TBX21: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''T-box transcription factor TBX21''' is a [[protein]] that in humans is encoded by the ''TBX21'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBX21 T-box 21| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30009| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T-box 21
| HGNCid = 11599
| Symbol = TBX21
| AltSymbols =; T-PET; T-bet; TBET; TBLYM
| OMIM = 604895
| ECnumber = 
| Homologene = 8353
| MGIid = 1888984
| GeneAtlas_image1 = PBB_GE_TBX21_220684_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0048304 |text = positive regulation of isotype switching to IgG isotypes}} {{GNF_GO|id=GO:0050776 |text = regulation of immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30009
    | Hs_Ensembl = ENSG00000073861
    | Hs_RefseqProtein = NP_037483
    | Hs_RefseqmRNA = NM_013351
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43165609
    | Hs_GenLoc_end = 43178484
    | Hs_Uniprot = Q9UL17
    | Mm_EntrezGene = 57765
    | Mm_Ensembl = ENSMUSG00000001444
    | Mm_RefseqmRNA = XM_977626
    | Mm_RefseqProtein = XP_982720
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96914097
    | Mm_GenLoc_end = 96931418
    | Mm_Uniprot = Q3U150
  }}
}}
'''T-box 21''', also known as '''TBX21''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBX21 T-box 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30009| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of a phylogenetically conserved family of genes that share a common [[DNA-binding domain]], the [[T-box]]. T-box genes encode [[transcription factor]]s involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a [[Th1 cell]]-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma ([[IFNG]]). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.<ref name="entrez">{{cite web | title = Entrez Gene: TBX21 T-box 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30009| accessdate = }}</ref>
}}


