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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor E2F3''' is a [[protein]] that in humans is encoded by the ''E2F3'' [[gene]].<ref name="pmid8246996">{{cite journal | vauthors = Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K | title = The retinoblastoma protein binds to a family of E2F transcription factors | journal = Molecular and Cellular Biology | volume = 13 | issue = 12 | pages = 7813–25 | date = Dec 1993 | pmid = 8246996 | pmc = 364853 | doi = 10.1128/mcb.13.12.7813}}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = E2F transcription factor 3
| HGNCid = 3115
| Symbol = E2F3
| AltSymbols =; DKFZp686C18211; E2F-3; KIAA0075; MGC104598
| OMIM = 600427
| ECnumber = 
| Homologene = 74413
| MGIid = 1096340
| GeneAtlas_image1 = PBB_GE_E2F3_203692_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1871
    | Hs_Ensembl = ENSG00000112242
    | Hs_RefseqProtein = NP_001940
    | Hs_RefseqmRNA = NM_001949
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 20510377
    | Hs_GenLoc_end = 20601921
    | Hs_Uniprot = O00716
    | Mm_EntrezGene = 13557
    | Mm_Ensembl = ENSMUSG00000016477
    | Mm_RefseqmRNA = NM_010093
    | Mm_RefseqProtein = NP_034223
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 29914040
    | Mm_GenLoc_end = 29993528
    | Mm_Uniprot = Q3TMJ9
  }}
}}
'''E2F transcription factor 3''', also known as '''E2F3''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.<ref name="entrez">{{cite web | title = Entrez Gene: E2F3 E2F transcription factor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.<ref name="entrez">{{cite web | title = Entrez Gene: E2F3 E2F transcription factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
E2F3 has been shown to [[Protein-protein interaction|interact]] with [[TFE3]]<ref name=pmid12748276>{{cite journal | vauthors = Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR | title = Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor | journal = Molecular and Cellular Biology | volume = 23 | issue = 11 | pages = 3707–20 | date = Jun 2003 | pmid = 12748276 | pmc = 155231 | doi = 10.1128/MCB.23.11.3707-3720.2003 }}</ref> and [[RYBP]].<ref name=pmid12411495>{{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = The EMBO Journal | volume = 21 | issue = 21 | pages = 5775–86 | date = Nov 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}</ref>
 
