PITX1: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Revision as of 15:59, 8 October 2017

paired-like homeodomain 1 is a protein that in humans is encoded by the PITX1 gene.^[1]^[2]^[3]

Function

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.^[3]

Clinical relevance

Mutations in this gene have been associated with autism^[4] and polydactyly^[5] in humans.

Genomic rearrangements at the PITX1 locus are associated with Liebenberg syndrome.

Interactions

PITX1 has been shown to interact with Pituitary-specific positive transcription factor 1.^[6]

References

↑ Crawford MJ, Lanctôt C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B, Drouin J (1997). "Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome". Mammalian Genome. 8 (11): 841–5. doi:10.1007/s003359900589. PMID 9337397.
↑ Shang J, Li X, Ring HZ, Clayton DA, Francke U (Feb 1997). "Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)". Genomics. 40 (1): 108–13. doi:10.1006/geno.1996.4558. PMID 9070926.
↑ ^3.0 ^3.1 "Entrez Gene: PITX1 paired-like homeodomain transcription factor 1".
↑ Philippi A, Tores F, Carayol J, Rousseau F, Letexier M, Roschmann E, Lindenbaum P, Benajjou A, Fontaine K, Vazart C, Gesnouin P, Brooks P, Hager J (2007). "Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis". BMC Medical Genetics. 8: 74. doi:10.1186/1471-2350-8-74. PMC 2222245. PMID 18053270.
↑ Klopocki E, Kähler C, Foulds N, Shah H, Joseph B, Vogel H, Lüttgen S, Bald R, Besoke R, Held K, Mundlos S, Kurth I (Jun 2012). "Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly". European Journal of Human Genetics. 20 (6): 705–8. doi:10.1038/ejhg.2011.264. PMID 22258522.
↑ Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (Jul 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proceedings of the National Academy of Sciences of the United States of America. 93 (15): 7706–10. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (Jul 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proceedings of the National Academy of Sciences of the United States of America. 93 (15): 7706–10. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.
Shang J, Luo Y, Clayton DA (Jun 1997). "Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb". Developmental Dynamics. 209 (2): 242–53. doi:10.1002/(SICI)1097-0177(199706)209:2<242::AID-AJA10>3.0.CO;2-0. PMID 9186059.
Poulin G, Turgeon B, Drouin J (Nov 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology. 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
Tremblay JJ, Drouin J (Apr 1999). "Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription". Molecular and Cellular Biology. 19 (4): 2567–76. doi:10.1128/mcb.19.4.2567. PMC 84049. PMID 10082522.
Tremblay JJ, Marcil A, Gauthier Y, Drouin J (Jun 1999). "Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain". The EMBO Journal. 18 (12): 3431–41. doi:10.1093/emboj/18.12.3431. PMC 1171422. PMID 10369682.
Pellegrini-Bouiller I, Manrique C, Gunz G, Grino M, Zamora AJ, Figarella-Branger D, Grisoli F, Jaquet P, Enjalbert A (Jun 1999). "Expression of the members of the Ptx family of transcription factors in human pituitary adenomas". The Journal of Clinical Endocrinology and Metabolism. 84 (6): 2212–20. doi:10.1210/jc.84.6.2212. PMID 10372733.
Tahara S, Kurotani R, Sanno N, Takumi I, Yoshimura S, Osamura RY, Teramoto A (Oct 2000). "Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas". Modern Pathology. 13 (10): 1097–108. doi:10.1038/modpathol.3880204. PMID 11048804.
Quentien MH, Manfroid I, Moncet D, Gunz G, Muller M, Grino M, Enjalbert A, Pellegrini I (Nov 2002). "Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter". The Journal of Biological Chemistry. 277 (46): 44408–16. doi:10.1074/jbc.M207824200. PMID 12223489.
Ghosh AK, Majumder M, Steele R, Ray R, Ray RB (Feb 2003). "Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1". Virology. 306 (1): 51–9. doi:10.1016/S0042-6822(02)00029-6. PMID 12620797.
Hiroi N, Kino T, Bassett M, Rainey WE, Phung M, Abu-Asab M, Fojo T, Briata P, Chrousos GP, Bornstein SR (May 2003). "Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase". Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme. 35 (5): 273–8. doi:10.1055/s-2003-41301. PMID 12915995.
Kolfschoten IG, van Leeuwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM, Agami R (Jun 2005). "A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity". Cell. 121 (6): 849–58. doi:10.1016/j.cell.2005.04.017. PMID 15960973.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV, DeMeester TR (Nov 2005). "Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma". Surgery. 138 (5): 924–31. doi:10.1016/j.surg.2005.05.007. PMID 16291394.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Picard C, Azeddine B, Moldovan F, Martel-Pelletier J, Moreau A (Sep 2007). "New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis". Clinical Orthopaedics and Related Research. 462: 59–66. doi:10.1097/BLO.0b013e3180d09d9c. PMID 17549029.
Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M, Kugoh H (Apr 2011). "Identification of PITX1 as a TERT suppressor gene located on human chromosome 5". Molecular and Cellular Biology. 31 (8): 1624–36. doi:10.1128/MCB.00470-10. PMC 3126332. PMID 21300782.

