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{{Infobox_gene}}
{{PBB_Controls
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}</ref><ref name="pmid8530078">{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = Sep 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 }}</ref> This protein is a member of [[nuclear receptor|nuclear hormone receptor]]  family of [[steroid hormone receptor]]s.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor subfamily 2, group F, member 1
| HGNCid = 7975
| Symbol = NR2F1
| AltSymbols =; COUP-TFI; EAR-3; EAR3; ERBAL3; NR2F2; SVP44; TCFCOUP1; TFCOUP1
| OMIM = 132890
| ECnumber = 
| Homologene = 21158
| MGIid = 1352451
| GeneAtlas_image1 = PBB_GE_NR2F1_209505_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR2F1_209506_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003706 |text = ligand-regulated transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030900 |text = forebrain development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7025
    | Hs_Ensembl = ENSG00000175745
    | Hs_RefseqProtein = NP_005645
    | Hs_RefseqmRNA = NM_005654
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 92944799
    | Hs_GenLoc_end = 92956077
    | Hs_Uniprot = P10589
    | Mm_EntrezGene = 13865
    | Mm_Ensembl = ENSMUSG00000069171
    | Mm_RefseqmRNA = XM_980546
    | Mm_RefseqProtein = XP_985640
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 78652996
    | Mm_GenLoc_end = 78663332
    | Mm_Uniprot = Q32NY6
  }}
}}
'''COUP-TFI''' ('''COUP transcription factor 1'''), also known as '''NR2F1''' (nuclear receptor subfamily 2, group F, member 1) is a human protein encoded by the {{gene|NR2F1}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025| accessdate = }}</ref>


This protein is a member of [[nuclear receptor|nuclear hormone receptor]]  family of [[steroid hormone receptor]]s. Coup (chicken [[ovalbumin]] upstream promoter)) [[transcription factor]] binds to the ovalbumin [[promoter]] and, in conjunction with another protein ([[S300-II]]) stimulates [[initiation of transcription]]. Binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif. It interacts with [[COPS2]].
Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | vauthors = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 12 | pages = 4259–67 | date = Dec 1986 | pmid = 3796602 | pmc = 367207 | doi = 10.1128/MCB.6.12.4259 | url = http://mcb.asm.org/cgi/content/abstract/6/12/4259 }}</ref><ref name="pmid3040258">{{cite journal | vauthors = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | date = Aug 1987 | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal | vauthors = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocrine Reviews | volume = 18 | issue = 2 | pages = 229–40 | date = Apr 1997 | pmid = 9101138 | doi = 10.1210/er.18.2.229 }}</ref>


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== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
COUP-TFI has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[BCL11A]],<ref name="pmid10744719">{{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}</ref>
==Further reading==
* [[BCL11B]],<ref name=pmid10744719/>
{{refbegin | 2}}
* [[COPS2]],<ref name="pmid10207062">{{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | url = http://mcb.asm.org/cgi/content/abstract/19/5/3383 | doi=10.1128/mcb.19.5.3383}}</ref> and
{{PBB_Further_reading
* [[estrogen receptor alpha|ESR1]].<ref name="pmid12093745">{{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}</ref>
| citations =  
 
*{{cite journal  | author=Kliewer SA, Umesono K, Heyman RA, ''et al.'' |title=Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1448-52 |year= 1992 |pmid= 1311101 |doi= }}
== References ==
*{{cite journal | author=Berrodin TJ, Marks MS, Ozato K, ''et al.'' |title=Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. |journal=Mol. Endocrinol. |volume=6 |issue= 9 |pages= 1468-78 |year= 1992 |pmid= 1331778 |doi= }}
{{Reflist}}
*{{cite journal  | author=Ing NH, Beekman JM, Tsai SY, ''et al.'' |title=Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17617-23 |year= 1992 |pmid= 1517211 |doi= }}
{{clear}}
*{{cite journal  | author=Wang LH, Tsai SY, Cook RG, ''et al.'' |title=COUP transcription factor is a member of the steroid receptor superfamily. |journal=Nature |volume=340 |issue= 6229 |pages= 163-6 |year= 1989 |pmid= 2739739 |doi= 10.1038/340163a0 }}
 