==References==
== Role in disease ==
{{reflist|2}}
 
==Further reading==
===Asthma===
The transcription factor encoded by TBX21 is T-bet, which regulates the development of naive [[#T cell|T lymphocytes]]. Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop abnormal lung function consistent with asthma. It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well.<ref name="Pubmed">{{cite journal | vauthors = Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, and Weiss ST| title = TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids | journal = PNAS | volume = 101 | issue = 52 | pages = 18099–18104 | date = Dec 2004 | pmc = 539815 | doi = 10.1073/pnas.0408532102 | pmid=15604153}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH | title = A novel transcription factor, T-bet, directs Th1 lineage commitment | journal = Cell | volume = 100 | issue = 6 | pages = 655–69 | date = Mar 2000 | pmid = 10761931 | doi = 10.1016/S0092-8674(00)80702-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Zhang WX, Yang SY | title = Cloning and characterization of a new member of the T-box gene family | journal = Genomics | volume = 70 | issue = 1 | pages = 41–8 | date = Nov 2000 | pmid = 11087660 | doi = 10.1006/geno.2000.6361 }}
*{{cite journal | author=Szabo SJ, Kim ST, Costa GL, ''et al.'' |title=A novel transcription factor, T-bet, directs Th1 lineage commitment. |journal=Cell |volume=100 |issue= 6 |pages= 655-69 |year= 2000 |pmid= 10761931 |doi= }}
* {{cite journal | vauthors = Faedo A, Ficara F, Ghiani M, Aiuti A, Rubenstein JL, Bulfone A | title = Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis | journal = Mechanisms of Development | volume = 116 | issue = 1–2 | pages = 157–60 | date = Aug 2002 | pmid = 12128215 | doi = 10.1016/S0925-4773(02)00114-4 }}
*{{cite journal | author=Zhang WX, Yang SY |title=Cloning and characterization of a new member of the T-box gene family. |journal=Genomics |volume=70 |issue= 1 |pages= 41-8 |year= 2001 |pmid= 11087660 |doi= 10.1006/geno.2000.6361 }}
* {{cite journal | vauthors = Chung HT, Kim LH, Park BL, Lee JH, Park HS, Choi BW, Hong SJ, Chae SC, Kim JJ, Park CS, Shin HD | title = Association analysis of novel TBX21 variants with asthma phenotypes | journal = Human Mutation | volume = 22 | issue = 3 | pages = 257 | date = Sep 2003 | pmid = 12938094 | doi = 10.1002/humu.9169 }}
*{{cite journal | author=Faedo A, Ficara F, Ghiani M, ''et al.'' |title=Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. |journal=Mech. Dev. |volume=116 |issue= 1-2 |pages= 157-60 |year= 2003 |pmid= 12128215 |doi= }}
* {{cite journal | vauthors = Yu HR, Chang JC, Chen RF, Chuang H, Hong KC, Wang L, Yang KD | title = Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression | journal = Journal of Leukocyte Biology | volume = 74 | issue = 5 | pages = 952–8 | date = Nov 2003 | pmid = 12960249 | doi = 10.1189/jlb.0902474 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lametschwandtner G, Biedermann T, Schwärzler C, Günther C, Kund J, Fassl S, Hinteregger S, Carballido-Perrig N, Szabo SJ, Glimcher LH, Carballido JM | title = Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities | journal = The Journal of Allergy and Clinical Immunology | volume = 113 | issue = 5 | pages = 987–94 | date = May 2004 | pmid = 15131585 | doi = 10.1016/j.jaci.2004.02.004 }}
*{{cite journal | author=Chung HT, Kim LH, Park BL, ''et al.'' |title=Association analysis of novel TBX21 variants with asthma phenotypes. |journal=Hum. Mutat. |volume=22 |issue= 3 |pages= 257 |year= 2003 |pmid= 12938094 |doi= 10.1002/humu.9169 }}
* {{cite journal | vauthors = Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, Kusuhara K, Takeya R, Hoey T, Sumimoto H, Hara T | title = Identification of a novel type 1 diabetes susceptibility gene, T-bet | journal = Human Genetics | volume = 115 | issue = 3 | pages = 177–84 | date = Aug 2004 | pmid = 15241679 | doi = 10.1007/s00439-004-1146-2 }}
*{{cite journal | author=Yu HR, Chang JC, Chen RF, ''et al.'' |title=Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 952-8 |year= 2004 |pmid= 12960249 |doi= 10.1189/jlb.0902474 }}
* {{cite journal | vauthors = Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, Weiss ST | title = TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 52 | pages = 18099–104 | date = Dec 2004 | pmid = 15604153 | pmc = 539815 | doi = 10.1073/pnas.0408532102 }}
*{{cite journal | author=Lametschwandtner G, Biedermann T, Schwärzler C, ''et al.'' |title=Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. |journal=J. Allergy Clin. Immunol. |volume=113 |issue= 5 |pages= 987-94 |year= 2004 |pmid= 15131585 |doi= 10.1016/j.jaci.2004.02.004 }}
* {{cite journal | vauthors = Atayar C, Poppema S, Blokzijl T, Harms G, Boot M, van den Berg A | title = Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas | journal = The American Journal of Pathology | volume = 166 | issue = 1 | pages = 127–34 | date = Jan 2005 | pmid = 15632006 | pmc = 1602286 | doi = 10.1016/S0002-9440(10)62238-9 }}
*{{cite journal | author=Sasaki Y, Ihara K, Matsuura N, ''et al.'' |title=Identification of a novel type 1 diabetes susceptibility gene, T-bet. |journal=Hum. Genet. |volume=115 |issue= 3 |pages= 177-84 |year= 2004 |pmid= 15241679 |doi= 10.1007/s00439-004-1146-2 }}
* {{cite journal | vauthors = Tong Y, Aune T, Boothby M | title = T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 6 | pages = 2034–9 | date = Feb 2005 | pmid = 15684083 | pmc = 548570 | doi = 10.1073/pnas.0409510102 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH | title = T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma | journal = Human Pathology | volume = 36 | issue = 1 | pages = 10–5 | date = Jan 2005 | pmid = 15712176 | doi = 10.1016/j.humpath.2004.10.006 }}