External links

PITX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[pmid9337397-1] Crawford MJ, Lanctôt C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B, Drouin J (1997). "Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome". Mammalian Genome. 8 (11): 841–5. doi:10.1007/s003359900589. PMID 9337397.

[pmid9070926-2] Shang J, Li X, Ring HZ, Clayton DA, Francke U (Feb 1997). "Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)". Genomics. 40 (1): 108–13. doi:10.1006/geno.1996.4558. PMID 9070926.

[entrez-3] 3.0 ^3.1 "Entrez Gene: PITX1 paired-like homeodomain transcription factor 1".

[4] Philippi A, Tores F, Carayol J, Rousseau F, Letexier M, Roschmann E, Lindenbaum P, Benajjou A, Fontaine K, Vazart C, Gesnouin P, Brooks P, Hager J (2007). "Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis". BMC Medical Genetics. 8: 74. doi:10.1186/1471-2350-8-74. PMC 2222245. PMID 18053270.

[pmid.22258522-5] Klopocki E, Kähler C, Foulds N, Shah H, Joseph B, Vogel H, Lüttgen S, Bald R, Besoke R, Held K, Mundlos S, Kurth I (Jun 2012). "Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly". European Journal of Human Genetics. 20 (6): 705–8. doi:10.1038/ejhg.2011.264. PMID 22258522.

