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{{Infobox_gene}}
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'''DNA-binding protein Ikaros''' also known as '''Ikaros family zinc finger protein 1''' is a [[protein]] that in humans is encoded by the ''IKZF1'' [[gene]].<ref name=pmid1439790>{{cite journal | vauthors = Georgopoulos K, Moore DD, Derfler B | title = Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment | journal = Science | volume = 258 | issue = 5083 | pages = 808–12 | date = Oct 1992 | pmid = 1439790 | pmc =  | doi = 10.1126/science.1439790 }}</ref><ref name=pmid7935426>{{cite journal | vauthors = Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST | title = The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene | journal = Molecular and Cellular Biology | volume = 14 | issue = 11 | pages = 7111–23 | date = Nov 1994 | pmid = 7935426 | pmc = 359245 | doi =  10.1128/mcb.14.11.7111}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10320| accessdate = }}</ref> Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.<ref name=pmid21765975>{{cite journal | vauthors = Kastner P, Chan S | title = Role of Ikaros in T-cell acute lymphoblastic leukemia | journal = World Journal of Biological Chemistry | volume = 2 | issue = 6 | pages = 108–14 | date = Jun 2011 | pmid = 21765975 | pmc = 3135856 | doi = 10.4331/wjbc.v2.i6.108 }}</ref> In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.<ref name=pmid21765975/> IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes.<ref name=pmid19228925>{{cite journal | vauthors = Watkins NA, Gusnanto A, de Bono B, De S, Miranda-Saavedra D, Hardie DL, Angenent WG, Attwood AP, Ellis PD, Erber W, Foad NS, Garner SF, Isacke CM, Jolley J, Koch K, Macaulay IC, Morley SL, Rendon A, Rice KM, Taylor N, Thijssen-Timmer DC, Tijssen MR, van der Schoot CE, Wernisch L, Winzer T, Dudbridge F, Buckley CD, Langford CF, Teichmann S, Göttgens B, Ouwehand WH | title = A HaemAtlas: characterizing gene expression in differentiated human blood cells | journal = Blood | volume = 113 | issue = 19 | pages = e1-9 | date = May 2009 | pmid = 19228925 | pmc = 2680378 | doi = 10.1182/blood-2008-06-162958 }}</ref> In Ikaros knockout mice, T cells but not B cells are generated late in mouse development due to late compensatory expression of the related gene Aiolos (IKZF3).<ref name= pmid9143685>{{cite journal | vauthors = Georgopoulos K, Winandy S, Avitahl N | title = The role of the Ikaros gene in lymphocyte development and homeostasis | journal = Annual Review of Immunology | volume = 15 | issue =  | pages = 155–76 | year = 1997 | pmid = 9143685 | pmc =  | doi = 10.1146/annurev.immunol.15.1.155 }}</ref> Ikaros point mutant mice are embryonic lethal due to anemia; they have severe defects in terminal erythrocyte and granulocyte differentiation, and excessive macrophage formation.<ref name=pmid12871645>{{cite journal | vauthors = Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC | title = Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor | journal = Immunity | volume = 19 | issue = 1 | pages = 131–44 |date=July 2003 | doi=10.1016/s1074-7613(03)00168-7}}</ref> SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood [[Acute lymphoblastic leukemia|acute lymphoblastic leukemia (ALL)]] <ref name=pmid19684604>{{cite journal | vauthors = Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS | title = Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia | journal = Nature Genetics | volume = 41 | issue = 9 | pages = 1006–10 | date = Sep 2009 | pmid = 19684604 | pmc =  | doi = 10.1038/ng.430 }}</ref> as well as [[Diabetes mellitus type 1|type 1 diabetes]].<ref name=pmid21270240>{{cite journal | vauthors = Swafford AD, Howson JM, Davison LJ, Wallace C, Smyth DJ, Schuilenburg H, Maisuria-Armer M, Mistry T, Lenardo MJ, Todd JA | title = An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes | journal = Diabetes | volume = 60 | issue = 3 | pages = 1041–4 | date = Mar 2011 | pmid = 21270240 | pmc = 3046822 | doi = 10.2337/db10-0446 }}</ref> The two effects appear to be in opposite directions, with the allele marking susceptibility to [[Acute lymphoblastic leukemia|ALL]] protecting from [[Diabetes mellitus type 1|T1D]] and vice versa.<ref name =pmid21270240/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = IKAROS family zinc finger 1 (Ikaros)
| HGNCid = 13176
| Symbol = IKZF1
| AltSymbols =; IK1; Hs.54452; IKAROS; LYF1; PRO0758; ZNFN1A1; hIk-1
| OMIM = 603023
| ECnumber = 
| Homologene = 55948