== See also ==
* [[E2F]]
* [[E2F]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 1 | issue = 5 | pages = 223–9 | year = 1995 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 }}
| citations =
* {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Molecular and Cellular Biology | volume = 15 | issue = 5 | pages = 2536–46 | date = May 1995 | pmid = 7739537 | pmc = 230484 | doi =  10.1128/mcb.15.5.2536}}
*{{cite journal | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi= }}
* {{cite journal | vauthors = Karlseder J, Rotheneder H, Wintersberger E | title = Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F | journal = Molecular and Cellular Biology | volume = 16 | issue = 4 | pages = 1659–67 | date = Apr 1996 | pmid = 8657141 | pmc = 231152 | doi =  10.1128/mcb.16.4.1659}}
*{{cite journal | author=Wu CL, Zukerberg LR, Ngwu C, ''et al.'' |title=In vivo association of E2F and DP family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2536-46 |year= 1995 |pmid= 7739537 |doi=  }}
* {{cite journal | vauthors = Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM | title = DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 15 | pages = 7594–9 | date = Jul 1996 | pmid = 8755520 | pmc = 38791 | doi = 10.1073/pnas.93.15.7594 }}
*{{cite journal | author=Lees JA, Saito M, Vidal M, ''et al.'' |title=The retinoblastoma protein binds to a family of E2F transcription factors. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7813-25 |year= 1994 |pmid= 8246996 |doi=  }}
* {{cite journal | vauthors = Magae J, Wu CL, Illenye S, Harlow E, Heintz NH | title = Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members | journal = Journal of Cell Science | volume = 109 | issue = 7 | pages = 1717–26 | date = Jul 1996 | pmid = 8832394 | doi =  }}
*{{cite journal | author=Karlseder J, Rotheneder H, Wintersberger E |title=Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1659-67 |year= 1996 |pmid= 8657141 |doi= }}
* {{cite journal | vauthors = Hofmann F, Livingston DM | title = Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit | journal = Genes & Development | volume = 10 | issue = 7 | pages = 851–61 | date = Apr 1996 | pmid = 8846921 | doi = 10.1101/gad.10.7.851 }}
*{{cite journal | author=Rogers KT, Higgins PD, Milla MM, ''et al.'' |title=DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7594-9 |year= 1996 |pmid= 8755520 |doi=  }}
* {{cite journal | vauthors = Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D | title = The subcellular localization of E2F-4 is cell-cycle dependent | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 10 | pages = 5095–100 | date = May 1997 | pmid = 9144196 | pmc = 24637 | doi = 10.1073/pnas.94.10.5095 }}
*{{cite journal | author=Magae J, Wu CL, Illenye S, ''et al.'' |title=Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. |journal=J. Cell. Sci. |volume=109 ( Pt 7) |issue= |pages= 1717-26 |year= 1997 |pmid= 8832394 |doi= }}
* {{cite journal | vauthors = Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L | title = Specific regulation of E2F family members by cyclin-dependent kinases | journal = Molecular and Cellular Biology | volume = 17 | issue = 7 | pages = 3867–75 | date = Jul 1997 | pmid = 9199321 | pmc = 232239 | doi =  10.1128/mcb.17.7.3867}}
*{{cite journal | author=Hofmann F, Livingston DM |title=Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. |journal=Genes Dev. |volume=10 |issue= 7 |pages= 851-61 |year= 1996 |pmid= 8846921 |doi= }}
* {{cite journal | vauthors = Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG | title = Differential activities of E2F family members: unique functions in regulating transcription | journal = Molecular Carcinogenesis | volume = 22 | issue = 3 | pages = 190–8 | date = Jul 1998 | pmid = 9688145 | doi = 10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P }}
*{{cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095-100 |year= 1997 |pmid= 9144196 |doi=  }}
* {{cite journal | vauthors = Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA | title = E2f3 is critical for normal cellular proliferation | journal = Genes & Development | volume = 14 | issue = 6 | pages = 690–703 | date = Mar 2000 | pmid = 10733529 | pmc = 316459 | doi =  }}
*{{cite journal | author=Dynlacht BD, Moberg K, Lees JA, ''et al.'' |title=Specific regulation of E2F family members by cyclin-dependent kinases. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3867-75 |year= 1997 |pmid= 9199321 |doi= }}
* {{cite journal | vauthors = Takahashi Y, Rayman JB, Dynlacht BD | title = Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression | journal = Genes & Development | volume = 14 | issue = 7 | pages = 804–16 | date = Apr 2000 | pmid = 10766737 | pmc = 316494 | doi = 10.1101/gad.14.7.804 }}
*{{cite journal  | author=Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG |title=Differential activities of E2F family members: unique functions in regulating transcription. |journal=Mol. Carcinog. |volume=22 |issue= 3 |pages= 190-8 |year= 1998 |pmid= 9688145 |doi=  }}
* {{cite journal | vauthors = Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR | title = Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins | journal = Molecular and Cellular Biology | volume = 20 | issue = 10 | pages = 3626–32 | date = May 2000 | pmid = 10779352 | pmc = 85655 | doi = 10.1128/MCB.20.10.3626-3632.2000 }}
*{{cite journal | author=Humbert PO, Verona R, Trimarchi JM, ''et al.'' |title=E2f3 is critical for normal cellular proliferation. |journal=Genes Dev. |volume=14 |issue= 6 |pages= 690-703 |year= 2000 |pmid= 10733529 |doi= }}
* {{cite journal | vauthors = He Y, Armanious MK, Thomas MJ, Cress WD | title = Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region | journal = Oncogene | volume = 19 | issue = 30 | pages = 3422–33 | date = Jul 2000 | pmid = 10918599 | doi = 10.1038/sj.onc.1203682 }}
*{{cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804-16 |year= 2000 |pmid= 10766737 |doi= }}
* {{cite journal | vauthors = Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M | title = ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) | journal = European Journal of Biochemistry / FEBS | volume = 268 | issue = 23 | pages = 6076–82 | date = Dec 2001 | pmid = 11733001 | doi = 10.1046/j.0014-2956.2001.02555.x }}
*{{cite journal | author=Leone G, Nuckolls F, Ishida S, ''et al.'' |title=Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3626-32 |year= 2000 |pmid= 10779352 |doi= }}
* {{cite journal | vauthors = Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ | title = Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis | journal = Genes & Development | volume = 16 | issue = 2 | pages = 235–44 | date = Jan 2002 | pmid = 11799066 | pmc = 155318 | doi = 10.1101/gad.943102 }}
*{{cite journal | author=He Y, Armanious MK, Thomas MJ, Cress WD |title=Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region. |journal=Oncogene |volume=19 |issue= 30 |pages= 3422-33 |year= 2000 |pmid= 10918599 |doi= 10.1038/sj.onc.1203682 }}
* {{cite journal | vauthors = Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD | title = E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints | journal = Genes & Development | volume = 16 | issue = 2 | pages = 245–56 | date = Jan 2002 | pmid = 11799067 | pmc = 155321 | doi = 10.1101/gad.949802 }}
*{{cite journal | author=Yamochi T, Semba K, Tsuji K, ''et al.'' |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076-82 |year= 2002 |pmid= 11733001 |doi= }}
* {{cite journal | vauthors = He Y, Cress WD | title = E2F-3B is a physiological target of cyclin A | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23493–9 | date = Jun 2002 | pmid = 11980909 | doi = 10.1074/jbc.M202629200 }}
*{{cite journal | author=Weinmann AS, Yan PS, Oberley MJ, ''et al.'' |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235-44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102 }}
* {{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = The EMBO Journal | volume = 21 | issue = 21 | pages = 5775–86 | date = Nov 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}
*{{cite journal | author=Ren B, Cam H, Takahashi Y, ''et al.'' |title=E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 245-56 |year= 2002 |pmid= 11799067 |doi= 10.1101/gad.949802 }}
*{{cite journal | author=He Y, Cress WD |title=E2F-3B is a physiological target of cyclin A. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23493-9 |year= 2002 |pmid= 11980909 |doi= 10.1074/jbc.M202629200 }}
*{{cite journal  | author=Schlisio S, Halperin T, Vidal M, Nevins JR |title=Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. |journal=EMBO J. |volume=21 |issue= 21 |pages= 5775-86 |year= 2002 |pmid= 12411495 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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{{Transcription factors|g3}}
[[Category:Transcription factors]]
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{{Transcription factors}}
[[Category:Transcription factors]]
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Latest revision as of 00:16, 31 August 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene.[1]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.[2]

Interactions

E2F3 has been shown to interact with TFE3[3] and RYBP.[4]

See also

References

  1. ↑ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (Dec 1993). "The retinoblastoma protein binds to a family of E2F transcription factors". Molecular and Cellular Biology. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.
  2. ↑ "Entrez Gene: E2F3 E2F transcription factor 3".
  3. ↑ Giangrande PH, Hallstrom TC, Tunyaplin C, Calame K, Nevins JR (Jun 2003). "Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor". Molecular and Cellular Biology. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276.
  4. ↑ Schlisio S, Halperin T, Vidal M, Nevins JR (Nov 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". The EMBO Journal. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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