GATA6: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
{{Expand|date=December 2007}}
{{Infobox_gene}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
'''Transcription factor GATA-6''', also known as '''GATA-binding factor 6''' (GATA6), is [[protein]] that in humans is encoded by the ''GATA6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GATA6 GATA binding protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2627| accessdate = }}</ref> The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the [[Consensus sequence|consensus binding sequence]].<ref>{{cite journal | vauthors = Sakai Y, Nakagawa R, Sato R, Maeda M | title = Selection of DNA binding sites for human transcriptional regulator GATA-6. | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 682–688 | year = 1998 | doi = 10.1006/bbrc.1998.9374 | pmid = 9784406 }}</ref>
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = GATA binding protein 6
| HGNCid = 4174
| Symbol = GATA6
| AltSymbols =;
| OMIM = 601656
| ECnumber = 
| Homologene = 68449
| MGIid = 107516
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001889 |text = liver development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2627
    | Hs_Ensembl = ENSG00000141448
    | Hs_RefseqProtein = NP_005248
    | Hs_RefseqmRNA = NM_005257
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 18003414
    | Hs_GenLoc_end = 18036225
    | Hs_Uniprot = Q92908
    | Mm_EntrezGene = 14465
    | Mm_Ensembl = ENSMUSG00000005836
    | Mm_RefseqmRNA = NM_010258
    | Mm_RefseqProtein = NP_034388
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 11052506
    | Mm_GenLoc_end = 11085630
    | Mm_Uniprot = Q3UQJ2
  }}
}}
'''GATA binding protein 6''', also known as '''GATA6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GATA6 GATA binding protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2627| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mutations in the gene have been linked with pancreatic [[agenesis]] and [[congenital heart defect]]s.<ref name="pmid25706805">{{cite journal | vauthors = Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ | title = Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations | journal = PLoS ONE | volume = 10 | issue = 2 | pages = e0118449 | year = 2015 | pmid = 25706805 | doi = 10.1371/journal.pone.0118449 | pmc=4338276| bibcode = 2015PLoSO..1018449C }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
=== Lung Endodermal Epithelial Development ===
 
GATA-6, a [[zinc finger transcription factor]], is important in the endodermal differentiation of organ tissues.<ref name="Yang_2002">{{cite journal | vauthors = Yang H, Lu MM, Zhang L, Whitsett JA, Morrisey EE | title = GATA6 regulates differentiation of distal lung epithelium | journal = Development | volume = 129 | issue = 9 | pages = 2233–46 | date = May 2002 | pmid = 11959831 }}</ref> It is also indicated in proper lung development by controlling the late differentiation stages of alveolar epithelium and aquaporin-5 promoter activation. Furthermore, GATA-6 has been linked to the production of LIF, a cytokine that encourages proliferation of endodermal embryonic stem cells and blocks early epiblast differentiation. If left unregulated in the developing embryo, this cytokine production and chemical signal contributes to the phenotypes discussed further below.<ref>{{cite journal | vauthors = Morgani SM, Brickman JM | title = LIF supports primitive endoderm expansion during pre-implantation development | journal = Development | volume = 142 | issue = 20 | pages = 3488–99 | date = October 2015 | pmid = 26395492 | doi = 10.1242/dev.125021 }}</ref>
 
Upon the disruption of GATA-6 in an embryo, the distal lung epithelial development is stunted in transgenic mice models<ref name="Yang_2002" /> The [[progenitor cell]]s, or stem cells, for alveolar epithelial tissues develop and are specified appropriately, however further differentiation does not occur. Also the distal-proximal bronchiole development is affected, resulting in a reduced quantity of airway exchange sites.<ref name="Yang_2002" />
 
This branching deficit, which will cause bilateral [[pulmonary hypoplasia]] after birth, has been locally associated with areas lacking differentiated alveolar epithelium, implicating this phenotype as inherent to endodermal function, and thus may be indirectly linked to improper GATA-6 expression.<ref>{{cite journal | vauthors = Keijzer R, van Tuyl M, Meijers C, Post M, Tibboel D, Grosveld F, Koutsourakis M | title = The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development | journal = Development | volume = 128 | issue = 4 | pages = 503–11 | date = February 2001 | pmid = 11171334 }}</ref><ref>{{cite book | title = Rennie & Robertson's Textbook on Neonatology | last = Rennie | first = Janet | name-list-format = vanc | publisher = Elsevier Health Sciences | year = 2012 | isbn = 978-0-7020-3479-4 | location = | pages = }}</ref> That is, a deficit of bronchiole branching may not be a result of direct transcriptional error in GATA-6, but rather a side effect of such an error.
 