| MGIid = 1342540
| GeneAtlas_image1 = PBB_GE_IKZF1_205039_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IKZF1_216901_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007498 |text = mesoderm development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10320
    | Hs_Ensembl = ENSG00000185811
    | Hs_RefseqProtein = NP_006051
    | Hs_RefseqmRNA = NM_006060
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 50314924
    | Hs_GenLoc_end = 50438053
    | Hs_Uniprot = Q13422
    | Mm_EntrezGene = 22778
    | Mm_Ensembl = ENSMUSG00000018654
    | Mm_RefseqmRNA = NM_001025597
    | Mm_RefseqProtein = NP_001020768
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 11585928
    | Mm_GenLoc_end = 11672929
    | Mm_Uniprot = Q5GGW4
  }}
}}
'''IKAROS family zinc finger 1 (Ikaros)''', also known as '''IKZF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10320| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
IKZF1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CTBP1]],<ref name = pmid10766745>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 26 | pages = 19594–602 | date = Jun 2000 | pmid = 10766745 | doi = 10.1074/jbc.M000254200 }}</ref>
| summary_text =  
* [[HDAC1]],<ref name = pmid10357820 /><ref name = pmid12015313/>
}}
* [[HDAC7A]],<ref name = pmid12015313/>
* [[Histone deacetylase 5]],<ref name = pmid12015313>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}</ref>
* [[IKZF2]],<ref name = pmid9560339>{{cite journal | vauthors = Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA | title = Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors | journal = Current Biology | volume = 8 | issue = 9 | pages = 508–15 | date = Apr 1998 | pmid = 9560339 | doi =  10.1016/s0960-9822(98)70202-7}}</ref>
* [[IKZF3]],<ref name = "pmid9155026">{{cite journal | vauthors = Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K | title = Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation | journal = The EMBO Journal | volume = 16 | issue = 8 | pages = 2004–13 | date = Apr 1997 | pmid = 9155026 | pmc = 1169803 | doi = 10.1093/emboj/16.8.2004 }}</ref><ref name = pmid10357820>{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}</ref><ref name = pmid10204490>{{cite journal | vauthors = Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K | title = Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes | journal = Immunity | volume = 10 | issue = 3 | pages = 345–55 | date = Mar 1999 | pmid = 10204490 | doi = 10.1016/s1074-7613(00)80034-5}}</ref>
* [[IKZF4]],<ref name = pmid10218586>{{cite journal | vauthors = Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A | title = Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system | journal = FEBS Letters | volume = 447 | issue = 1 | pages = 76–80 | date = Mar 1999 | pmid = 10218586 | doi =  10.1016/s0014-5793(99)00265-3| author13 = Wanaka A }}</ref><ref name = pmid10978333>{{cite journal | vauthors = Perdomo J, Holmes M, Chong B, Crossley M | title = Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38347–54 | date = Dec 2000 | pmid = 10978333 | doi = 10.1074/jbc.M005457200 }}</ref>  
* [[SIN3A]],<ref name = pmid10357820/><ref name = pmid12015313/><ref name = pmid11959865>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23143–9 | date = Jun 2002 | pmid = 11959865 | doi = 10.1074/jbc.M202079200 }}</ref>  and
* [[SIN3B]].<ref name = pmid10357820/><ref name = pmid12015313/>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{clear}}
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|33em}}
| citations =
* {{cite journal | vauthors = Tonnelle C, Calmels B, Maroc C, Gabert J, Chabannon C | title = Ikaros gene expression and leukemia | journal = Leukemia & Lymphoma | volume = 43 | issue = 1 | pages = 29–35 | date = Jan 2002 | pmid = 11908734 | doi = 10.1080/10428190210186 }}
*{{cite journal | author=Tonnelle C, Calmels B, Maroc C, ''et al.'' |title=Ikaros gene expression and leukemia. |journal=Leuk. Lymphoma |volume=43 |issue= 1 |pages= 29-35 |year= 2003 |pmid= 11908734 |doi= }}
* {{cite journal | vauthors = Westman BJ, Mackay JP, Gell D | title = Ikaros: a key regulator of haematopoiesis | journal = The International Journal of Biochemistry & Cell Biology | volume = 34 | issue = 10 | pages = 1304–7 | date = Oct 2002 | pmid = 12127581 | doi = 10.1016/S1357-2725(02)00070-5 }}
*{{cite journal | author=Westman BJ, Mackay JP, Gell D |title=Ikaros: a key regulator of haematopoiesis. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1304-7 |year= 2002 |pmid= 12127581 |doi= }}
