RFX2: Difference between revisions

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Revision as of 09:09, 10 September 2017

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.^[1]^[2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.^[2]

References

↑ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.
↑ ^2.0 ^2.1 "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".

Reith W, Ucla C, Barras E, et al. (1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol. Cell. Biol. 14 (2): 1230–44. PMC 358479. PMID 8289803.
Doyle J, Hoffman S, Ucla C, et al. (1996). "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins". Genomics. 35 (1): 227–30. doi:10.1006/geno.1996.0343. PMID 8661125.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains". Mol. Cell. Biol. 19 (6): 3940–50. PMC 104353. PMID 10330134.
Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.
Sengupta PK, Fargo J, Smith BD (2002). "The RFX family interacts at the collagen (COL1A2) start site and represses transcription". J. Biol. Chem. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578.
Horvath GC, Kistler WS, Kistler MK (2005). "RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis". Biol. Reprod. 71 (5): 1551–9. doi:10.1095/biolreprod.104.032268. PMID 15229132.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

RFX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid1505960-1] Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID 1505960.

[entrez-2] 2.0 ^2.1 "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''DNA-binding protein RFX2''' is a [[protein]] that in humans is encoded by the ''RFX2'' [[gene]].<ref name="pmid1505960">{{cite journal | vauthors = Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B | title = The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19 | journal = Genomics | volume = 13 | issue = 4 | pages = 1307–10 |date=Sep 1992 | pmid = 1505960 | pmc =  | doi =10.1016/0888-7543(92)90052-T  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Regulatory factor X, 2 (influences HLA class II expression)
- | HGNCid = 9983
- | Symbol = RFX2
- | AltSymbols =; FLJ14226
- | OMIM = 142765
- | ECnumber =
- | Homologene = 30980
- | MGIid = 106583
-  | GeneAtlas_image1 = PBB_GE_RFX2_208031_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5990
-    | Hs_Ensembl = ENSG00000087903
-    | Hs_RefseqProtein = NP_000626
-    | Hs_RefseqmRNA = NM_000635
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 5944175
-    | Hs_GenLoc_end = 6061554
-    | Hs_Uniprot = P48378
-    | Mm_EntrezGene = 19725
-    | Mm_Ensembl = ENSMUSG00000024206
-    | Mm_RefseqmRNA = NM_009056
-    | Mm_RefseqProtein = NP_033082
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 56461022
-    | Mm_GenLoc_end = 56516137
-    | Mm_Uniprot = P48379
-  }}
-}}
-'''Regulatory factor X, 2 (influences HLA class II expression)''', also known as '''RFX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.<ref name="entrez">{{cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = }}</ref>
+| summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Pugliatti L, Derré J, Berger R, ''et al.'' |title=The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. |journal=Genomics |volume=13 |issue= 4 |pages= 1307-10 |year= 1992 |pmid= 1505960 |doi=  }}
+*{{cite journal   |vauthors=Reith W, Ucla C, Barras E, etal |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi=  | pmc=358479  }}
-*{{cite journal  | author=Reith W, Ucla C, Barras E, ''et al.'' |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230-44 |year= 1994 |pmid= 8289803 |doi=  }}
+*{{cite journal   |vauthors=Doyle J, Hoffman S, Ucla C, etal |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227–30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
-*{{cite journal  | author=Doyle J, Hoffman S, Ucla C, ''et al.'' |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227-30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343 }}
+*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  }}
-*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
+*{{cite journal   |vauthors=Iwama A, Pan J, Zhang P, etal |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940–50 |year= 1999 |pmid= 10330134 |doi=  | pmc=104353  }}
-*{{cite journal  | author=Iwama A, Pan J, Zhang P, ''et al.'' |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940-50 |year= 1999 |pmid= 10330134 |doi=  }}
+*{{cite journal   |vauthors=Morotomi-Yano K, Yano K, Saito H, etal |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
-*{{cite journal  | author=Morotomi-Yano K, Yano K, Saito H, ''et al.'' |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836-42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200 }}
+*{{cite journal  | vauthors=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926–37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
-*{{cite journal  | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926-37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482–9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
-*{{cite journal  | author=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482-9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5 }}
+*{{cite journal  | vauthors=Horvath GC, Kistler WS, Kistler MK |title=RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1551–9 |year= 2005 |pmid= 15229132 |doi= 10.1095/biolreprod.104.032268 }}
-*{{cite journal  | author=Horvath GC, Kistler WS, Kistler MK |title=RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1551-9 |year= 2005 |pmid= 15229132 |doi= 10.1095/biolreprod.104.032268 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
 }}
 {{refend}}
@@ Line 78: / Line 33: @@
 * {{MeshName|RFX2+protein,+human}}
+{{NLM content}}
+{{Transcription factors|g1}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
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+| update_citations = yes
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-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-19-stub}}

RFX2: Difference between revisions

Revision as of 09:09, 10 September 2017

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