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{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein Aiolos''' also known as '''Ikaros family zinc finger protein 3''' is a [[protein]] that in humans is encoded by the ''IKZF3'' [[gene]].<ref name="pmid9155026">{{cite journal |vauthors=Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K | title = Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation | journal = EMBO J | volume = 16 | issue = 8 | pages = 2004–13 |date=Jun 1997 | pmid = 9155026 | pmc = 1169803 | doi = 10.1093/emboj/16.8.2004 }}</ref><ref name="pmid10552935">{{cite journal |vauthors=Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M | title = Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping | journal = Genomics | volume = 61 | issue = 3 | pages = 326–9 |date=Feb 2000 | pmid = 10552935 | pmc = | doi = 10.1006/geno.1999.5949 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806| accessdate = }}</ref>
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== Function ==
| update_protein_box = yes
 
| update_summary = yes
This gene encodes a member of the Ikaros family of [[zinc finger|zinc-finger]] proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are [[hematopoietic]]-specific [[transcription factor]]s involved in the regulation of [[lymphocyte]] development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in [[chromatin]] remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.<ref name="entrez"/>
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}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
 
| image =
IKZF3 has been shown to [[Protein-protein interaction|interact]] with [[BCL2-like 1 (gene)|BCL2-like 1]]<ref name="pmid11714801">{{cite journal |vauthors=Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A | title = The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis | journal = J. Immunol. | volume = 167 | issue = 11 | pages = 6366–73 |date=December 2001 | pmid = 11714801 | doi = 10.4049/jimmunol.167.11.6366| url = | issn = }}</ref> and [[HRAS]].<ref name="pmid10369681">{{cite journal |vauthors=Romero F, Martínez-A C, Camonis J, Rebollo A | title = Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization | journal = EMBO J. | volume = 18 | issue = 12 | pages = 3419–30 |date=June 1999 | pmid = 10369681 | pmc = 1171421 | doi = 10.1093/emboj/18.12.3419 | url = | issn = }}</ref>
| image_source = 
| PDB =  
| Name = IKAROS family zinc finger 3 (Aiolos)
| HGNCid = 13178
| Symbol = IKZF3
| AltSymbols =; AIOLOS; ZNFN1A3
| OMIM = 606221
| ECnumber =
| Homologene = 8269
| MGIid = 1342542
| GeneAtlas_image1 = PBB_GE_IKZF3_221092_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22806
    | Hs_Ensembl = ENSG00000161405
    | Hs_RefseqProtein = NP_036613
    | Hs_RefseqmRNA = NM_012481
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 35174724
    | Hs_GenLoc_end = 35273967
    | Hs_Uniprot = Q9UKT9
    | Mm_EntrezGene = 22780
    | Mm_Ensembl = ENSMUSG00000018168
    | Mm_RefseqmRNA = XM_283022
    | Mm_RefseqProtein = XP_283022
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 98280992
    | Mm_GenLoc_end = 98361890
    | Mm_Uniprot = Q3V3P9
  }}
}}
'''IKAROS family zinc finger 3 (Aiolos)''', also known as '''IKZF3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Schmitt C, Tonnelle C, Dalloul A, ''et al.'' |title=Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. |journal=Apoptosis |volume=7 |issue= 3 |pages= 277-84 |year= 2003 |pmid= 11997672 |doi= }}
* {{cite journal |vauthors=Sun J, Matthias G, Mihatsch MJ, Georgopoulos K, Matthias P | title = Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice | journal = J. Immunol. | volume = 170 | issue = 4 | pages = 1699–706 |date=February 2003 | pmid = 12574333 | doi = 10.4049/jimmunol.170.4.1699| url = | issn = }}
*{{cite journal | author=Morgan B, Sun L, Avitahl N, ''et al.'' |title=Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. |journal=EMBO J. |volume=16 |issue= 8 |pages= 2004-13 |year= 1997 |pmid= 9155026 |doi= 10.1093/emboj/16.8.2004 }}
*{{cite journal   |vauthors=Schmitt C, Tonnelle C, Dalloul A, etal |title=Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. |journal=Apoptosis |volume=7 |issue= 3 |pages= 277–84 |year= 2003 |pmid= 11997672 |doi=10.1023/A:1015372322419  }}
*{{cite journal | author=Wang JH, Avitahl N, Cariappa A, ''et al.'' |title=Aiolos regulates B cell activation and maturation to effector state. |journal=Immunity |volume=9 |issue= 4 |pages= 543-53 |year= 1998 |pmid= 9806640 |doi=  }}
*{{cite journal   |vauthors=Wang JH, Avitahl N, Cariappa A, etal |title=Aiolos regulates B cell activation and maturation to effector state. |journal=Immunity |volume=9 |issue= 4 |pages= 543–53 |year= 1998 |pmid= 9806640 |doi=10.1016/S1074-7613(00)80637-8 }}
*{{cite journal | author=Kim J, Sif S, Jones B, ''et al.'' |title=Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. |journal=Immunity |volume=10 |issue= 3 |pages= 345-55 |year= 1999 |pmid= 10204490 |doi=  }}
*{{cite journal   |vauthors=Kim J, Sif S, Jones B, etal |title=Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. |journal=Immunity |volume=10 |issue= 3 |pages= 345–55 |year= 1999 |pmid= 10204490 |doi=10.1016/S1074-7613(00)80034-5 }}
*{{cite journal  | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090-100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090 }}
*{{cite journal  |vauthors=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090 | pmc=1171390 }}
*{{cite journal  | author=Romero F, Martínez-A C, Camonis J, Rebollo A |title=Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3419-30 |year= 1999 |pmid= 10369681 |doi= 10.1093/emboj/18.12.3419 }}
