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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B7''' is a [[protein]] that in humans is encoded by the ''HOXB7'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460  | date = August 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3  | date = December 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HOXB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ahd.
| PDB = {{PDB2|1ahd}}, {{PDB2|1hom}}, {{PDB2|1san}}, {{PDB2|2hoa}}, {{PDB2|9ant}}
| Name = Homeobox B7
| HGNCid = 5118
| Symbol = HOXB7
| AltSymbols =; HOX2; HHO.C1; HOX2C; Hox-2.3
| OMIM = 142962
| ECnumber = 
| Homologene = 55828
| MGIid = 96188
| GeneAtlas_image1 = PBB_GE_HOXB7_216973_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HOXB7_204778_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_HOXB7_204779_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3217
    | Hs_Ensembl = ENSG00000120087
    | Hs_RefseqProtein = NP_004493
    | Hs_RefseqmRNA = NM_004502
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 44039596
    | Hs_GenLoc_end = 44043378
    | Hs_Uniprot = P09629
    | Mm_EntrezGene = 15415
    | Mm_Ensembl = ENSMUSG00000038721
    | Mm_RefseqmRNA = NM_010460
    | Mm_RefseqProtein = NP_034590
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96102736
    | Mm_GenLoc_end = 96106253
    | Mm_Uniprot = P09024
  }}
}}
'''Homeobox B7''', also known as '''HOXB7''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB7 homeobox B7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3217| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB7 homeobox B7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3217| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
HOXB7 has been shown to [[Protein-protein interaction|interact]] with [[PBX1]]<ref name=pmid7729685>{{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–74  | date = March 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 }}</ref> and [[CREB-binding protein]].<ref name=pmid10435624>{{cite journal | vauthors = Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V | title = CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein | journal = Oncogene | volume = 18 | issue = 27 | pages = 4007–14  | date = July 1999 | pmid = 10435624 | doi = 10.1038/sj.onc.1202776 }}</ref>
 