== See also ==
* [[GATA transcription factor]]
* [[GATA transcription factor]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki E, Evans T, Lowry J, Truong L, Bell DW, Testa JR, Walsh K | title = The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals | journal = Genomics | volume = 38 | issue = 3 | pages = 283–90 | year = 1997 | pmid = 8975704 | doi = 10.1006/geno.1996.0630 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Huggon IC, Davies A, Gove C, Moscoso G, Moniz C, Foss Y, Farzaneh F, Towner P | title = Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut | journal = Biochim. Biophys. Acta | volume = 1353 | issue = 2 | pages = 98–102 | year = 1997 | pmid = 9294001 | doi = 10.1016/s0167-4781(97)00049-3 }}
*{{cite journal | author=Suzuki E, Evans T, Lowry J, ''et al.'' |title=The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals. |journal=Genomics |volume=38 |issue= 3 |pages= 283-90 |year= 1997 |pmid= 8975704 |doi= 10.1006/geno.1996.0630 }}
* {{cite journal | vauthors = Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M, Maeda M | title = GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells | journal = FEBS Lett. | volume = 414 | issue = 2 | pages = 333–7 | year = 1997 | pmid = 9315713 | doi = 10.1016/S0014-5793(97)01017-X }}
*{{cite journal | author=Huggon IC, Davies A, Gove C, ''et al.'' |title=Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut. |journal=Biochim. Biophys. Acta |volume=1353 |issue= 2 |pages= 98-102 |year= 1997 |pmid= 9294001 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Yoshida T, Sato R, Mahmood S, ''et al.'' |title=GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. |journal=FEBS Lett. |volume=414 |issue= 2 |pages= 333-7 |year= 1997 |pmid= 9315713 |doi= }}
* {{cite journal | vauthors = Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, Sasayama S | title = A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25330–5 | year = 2000 | pmid = 10851229 | doi = 10.1074/jbc.M000828200 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, Reddy JK | title = Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3585–92 | year = 2002 | pmid = 11724781 | doi = 10.1074/jbc.M107995200 }}
*{{cite journal | author=Wada H, Hasegawa K, Morimoto T, ''et al.'' |title=A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25330-5 |year= 2000 |pmid= 10851229 |doi= 10.1074/jbc.M000828200 }}
* {{cite journal | vauthors = Liu C, Glasser SW, Wan H, Whitsett JA | title = GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression | journal = J. Biol. Chem. | volume = 277 | issue = 6 | pages = 4519–25 | year = 2002 | pmid = 11733512 | doi = 10.1074/jbc.M107585200 }}
*{{cite journal | author=Crawford SE, Qi C, Misra P, ''et al.'' |title=Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3585-92 |year= 2002 |pmid= 11724781 |doi= 10.1074/jbc.M107995200 }}
* {{cite journal | vauthors = Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M | title = Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development | journal = Endocr. Res. | volume = 28 | issue = 4 | pages = 647–50 | year = 2003 | pmid = 12530677 | doi = 10.1081/ERC-120016980 }}
*{{cite journal | author=Liu C, Glasser SW, Wan H, Whitsett JA |title=GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4519-25 |year= 2002 |pmid= 11733512 |doi= 10.1074/jbc.M107585200 }}
* {{cite journal | vauthors = Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ | title = Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors | journal = Dev. Cell | volume = 4 | issue = 1 | pages = 107–18 | year = 2003 | pmid = 12530967 | doi = 10.1016/S1534-5807(02)00396-9 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nemer G, Nemer M | title = Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6 | journal = Dev. Biol. | volume = 254 | issue = 1 | pages = 131–48 | year = 2003 | pmid = 12606287 | doi = 10.1016/S0012-1606(02)00026-X }}
*{{cite journal | author=Kiiveri S, Liu J, Westerholm-Ormio M, ''et al.'' |title=Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development. |journal=Endocr. Res. |volume=28 |issue= 4 |pages= 647-50 |year= 2003 |pmid= 12530677 |doi= }}
* {{cite journal | vauthors = Abe M, Hasegawa K, Wada H, Morimoto T, Yanazume T, Kawamura T, Hirai M, Furukawa Y, Kita T | title = GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells | journal = Arterioscler. Thromb. Vasc. Biol. | volume = 23 | issue = 3 | pages = 404–10 | year = 2003 | pmid = 12615657 | doi = 10.1161/01.ATV.0000059405.51042.A0 }}
