LYL1: Difference between revisions

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Revision as of 18:14, 2 September 2017

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.^[1]^[2]

Interactions

LYL1 has been shown to interact with TCF3^[3] and NFKB1.^[4]

References

↑ Mellentin JD, Smith SD, Cleary ML (Aug 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424.
↑ "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
↑ Miyamoto, A; Cui X; Naumovski L; Cleary M L (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. UNITED STATES. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. ISSN 0270-7306. PMC 231228. PMID 8628307.
↑ Ferrier, R; Nougarede R; Doucet S; Kahn-Perles B; Imbert J; Mathieu-Mahul D (Jan 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. ENGLAND. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675.

Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
Kuo SS, Mellentin JD, Copeland NG, et al. (1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene". Oncogene. 6 (6): 961–8. PMID 2067848.
Saltman DL, Mellentin JD, Smith SD, Cleary ML (1991). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization". Genes Chromosomes Cancer. 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576.
Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052.
Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
Miyamoto A, Cui X, Naumovski L, Cleary ML (1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. 12 (11): 2343–50. PMID 8649774.
Ferrier R, Nougarede R, Doucet S, et al. (1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Meng YS, Khoury H, Dick JE, Minden MD (2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia". Leukemia. 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

External links

LYL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid2752424-1] Mellentin JD, Smith SD, Cleary ML (Aug 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell. 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424.

[entrez-2] "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".

[pmid8628307-3] Miyamoto, A; Cui X; Naumovski L; Cleary M L (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. UNITED STATES. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. ISSN 0270-7306. PMC 231228. PMID 8628307.

