RFX1: Difference between revisions

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Latest revision as of 09:08, 10 September 2017

MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.^[1]^[2]^[3]

Structure

The RFX1 gene is a member of the regulatory factor X (RFX) gene family, which encodes transcription factors that contain five conserved domains including a highly conserved, centrally located, winged helix DNA binding domain as well as a dimerization domain located in the C-terminal region of the sequence.^[4] Apart from the five conserved domains, the RFX proteins diverge significantly. The DNA binding and dimerization domains of the RFX family proteins show no similarities to the other domains with the same functions in other proteins.^[2]

Species distribution

The RFX protein family is conserved in S. pombe, S. cerevisiae, C. elegans, mice and humans.^[5] There are seven known RFX proteins in humans, five in mice, and one in C. elegans as well as one in each of the two species of yeast.^[5]^[6]

Function

The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the Xboxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.^[3] The RFX proteins were originally cloned and characterized due to their high affinity for a cis-acting promoter sequence, called the Xbox, found in all MHC class II genes.^[2]

Levels of mRNA encoding this protein as well as RFX2 and RFX3 are found to be consistently elevated in the testis and are variable in other tissues throughout the body.^[2]

RFX1 contains a C-terminal sequence with no apparent homology to other RFX proteins. This C-terminal tail contains an acidic region that is thought to aid in crossing the nuclear membrane. Two major functions are hypothesized to this exist for this domain: a contribution to the nuclear localization signal (NLS) as well as the contradictory down-regulation of DNA binding as well as nuclear association. These two functions were originally identified through sequence mutations and translational fusions with gfp (green fluorescent protein) and remain to be confirmed.^[7]

Interactions

RFX1 has been shown to interact with Abl gene.^[5]

References

↑ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. PMC 358479. PMID 8289803.
↑ ^3.0 ^3.1 "Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)".
↑ Emery P, Durand B, Mach B, Reith W (March 1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.
↑ ^5.0 ^5.1 ^5.2 Agami R, Shaul Y (April 1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes". Oncogene. 16 (14): 1779–88. doi:10.1038/sj.onc.1201708. PMID 9583676.
↑ Aftab S, Semenec L, Chu JS, Chen N (2008). "Identification and characterization of novel human tissue-specific RFX transcription factors". BMC Evol. Biol. 8: 226. doi:10.1186/1471-2148-8-226. PMC 2533330. PMID 18673564.
↑ Katan-Khaykovich Y, Shaul Y (May 2001). "Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism". Eur. J. Biochem. 268 (10): 3108–16. doi:10.1046/j.1432-1327.2001.02211.x. PMID 11358531.

External links

RFX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[pmid1505960-1] Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.

[Reith_1994-2] 2.0 ^2.1 ^2.2 ^2.3 Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. PMC 358479. PMID 8289803.

[entrez-3] 3.0 ^3.1 "Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)".

[pmid8600444-4] Emery P, Durand B, Mach B, Reith W (March 1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.

[Agami_1998-5] 5.0 ^5.1 ^5.2 Agami R, Shaul Y (April 1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes". Oncogene. 16 (14): 1779–88. doi:10.1038/sj.onc.1201708. PMID 9583676.

[pmid18673564-6] Aftab S, Semenec L, Chu JS, Chen N (2008). "Identification and characterization of novel human tissue-specific RFX transcription factors". BMC Evol. Biol. 8: 226. doi:10.1186/1471-2148-8-226. PMC 2533330. PMID 18673564.