*{{cite journal | author=Chang DF, Belaguli NS, Iyer D, ''et al.'' |title=Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. |journal=Dev. Cell |volume=4 |issue= 1 |pages= 107-18 |year= 2003 |pmid= 12530967 |doi= }}
* {{cite journal | vauthors = Ketola I, Toppari J, Vaskivuo T, Herva R, Tapanainen JS, Heikinheimo M | title = Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis | journal = J. Clin. Endocrinol. Metab. | volume = 88 | issue = 4 | pages = 1858–65 | year = 2003 | pmid = 12679484 | doi = 10.1210/jc.2002-021647 }}
*{{cite journal | author=Nemer G, Nemer M |title=Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. |journal=Dev. Biol. |volume=254 |issue= 1 |pages= 131-48 |year= 2003 |pmid= 12606287 |doi= }}
* {{cite journal | vauthors = Siltanen S, Heikkilä P, Bielinska M, Wilson DB, Heikinheimo M | title = Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas | journal = Pediatr. Res. | volume = 54 | issue = 4 | pages = 542–6 | year = 2004 | pmid = 12867597 | doi = 10.1203/01.PDR.0000081295.56529.E9 }}
*{{cite journal | author=Abe M, Hasegawa K, Wada H, ''et al.'' |title=GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 3 |pages= 404-10 |year= 2003 |pmid= 12615657 |doi= 10.1161/01.ATV.0000059405.51042.A0 }}
* {{cite journal | vauthors = Liu C, Ikegami M, Stahlman MT, Dey CR, Whitsett JA | title = Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6 | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 285 | issue = 6 | pages = L1246–54 | year = 2003 | pmid = 12909592 | doi = 10.1152/ajplung.00443.2002 }}
*{{cite journal | author=Ketola I, Toppari J, Vaskivuo T, ''et al.'' |title=Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 4 |pages= 1858-65 |year= 2003 |pmid= 12679484 |doi= }}
* {{cite journal | vauthors = Benchabane H, Wrana JL | title = GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations | journal = Mol. Cell. Biol. | volume = 23 | issue = 18 | pages = 6646–61 | year = 2003 | pmid = 12944489 | pmc = 193708 | doi = 10.1128/MCB.23.18.6646-6661.2003 }}
*{{cite journal | author=Siltanen S, Heikkilä P, Bielinska M, ''et al.'' |title=Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas. |journal=Pediatr. Res. |volume=54 |issue= 4 |pages= 542-6 |year= 2004 |pmid= 12867597 |doi= 10.1203/01.PDR.0000081295.56529.E9 }}
* {{cite journal | vauthors = Jimenez P, Saner K, Mayhew B, Rainey WE | title = GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis | journal = Endocrinology | volume = 144 | issue = 10 | pages = 4285–8 | year = 2003 | pmid = 12959982 | doi = 10.1210/en.2003-0472 }}
*{{cite journal | author=Liu C, Ikegami M, Stahlman MT, ''et al.'' |title=Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 6 |pages= L1246-54 |year= 2003 |pmid= 12909592 |doi= 10.1152/ajplung.00443.2002 }}
* {{cite journal | vauthors = Saner KJ, Suzuki T, Sasano H, Pizzey J, Ho C, Strauss JF, Carr BR, Rainey WE | title = Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal | journal = Mol. Endocrinol. | volume = 19 | issue = 1 | pages = 184–97 | year = 2005 | pmid = 15388788 | doi = 10.1210/me.2003-0332 }}
*{{cite journal | author=Benchabane H, Wrana JL |title=GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. |journal=Mol. Cell. Biol. |volume=23 |issue= 18 |pages= 6646-61 |year= 2003 |pmid= 12944489 |doi= }}
* {{cite journal | vauthors = Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M | title = Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors | journal = Endocr. Res. | volume = 30 | issue = 4 | pages = 919–23 | year = 2005 | pmid = 15666845 | doi = 10.1081/ERC-200044149 }}
*{{cite journal | author=Jimenez P, Saner K, Mayhew B, Rainey WE |title=GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis. |journal=Endocrinology |volume=144 |issue= 10 |pages= 4285-8 |year= 2003 |pmid= 12959982 |doi= 10.1210/en.2003-0472 }}
*{{cite journal | author=Saner KJ, Suzuki T, Sasano H, ''et al.'' |title=Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal. |journal=Mol. Endocrinol. |volume=19 |issue= 1 |pages= 184-97 |year= 2005 |pmid= 15388788 |doi= 10.1210/me.2003-0332 }}
*{{cite journal  | author=Kiiveri S, Liu J, Heikkilä P, ''et al.'' |title=Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 919-23 |year= 2005 |pmid= 15666845 |doi=  }}
}}
{{refend}}
{{refend}}


