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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Pre-B-cell leukemia transcription factor 2''' is a [[protein]] that in humans is encoded by the ''PBX2'' [[gene]].<ref name="pmid7835890">{{cite journal | vauthors = Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T | title = Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3 | journal = Genomics | volume = 23 | issue = 2 | pages = 408–19 | date = Sep 1994 | pmid = 7835890 | pmc =  | doi = 10.1006/geno.1994.1517 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PBX2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b72.
| PDB = {{PDB2|1b72}}, {{PDB2|1b8i}}, {{PDB2|1du6}}, {{PDB2|1lfu}}, {{PDB2|1puf}}
| Name = Pre-B-cell leukemia homeobox 2
| HGNCid = 8633
| Symbol = PBX2
| AltSymbols =; G17; HOX12; PBX2MHC
| OMIM = 176311
| ECnumber = 
| Homologene = 48115
| MGIid = 1341793
| GeneAtlas_image1 = PBB_GE_PBX2_202876_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PBX2_202875_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PBX2_211096_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007387 |text = anterior compartment specification}} {{GNF_GO|id=GO:0007388 |text = posterior compartment specification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5089
    | Hs_Ensembl = ENSG00000204304
    | Hs_RefseqProtein = NP_002577
    | Hs_RefseqmRNA = NM_002586
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 32260496
    | Hs_GenLoc_end = 32265941
    | Hs_Uniprot = P40425
    | Mm_EntrezGene = 18515
    | Mm_Ensembl = ENSMUSG00000034673
    | Mm_RefseqmRNA = XM_994405
    | Mm_RefseqProtein = XP_999499
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34200527
    | Mm_GenLoc_end = 34205397
    | Mm_Uniprot = Q3TMM2
  }}
}}
'''Pre-B-cell leukemia homeobox 2''', also known as '''PBX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.<ref name="entrez">{{cite web | title = Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5089| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PBX2 has been shown to [[Protein-protein interaction|interact]] with [[HOXA9]].<ref name=pmid10082572>{{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Monica K, Galili N, Nourse J, Saltman D, Cleary ML | title = PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1 | journal = Molecular and Cellular Biology | volume = 11 | issue = 12 | pages = 6149–57 | date = Dec 1991 | pmid = 1682799 | pmc = 361792 | doi =  10.1128/mcb.11.12.6149}}
| citations =
* {{cite journal | vauthors = Aguado B, Campbell RD | title = The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein | journal = Genomics | volume = 25 | issue = 3 | pages = 650–9 | date = Feb 1995 | pmid = 7759099 | doi = 10.1016/0888-7543(95)80007-9 }}
*{{cite journal | author=Monica K, Galili N, Nourse J, ''et al.'' |title=PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. |journal=Mol. Cell. Biol. |volume=11 |issue= 12 |pages= 6149-57 |year= 1991 |pmid= 1682799 |doi=  }}
* {{cite journal | vauthors = Lu Q, Wright DD, Kamps MP | title = Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation | journal = Molecular and Cellular Biology | volume = 14 | issue = 6 | pages = 3938–48 | date = Jun 1994 | pmid = 7910944 | pmc = 358760 | doi =  10.1128/mcb.14.6.3938}}
*{{cite journal | author=Aguado B, Campbell RD |title=The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein. |journal=Genomics |volume=25 |issue= 3 |pages= 650-9 |year= 1995 |pmid= 7759099 |doi= }}
* {{cite journal | vauthors = Katsanis N, Fitzgibbon J, Fisher EM | title = Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci | journal = Genomics | volume = 35 | issue = 1 | pages = 101–8 | date = Jul 1996 | pmid = 8661110 | doi = 10.1006/geno.1996.0328 }}
*{{cite journal  | author=Sugaya K, Fukagawa T, Matsumoto K, ''et al.'' |title=Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. |journal=Genomics |volume=23 |issue= 2 |pages= 408-19 |year= 1995 |pmid= 7835890 |doi=  }}
* {{cite journal | vauthors = Berthelsen J, Zappavigna V, Mavilio F, Blasi F | title = Prep1, a novel functional partner of Pbx proteins | journal = The EMBO Journal | volume = 17 | issue = 5 | pages = 1423–33 | date = Mar 1998 | pmid = 9482739 | pmc = 1170490 | doi = 10.1093/emboj/17.5.1423 }}