[pmid8755540-6] Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (Jul 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proceedings of the National Academy of Sciences of the United States of America. 93 (15): 7706–10. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''paired-like homeodomain 1''' is a [[protein]] that in humans is encoded by the ''PITX1'' [[gene]].<ref name="pmid9337397">{{cite journal | vauthors = Crawford MJ, Lanctôt C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B, Drouin J | title = Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome | journal = Mammalian Genome | volume = 8 | issue = 11 | pages = 841–5 | year = 1997 | pmid = 9337397 | doi = 10.1007/s003359900589 }}</ref><ref name="pmid9070926">{{cite journal | vauthors = Shang J, Li X, Ring HZ, Clayton DA, Francke U | title = Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft) | journal = Genomics | volume = 40 | issue = 1 | pages = 108–13 | date = Feb 1997 | pmid = 9070926 | doi = 10.1006/geno.1996.4558 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PITX1 paired-like homeodomain transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5307| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_PITX1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yz8.
- | PDB = {{PDB2|1yz8}}
- | Name = Paired-like homeodomain transcription factor 1
- | HGNCid = 9004
- | Symbol = PITX1
- | AltSymbols =; PTX1; BFT; POTX
- | OMIM = 602149
- | ECnumber =
- | Homologene = 20584
- | MGIid = 107374
- | GeneAtlas_image1 = PBB_GE_PITX1_209587_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PITX1_208502_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5307
-    | Hs_Ensembl = ENSG00000069011
-    | Hs_RefseqProtein = NP_002644
-    | Hs_RefseqmRNA = NM_002653
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 134391368
-    | Hs_GenLoc_end = 134397887
-    | Hs_Uniprot = P78337
-    | Mm_EntrezGene = 18740
-    | Mm_Ensembl = ENSMUSG00000021506
-    | Mm_RefseqmRNA = XM_984816
-    | Mm_RefseqProtein = XP_989910
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 13
-    | Mm_GenLoc_start = 55834676
-    | Mm_GenLoc_end = 55841047
-    | Mm_Uniprot = Q3UQH0
-  }}
-}}
-'''Paired-like homeodomain transcription factor 1''', also known as '''PITX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PITX1 paired-like homeodomain transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5307| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
+== Clinical relevance ==
-| summary_text = This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin <ref name="entrez">{{cite web | title = Entrez Gene: PITX1 paired-like homeodomain transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5307| accessdate = }}</ref> and it could be associated with [[autism]]<ref>{{Citation
-|id = PMID:18053270
+Mutations in this gene have been associated with [[autism]]<ref>{{cite journal | vauthors = Philippi A, Tores F, Carayol J, Rousseau F, Letexier M, Roschmann E, Lindenbaum P, Benajjou A, Fontaine K, Vazart C, Gesnouin P, Brooks P, Hager J | title = Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis | journal = BMC Medical Genetics | volume = 8 | pages = 74 | year = 2007 | pmid = 18053270 | pmc = 2222245 | doi = 10.1186/1471-2350-8-74 }}</ref> and [[polydactyly]]<ref name=pmid.22258522>{{cite journal | vauthors = Klopocki E, Kähler C, Foulds N, Shah H, Joseph B, Vogel H, Lüttgen S, Bald R, Besoke R, Held K, Mundlos S, Kurth I | title = Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly | journal = European Journal of Human Genetics | volume = 20 | issue = 6 | pages = 705–8 | date = Jun 2012 | pmid = 22258522 | doi = 10.1038/ejhg.2011.264 }}</ref> in humans.
-|url=http://www.ncbi.nlm.nih.gov/pubmed/18053270
-|last=Philippi
+Genomic rearrangements at the PITX1 locus are associated with [[Liebenberg syndrome]].
-|first=Anne
-|last2=Tores
+== Interactions ==
-|first2=Frédéric
-|last3=Carayol
+PITX1 has been shown to [[Protein-protein interaction|interact]] with [[Pituitary-specific positive transcription factor 1]].<ref name=pmid8755540>{{cite journal | vauthors = Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG | title = P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 15 | pages = 7706–10 | date = Jul 1996 | pmid = 8755540 | pmc = 38811 | doi = 10.1073/pnas.93.15.7706 }}</ref>
-|first3=Jérome