Line 90: Line 46:
* {{MeshName|GATA6+protein,+human}}
* {{MeshName|GATA6+protein,+human}}


{{protein-stub}}
{{Transcription factors|g2}}
{{Transcription factors}}
 
{{DEFAULTSORT:Gata6}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 01:52, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene.[1] The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence.[2]

Clinical significance

Mutations in the gene have been linked with pancreatic agenesis and congenital heart defects.[3]

Lung Endodermal Epithelial Development

GATA-6, a zinc finger transcription factor, is important in the endodermal differentiation of organ tissues.[4] It is also indicated in proper lung development by controlling the late differentiation stages of alveolar epithelium and aquaporin-5 promoter activation. Furthermore, GATA-6 has been linked to the production of LIF, a cytokine that encourages proliferation of endodermal embryonic stem cells and blocks early epiblast differentiation. If left unregulated in the developing embryo, this cytokine production and chemical signal contributes to the phenotypes discussed further below.[5]

Upon the disruption of GATA-6 in an embryo, the distal lung epithelial development is stunted in transgenic mice models[4] The progenitor cells, or stem cells, for alveolar epithelial tissues develop and are specified appropriately, however further differentiation does not occur. Also the distal-proximal bronchiole development is affected, resulting in a reduced quantity of airway exchange sites.[4]

This branching deficit, which will cause bilateral pulmonary hypoplasia after birth, has been locally associated with areas lacking differentiated alveolar epithelium, implicating this phenotype as inherent to endodermal function, and thus may be indirectly linked to improper GATA-6 expression.[6][7] That is, a deficit of bronchiole branching may not be a result of direct transcriptional error in GATA-6, but rather a side effect of such an error.