[pmid11358531-7] Katan-Khaykovich Y, Shaul Y (May 2001). "Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism". Eur. J. Biochem. 268 (10): 3108–16. doi:10.1046/j.1432-1327.2001.02211.x. PMID 11358531.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''MHC class II regulatory factor RFX1''' is a [[protein]] that, in humans, is encoded by the ''RFX1'' [[gene]] located on the short arm of chromosome 19.<ref name="pmid1505960">{{cite journal | vauthors = Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B | title = The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19 | journal = Genomics | volume = 13 | issue = 4 | pages = 1307–10 |date=Sep 1992 | pmid = 1505960 | pmc =  | doi =10.1016/0888-7543(92)90052-T  }}</ref><ref name="Reith_1994">{{cite journal | vauthors = Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B | title = RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins | journal = Mol Cell Biol | volume = 14 | issue = 2 | pages = 1230–44 |date=Feb 1994 | pmid = 8289803 | pmc = 358479 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5989| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Structure ==
-{{GNF_Protein_box
- | image = PBB_Protein_RFX1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dp7.
- | PDB = {{PDB2|1dp7}}
- | Name = Regulatory factor X, 1 (influences HLA class II expression)
- | HGNCid = 9982
- | Symbol = RFX1
- | AltSymbols =; EF-C
- | OMIM = 600006
- | ECnumber =
- | Homologene = 2189
- | MGIid = 105982
- | GeneAtlas_image1 = PBB_GE_RFX1_206321_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RFX1_222012_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5989
-    | Hs_Ensembl = ENSG00000132005
-    | Hs_RefseqProtein = NP_002909
-    | Hs_RefseqmRNA = NM_002918
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 13933353
-    | Hs_GenLoc_end = 13978097
-    | Hs_Uniprot = P22670
-    | Mm_EntrezGene = 19724
-    | Mm_Ensembl = ENSMUSG00000031706
-    | Mm_RefseqmRNA = NM_009055
-    | Mm_RefseqProtein = NP_033081
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 86956971
-    | Mm_GenLoc_end = 86987107
-    | Mm_Uniprot = Q3V383
-  }}
-}}
-'''Regulatory factor X, 1 (influences HLA class II expression)''', also known as '''RFX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5989| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The RFX1 gene is a member of the regulatory factor X (RFX) gene family, which encodes [[transcription factor]]s that contain five conserved domains including a highly conserved, centrally located, [[winged helix]] DNA binding domain as well as a dimerization domain located in the [[C-terminal]] region of the sequence.<ref name="pmid8600444">{{cite journal | vauthors = Emery P, Durand B, Mach B, Reith W | title = RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom | journal = Nucleic Acids Res. | volume = 24 | issue = 5 | pages = 803–7 |date=March 1996 | pmid = 8600444 | pmc = 145730 | doi = 10.1093/nar/24.5.803 }}</ref> Apart from the five conserved domains, the RFX proteins diverge significantly. The DNA binding and dimerization domains of the RFX family proteins show no similarities to the other domains with the same functions in other proteins.<ref name="Reith_1994"/>
-{{PBB_Summary
-| section_title =
+== Species distribution ==
-| summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression.  Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.<ref name="entrez">{{cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5989| accessdate = }}</ref>
-}}
+The RFX protein family is conserved in ''[[Schizosaccharomyces pombe|S. pombe]]'', ''[[Saccharomyces cerevisiae|S. cerevisiae]]'', ''[[Caenorhabditis elegans|C. elegans]]'', mice and humans.<ref name="Agami_1998"/> There are seven known RFX proteins in humans, five in mice, and one in ''C. elegans'' as well as one in each of the two species of yeast.<ref name="Agami_1998"/><ref name="pmid18673564">{{cite journal | vauthors = Aftab S, Semenec L, Chu JS, Chen N | title = Identification and characterization of novel human tissue-specific RFX transcription factors | journal = BMC Evol. Biol. | volume = 8 | issue = | pages = 226 | year = 2008 | pmid = 18673564 | pmc = 2533330 | doi = 10.1186/1471-2148-8-226 }}</ref>
+== Function ==