-|last4=Rousseau
+== References ==
-|first4=Francis
+{{reflist|33em}}
-|publication-date=2007
-|year=2007
+== Further reading ==
-|title=Association of autism with polymorphisms in the paired-like homeodomain t
+{{refbegin|33em}}
-ranscription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis.
+* {{cite journal | vauthors = Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG | title = P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 15 | pages = 7706–10 | date = Jul 1996 | pmid = 8755540 | pmc = 38811 | doi = 10.1073/pnas.93.15.7706 }}
-|volume=8
+* {{cite journal | vauthors = Shang J, Luo Y, Clayton DA | title = Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb | journal = Developmental Dynamics | volume = 209 | issue = 2 | pages = 242–53 | date = Jun 1997 | pmid = 9186059 | doi = 10.1002/(SICI)1097-0177(199706)209:2<242::AID-AJA10>3.0.CO;2-0 }}
-|issue=
+* {{cite journal | vauthors = Poulin G, Turgeon B, Drouin J | title = NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6673–82 | date = Nov 1997 | pmid = 9343431 | pmc = 232521 | doi =  10.1128/mcb.17.11.6673}}
-|periodical=BMC Med. Genet.
+* {{cite journal | vauthors = Tremblay JJ, Drouin J | title = Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 2567–76 | date = Apr 1999 | pmid = 10082522 | pmc = 84049 | doi =  10.1128/mcb.19.4.2567}}
-|pages=741471-2350-8-74
+* {{cite journal | vauthors = Tremblay JJ, Marcil A, Gauthier Y, Drouin J | title = Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain | journal = The EMBO Journal | volume = 18 | issue = 12 | pages = 3431–41 | date = Jun 1999 | pmid = 10369682 | pmc = 1171422 | doi = 10.1093/emboj/18.12.3431 }}
-|doi = 10.1186/1471-2350-8-7418053270
+* {{cite journal | vauthors = Pellegrini-Bouiller I, Manrique C, Gunz G, Grino M, Zamora AJ, Figarella-Branger D, Grisoli F, Jaquet P, Enjalbert A | title = Expression of the members of the Ptx family of transcription factors in human pituitary adenomas | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 84 | issue = 6 | pages = 2212–20 | date = Jun 1999 | pmid = 10372733 | doi = 10.1210/jc.84.6.2212 }}
-}}</ref>
+* {{cite journal | vauthors = Tahara S, Kurotani R, Sanno N, Takumi I, Yoshimura S, Osamura RY, Teramoto A | title = Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas | journal = Modern Pathology | volume = 13 | issue = 10 | pages = 1097–108 | date = Oct 2000 | pmid = 11048804 | doi = 10.1038/modpathol.3880204 }}
-}}
+* {{cite journal | vauthors = Quentien MH, Manfroid I, Moncet D, Gunz G, Muller M, Grino M, Enjalbert A, Pellegrini I | title = Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter | journal = The Journal of Biological Chemistry | volume = 277 | issue = 46 | pages = 44408–16 | date = Nov 2002 | pmid = 12223489 | doi = 10.1074/jbc.M207824200 }}
+* {{cite journal | vauthors = Ghosh AK, Majumder M, Steele R, Ray R, Ray RB | title = Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1 | journal = Virology | volume = 306 | issue = 1 | pages = 51–9 | date = Feb 2003 | pmid = 12620797 | doi = 10.1016/S0042-6822(02)00029-6 }}
+* {{cite journal | vauthors = Hiroi N, Kino T, Bassett M, Rainey WE, Phung M, Abu-Asab M, Fojo T, Briata P, Chrousos GP, Bornstein SR | title = Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase | journal = Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme | volume = 35 | issue = 5 | pages = 273–8 | date = May 2003 | pmid = 12915995 | doi = 10.1055/s-2003-41301 }}
+* {{cite journal | vauthors = Kolfschoten IG, van Leeuwen B, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Voorhoeve PM, Agami R | title = A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity | journal = Cell | volume = 121 | issue = 6 | pages = 849–58 | date = Jun 2005 | pmid = 15960973 | doi = 10.1016/j.cell.2005.04.017 }}
+* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
+* {{cite journal | vauthors = Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV, DeMeester TR | title = Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma | journal = Surgery | volume = 138 | issue = 5 | pages = 924–31 | date = Nov 2005 | pmid = 16291394 | doi = 10.1016/j.surg.2005.05.007 }}
+* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
