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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CCAAT/enhancer-binding protein delta''' is a [[protein]] that in humans is encoded by the ''CEBPD'' [[gene]].<ref name="pmid1840554">{{cite journal | vauthors = Cao Z, Umek RM, McKnight SL | title = Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells | journal = Genes & Development | volume = 5 | issue = 9 | pages = 1538–52 | date = Sep 1991 | pmid = 1840554 | pmc =  | doi = 10.1101/gad.5.9.1538 }}</ref><ref name="pmid1884998">{{cite journal | vauthors = Williams SC, Cantwell CA, Johnson PF | title = A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro | journal = Genes & Development | volume = 5 | issue = 9 | pages = 1553–67 | date = Sep 1991 | pmid = 1884998 | pmc = | doi = 10.1101/gad.5.9.1553 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CCAAT/enhancer binding protein (C/EBP), delta
| HGNCid = 1835
| Symbol = CEBPD
| AltSymbols =; C/EBP-delta; CELF; CRP3; NF-IL6-beta
| OMIM = 116898
| ECnumber = 
| Homologene = 3808
| MGIid = 103573
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1052
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_005186
    | Hs_RefseqmRNA = NM_005195
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12609
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_007679
    | Mm_RefseqProtein = NP_031705
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =
  }}
}}
'''CCAAT/enhancer binding protein (C/EBP), delta''', also known as '''CEBPD''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.<ref name="entrez">{{cite web | title = Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1052| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.<ref name="entrez">{{cite web | title = Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1052| accessdate = }}</ref>
}}


==See also==
==Functions==
 
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.<ref name=" pmid = 15674331">{{cite journal | vauthors = Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP | title = C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation | journal = Oncogene | volume = 24 | issue = 9 | pages = 1589–97 | date = Feb 2005 | pmid = 15674331 | doi = 10.1038/sj.onc.1208393 | url = http://www.nature.com/onc/journal/v24/n9/full/1208393a.html }}</ref>
 
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.<ref name=" pmid = 24247561">{{cite journal | vauthors = Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA | title = CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 94 | issue = 1 | pages = 89–97 | date = Jan 2014 | pmid = 24247561 | doi = 10.1038/labinvest.2013.127 | url = http://www.nature.com/labinvest/journal/v94/n1/full/labinvest2013127a.html }}</ref>
 
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.<ref>{{Cite journal|last=Munkácsy|first=Gyöngyi|last2=Sztupinszki|first2=Zsófia|last3=Herman|first3=Péter|last4=Bán|first4=Bence|last5=Pénzváltó|first5=Zsófia|last6=Szarvas|first6=Nóra|last7=Győrffy|first7=Balázs|date=2016|title=Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments|url=http://www.cell.com/molecular-therapy-family/nucleic-acids/abstract/S2162-2531(17)30085-9|journal=Molecular Therapy - Nucleic Acids|language=English|volume=5|doi=10.1038/mtna.2016.66|issn=2162-2531|pmc=5056990|pmid=28131298}}</ref>
 
== Interactions ==
 
CEBPD has been shown to [[Protein-protein interaction|interact]] with [[Mothers against decapentaplegic homolog 3]].<ref name=pmid12524424>{{cite journal | vauthors = Choy L, Derynck R | title = Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9609–19 | date = Mar 2003 | pmid = 12524424 | doi = 10.1074/jbc.M212259200 }}</ref>
 
== See also ==
* [[Ccaat-enhancer-binding proteins]]
* [[Ccaat-enhancer-binding proteins]]


