero SE, ''et al.'' |title=Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering. |journal=Eur. J. Immunol. |volume=26 |issue= 9 |pages= 2181-8 |year= 1996 |pmid= 8814265 |doi= }}
* {{cite journal | vauthors = Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N | title = Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets | journal = Journal of Immunology | volume = 160 | issue = 5 | pages = 2324–33 | date = Mar 1998 | pmid = 9498773 | doi =  }}
*{{cite journal | author=Masuda ES, Liu J, Imamura R, ''et al.'' |title=Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 2066-75 |year= 1997 |pmid= 9121455 |doi=  }}
* {{cite journal | vauthors = Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dötsch V, Wagner G, Ferrara P, McKeon F | title = Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1 | journal = Cell | volume = 93 | issue = 5 | pages = 851–61 | date = May 1998 | pmid = 9630228 | doi = 10.1016/S0092-8674(00)81445-2 }}
*{{cite journal | author=Chow CW, Rincón M, Cavanagh J, ''et al.'' |title=Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. |journal=Science |volume=278 |issue= 5343 |pages= 1638-41 |year= 1997 |pmid= 9374467 |doi= }}
* {{cite journal | vauthors = Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG | title = Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT | journal = Molecular Cell | volume = 1 | issue = 5 | pages = 627–37 | date = Apr 1998 | pmid = 9660947 | doi = 10.1016/S1097-2765(00)80063-5 }}
*{{cite journal | author=Amasaki Y, Masuda ES, Imamura R, ''et al.'' |title=Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets. |journal=J. Immunol. |volume=160 |issue= 5 |pages= 2324-33 |year= 1998 |pmid= 9498773 |doi=  }}
* {{cite journal | vauthors = Imamura R, Masuda ES, Naito Y, Imai S, Fujino T, Takano T, Arai K, Arai N | title = Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells | journal = Journal of Immunology | volume = 161 | issue = 7 | pages = 3455–63 | date = Oct 1998 | pmid = 9759864 | doi =  }}
*{{cite journal | author=Zhu J, Shibasaki F, Price R, ''et al.'' |title=Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. |journal=Cell |volume=93 |issue= 5 |pages= 851-61 |year= 1998 |pmid= 9630228 |doi= }}
* {{cite journal | vauthors = Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD | title = Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q | journal = Genomics | volume = 60 | issue = 3 | pages = 295–308 | date = Sep 1999 | pmid = 10493829 | doi = 10.1006/geno.1999.5927 }}
*{{cite journal | author=Aramburu J, Garcia-Cózar F, Raghavan A, ''et al.'' |title=Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. |journal=Mol. Cell |volume=1 |issue= 5 |pages= 627-37 |year= 1998 |pmid= 9660947 |doi= }}
* {{cite journal | vauthors = Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S | title = A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25640–8 | date = Jul 2002 | pmid = 11997392 | doi = 10.1074/jbc.M201860200 }}
*{{cite journal | author=Imamura R, Masuda ES, Naito Y, ''et al.'' |title=Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells. |journal=J. Immunol. |volume=161 |issue= 7 |pages= 3455-63 |year= 1998 |pmid= 9759864 |doi=  }}
* {{cite journal | vauthors = Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A | title = A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis | journal = American Journal of Human Genetics | volume = 71 | issue = 6 | pages = 1443–9 | date = Dec 2002 | pmid = 12417987 | pmc = 378590 | doi = 10.1086/344580 }}
*{{cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, ''et al.'' |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295-308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}
*{{cite journal | author=Amasaki Y, Adachi S, Ishida Y, ''et al.'' |title=A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25640-8 |year= 2002 |pmid= 11997392 |doi= 10.1074/jbc.M201860200 }}
*{{cite journal | author=Chagnon P, Michaud J, Mitchell G, ''et al.'' |title=A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. |journal=Am. J. Hum. Genet. |volume=71 |issue= 6 |pages= 1443-9 |year= 2003 |pmid= 12417987 |doi= }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g4}}
 
{{DEFAULTSORT:Nfatc3}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Human proteins]]
 
 
{{gene-16-stub}}

Latest revision as of 01:58, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2]

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also

References

  1. ↑ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
  2. ↑ 2.0 2.1 "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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