*{{cite journal  |vauthors=Romero F, Martínez-A C, Camonis J, Rebollo A |title=Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3419–30 |year= 1999 |pmid= 10369681 |doi= 10.1093/emboj/18.12.3419  | pmc=1171421 }}
*{{cite journal | author=Hosokawa Y, Maeda Y, Takahashi E, ''et al.'' |title=Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. |journal=Genomics |volume=61 |issue= 3 |pages= 326-9 |year= 2000 |pmid= 10552935 |doi= 10.1006/geno.1999.5949 }}
*{{cite journal  |vauthors=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594–602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200 }}
*{{cite journal  | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594-602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200 }}
*{{cite journal  |vauthors=Perdomo J, Holmes M, Chong B, Crossley M |title=Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38347–54 |year= 2001 |pmid= 10978333 |doi= 10.1074/jbc.M005457200 }}
*{{cite journal  | author=Perdomo J, Holmes M, Chong B, Crossley M |title=Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38347-54 |year= 2001 |pmid= 10978333 |doi= 10.1074/jbc.M005457200 }}
*{{cite journal   |vauthors=Rebollo A, Ayllón V, Fleischer A, etal |title=The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6366–73 |year= 2002 |pmid= 11714801 |doi=  10.4049/jimmunol.167.11.6366}}
*{{cite journal | author=Rebollo A, Ayllón V, Fleischer A, ''et al.'' |title=The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6366-73 |year= 2002 |pmid= 11714801 |doi=  }}
*{{cite journal   |vauthors=Liippo J, Nera KP, Veistinen E, etal |title=Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3469–74 |year= 2002 |pmid= 11745366 |doi=10.1002/1521-4141(200112)31:12<3469::AID-IMMU3469>3.0.CO;2-G }}
*{{cite journal | author=Liippo J, Nera KP, Veistinen E, ''et al.'' |title=Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3469-74 |year= 2002 |pmid= 11745366 |doi=  }}
*{{cite journal   |vauthors=Nakase K, Ishimaru F, Fujii K, etal |title=Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 313–7 |year= 2002 |pmid= 11937265 |doi=10.1016/S0301-472X(01)00796-2 }}
*{{cite journal | author=Nakase K, Ishimaru F, Fujii K, ''et al.'' |title=Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 313-7 |year= 2002 |pmid= 11937265 |doi=  }}
*{{cite journal  |vauthors=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697–705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 }}
*{{cite journal  | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697-705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Antica M, Dubravcic K, Weber I, etal |title=A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia. |journal=Haematologica |volume=92 |issue= 2 |pages= 260–1 |year= 2007 |pmid= 17296582 |doi=10.3324/haematol.10753 }}
*{{cite journal | author=Antica M, Dubravcic K, Weber I, ''et al.'' |title=A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia. |journal=Haematologica |volume=92 |issue= 2 |pages= 260-1 |year= 2007 |pmid= 17296582 |doi=  }}
*{{cite journal   |vauthors=Ghadiri A, Duhamel M, Fleischer A, etal |title=Critical function of Ikaros in controlling Aiolos gene expression. |journal=FEBS Lett. |volume=581 |issue= 8 |pages= 1605–16 |year= 2007 |pmid= 17383641 |doi= 10.1016/j.febslet.2007.03.025 }}
*{{cite journal | author=Ghadiri A, Duhamel M, Fleischer A, ''et al.'' |title=Critical function of Ikaros in controlling Aiolos gene expression. |journal=FEBS Lett. |volume=581 |issue= 8 |pages= 1605-16 |year= 2007 |pmid= 17383641 |doi= 10.1016/j.febslet.2007.03.025 }}
*{{cite journal   |vauthors=Caballero R, Setien F, Lopez-Serra L, etal |title=Combinatorial effects of splice variants modulate function of Aiolos. |journal=J. Cell Sci. |volume=120 |issue= Pt 15 |pages= 2619–30 |year= 2007 |pmid= 17646674 |doi= 10.1242/jcs.007344 }}
*{{cite journal | author=Caballero R, Setien F, Lopez-Serra L, ''et al.'' |title=Combinatorial effects of splice variants modulate function of Aiolos. |journal=J. Cell. Sci. |volume=120 |issue= Pt 15 |pages= 2619-30 |year= 2007 |pmid= 17646674 |doi= 10.1242/jcs.007344 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|IKZF3+protein,+human}}
* {{MeshName|IKZF3+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
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{{protein-stub}}
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{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-17-stub}}

Revision as of 20:06, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[1][2][3]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[3]

Interactions

IKZF3 has been shown to interact with BCL2-like 1[4] and HRAS.[5]

References

  1. ↑ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Jun 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". EMBO J. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803. PMID 9155026.
  2. ↑ Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M (Feb 2000). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics. 61 (3): 326–9. doi:10.1006/geno.1999.5949. PMID 10552935.
  3. ↑ 3.0 3.1 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)".
  4. ↑ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". J. Immunol. 167 (11): 6366–73. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
  5. ↑ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". EMBO J. 18 (12): 3419–30. doi:10.1093/emboj/18.12.3419. PMC 1171421. PMID 10369681.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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