*{{cite journal | author=Tantisira KG, Hwang ES, Raby BA, ''et al.'' |title=TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 52 |pages= 18099-104 |year= 2005 |pmid= 15604153 |doi= 10.1073/pnas.0408532102 }}
* {{cite journal | vauthors = Kulkarni A, Ravi DS, Singh K, Rampalli S, Parekh V, Mitra D, Chattopadhyay S | title = HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response | journal = Biochemical and Biophysical Research Communications | volume = 329 | issue = 2 | pages = 706–12 | date = Apr 2005 | pmid = 15737643 | doi = 10.1016/j.bbrc.2005.02.042 }}
*{{cite journal | author=Atayar C, Poppema S, Blokzijl T, ''et al.'' |title=Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas. |journal=Am. J. Pathol. |volume=166 |issue= 1 |pages= 127-34 |year= 2005 |pmid= 15632006 |doi= }}
* {{cite journal | vauthors = Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T | title = Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma | journal = Human Genetics | volume = 117 | issue = 1 | pages = 16–26 | date = Jun 2005 | pmid = 15806396 | doi = 10.1007/s00439-005-1285-0 }}
*{{cite journal | author=Tong Y, Aune T, Boothby M |title=T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 6 |pages= 2034-9 |year= 2005 |pmid= 15684083 |doi= 10.1073/pnas.0409510102 }}
* {{cite journal | vauthors = Kawana K, Kawana Y, Schust DJ | title = Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract | journal = Molecular Endocrinology | volume = 19 | issue = 8 | pages = 2047–59 | date = Aug 2005 | pmid = 15860546 | doi = 10.1210/me.2004-0489 }}
*{{cite journal | author=Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH |title=T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma. |journal=Hum. Pathol. |volume=36 |issue= 1 |pages= 10-5 |year= 2005 |pmid= 15712176 |doi= 10.1016/j.humpath.2004.10.006 }}
* {{cite journal | vauthors = Harashima A, Matsuo Y, Drexler HG, Okochi A, Motoda R, Tanimoto M, Orita K | title = Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet | journal = Leukemia Research | volume = 29 | issue = 7 | pages = 841–8 | date = Jul 2005 | pmid = 15927679 | doi = 10.1016/j.leukres.2004.12.010 }}
*{{cite journal | author=Kulkarni A, Ravi DS, Singh K, ''et al.'' |title=HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response. |journal=Biochem. Biophys. Res. Commun. |volume=329 |issue= 2 |pages= 706-12 |year= 2005 |pmid= 15737643 |doi= 10.1016/j.bbrc.2005.02.042 }}
* {{cite journal | vauthors = Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y, Chen X, Mao H, Zhang L, Zhang J, Hughes T, Deng Y, Zhang Q, Wang F, Zou X, Liu CG, Freud AG, Li X, Caligiuri MA, Vivier E, Yu J | title = Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function | journal = Immunity | volume = 42 | issue = 3 | pages = 457–70 | date = Mar 2015 | pmid = 25769609| pmc =  4400836| doi = 10.1016/j.immuni.2015.02.006 }}
*{{cite journal | author=Akahoshi M, Obara K, Hirota T, ''et al.'' |title=Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. |journal=Hum. Genet. |volume=117 |issue= 1 |pages= 16-26 |year= 2005 |pmid= 15806396 |doi= 10.1007/s00439-005-1285-0 }}
* {{cite journal | vauthors = Raby BA, Hwang ES, Van Steen K, Tantisira K, Peng S, Litonjua A, Lazarus R, Giallourakis C, Rioux JD, Sparrow D, Silverman EK, Glimcher LH, Weiss ST | title = T-bet polymorphisms are associated with asthma and airway hyperresponsiveness | journal = American Journal of Respiratory and Critical Care Medicine | volume = 173 | issue = 1 | pages = 64–70 | date = Jan 2006 | pmid = 16179640 | pmc = 2662983 | doi = 10.1164/rccm.200503-505OC }}
*{{cite journal | author=Kawana K, Kawana Y, Schust DJ |title=Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. |journal=Mol. Endocrinol. |volume=19 |issue= 8 |pages= 2047-59 |year= 2005 |pmid= 15860546 |doi= 10.1210/me.2004-0489 }}
*{{cite journal | author=Harashima A, Matsuo Y, Drexler HG, ''et al.'' |title=Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet. |journal=Leuk. Res. |volume=29 |issue= 7 |pages= 841-8 |year= 2005 |pmid= 15927679 |doi= 10.1016/j.leukres.2004.12.010 }}
*{{cite journal  | author=Raby BA, Hwang ES, Van Steen K, ''et al.'' |title=T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. |journal=Am. J. Respir. Crit. Care Med. |volume=173 |issue= 1 |pages= 64-70 |year= 2006 |pmid= 16179640 |doi= 10.1164/rccm.200503-505OC }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|TBX21+protein,+human}}
 
{{Transcription factors|g4}}
 
[[Category:Transcription factors]]
 
 
{{gene-17-stub}}

Latest revision as of 00:49, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]

Function

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]

Role in disease

Asthma

The transcription factor encoded by TBX21 is T-bet, which regulates the development of naive T lymphocytes. Asthma is a disease of chronic inflammation, and it is known that transgenic mice born without TBX21 spontaneously develop abnormal lung function consistent with asthma. It is thought that TBX21, therefore, may play a role in the development of asthma in humans as well.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TBX21 T-box 21".
  2. ↑ Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, and Weiss ST (Dec 2004). "TBX21: A functional variant predicts improvement in asthma with the use of inhaled corticosteroids". PNAS. 101 (52): 18099–18104. doi:10.1073/pnas.0408532102. PMC 539815. PMID 15604153.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=TBX21&oldid=1418350"