+The protein encoded by this gene is structurally related to regulatory factors [[RFX2|X2]], [[RFX3|X3]], [[RFX4|X4]], and [[RFX5|X5]]. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the Xboxes of [[MHC class II]] genes and is essential for their expression.  Also, it can bind to an [[inverted repeat]] that is required for expression of [[hepatitis B]] virus genes.<ref name="entrez"/> The RFX proteins were originally cloned and characterized due to their high affinity for a cis-acting promoter sequence, called the Xbox, found in all MHC class II genes.<ref name="Reith_1994"/>
+Levels of mRNA encoding this protein as well as RFX2 and RFX3 are found to be consistently elevated in the [[testis]] and are variable in other tissues throughout the body.<ref name="Reith_1994"/>
+RFX1 contains a C-terminal sequence with no apparent homology to other RFX proteins. This C-terminal tail contains an acidic region that is thought to aid in crossing the nuclear membrane. Two major functions are hypothesized to this exist for this domain: a contribution to the [[nuclear localization signal]] (NLS) as well as the contradictory down-regulation of DNA binding as well as nuclear association. These two functions were originally identified through sequence mutations and translational fusions with gfp ([[green fluorescent protein]]) and remain to be confirmed.<ref name="pmid11358531">{{cite journal | vauthors = Katan-Khaykovich Y, Shaul Y | title = Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism | journal = Eur. J. Biochem. | volume = 268 | issue = 10 | pages = 3108–16 |date=May 2001 | pmid = 11358531 | doi = 10.1046/j.1432-1327.2001.02211.x }}</ref>
+== Interactions ==
+RFX1 has been shown to [[Protein-protein interaction|interact]] with [[Abl gene]].<ref name="Agami_1998">{{cite journal | vauthors = Agami R, Shaul Y | title = The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes | journal = Oncogene | volume = 16 | issue = 14 | pages = 1779–88 |date=April 1998 | pmid = 9583676 | doi =  10.1038/sj.onc.1201708 }}</ref>
+== References ==
+{{reflist}}
-==References==
-{{reflist|2}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Herrero Sanchez C, Reith W, Silacci P, Mach B |title=The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. |journal=Mol. Cell. Biol. |volume=12 |issue= 9 |pages= 4076–83 |year= 1992 |pmid= 1508204 |doi=  | pmc=360302  }}
-| citations =
+*{{cite journal   |vauthors=Reith W, Herrero-Sanchez C, Kobr M, etal |title=MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. |journal=Genes Dev. |volume=4 |issue= 9 |pages= 1528–40 |year= 1991 |pmid= 2253877 |doi=10.1101/gad.4.9.1528  }}
-*{{cite journal  | author=Pugliatti L, Derré J, Berger R, ''et al.'' |title=The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. |journal=Genomics |volume=13 |issue= 4 |pages= 1307-10 |year= 1992 |pmid= 1505960 |doi=  }}
+*{{cite journal  | vauthors=Sáfrány G, Perry RP |title=Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. |journal=Gene |volume=132 |issue= 2 |pages= 279–83 |year= 1993 |pmid= 8224874 |doi=10.1016/0378-1119(93)90208-K  }}
-*{{cite journal  | author=Herrero Sanchez C, Reith W, Silacci P, Mach B |title=The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. |journal=Mol. Cell. Biol. |volume=12 |issue= 9 |pages= 4076-83 |year= 1992 |pmid= 1508204 |doi=  }}
+*{{cite journal   |vauthors=Siegrist CA, Durand B, Emery P, etal |title=RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6375–84 |year= 1993 |pmid= 8413236 |doi=  | pmc=364696  }}
-*{{cite journal  | author=Reith W, Herrero-Sanchez C, Kobr M, ''et al.'' |title=MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. |journal=Genes Dev. |volume=4 |issue= 9 |pages= 1528-40 |year= 1991 |pmid= 2253877 |doi=  }}
+*{{cite journal  | vauthors=Emery P, Durand B, Mach B, Reith W |title=RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 803–7 |year= 1996 |pmid= 8600444 |doi=10.1093/nar/24.5.803  | pmc=145730  }}
-*{{cite journal  | author=Sáfrány G, Perry RP |title=Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. |journal=Gene |volume=132 |issue= 2 |pages= 279-83 |year= 1993 |pmid= 8224874 |doi=  }}
+*{{cite journal   |vauthors=Doyle J, Hoffman S, Ucla C, etal |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227–30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