* {{cite journal | vauthors = Molnár A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K | title = The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse | journal = Journal of Immunology | volume = 156 | issue = 2 | pages = 585–92 | date = Jan 1996 | pmid = 8543809 | doi =  }}
*{{cite journal  | author=Georgopoulos K, Moore DD, Derfler B |title=Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. |journal=Science |volume=258 |issue= 5083 |pages= 808-12 |year= 1992 |pmid= 1439790 |doi=  }}
* {{cite journal | vauthors = Nietfeld W, Meyerhans A | title = Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1 | journal = Immunology Letters | volume = 49 | issue = 1-2 | pages = 139–41 | date = Jan 1996 | pmid = 8964602 | doi = 10.1016/0165-2478(95)02479-4 }}
*{{cite journal  | author=Hahm K, Ernst P, Lo K, ''et al.'' |title=The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. |journal=Mol. Cell. Biol. |volume=14 |issue= 11 |pages= 7111-23 |year= 1994 |pmid= 7935426 |doi=  }}
* {{cite journal | vauthors = Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K | title = Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation | journal = The EMBO Journal | volume = 16 | issue = 8 | pages = 2004–13 | date = Apr 1997 | pmid = 9155026 | pmc = 1169803 | doi = 10.1093/emboj/16.8.2004 }}
*{{cite journal | author=Molnár A, Wu P, Largespada DA, ''et al.'' |title=The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse. |journal=J. Immunol. |volume=156 |issue= 2 |pages= 585-92 |year= 1996 |pmid= 8543809 |doi=  }}
* {{cite journal | vauthors = Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA | title = Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors | journal = Current Biology | volume = 8 | issue = 9 | pages = 508–15 | date = Apr 1998 | pmid = 9560339 | doi = 10.1016/S0960-9822(98)70202-7 }}
*{{cite journal | author=Nietfeld W, Meyerhans A |title=Cloning and sequencing of hIk-1, a cDNA encoding a human homologue of mouse Ikaros/LyF-1. |journal=Immunol. Lett. |volume=49 |issue= 1-2 |pages= 139-41 |year= 1996 |pmid= 8964602 |doi= }}
* {{cite journal | vauthors = Sun L, Heerema N, Crotty L, Wu X, Navara C, Vassilev A, Sensel M, Reaman GH, Uckun FM | title = Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 2 | pages = 680–5 | date = Jan 1999 | pmid = 9892693 | pmc = 15196 | doi = 10.1073/pnas.96.2.680 }}
*{{cite journal | author=Morgan B, Sun L, Avitahl N, ''et al.'' |title=Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. |journal=EMBO J. |volume=16 |issue= 8 |pages= 2004-13 |year= 1997 |pmid= 9155026 |doi= 10.1093/emboj/16.8.2004 }}
* {{cite journal | vauthors = Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K | title = Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes | journal = Immunity | volume = 10 | issue = 3 | pages = 345–55 | date = Mar 1999 | pmid = 10204490 | doi = 10.1016/S1074-7613(00)80034-5 }}
*{{cite journal | author=Kelley CM, Ikeda T, Koipally J, ''et al.'' |title=Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. |journal=Curr. Biol. |volume=8 |issue= 9 |pages= 508-15 |year= 1998 |pmid= 9560339 |doi= }}
* {{cite journal | vauthors = Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A | title = Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system | journal = FEBS Letters | volume = 447 | issue = 1 | pages = 76–80 | date = Mar 1999 | pmid = 10218586 | doi = 10.1016/S0014-5793(99)00265-3 }}
*{{cite journal | author=Sun L, Heerema N, Crotty L, ''et al.'' |title=Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 680-5 |year= 1999 |pmid= 9892693 |doi= }}
* {{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}
*{{cite journal | author=Kim J, Sif S, Jones B, ''et al.'' |title=Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. |journal=Immunity |volume=10 |issue= 3 |pages= 345-55 |year= 1999 |pmid= 10204490 |doi= }}
* {{cite journal | vauthors = Sun L, Goodman PA, Wood CM, Crotty ML, Sensel M, Sather H, Navara C, Nachman J, Steinherz PG, Gaynon PS, Seibel N, Vassilev A, Juran BD, Reaman GH, Uckun FM | title = Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia | journal = Journal of Clinical Oncology | volume = 17 | issue = 12 | pages = 3753–66 | date = Dec 1999 | pmid = 10577847 | doi =  }}
*{{cite journal | author=Honma Y, Kiyosawa H, Mori T, ''et al.'' |title=Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. |journal=FEBS Lett. |volume=447 |issue= 1 |pages= 76-80 |year= 1999 |pmid= 10218586 |doi= }}