*{{cite journal | author=Miyajima N, Kadowaki Y, Fukushige S, ''et al.'' |title=Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. |journal=Nucleic Acids Res. |volume=16 |issue= 23 |pages= 11057-74 |year= 1989 |pmid= 2905047 |doi= }}
==External links==
*{{cite journal | author=Qiu Y, Krishnan V, Zeng Z, ''et al.'' |title=Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. |journal=Genomics |volume=29 |issue= 1 |pages= 240-6 |year= 1996 |pmid= 8530078 |doi=  }}
* {{UCSC gene info|NR2F1}}
*{{cite journal | author=Sawaya BE, Rohr O, Aunis D, Schaeffer E |title=Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23572-6 |year= 1996 |pmid= 8798567 |doi= }}
* {{UCSC gene info|NR2F2}}
*{{cite journal | author=Rohr O, Aunis D, Schaeffer E |title=COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 31149-55 |year= 1998 |pmid= 9388268 |doi= }}
 
*{{cite journal | author=Dressel U, Thormeyer D, Altincicek B, ''et al.'' |title=Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3383-94 |year= 1999 |pmid= 10207062 |doi= }}
== Further reading ==
*{{cite journal | author=Klinge CM, Kaur K, Swanson HI |title=The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. |journal=Arch. Biochem. Biophys. |volume=373 |issue= 1 |pages= 163-74 |year= 2000 |pmid= 10620335 |doi= 10.1006/abbi.1999.1552 }}
{{Refbegin|33em}}
*{{cite journal | author=Rohr O, Schwartz C, Hery C, ''et al.'' |title=The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2654-60 |year= 2000 |pmid= 10644726 |doi=  }}
* {{cite journal | vauthors = Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM | title = Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1448–52 | date = Feb 1992 | pmid = 1311101 | pmc = 48468 | doi = 10.1073/pnas.89.4.1448 }}
*{{cite journal | author=Sugiyama T, Wang JC, Scott DK, Granner DK |title=Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3446-54 |year= 2000 |pmid= 10652338 |doi= }}
* {{cite journal | vauthors = Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA | title = Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein | journal = Molecular Endocrinology | volume = 6 | issue = 9 | pages = 1468–78 | date = Sep 1992 | pmid = 1331778 | doi = 10.1210/me.6.9.1468 }}
*{{cite journal | author=Vlahou A, Flytzanis CN |title=Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle. |journal=Dev. Biol. |volume=218 |issue= 2 |pages= 284-98 |year= 2000 |pmid= 10656770 |doi= 10.1006/dbio.1999.9456 }}
* {{cite journal | vauthors = Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW | title = Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) | journal = The Journal of Biological Chemistry | volume = 267 | issue = 25 | pages = 17617–23 | date = Sep 1992 | pmid = 1517211 | doi =  }}
*{{cite journal | author=Avram D, Fields A, Pretty On Top K, ''et al.'' |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315-22 |year= 2000 |pmid= 10744719 |doi= }}
* {{cite journal | vauthors = Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW | title = COUP transcription factor is a member of the steroid receptor superfamily | journal = Nature | volume = 340 | issue = 6229 | pages = 163–6 | date = Jul 1989 | pmid = 2739739 | doi = 10.1038/340163a0 }}
*{{cite journal | author=Gay F, Anglade I, Gong Z, Salbert G |title=The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. |journal=Mol. Endocrinol. |volume=14 |issue= 10 |pages= 1627-48 |year= 2001 |pmid= 11043578 |doi= }}
* {{cite journal | vauthors = Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T | title = Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other | journal = Nucleic Acids Research | volume = 16 | issue = 23 | pages = 11057–74 | date = Dec 1988 | pmid = 2905047 | pmc = 338996 | doi = 10.1093/nar/16.23.11057 }}
*{{cite journal | author=You M, Fischer M, Cho WK, Crabb D |title=Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. |journal=Arch. Biochem. Biophys. |volume=398 |issue= 1 |pages= 79-86 |year= 2002 |pmid= 11811951 |doi= 10.1006/abbi.2001.2713 }}
* {{cite journal | vauthors = Sawaya BE, Rohr O, Aunis D, Schaeffer E | title = Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 23572–6 | date = Sep 1996 | pmid = 8798567 | doi = 10.1074/jbc.271.38.23572 }}
*{{cite journal | author=Lin F, Kolluri SK, Chen GQ, Zhang XK |title=Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21414-22 |year= 2002 |pmid= 11934895 |doi= 10.1074/jbc.M201885200 }}