*{{cite journal | author=Lu Q, Wright DD, Kamps MP |title=Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. |journal=Mol. Cell. Biol. |volume=14 |issue= 6 |pages= 3938-48 |year= 1994 |pmid= 7910944 |doi=  }}
* {{cite journal | vauthors = Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C | title = HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 4 | pages = 3051–61 | date = Apr 1999 | pmid = 10082572 | pmc = 84099 | doi =  }}
*{{cite journal | author=Katsanis N, Fitzgibbon J, Fisher EM |title=Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci. |journal=Genomics |volume=35 |issue= 1 |pages= 101-8 |year= 1996 |pmid= 8661110 |doi= 10.1006/geno.1996.0328 }}
* {{cite journal | vauthors = Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T | title = Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes | journal = Experimental Hematology | volume = 29 | issue = 7 | pages = 856–63 | date = Jul 2001 | pmid = 11438208 | doi = 10.1016/S0301-472X(01)00655-5 }}
*{{cite journal | author=Berthelsen J, Zappavigna V, Mavilio F, Blasi F |title=Prep1, a novel functional partner of Pbx proteins. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1423-33 |year= 1998 |pmid= 9482739 |doi= 10.1093/emboj/17.5.1423 }}
* {{cite journal | vauthors = Brake RL, Kees UR, Watt PM | title = A complex containing PBX2 contributes to activation of the proto-oncogene HOX11 | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 1 | pages = 23–34 | date = May 2002 | pmid = 12054735 | doi = 10.1016/S0006-291X(02)00426-6 }}
*{{cite journal | author=Shen WF, Rozenfeld S, Kwong A, ''et al.'' |title=HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3051-61 |year= 1999 |pmid= 10082572 |doi=  }}
* {{cite journal | vauthors = Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T | title = Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene | journal = Blood | volume = 101 | issue = 12 | pages = 4748–56 | date = Jun 2003 | pmid = 12609849 | doi = 10.1182/blood-2002-02-0380 }}
*{{cite journal | author=Fujino T, Yamazaki Y, Largaespada DA, ''et al.'' |title=Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. |journal=Exp. Hematol. |volume=29 |issue= 7 |pages= 856-63 |year= 2001 |pmid= 11438208 |doi= }}
* {{cite journal | vauthors = Longobardi E, Blasi F | title = Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 40 | pages = 39235–41 | date = Oct 2003 | pmid = 12871956 | doi = 10.1074/jbc.M304704200 }}
*{{cite journal | author=Brake RL, Kees UR, Watt PM |title=A complex containing PBX2 contributes to activation of the proto-oncogene HOX11. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 1 |pages= 23-34 |year= 2002 |pmid= 12054735 |doi= 10.1016/S0006-291X(02)00426-6 }}
* {{cite journal | vauthors = Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L | title = Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse | journal = Genome Research | volume = 13 | issue = 12 | pages = 2621–36 | date = Dec 2003 | pmid = 14656967 | pmc = 403804 | doi = 10.1101/gr.1736803 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
*{{cite journal  | author=Okada Y, Nagai R, Sato T, ''et al.'' |title=Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene. |journal=Blood |volume=101 |issue= 12 |pages= 4748-56 |year= 2004 |pmid= 12609849 |doi= 10.1182/blood-2002-02-0380 }}
*{{cite journal | author=Longobardi E, Blasi F |title=Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39235-41 |year= 2003 |pmid= 12871956 |doi= 10.1074/jbc.M304704200 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|PBX2+protein,+human}}
* {{MeshName|PBX2+protein,+human}}


{{PDB Gallery|geneid=5089}}
{{Transcription factors|g2}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{gene-6-stub}}
 
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 17:38, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[1][2]

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[2]

Interactions

PBX2 has been shown to interact with HOXA9.[3]

References

  1. ↑ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
  2. ↑ 2.0 2.1 "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
  3. ↑ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. PMC 84099. PMID 10082572.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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