HSF2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Heat shock factor protein 2''' is a [[protein]] that in humans is encoded by the ''HSF2'' [[gene]].<ref name="pmid1871106">{{cite journal | vauthors = Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE | title = Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 16 | pages = 6911–5 | date = Sep 1991 | pmid = 1871106 | pmc = 52203 | doi = 10.1073/pnas.88.16.6911 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HSF2 heat shock transcription factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3298| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heat shock transcription factor 2
| HGNCid = 5225
| Symbol = HSF2
| AltSymbols =; MGC117376; MGC156196; MGC75048
| OMIM = 140581
| ECnumber = 
| Homologene = 37931
| MGIid = 96239
| GeneAtlas_image1 = PBB_GE_HSF2_209657_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HSF2_211220_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006986 |text = response to unfolded protein}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3298
    | Hs_Ensembl = ENSG00000025156
    | Hs_RefseqProtein = NP_004497
    | Hs_RefseqmRNA = NM_004506
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 122762390
    | Hs_GenLoc_end = 122795810
    | Hs_Uniprot = Q03933
    | Mm_EntrezGene = 15500
    | Mm_Ensembl = ENSMUSG00000019878
    | Mm_RefseqmRNA = NM_008297
    | Mm_RefseqProtein = NP_032323
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 57174901
    | Mm_GenLoc_end = 57201550
    | Mm_Uniprot = P38533
  }}
}}
'''Heat shock transcription factor 2''', also known as '''HSF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HSF2 heat shock transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3298| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.<ref name="entrez">{{cite web | title = Entrez Gene: HSF2 heat shock transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3298| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
HSF2 has been shown to [[Protein-protein interaction|interact]] with [[Nucleoporin 62]]<ref name=pmid9367915>{{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62 | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 228–33 | date = Nov 1997 | pmid = 9367915 | doi = 10.1006/bbrc.1997.7662  }}</ref> and [[HSF1]].<ref name=pmid12813038>{{cite journal | vauthors = He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK | title = Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress | language =  | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35465–75 | date = Sep 2003 | pmid = 12813038 | doi = 10.1074/jbc.M304663200 }}</ref>
 