+* {{cite journal | vauthors = Picard C, Azeddine B, Moldovan F, Martel-Pelletier J, Moreau A | title = New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis | journal = Clinical Orthopaedics and Related Research | volume = 462 | issue =  | pages = 59–66 | date = Sep 2007 | pmid = 17549029 | doi = 10.1097/BLO.0b013e3180d09d9c }}
+* {{cite journal | vauthors = Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M, Kugoh H | title = Identification of PITX1 as a TERT suppressor gene located on human chromosome 5 | journal = Molecular and Cellular Biology | volume = 31 | issue = 8 | pages = 1624–36 | date = Apr 2011 | pmid = 21300782 | pmc = 3126332 | doi = 10.1128/MCB.00470-10 }}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG |title=P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7706-10 |year= 1996 |pmid= 8755540 |doi=  }}
-*{{cite journal  | author=Shang J, Li X, Ring HZ, ''et al.'' |title=Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft). |journal=Genomics |volume=40 |issue= 1 |pages= 108-13 |year= 1997 |pmid= 9070926 |doi= 10.1006/geno.1996.4558 }}
-*{{cite journal  | author=Shang J, Luo Y, Clayton DA |title=Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb. |journal=Dev. Dyn. |volume=209 |issue= 2 |pages= 242-53 |year= 1997 |pmid= 9186059 |doi= 10.1002/(SICI)1097-0177(199706)209:2<242::AID-AJA10>3.0.CO;2-0 }}
-*{{cite journal  | author=Crawford MJ, Lanctôt C, Tremblay JJ, ''et al.'' |title=Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. |journal=Mamm. Genome |volume=8 |issue= 11 |pages= 841-5 |year= 1998 |pmid= 9337397 |doi=  }}
-*{{cite journal  | author=Poulin G, Turgeon B, Drouin J |title=NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6673-82 |year= 1997 |pmid= 9343431 |doi=  }}
-*{{cite journal  | author=Tremblay JJ, Drouin J |title=Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2567-76 |year= 1999 |pmid= 10082522 |doi=  }}
-*{{cite journal  | author=Tremblay JJ, Marcil A, Gauthier Y, Drouin J |title=Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3431-41 |year= 1999 |pmid= 10369682 |doi= 10.1093/emboj/18.12.3431 }}
-*{{cite journal  | author=Pellegrini-Bouiller I, Manrique C, Gunz G, ''et al.'' |title=Expression of the members of the Ptx family of transcription factors in human pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 6 |pages= 2212-20 |year= 1999 |pmid= 10372733 |doi=  }}
-*{{cite journal  | author=Tahara S, Kurotani R, Sanno N, ''et al.'' |title=Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas. |journal=Mod. Pathol. |volume=13 |issue= 10 |pages= 1097-108 |year= 2001 |pmid= 11048804 |doi= 10.1038/modpathol.3880204 }}
-*{{cite journal  | author=Quentien MH, Manfroid I, Moncet D, ''et al.'' |title=Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44408-16 |year= 2003 |pmid= 12223489 |doi= 10.1074/jbc.M207824200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ghosh AK, Majumder M, Steele R, ''et al.'' |title=Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1. |journal=Virology |volume=306 |issue= 1 |pages= 51-9 |year= 2003 |pmid= 12620797 |doi=  }}
-*{{cite journal  | author=Hiroi N, Kino T, Bassett M, ''et al.'' |title=Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase. |journal=Horm. Metab. Res. |volume=35 |issue= 5 |pages= 273-8 |year= 2004 |pmid= 12915995 |doi= 10.1055/s-2003-41301 }}
-*{{cite journal  | author=Schmutz J, Martin J, Terry A, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Kolfschoten IG, van Leeuwen B, Berns K, ''et al.'' |title=A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. |journal=Cell |volume=121 |issue= 6 |pages= 849-58 |year= 2005 |pmid= 15960973 |doi= 10.1016/j.cell.2005.04.017 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Lord RV, Brabender J, Wickramasinghe K, ''et al.'' |title=Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. |journal=Surgery |volume=138 |issue= 5 |pages= 924-31 |year= 2006 |pmid= 16291394 |doi= 10.1016/j.surg.2005.05.007 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
-*{{cite journal  | author=Picard C, Azeddine B, Moldovan F, ''et al.'' |title=New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis. |journal=Clin. Orthop. Relat. Res. |volume=462 |issue=  |pages= 59-66 |year= 2007 |pmid= 17549029 |doi= 10.1097/BLO.0b013e3180d09d9c }}
-}}
 {{refend}}
@@ Line 107: / Line 43: @@
 * {{MeshName|PITX1+protein,+human}}
+{{NLM content}}
+{{PDB Gallery|geneid=5307}}
+{{Transcription factors|g3}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-5-stub}}