-*{{cite journal  | author=Reith W, Ucla C, Barras E, ''et al.'' |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230-44 |year= 1994 |pmid= 8289803 |doi=  }}
+*{{cite journal  | vauthors=Katan-Khaykovich Y, Shaul Y |title=RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24504–12 |year= 1998 |pmid= 9733744 |doi=10.1074/jbc.273.38.24504  }}
-*{{cite journal  | author=Siegrist CA, Durand B, Emery P, ''et al.'' |title=RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6375-84 |year= 1993 |pmid= 8413236 |doi=  }}
+*{{cite journal   |vauthors=Iwama A, Pan J, Zhang P, etal |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940–50 |year= 1999 |pmid= 10330134 |doi=  | pmc=104353  }}
-*{{cite journal  | author=Emery P, Durand B, Mach B, Reith W |title=RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 803-7 |year= 1996 |pmid= 8600444 |doi=  }}
+*{{cite journal   |vauthors=Zajac-Kaye M, Ben-Baruch N, Kastanos E, etal |title=Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.  | series=345 |journal=Biochem. J. |volume=345 |issue=  3|pages= 535–41 |year= 2000 |pmid= 10642512 |doi=10.1042/0264-6021:3450535  | pmc=1220788  }}
-*{{cite journal  | author=Doyle J, Hoffman S, Ucla C, ''et al.'' |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227-30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
+*{{cite journal   |vauthors=Morotomi-Yano K, Yano K, Saito H, etal |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
-*{{cite journal  | author=Agami R, Shaul Y |title=The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes. |journal=Oncogene |volume=16 |issue= 14 |pages= 1779-88 |year= 1998 |pmid= 9583676 |doi= 10.1038/sj.onc.1201708 }}
+*{{cite journal  | vauthors=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926–37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
-*{{cite journal  | author=Katan-Khaykovich Y, Shaul Y |title=RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24504-12 |year= 1998 |pmid= 9733744 |doi=  }}
+*{{cite journal   |vauthors=Nakayama A, Murakami H, Maeyama N, etal |title=Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 233–40 |year= 2003 |pmid= 12411430 |doi= 10.1074/jbc.M209574200 }}
-*{{cite journal  | author=Iwama A, Pan J, Zhang P, ''et al.'' |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940-50 |year= 1999 |pmid= 10330134 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Zajac-Kaye M, Ben-Baruch N, Kastanos E, ''et al.'' |title=Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells. |journal=Biochem. J. |volume=345 Pt 3 |issue=  |pages= 535-41 |year= 2000 |pmid= 10642512 |doi=  }}
+*{{cite journal   |vauthors=Norquay LD, Yang X, Sheppard P, etal |title=RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. |journal=Mol. Endocrinol. |volume=17 |issue= 6 |pages= 1027–38 |year= 2003 |pmid= 12624117 |doi= 10.1210/me.2003-0025 }}
-*{{cite journal  | author=Katan-Khaykovich Y, Shaul Y |title=Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism. |journal=Eur. J. Biochem. |volume=268 |issue= 10 |pages= 3108-16 |year= 2001 |pmid= 11358531 |doi=  }}
+*{{cite journal  | vauthors=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482–9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
-*{{cite journal  | author=Morotomi-Yano K, Yano K, Saito H, ''et al.'' |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836-42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
+*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
-*{{cite journal  | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926-37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
-*{{cite journal  | author=Nakayama A, Murakami H, Maeyama N, ''et al.'' |title=Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 233-40 |year= 2003 |pmid= 12411430 |doi= 10.1074/jbc.M209574200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Norquay LD, Yang X, Sheppard P, ''et al.'' |title=RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin. |journal=Mol. Endocrinol. |volume=17 |issue= 6 |pages= 1027-38 |year= 2003 |pmid= 12624117 |doi= 10.1210/me.2003-0025 }}
-*{{cite journal  | author=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482-9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
-}}
 {{refend}}
@@ Line 87: / Line 48: @@
 * {{MeshName|RFX1+protein,+human}}
+{{NLM content}}
+{{PDB Gallery|geneid=5989}}
+{{Transcription factors|g1}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}