* {{cite journal | vauthors = Hosokawa Y, Maeda Y, Ichinohasama R, Miura I, Taniwaki M, Seto M | title = The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma | journal = Blood | volume = 95 | issue = 8 | pages = 2719–21 | date = Apr 2000 | pmid = 10753856 | doi =  }}
*{{cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090-100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090 }}
* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 275 | issue = 26 | pages = 19594–602 | date = Jun 2000 | pmid = 10766745 | doi = 10.1074/jbc.M000254200 }}
*{{cite journal | author=Sun L, Goodman PA, Wood CM, ''et al.'' |title=Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia. |journal=J. Clin. Oncol. |volume=17 |issue= 12 |pages= 3753-66 |year= 2000 |pmid= 10577847 |doi=  }}
* {{cite journal | vauthors = Perdomo J, Holmes M, Chong B, Crossley M | title = Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38347–54 | date = Dec 2000 | pmid = 10978333 | doi = 10.1074/jbc.M005457200 }}
*{{cite journal | author=Hosokawa Y, Maeda Y, Ichinohasama R, ''et al.'' |title=The Ikaros gene, a central regulator of lymphoid differentiation, fuses to the BCL6 gene as a result of t(3;7)(q27;p12) translocation in a patient with diffuse large B-cell lymphoma. |journal=Blood |volume=95 |issue= 8 |pages= 2719-21 |year= 2000 |pmid= 10753856 |doi=  }}
* {{cite journal | vauthors = Payne KJ, Nicolas JH, Zhu JY, Barsky LW, Crooks GM | title = Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis | journal = Journal of Immunology | volume = 167 | issue = 4 | pages = 1867–70 | date = Aug 2001 | pmid = 11489963 | doi = 10.4049/jimmunol.167.4.1867 }}
*{{cite journal | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594-602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200 }}
* {{cite journal | vauthors = Koipally J, Heller EJ, Seavitt JR, Georgopoulos K | title = Unconventional potentiation of gene expression by Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 15 | pages = 13007–15 | date = Apr 2002 | pmid = 11799125 | doi = 10.1074/jbc.M111371200 }}
*{{cite journal | author=Perdomo J, Holmes M, Chong B, Crossley M |title=Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38347-54 |year= 2001 |pmid= 10978333 |doi= 10.1074/jbc.M005457200 }}
* {{cite journal | vauthors = Dorsam G, Goetzl EJ | title = Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 13488–93 | date = Apr 2002 | pmid = 11812772 | doi = 10.1074/jbc.M107922200 }}
*{{cite journal | author=Payne KJ, Nicolas JH, Zhu JY, ''et al.'' |title=Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 1867-70 |year= 2001 |pmid= 11489963 |doi= }}
*{{cite journal | author=Koipally J, Heller EJ, Seavitt JR, Georgopoulos K |title=Unconventional potentiation of gene expression by Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13007-15 |year= 2002 |pmid= 11799125 |doi= 10.1074/jbc.M111371200 }}
*{{cite journal | author=Dorsam G, Goetzl EJ |title=Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13488-93 |year= 2002 |pmid= 11812772 |doi= 10.1074/jbc.M107922200 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|IKZF1+protein,+human}}
* {{MeshName|IKZF1+protein,+human}}
* {{UCSC genome browser|IKZF1}}
* {{UCSC gene details|IKZF1}}
{{Transcription factors|g2}}




{{protein-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 23:46, 31 August 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene.[1][2][3] Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.[4] In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.[4] IKZF1 is upregulated in granulocytes, B cells, CD4 and CD8 T cells, and NK cells, and downregulated in erythroblasts, megakaryocytes and monocytes.[5] In Ikaros knockout mice, T cells but not B cells are generated late in mouse development due to late compensatory expression of the related gene Aiolos (IKZF3).[6] Ikaros point mutant mice are embryonic lethal due to anemia; they have severe defects in terminal erythrocyte and granulocyte differentiation, and excessive macrophage formation.[7] SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood acute lymphoblastic leukemia (ALL) [8] as well as type 1 diabetes.[9] The two effects appear to be in opposite directions, with the allele marking susceptibility to ALL protecting from T1D and vice versa.[9]

Interactions

IKZF1 has been shown to interact with:

References

  1. ↑ Georgopoulos K, Moore DD, Derfler B (Oct 1992). "Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment". Science. 258 (5083): 808–12. doi:10.1126/science.1439790. PMID 1439790.