* {{cite journal | vauthors = Rohr O, Aunis D, Schaeffer E | title = COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 49 | pages = 31149–55 | date = Dec 1997 | pmid = 9388268 | doi = 10.1074/jbc.272.49.31149 }}
*{{cite journal | author=Métivier R, Gay FA, Hübner MR, ''et al.'' |title=Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3443-53 |year= 2002 |pmid= 12093745 |doi= 10.1093/emboj/cdf344 }}
* {{cite journal | vauthors = Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A | title = Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3383–94 | date = May 1999 | pmid = 10207062 | pmc = 84131 | doi =  10.1128/mcb.19.5.3383}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Klinge CM, Kaur K, Swanson HI | title = The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 | journal = Archives of Biochemistry and Biophysics | volume = 373 | issue = 1 | pages = 163–74 | date = Jan 2000 | pmid = 10620335 | doi = 10.1006/abbi.1999.1552 }}
*{{cite journal | author=Yu X, Mertz JE |title=Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2489-99 |year= 2003 |pmid= 12551987 |doi=  }}
* {{cite journal | vauthors = Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E | title = The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 4 | pages = 2654–60 | date = Jan 2000 | pmid = 10644726 | doi = 10.1074/jbc.275.4.2654 }}
}}
* {{cite journal | vauthors = Sugiyama T, Wang JC, Scott DK, Granner DK | title = Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene | journal = The Journal of Biological Chemistry | volume = 275 | issue = 5 | pages = 3446–54 | date = Feb 2000 | pmid = 10652338 | doi = 10.1074/jbc.275.5.3446 }}
{{refend}}
* {{cite journal | vauthors = Vlahou A, Flytzanis CN | title = Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle | journal = Developmental Biology | volume = 218 | issue = 2 | pages = 284–98 | date = Feb 2000 | pmid = 10656770 | doi = 10.1006/dbio.1999.9456 }}
* {{cite journal | vauthors = Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M | title = Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors | journal = The Journal of Biological Chemistry | volume = 275 | issue = 14 | pages = 10315–22 | date = Apr 2000 | pmid = 10744719 | pmc = 2819356 | doi = 10.1074/jbc.275.14.10315 }}
* {{cite journal | vauthors = Gay F, Anglade I, Gong Z, Salbert G | title = The LIM/homeodomain protein islet-1 modulates estrogen receptor functions | journal = Molecular Endocrinology | volume = 14 | issue = 10 | pages = 1627–48 | date = Oct 2000 | pmid = 11043578 | doi = 10.1210/me.14.10.1627 }}
* {{cite journal | vauthors = You M, Fischer M, Cho WK, Crabb D | title = Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors | journal = Archives of Biochemistry and Biophysics | volume = 398 | issue = 1 | pages = 79–86 | date = Feb 2002 | pmid = 11811951 | doi = 10.1006/abbi.2001.2713 }}
* {{cite journal | vauthors = Lin F, Kolluri SK, Chen GQ, Zhang XK | title = Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21414–22 | date = Jun 2002 | pmid = 11934895 | doi = 10.1074/jbc.M201885200 }}
* {{cite journal | vauthors = Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F | title = Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3443–53 | date = Jul 2002 | pmid = 12093745 | pmc = 126093 | doi = 10.1093/emboj/cdf344 }}
* {{cite journal | vauthors = Yu X, Mertz JE | title = Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1 | journal = Journal of Virology | volume = 77 | issue = 4 | pages = 2489–99 | date = Feb 2003 | pmid = 12551987 | pmc = 141100 | doi = 10.1128/JVI.77.4.2489-2499.2003 }}
{{Refend}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g2}}
 
 
{{DEFAULTSORT:Coup-Tfi}}
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 09:57, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[5]

Interactions

COUP-TFI has been shown to interact with:

References

  1. ↑ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
  2. ↑ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
  3. ↑ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
  4. ↑ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258.
  5. ↑ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews. 18 (2): 229–40. doi:10.1210/er.18.2.229. PMID 9101138.
  6. ↑ 6.0 6.1 Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  7. ↑ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
  8. ↑ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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