HOXA11: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-A11''' is a [[protein]] that in humans is encoded by the ''HOXA11'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXA11 homeobox A11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3207| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox A11
| HGNCid = 5101
| Symbol = HOXA11
| AltSymbols =; HOX1; HOX1I
| OMIM = 142958
| ECnumber = 
| Homologene = 4033
| MGIid = 96172
| GeneAtlas_image1 = PBB_GE_HOXA11_208493_at_tn.png
| GeneAtlas_image2 = PBB_GE_HOXA11_213823_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0001759 |text = induction of an organ}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3207
    | Hs_Ensembl = ENSG00000005073
    | Hs_RefseqProtein = NP_005514
    | Hs_RefseqmRNA = NM_005523
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 27187654
    | Hs_GenLoc_end = 27191355
    | Hs_Uniprot = P31270
    | Mm_EntrezGene = 15396
    | Mm_Ensembl = ENSMUSG00000038210
    | Mm_RefseqmRNA = NM_010450
    | Mm_RefseqProtein = NP_034580
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 52171690
    | Mm_GenLoc_end = 52175371
    | Mm_Uniprot = P31311
  }}
}}
'''Homeobox A11''', also known as '''HOXA11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXA11 homeobox A11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3207| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause [[radioulnar synostosis]] with amegakaryocytic thrombocytopenia.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA11 homeobox A11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3207| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Daftary GS, Taylor HS | title = Implantation in the human: the role of HOX genes | journal = Seminars in Reproductive Medicine | volume = 18 | issue = 3 | pages = 311–20 | year = 2001 | pmid = 11299969 | doi = 10.1055/s-2000-12568 }}
| citations =
* {{cite journal | vauthors = Daftary GS, Taylor HS | title = Molecular markers of implantation: clinical implications | journal = Current Opinion in Obstetrics and Gynecology | volume = 13 | issue = 3 | pages = 269–74 | date = Jun 2001 | pmid = 11396649 | doi = 10.1097/00001703-200106000-00004 }}
*{{cite journal | author=Daftary GS, Taylor HS |title=Implantation in the human: the role of HOX genes. |journal=Semin. Reprod. Med. |volume=18 |issue= 3 |pages= 311-20 |year= 2001 |pmid= 11299969 |doi= }}
* {{cite journal | vauthors = Davies JA, Fisher CE | title = Genes and proteins in renal development | journal = Experimental Nephrology | volume = 10 | issue = 2 | pages = 102–13 | year = 2002 | pmid = 11937757 | doi = 10.1159/000049905 }}
*{{cite journal | author=Daftary GS, Taylor HS |title=Molecular markers of implantation: clinical implications. |journal=Curr. Opin. Obstet. Gynecol. |volume=13 |issue= 3 |pages= 269-74 |year= 2001 |pmid= 11396649 |doi= }}
* {{cite journal | vauthors = Eun Kwon H, Taylor HS | title = The role of HOX genes in human implantation | journal = Annals of the New York Academy of Sciences | volume = 1034 | issue =  | pages = 1–18 | date = Dec 2004 | pmid = 15731295 | doi = 10.1196/annals.1335.001 }}
*{{cite journal | author=Davies JA, Fisher CE |title=Genes and proteins in renal development. |journal=Exp. Nephrol. |volume=10 |issue= 2 |pages= 102-13 |year= 2002 |pmid= 11937757 |doi= }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal | author=Eun Kwon H, Taylor HS |title=The role of HOX genes in human implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue=  |pages= 1-18 |year= 2005 |pmid= 15731295 |doi= 10.1196/annals.1335.001 }}
* {{cite journal | vauthors = Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM | title = Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 2 | pages = 900–5 | date = Jan 1996 | pmid = 8570656 | pmc = 40155 | doi = 10.1073/pnas.93.2.900 }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Potter SS, Branford WW | title = Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts | journal = Mammalian Genome | volume = 9 | issue = 10 | pages = 799–806 | date = Oct 1998 | pmid = 9745033 | doi = 10.1007/s003359900870 }}
*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Taylor HS, Igarashi P, Olive DL, Arici A | title = Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 84 | issue = 3 | pages = 1129–35 | date = Mar 1999 | pmid = 10084606 | doi = 10.1210/jc.84.3.1129 }}
*{{cite journal | author=Miano JM, Firulli AB, Olson EN, ''et al.'' |title=Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 2 |pages= 900-5 |year= 1996 |pmid= 8570656 |doi= }}
* {{cite journal | vauthors = Thompson AA, Nguyen LT | title = Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation | journal = Nature Genetics | volume = 26 | issue = 4 | pages = 397–8 | date = Dec 2000 | pmid = 11101832 | doi = 10.1038/82511 }}
*{{cite journal | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi= }}
* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
*{{cite journal | author=Potter SS, Branford WW |title=Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts. |journal=Mamm. Genome |volume=9 |issue= 10 |pages= 799-806 |year= 1998 |pmid= 9745033 |doi= }}
* {{cite journal | vauthors = Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, Nakamura T | title = Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15) | journal = Blood | volume = 99 | issue = 4 | pages = 1428–33 | date = Feb 2002 | pmid = 11830496 | doi = 10.1182/blood.V99.4.1428 }}
*{{cite journal | author=Taylor HS, Igarashi P, Olive DL, Arici A |title=Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 1129-35 |year= 1999 |pmid= 10084606 |doi= }}
* {{cite journal | vauthors = Fleischman RA, Letestu R, Mi X, Stevens D, Winters J, Debili N, Vainchenker W | title = Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome | journal = British Journal of Haematology | volume = 116 | issue = 2 | pages = 367–75 | date = Feb 2002 | pmid = 11841440 | doi = 10.1046/j.1365-2141.2002.03263.x }}
*{{cite journal | author=Thompson AA, Nguyen LT |title=Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. |journal=Nat. Genet. |volume=26 |issue= 4 |pages= 397-8 |year= 2001 |pmid= 11101832 |doi= 10.1038/82511 }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}
* {{cite journal | vauthors = Chau YM, Pando S, Taylor HS | title = HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 87 | issue = 6 | pages = 2674–80 | date = Jun 2002 | pmid = 12050232 | doi = 10.1210/jc.87.6.2674 }}
*{{cite journal | author=Fujino T, Suzuki A, Ito Y, ''et al.'' |title=Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). |journal=Blood |volume=99 |issue= 4 |pages= 1428-33 |year= 2002 |pmid= 11830496 |doi= }}
*{{cite journal | author=Fleischman RA, Letestu R, Mi X, ''et al.'' |title=Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome. |journal=Br. J. Haematol. |volume=116 |issue= 2 |pages= 367-75 |year= 2002 |pmid= 11841440 |doi= }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Chau YM, Pando S, Taylor HS |title=HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2674-80 |year= 2002 |pmid= 12050232 |doi= }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-7-stub}}

Revision as of 03:55, 26 November 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.[1][2][3]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXA11 homeobox A11".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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