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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 350''' is a [[protein]] that in humans is encoded by the ''ZNF350'' [[gene]].<ref name="pmid11090615">{{cite journal | vauthors = Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH | title = Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1 | journal = Molecular Cell | volume = 6 | issue = 4 | pages = 757–68 | date = Oct 2000 | pmid = 11090615 | pmc =  | doi = 10.1016/S1097-2765(00)00075-7 }}</ref><ref name="pmid11161714">{{cite journal | vauthors = Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM | title = Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells | journal = Experimental Cell Research | volume = 263 | issue = 1 | pages = 156–62 | date = Feb 2001 | pmid = 11161714 | pmc = | doi = 10.1006/excr.2000.5068 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF350 zinc finger protein 350| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59348| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Zinc finger protein 350
| HGNCid = 16656
| Symbol = ZNF350
| AltSymbols =; ZBRK1; ZFQR
| OMIM = 605422
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_ZNF350_219266_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0017053 |text = transcriptional repressor complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 59348
    | Hs_Ensembl = ENSG00000171032
    | Hs_RefseqProtein = NP_067645
    | Hs_RefseqmRNA = NM_021632
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 57159406
    | Hs_GenLoc_end = 57181891
    | Hs_Uniprot = Q9GZX5
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Zinc finger protein 350''', also known as '''ZNF350''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF350 zinc finger protein 350| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59348| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ZNF350 has been shown to [[Protein-protein interaction|interact]] with [[BRCA1]].<ref name=pmid11090615 />
{{PBB_Summary
| section_title =  
| summary_text =
}}


==See also==
== See also ==
* [[Zinc finger]]
* [[Zinc finger]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, Doody MM, Tucker MA, Greene MH, Zhang J, Struewing JP | title = Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals | journal = Human Mutation | volume = 22 | issue = 2 | pages = 121–8 | date = Aug 2003 | pmid = 12872252 | doi = 10.1002/humu.10238 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
* {{cite journal | vauthors = Yun J, Lee WH | title = Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage | journal = Molecular and Cellular Biology | volume = 23 | issue = 20 | pages = 7305–14 | date = Oct 2003 | pmid = 14517299 | pmc = 230312 | doi = 10.1128/MCB.23.20.7305-7314.2003 }}
*{{cite journal  | author=Zheng L, Pan H, Li S, ''et al.'' |title=Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 757-68 |year= 2000 |pmid= 11090615 |doi=  }}
* {{cite journal | vauthors = Tan W, Zheng L, Lee WH, Boyer TG | title = Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 6576–87 | date = Feb 2004 | pmid = 14660588 | doi = 10.1074/jbc.M312270200 }}
*{{cite journal  | author=Ran Q, Wadhwa R, Bischof O, ''et al.'' |title=Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. |journal=Exp. Cell Res. |volume=263 |issue= 1 |pages= 156-62 |year= 2001 |pmid= 11161714 |doi= 10.1006/excr.2000.5068 }}
* {{cite journal | vauthors = Surpili MJ, Delben TM, Kobarg J | title = Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 | journal = Biochemistry | volume = 42 | issue = 51 | pages = 15369–76 | date = Dec 2003 | pmid = 14690447 | doi = 10.1021/bi034575v }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li H, Seth A | title = An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein | journal = Oncogene | volume = 23 | issue = 10 | pages = 1801–8 | date = Mar 2004 | pmid = 14755250 | doi = 10.1038/sj.onc.1207319 }}
*{{cite journal | author=Rutter JL, Smith AM, Dávila MR, ''et al.'' |title=Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals. |journal=Hum. Mutat. |volume=22 |issue= 2 |pages= 121-8 |year= 2004 |pmid= 12872252 |doi= 10.1002/humu.10238 }}
* {{cite journal | vauthors = Tan W, Kim S, Boyer TG | title = Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 53 | pages = 55153–60 | date = Dec 2004 | pmid = 15496401 | doi = 10.1074/jbc.M410926200 }}
*{{cite journal | author=Yun J, Lee WH |title=Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7305-14 |year= 2003 |pmid= 14517299 |doi= }}
* {{cite journal | vauthors = Liao G, Huang J, Fixman ED, Hayward SD | title = The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor | journal = Journal of Virology | volume = 79 | issue = 1 | pages = 245–56 | date = Jan 2005 | pmid = 15596820 | pmc = 538732 | doi = 10.1128/JVI.79.1.245-256.2005 }}
*{{cite journal | author=Tan W, Zheng L, Lee WH, Boyer TG |title=Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6576-87 |year= 2004 |pmid= 14660588 |doi= 10.1074/jbc.M312270200 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Surpili MJ, Delben TM, Kobarg J |title=Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. |journal=Biochemistry |volume=42 |issue= 51 |pages= 15369-76 |year= 2004 |pmid= 14690447 |doi= 10.1021/bi034575v }}
* {{cite journal | vauthors = Bulliard Y, Wiznerowicz M, Barde I, Trono D | title = KRAB can repress lentivirus proviral transcription independently of integration site | journal = The Journal of Biological Chemistry | volume = 281 | issue = 47 | pages = 35742–6 | date = Nov 2006 | pmid = 16997916 | doi = 10.1074/jbc.M602843200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Desjardins S, Belleau P, Labrie Y, Ouellette G, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F | title = Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families | journal = International Journal of Cancer | volume = 122 | issue = 1 | pages = 108–16 | date = Jan 2008 | pmid = 17764113 | doi = 10.1002/ijc.23058 }}
*{{cite journal  | author=Li H, Seth A |title=An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. |journal=Oncogene |volume=23 |issue= 10 |pages= 1801-8 |year= 2004 |pmid= 14755250 |doi= 10.1038/sj.onc.1207319 }}
*{{cite journal | author=Tan W, Kim S, Boyer TG |title=Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55153-60 |year= 2005 |pmid= 15496401 |doi= 10.1074/jbc.M410926200 }}
*{{cite journal | author=Liao G, Huang J, Fixman ED, Hayward SD |title=The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor. |journal=J. Virol. |volume=79 |issue= 1 |pages= 245-56 |year= 2005 |pmid= 15596820 |doi= 10.1128/JVI.79.1.245-256.2005 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Bulliard Y, Wiznerowicz M, Barde I, Trono D |title=KRAB can repress lentivirus proviral transcription independently of integration site. |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 35742-6 |year= 2007 |pmid= 16997916 |doi= 10.1074/jbc.M602843200 }}
*{{cite journal | author=Desjardins S, Belleau P, Labrie Y, ''et al.'' |title=Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. |journal=Int. J. Cancer |volume=122 |issue= 1 |pages= 108-16 |year= 2007 |pmid= 17764113 |doi= 10.1002/ijc.23058 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g2}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 22:09, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.[1][2][3]

Interactions

ZNF350 has been shown to interact with BRCA1.[1]

See also

References

  1. ↑ 1.0 1.1 Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Oct 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Molecular Cell. 6 (4): 757–68. doi:10.1016/S1097-2765(00)00075-7. PMID 11090615.
  2. ↑ Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Experimental Cell Research. 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.
  3. ↑ "Entrez Gene: ZNF350 zinc finger protein 350".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



Retrieved from "https://www.wikidoc.org/index.php?title=ZNF350&oldid=1419010"