  2. ↑ Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST (Nov 1994). "The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene". Molecular and Cellular Biology. 14 (11): 7111–23. doi:10.1128/mcb.14.11.7111. PMC 359245. PMID 7935426.
  3. ↑ "Entrez Gene: IKZF1 IKAROS family zinc finger 1 (Ikaros)".
  4. ↑ 4.0 4.1 Kastner P, Chan S (Jun 2011). "Role of Ikaros in T-cell acute lymphoblastic leukemia". World Journal of Biological Chemistry. 2 (6): 108–14. doi:10.4331/wjbc.v2.i6.108. PMC 3135856. PMID 21765975.
  5. ↑ Watkins NA, Gusnanto A, de Bono B, De S, Miranda-Saavedra D, Hardie DL, Angenent WG, Attwood AP, Ellis PD, Erber W, Foad NS, Garner SF, Isacke CM, Jolley J, Koch K, Macaulay IC, Morley SL, Rendon A, Rice KM, Taylor N, Thijssen-Timmer DC, Tijssen MR, van der Schoot CE, Wernisch L, Winzer T, Dudbridge F, Buckley CD, Langford CF, Teichmann S, Göttgens B, Ouwehand WH (May 2009). "A HaemAtlas: characterizing gene expression in differentiated human blood cells". Blood. 113 (19): e1–9. doi:10.1182/blood-2008-06-162958. PMC 2680378. PMID 19228925.
  6. ↑ Georgopoulos K, Winandy S, Avitahl N (1997). "The role of the Ikaros gene in lymphocyte development and homeostasis". Annual Review of Immunology. 15: 155–76. doi:10.1146/annurev.immunol.15.1.155. PMID 9143685.
  7. ↑ Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC (July 2003). "Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor". Immunity. 19 (1): 131–44. doi:10.1016/s1074-7613(03)00168-7.
  8. ↑ Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS (Sep 2009). "Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia". Nature Genetics. 41 (9): 1006–10. doi:10.1038/ng.430. PMID 19684604.
  9. ↑ 9.0 9.1 Swafford AD, Howson JM, Davison LJ, Wallace C, Smyth DJ, Schuilenburg H, Maisuria-Armer M, Mistry T, Lenardo MJ, Todd JA (Mar 2011). "An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes". Diabetes. 60 (3): 1041–4. doi:10.2337/db10-0446. PMC 3046822. PMID 21270240.
  10. ↑ Koipally J, Georgopoulos K (Jun 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
  11. ↑ 11.0 11.1 11.2 11.3 Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
  12. ↑ 12.0 12.1 12.2 12.3 12.4 Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
  13. ↑ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Apr 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–15. doi:10.1016/s0960-9822(98)70202-7. PMID 9560339.
  14. ↑ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Apr 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal. 16 (8): 2004–13. doi:10.1093/emboj/16.8.2004. PMC 1169803. PMID 9155026.
  15. ↑ Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K (Mar 1999). "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity. 10 (3): 345–55. doi:10.1016/s1074-7613(00)80034-5. PMID 10204490.
  16. ↑ Honma Y, Kiyosawa H, Mori T, Oguri A, Nikaido T, Kanazawa K, Tojo M, Takeda J, Tanno Y, Yokoya S, Kawabata I, Ikeda H, Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Letters. 447 (1): 76–80. doi:10.1016/s0014-5793(99)00265-3. PMID 10218586.
  17. ↑ Perdomo J, Holmes M, Chong B, Crossley M (Dec 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
  18. ↑ Koipally J, Georgopoulos K (Jun 2002). "Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression". The Journal of Biological Chemistry. 277 (26): 23143–9. doi:10.1074/jbc.M202079200. PMID 11959865.

Further reading

External links

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