== See also ==
* [[Heat shock factor]]
* [[Heat shock factor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Walsh D, Li Z, Wu Y, Nagata K | title = Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. | journal = Cell. Mol. Life Sci. | volume = 53 | issue = 2 | pages = 198–211 | year = 1997 | pmid = 9118008 | doi = 10.1007/PL00000592 }}
| citations =
* {{cite journal | vauthors = Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI | title = Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. | journal = Genes Dev. | volume = 5 | issue = 10 | pages = 1902–11 | year = 1991 | pmid = 1717345 | doi = 10.1101/gad.5.10.1902 }}
*{{cite journal | author=Walsh D, Li Z, Wu Y, Nagata K |title=Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. |journal=Cell. Mol. Life Sci. |volume=53 |issue= 2 |pages= 198-211 |year= 1997 |pmid= 9118008 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Sarge KD, Zimarino V, Holm K, ''et al.'' |title=Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. |journal=Genes Dev. |volume=5 |issue= 10 |pages= 1902-11 |year= 1991 |pmid= 1717345 |doi= }}
* {{cite journal | vauthors = Sheldon LA, Kingston RE | title = Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. | journal = Genes Dev. | volume = 7 | issue = 8 | pages = 1549–58 | year = 1993 | pmid = 8339932 | doi = 10.1101/gad.7.8.1549 }}
*{{cite journal  | author=Schuetz TJ, Gallo GJ, Sheldon L, ''et al.'' |title=Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 6911-5 |year= 1991 |pmid= 1871106 |doi=  }}
* {{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 228–33 | year = 1997 | pmid = 9367915 | doi = 10.1006/bbrc.1997.7662 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Sheldon LA, Kingston RE |title=Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. |journal=Genes Dev. |volume=7 |issue= 8 |pages= 1549-58 |year= 1993 |pmid= 8339932 |doi= }}
* {{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = Novel testis-specific protein that interacts with heat shock factor 2. | journal = Gene | volume = 214 | issue = 1-2 | pages = 139–46 | year = 1998 | pmid = 9651507 | doi = 10.1016/S0378-1119(98)00208-X }}
*{{cite journal | author=Yoshima T, Yura T, Yanagi H |title=The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. |journal=Biochem. Biophys. Res. Commun. |volume=240 |issue= 1 |pages= 228-33 |year= 1997 |pmid= 9367915 |doi= 10.1006/bbrc.1997.7662 }}
* {{cite journal | vauthors = Hong Y, Sarge KD | title = Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 12967–70 | year = 1999 | pmid = 10224043 | doi = 10.1074/jbc.274.19.12967 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD | title = Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. | journal = J. Biol. Chem. | volume = 276 | issue = 21 | pages = 18513–8 | year = 2001 | pmid = 11278381 | doi = 10.1074/jbc.M008066200 }}
*{{cite journal | author=Yoshima T, Yura T, Yanagi H |title=Novel testis-specific protein that interacts with heat shock factor 2. |journal=Gene |volume=214 |issue= 1-2 |pages= 139-46 |year= 1998 |pmid= 9651507 |doi= }}
* {{cite journal | vauthors = Nykänen P, Alastalo TP, Ahlskog J, Horelli-Kuitunen N, Pirkkala L, Sistonen L | title = Genomic organization and promoter analysis of the human heat shock factor 2 gene. | journal = Cell Stress Chaperones | volume = 6 | issue = 4 | pages = 377–85 | year = 2002 | pmid = 11795475 | pmc = 434421 | doi = 10.1379/1466-1268(2001)006<0377:GOAPAO>2.0.CO;2 }}
*{{cite journal | author=Hong Y, Sarge KD |title=Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12967-70 |year= 1999 |pmid= 10224043 |doi= }}
* {{cite journal | vauthors = He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK | title = Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35465–75 | year = 2003 | pmid = 12813038 | doi = 10.1074/jbc.M304663200 }}
*{{cite journal | author=Goodson ML, Hong Y, Rogers R, ''et al.'' |title=Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18513-8 |year= 2001 |pmid= 11278381 |doi= 10.1074/jbc.M008066200 }}
* {{cite journal | vauthors = Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L | title = Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. | journal = J. Cell Sci. | volume = 116 | issue = Pt 17 | pages = 3557–70 | year = 2004 | pmid = 12865437 | doi = 10.1242/jcs.00671 }}
*{{cite journal | author=Nykänen P, Alastalo TP, Ahlskog J, ''et al.'' |title=Genomic organization and promoter analysis of the human heat shock factor 2 gene. |journal=Cell Stress Chaperones |volume=6 |issue= 4 |pages= 377-85 |year= 2002 |pmid= 11795475 |doi=  }}
* {{cite journal | vauthors = Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV | title = Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. | journal = J. Biol. Chem. | volume = 279 | issue = 11 | pages = 10500–7 | year = 2004 | pmid = 14699143 | doi = 10.1074/jbc.M303727200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD | title = Mechanism of hsp70i gene bookmarking. | journal = Science | volume = 307 | issue = 5708 | pages = 421–3 | year = 2005 | pmid = 15662014 | doi = 10.1126/science.1106478 }}
*{{cite journal | author=He H, Soncin F, Grammatikakis N, ''et al.'' |title=Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35465-75 |year= 2003 |pmid= 12813038 |doi= 10.1074/jbc.M304663200 }}
* {{cite journal | vauthors = Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L | title = Inhibition of DNA binding by differential sumoylation of heat shock factors. | journal = Mol. Cell. Biol. | volume = 26 | issue = 3 | pages = 955–64 | year = 2006 | pmid = 16428449 | pmc = 1347039 | doi = 10.1128/MCB.26.3.955-964.2006 }}
*{{cite journal | author=Alastalo TP, Hellesuo M, Sandqvist A, ''et al.'' |title=Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. |journal=J. Cell. Sci. |volume=116 |issue= Pt 17 |pages= 3557-70 |year= 2004 |pmid= 12865437 |doi= 10.1242/jcs.00671 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Roccisana JL, Kawanabe N, Kajiya H, ''et al.'' |title=Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10500-7 |year= 2004 |pmid= 14699143 |doi= 10.1074/jbc.M303727200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Xing H, Wilkerson DC, Mayhew CN, ''et al.'' |title=Mechanism of hsp70i gene bookmarking. |journal=Science |volume=307 |issue= 5708 |pages= 421-3 |year= 2005 |pmid= 15662014 |doi= 10.1126/science.1106478 }}
*{{cite journal | author=Anckar J, Hietakangas V, Denessiouk K, ''et al.'' |title=Inhibition of DNA binding by differential sumoylation of heat shock factors. |journal=Mol. Cell. Biol. |volume=26 |issue= 3 |pages= 955-64 |year= 2006 |pmid= 16428449 |doi= 10.1128/MCB.26.3.955-964.2006 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|HSF2+protein,+human}}
* {{MeshName|HSF2+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-6-stub}}

Latest revision as of 20:04, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[1][2]

Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[2]

Interactions

HSF2 has been shown to interact with Nucleoporin 62[3] and HSF1.[4]

See also

References

  1. ↑ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A. 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106.
  2. ↑ 2.0 2.1 "Entrez Gene: HSF2 heat shock transcription factor 2".
  3. ↑ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915.
  4. ↑ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. doi:10.1074/jbc.M304663200. PMID 12813038.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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