[pmid10023675-4] Ferrier, R; Nougarede R; Doucet S; Kahn-Perles B; Imbert J; Mathieu-Mahul D (Jan 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene. ENGLAND. 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Protein lyl-1''' is a [[protein]] that in humans is encoded by the ''LYL1'' [[gene]].<ref name="pmid2752424">{{cite journal |vauthors=Mellentin JD, Smith SD, Cleary ML | title = lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif | journal = Cell | volume = 58 | issue = 1 | pages = 77–83 |date=Aug 1989 | pmid = 2752424 | pmc =  | doi =10.1016/0092-8674(89)90404-2  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4066| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Lymphoblastic leukemia derived sequence 1
- | HGNCid = 6734
- | Symbol = LYL1
- | AltSymbols =;
- | OMIM = 151440
- | ECnumber =
- | Homologene = 4078
- | MGIid = 96891
-  | GeneAtlas_image1 = PBB_GE_LYL1_210044_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4066
-    | Hs_Ensembl = ENSG00000104903
-    | Hs_RefseqProtein = NP_005574
-    | Hs_RefseqmRNA = NM_005583
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 13070848
-    | Hs_GenLoc_end = 13074681
-    | Hs_Uniprot = P12980
-    | Mm_EntrezGene = 17095
-    | Mm_Ensembl = ENSMUSG00000034041
-    | Mm_RefseqmRNA = NM_008535
-    | Mm_RefseqProtein = NP_032561
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 87591649
-    | Mm_GenLoc_end = 87594797
-    | Mm_Uniprot = Q4FK84
-  }}
-}}
-'''Lymphoblastic leukemia derived sequence 1''', also known as '''LYL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4066| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 53: / Line 7: @@
 | summary_text =
 }}
+==Interactions==
+LYL1 has been shown to [[Protein-protein interaction|interact]] with [[TCF3]]<ref name=pmid8628307>{{cite journal |last=Miyamoto |first=A |authorlink= |author2=Cui X |author3=Naumovski L |author4=Cleary M L  |date=May 1996 |title=Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells |journal=Mol. Cell. Biol. |volume=16 |issue=5 |pages=2394–401 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 8628307 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231228 | doi=10.1128/mcb.16.5.2394}}</ref> and [[NFKB1]].<ref name=pmid10023675>{{cite journal |last=Ferrier |first=R |authorlink= |author2=Nougarede R |author3=Doucet S |author4=Kahn-Perles B |author5=Imbert J |author6=Mathieu-Mahul D  |date=Jan 1999 |title=Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105 |journal=Oncogene |volume=18 |issue=4 |pages=995–1005 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10023675 |doi = 10.1038/sj.onc.1202374 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Xia Y, Brown L, Yang CY, ''et al.'' |title=TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11416-20 |year= 1992 |pmid= 1763056 |doi=  }}
+*{{cite journal   |vauthors=Xia Y, Brown L, Yang CY, etal |title=TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 24 |pages= 11416–20 |year= 1992 |pmid= 1763056 |doi=10.1073/pnas.88.24.11416  | pmc=53146  }}
-*{{cite journal  | author=Kuo SS, Mellentin JD, Copeland NG, ''et al.'' |title=Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. |journal=Oncogene |volume=6 |issue= 6 |pages= 961-8 |year= 1991 |pmid= 2067848 |doi=  }}
+*{{cite journal   |vauthors=Kuo SS, Mellentin JD, Copeland NG, etal |title=Structure, chromosome mapping, and expression of the mouse Lyl-1 gene. |journal=Oncogene |volume=6 |issue= 6 |pages= 961–8 |year= 1991 |pmid= 2067848 |doi=  }}
-*{{cite journal  | author=Saltman DL, Mellentin JD, Smith SD, Cleary ML |title=Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. |journal=Genes Chromosomes Cancer |volume=2 |issue= 4 |pages= 259-65 |year= 1991 |pmid= 2268576 |doi=  }}
+*{{cite journal  |vauthors=Saltman DL, Mellentin JD, Smith SD, Cleary ML |title=Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization. |journal=Genes Chromosomes Cancer |volume=2 |issue= 4 |pages= 259–65 |year= 1991 |pmid= 2268576 |doi=10.1002/gcc.2870020402  }}
-*{{cite journal  | author=Mellentin JD, Smith SD, Cleary ML |title=lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. |journal=Cell |volume=58 |issue= 1 |pages= 77-83 |year= 1989 |pmid= 2752424 |doi=  }}
+*{{cite journal   |vauthors=Wadman I, Li J, Bash RO, etal |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=  | pmc=395422  }}
-*{{cite journal  | author=Wadman I, Li J, Bash RO, ''et al.'' |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831-9 |year= 1994 |pmid= 7957052 |doi=  }}
+*{{cite journal   |vauthors=Trask B, Fertitta A, Christensen M, etal |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=10.1006/geno.1993.1021  }}
-*{{cite journal  | author=Trask B, Fertitta A, Christensen M, ''et al.'' |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133-45 |year= 1993 |pmid= 8432525 |doi=  }}
+*{{cite journal  |vauthors=Miyamoto A, Cui X, Naumovski L, Cleary ML |title=Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2394–401 |year= 1996 |pmid= 8628307 |doi=  10.1128/mcb.16.5.2394| pmc=231228  }}
-*{{cite journal  | author=Miyamoto A, Cui X, Naumovski L, Cleary ML |title=Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. |journal=Mol. Cell. Biol. |volume=16 |issue= 5 |pages= 2394-401 |year= 1996 |pmid= 8628307 |doi=  }}
+*{{cite journal  |vauthors=Mahajan MA, Park ST, Sun XH |title=Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. |journal=Oncogene |volume=12 |issue= 11 |pages= 2343–50 |year= 1996 |pmid= 8649774 |doi=  }}
-*{{cite journal  | author=Mahajan MA, Park ST, Sun XH |title=Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. |journal=Oncogene |volume=12 |issue= 11 |pages= 2343-50 |year= 1996 |pmid= 8649774 |doi=  }}
+*{{cite journal   |vauthors=Ferrier R, Nougarede R, Doucet S, etal |title=Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. |journal=Oncogene |volume=18 |issue= 4 |pages= 995–1005 |year= 1999 |pmid= 10023675 |doi= 10.1038/sj.onc.1202374 }}
-*{{cite journal  | author=Ferrier R, Nougarede R, Doucet S, ''et al.'' |title=Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. |journal=Oncogene |volume=18 |issue= 4 |pages= 995-1005 |year= 1999 |pmid= 10023675 |doi= 10.1038/sj.onc.1202374 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
-*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Meng YS, Khoury H, Dick JE, Minden MD |title=Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. |journal=Leukemia |volume=19 |issue= 11 |pages= 1941–7 |year= 2005 |pmid= 16094422 |doi= 10.1038/sj.leu.2403836 }}
-*{{cite journal  | author=Meng YS, Khoury H, Dick JE, Minden MD |title=Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. |journal=Leukemia |volume=19 |issue= 11 |pages= 1941-7 |year= 2005 |pmid= 16094422 |doi= 10.1038/sj.leu.2403836 }}
 }}
 {{refend}}
@@ Line 79: / Line 36: @@
 * {{MeshName|LYL1+protein,+human}}
+{{Transcription factors|g1}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-19-stub}}

LYL1: Difference between revisions

Revision as of 18:14, 2 September 2017

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Interactions

References

Further reading

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