See also

References

  1. ↑ "Entrez Gene: GATA6 GATA binding protein 6".
  2. ↑ Sakai Y, Nakagawa R, Sato R, Maeda M (1998). "Selection of DNA binding sites for human transcriptional regulator GATA-6". Biochem Biophys Res Commun. 250 (3): 682–688. doi:10.1006/bbrc.1998.9374. PMID 9784406.
  3. ↑ Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ (2015). "Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations". PLoS ONE. 10 (2): e0118449. Bibcode:2015PLoSO..1018449C. doi:10.1371/journal.pone.0118449. PMC 4338276. PMID 25706805.
  4. ↑ 4.0 4.1 4.2 Yang H, Lu MM, Zhang L, Whitsett JA, Morrisey EE (May 2002). "GATA6 regulates differentiation of distal lung epithelium". Development. 129 (9): 2233–46. PMID 11959831.
  5. ↑ Morgani SM, Brickman JM (October 2015). "LIF supports primitive endoderm expansion during pre-implantation development". Development. 142 (20): 3488–99. doi:10.1242/dev.125021. PMID 26395492.
  6. ↑ Keijzer R, van Tuyl M, Meijers C, Post M, Tibboel D, Grosveld F, Koutsourakis M (February 2001). "The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development". Development. 128 (4): 503–11. PMID 11171334.
  7. ↑ Rennie J (2012). Rennie & Robertson's Textbook on Neonatology. Elsevier Health Sciences. ISBN 978-0-7020-3479-4.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki E, Evans T, Lowry J, Truong L, Bell DW, Testa JR, Walsh K (1997). "The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals". Genomics. 38 (3): 283–90. doi:10.1006/geno.1996.0630. PMID 8975704.
  • Huggon IC, Davies A, Gove C, Moscoso G, Moniz C, Foss Y, Farzaneh F, Towner P (1997). "Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut". Biochim. Biophys. Acta. 1353 (2): 98–102. doi:10.1016/s0167-4781(97)00049-3. PMID 9294001.
  • Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M, Maeda M (1997). "GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells". FEBS Lett. 414 (2): 333–7. doi:10.1016/S0014-5793(97)01017-X. PMID 9315713.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, Sasayama S (2000). "A p300 protein as a coactivator of GATA-6 in the transcription of the smooth muscle-myosin heavy chain gene". J. Biol. Chem. 275 (33): 25330–5. doi:10.1074/jbc.M000828200. PMID 10851229.
  • Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, Reddy JK (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781.
  • Liu C, Glasser SW, Wan H, Whitsett JA (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression". J. Biol. Chem. 277 (6): 4519–25. doi:10.1074/jbc.M107585200. PMID 11733512.
  • Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M (2003). "Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development". Endocr. Res. 28 (4): 647–50. doi:10.1081/ERC-120016980. PMID 12530677.
  • Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.
  • Nemer G, Nemer M (2003). "Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6". Dev. Biol. 254 (1): 131–48. doi:10.1016/S0012-1606(02)00026-X. PMID 12606287.
  • Abe M, Hasegawa K, Wada H, Morimoto T, Yanazume T, Kawamura T, Hirai M, Furukawa Y, Kita T (2003). "GATA-6 is involved in PPARgamma-mediated activation of differentiated phenotype in human vascular smooth muscle cells". Arterioscler. Thromb. Vasc. Biol. 23 (3): 404–10. doi:10.1161/01.ATV.0000059405.51042.A0. PMID 12615657.
  • Ketola I, Toppari J, Vaskivuo T, Herva R, Tapanainen JS, Heikinheimo M (2003). "Transcription factor GATA-6, cell proliferation, apoptosis, and apoptosis-related proteins Bcl-2 and Bax in human fetal testis". J. Clin. Endocrinol. Metab. 88 (4): 1858–65. doi:10.1210/jc.2002-021647. PMID 12679484.
  • Siltanen S, Heikkilä P, Bielinska M, Wilson DB, Heikinheimo M (2004). "Transcription factor GATA-6 is expressed in malignant endoderm of pediatric yolk sac tumors and in teratomas". Pediatr. Res. 54 (4): 542–6. doi:10.1203/01.PDR.0000081295.56529.E9. PMID 12867597.
  • Liu C, Ikegami M, Stahlman MT, Dey CR, Whitsett JA (2003). "Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (6): L1246–54. doi:10.1152/ajplung.00443.2002. PMID 12909592.
  • Benchabane H, Wrana JL (2003). "GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations". Mol. Cell. Biol. 23 (18): 6646–61. doi:10.1128/MCB.23.18.6646-6661.2003. PMC 193708. PMID 12944489.
  • Jimenez P, Saner K, Mayhew B, Rainey WE (2003). "GATA-6 is expressed in the human adrenal and regulates transcription of genes required for adrenal androgen biosynthesis". Endocrinology. 144 (10): 4285–8. doi:10.1210/en.2003-0472. PMID 12959982.
  • Saner KJ, Suzuki T, Sasano H, Pizzey J, Ho C, Strauss JF, Carr BR, Rainey WE (2005). "Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal". Mol. Endocrinol. 19 (1): 184–97. doi:10.1210/me.2003-0332. PMID 15388788.
  • Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M (2005). "Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors". Endocr. Res. 30 (4): 919–23. doi:10.1081/ERC-200044149. PMID 15666845.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=GATA6&oldid=1418465"