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Baier LJ, Hannibal MC, Hanley EW, Nabel GJ | title = Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain | journal = Blood | volume = 78 | issue = 4 | pages = 1047–55 | year = 1991 | pmid = 1678287 | doi =  }}
| citations =
* {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation | volume = 45 | issue = 1 | pages = 61–9 | year = 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation | volume = 40 | issue = 3 | pages = 191–7 | year = 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
*{{cite journal | author=Baier LJ, Hannibal MC, Hanley EW, Nabel GJ |title=Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain. |journal=Blood |volume=78 |issue= 4 |pages= 1047-55 |year= 1991 |pmid= 1678287 |doi= }}
* {{cite journal | vauthors = Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ | title = Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 21 | pages = 8536–40 | year = 1989 | pmid = 2573064 | pmc = 298317 | doi = 10.1073/pnas.86.21.8536 }}
*{{cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi= }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Res. | volume = 17 | issue = 24 | pages = 10385–402 | year = 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal | author=Peverali FA, D'Esposito M, Acampora D, ''et al.'' |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61-9 |year= 1991 |pmid= 1981366 |doi= }}
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1989 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal | author=Giampaolo A, Acampora D, Zappavigna V, ''et al.'' |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191-7 |year= 1989 |pmid= 2570724 |doi= }}
* {{cite journal | vauthors = Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E | title = Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 84 | issue = 14 | pages = 4914–8 | year = 1987 | pmid = 2885844 | pmc = 305217 | doi = 10.1073/pnas.84.14.4914 }}
*{{cite journal | author=Shen WF, Largman C, Lowney P, ''et al.'' |title=Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8536-40 |year= 1989 |pmid= 2573064 |doi= }}
* {{cite journal | vauthors = Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC | title = The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation | journal = Blood | volume = 85 | issue = 3 | pages = 692–7 | year = 1995 | pmid = 7530503 | doi =  }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML | title = Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins | journal = Genes Dev. | volume = 9 | issue = 6 | pages = 663–74 | year = 1995 | pmid = 7729685 | doi = 10.1101/gad.9.6.663 }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
* {{cite journal | vauthors = Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G | title = Nucleolar localisation of three Hox homeoproteins | journal = J. Cell Sci. | volume = 108 | issue = 1 | pages = 187–93 | year = 1995 | pmid = 7738096 | doi =  }}
*{{cite journal | author=Simeone A, Mavilio F, Acampora D, ''et al.'' |title=Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4914-8 |year= 1987 |pmid= 2885844 |doi= }}
* {{cite journal | vauthors = Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H | title = Identification of homeobox genes expressed in human T-lymphocytes | journal = Biochem. Biophys. Res. Commun. | volume = 196 | issue = 1 | pages = 203–8 | year = 1993 | pmid = 8105782 | doi = 10.1006/bbrc.1993.2235 }}
*{{cite journal | author=Lill MC, Fuller JF, Herzig R, ''et al.'' |title=The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation. |journal=Blood |volume=85 |issue= 3 |pages= 692-7 |year= 1995 |pmid= 7530503 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Chang CP, Shen WF, Rozenfeld S, ''et al.'' |title=Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 663-74 |year= 1995 |pmid= 7729685 |doi= }}
* {{cite journal | vauthors = Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM | title = Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 2 | pages = 900–5 | year = 1996 | pmid = 8570656 | pmc = 40155 | doi = 10.1073/pnas.93.2.900 }}
*{{cite journal | author=Corsetti MT, Levi G, Lancia F, ''et al.'' |title=Nucleolar localisation of three Hox homeoproteins. |journal=J. Cell. Sci. |volume=108 ( Pt 1) |issue= |pages= 187-93 |year= 1995 |pmid= 7738096 |doi= }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal | author=Inamori K, Takeshita K, Chiba S, ''et al.'' |title=Identification of homeobox genes expressed in human T-lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 1 |pages= 203-8 |year= 1993 |pmid= 8105782 |doi= 10.1006/bbrc.1993.2235 }}
* {{cite journal | vauthors = Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP | title = HOXB7 constitutively activates basic fibroblast growth factor in melanomas | journal = Mol. Cell. Biol. | volume = 16 | issue = 9 | pages = 4842–51 | year = 1996 | pmid = 8756643 | pmc = 231486 | doi =  10.1128/mcb.16.9.4842}}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = LeBrun DP, Matthews BP, Feldman BJ, Cleary ML | title = The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains | journal = Oncogene | volume = 15 | issue = 17 | pages = 2059–67 | year = 1997 | pmid = 9366523 | doi = 10.1038/sj.onc.1201367 }}
*{{cite journal | author=Miano JM, Firulli AB, Olson EN, ''et al.'' |title=Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 900-5 |year= 1996 |pmid= 8570656 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C | title = HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development | journal = J. Invest. Dermatol. | volume = 110 | issue = 2 | pages = 110–5 | year = 1998 | pmid = 9457903 | doi = 10.1046/j.1523-1747.1998.00092.x }}
*{{cite journal | author=Caré A, Silvani A, Meccia E, ''et al.'' |title=HOXB7 constitutively activates basic fibroblast growth factor in melanomas. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4842-51 |year= 1996 |pmid= 8756643 |doi= }}
*{{cite journal | author=LeBrun DP, Matthews BP, Feldman BJ, Cleary ML |title=The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains. |journal=Oncogene |volume=15 |issue= 17 |pages= 2059-67 |year= 1997 |pmid= 9366523 |doi= 10.1038/sj.onc.1201367 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Stelnicki EJ, Kömüves LG, Kwong AO, ''et al.'' |title=HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. |journal=J. Invest. Dermatol. |volume=110 |issue= 2 |pages= 110-5 |year= 1998 |pmid= 9457903 |doi= 10.1046/j.1523-1747.1998.00092.x }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:03, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3]

Interactions

HOXB7 has been shown to interact with PBX1[4] and CREB-binding protein.[5]

See also

References

  1. ↑ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ "Entrez Gene: HOXB7 homeobox B7".
  4. ↑ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
  5. ↑ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. PMID 10435624.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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