==References==
== References ==
{{reflist|2}}
{{reflist|33em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sladek FM, Darnell JE | title = Mechanisms of liver-specific gene expression | journal = Current Opinion in Genetics & Development | volume = 2 | issue = 2 | pages = 256–9 | date = Apr 1992 | pmid = 1638120 | doi = 10.1016/S0959-437X(05)80282-5 }}
| citations =
* {{cite journal | vauthors = Kinoshita S, Akira S, Kishimoto T | title = A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 4 | pages = 1473–6 | date = Feb 1992 | pmid = 1741402 | pmc = 48473 | doi = 10.1073/pnas.89.4.1473 }}
*{{cite journal | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256-9 |year= 1992 |pmid= 1638120 |doi= }}
* {{cite journal | vauthors = Nagulapalli S, Pongubala JM, Atchison ML | title = Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3) | journal = Journal of Immunology | volume = 155 | issue = 9 | pages = 4330–8 | date = Nov 1995 | pmid = 7594592 | doi =  }}
*{{cite journal | author=Kinoshita S, Akira S, Kishimoto T |title=A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1473-6 |year= 1992 |pmid= 1741402 |doi= }}
* {{cite journal | vauthors = Wood S, Schertzer M, Yaremko ML | title = Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3-4 | pages = 188–91 | year = 1995 | pmid = 7789168 | doi = 10.1159/000134030 }}
*{{cite journal  | author=Cao Z, Umek RM, McKnight SL |title=Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. |journal=Genes Dev. |volume=5 |issue= 9 |pages= 1538-52 |year= 1991 |pmid= 1840554 |doi=  }}
* {{cite journal | vauthors = Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J | title = The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization | journal = Genomics | volume = 16 | issue = 2 | pages = 520–3 | date = May 1993 | pmid = 8314590 | doi = 10.1006/geno.1993.1220 }}
*{{cite journal  | author=Williams SC, Cantwell CA, Johnson PF |title=A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. |journal=Genes Dev. |volume=5 |issue= 9 |pages= 1553-67 |year= 1991 |pmid= 1884998 |doi=  }}
* {{cite journal | vauthors = Chen PL, Riley DJ, Chen Y, Lee WH | title = Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs | journal = Genes & Development | volume = 10 | issue = 21 | pages = 2794–804 | date = Nov 1996 | pmid = 8946919 | doi = 10.1101/gad.10.21.2794 }}
*{{cite journal | author=Nagulapalli S, Pongubala JM, Atchison ML |title=Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). |journal=J. Immunol. |volume=155 |issue= 9 |pages= 4330-8 |year= 1995 |pmid= 7594592 |doi=  }}
* {{cite journal | vauthors = Xia C, Cheshire JK, Patel H, Woo P | title = Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes | journal = The International Journal of Biochemistry & Cell Biology | volume = 29 | issue = 12 | pages = 1525–39 | date = Dec 1997 | pmid = 9570146 | doi = 10.1016/S1357-2725(97)00083-6 }}
*{{cite journal | author=Wood S, Schertzer M, Yaremko ML |title=Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 188-91 |year= 1995 |pmid= 7789168 |doi= }}
* {{cite journal | vauthors = Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK | title = Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 6923–8 | date = Mar 2002 | pmid = 11741938 | doi = 10.1074/jbc.M108075200 }}
*{{cite journal | author=Cleutjens CB, van Eekelen CC, van Dekken H, ''et al.'' |title=The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. |journal=Genomics |volume=16 |issue= 2 |pages= 520-3 |year= 1993 |pmid= 8314590 |doi= }}
* {{cite journal | vauthors = Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E | title = C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2 | journal = Molecular and Cellular Probes | volume = 15 | issue = 6 | pages = 395–7 | date = Dec 2001 | pmid = 11851384 | doi = 10.1006/mcpr.2001.0377 }}
*{{cite journal | author=Chen PL, Riley DJ, Chen Y, Lee WH |title=Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. |journal=Genes Dev. |volume=10 |issue= 21 |pages= 2794-804 |year= 1997 |pmid= 8946919 |doi= }}
* {{cite journal | vauthors = Gao H, Parkin S, Johnson PF, Schwartz RC | title = C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters | journal = The Journal of Biological Chemistry | volume = 277 | issue = 41 | pages = 38827–37 | date = Oct 2002 | pmid = 12177065 | doi = 10.1074/jbc.M206224200 }}
*{{cite journal | author=Xia C, Cheshire JK, Patel H, Woo P |title=Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1525-39 |year= 1998 |pmid= 9570146 |doi= }}
* {{cite journal | vauthors = Dearth LR, DeWille J | title = Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11246–55 | date = Mar 2003 | pmid = 12554732 | doi = 10.1074/jbc.M207930200 }}
*{{cite journal | author=Zhu Y, Saunders MA, Yeh H, ''et al.'' |title=Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 6923-8 |year= 2002 |pmid= 11741938 |doi= 10.1074/jbc.M108075200 }}
* {{cite journal | vauthors = Milde-Langosch K, Löning T, Bamberger AM | title = Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins | journal = Breast Cancer Research and Treatment | volume = 79 | issue = 2 | pages = 175–85 | date = May 2003 | pmid = 12825852 | doi = 10.1023/A:1023929504884 }}
*{{cite journal | author=Angeloni D, Lee JD, Johnson BE, ''et al.'' |title=C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2. |journal=Mol. Cell. Probes |volume=15 |issue= 6 |pages= 395-7 |year= 2002 |pmid= 11851384 |doi= 10.1006/mcpr.2001.0377 }}
* {{cite journal | vauthors = Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR | title = CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36959–65 | date = Sep 2003 | pmid = 12857754 | doi = 10.1074/jbc.M303147200 }}
*{{cite journal | author=Gao H, Parkin S, Johnson PF, Schwartz RC |title=C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38827-37 |year= 2002 |pmid= 12177065 |doi= 10.1074/jbc.M206224200 }}
* {{cite journal | vauthors = Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM | title = Molecular responses of human muscle to eccentric exercise | journal = Journal of Applied Physiology | volume = 95 | issue = 6 | pages = 2485–94 | date = Dec 2003 | pmid = 12937035 | doi = 10.1152/japplphysiol.01161.2002 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J | title = CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease | journal = Neurobiology of Aging | volume = 25 | issue = 8 | pages = 991–9 | date = Sep 2004 | pmid = 15212823 | doi = 10.1016/j.neurobiolaging.2003.10.016 }}
*{{cite journal  | author=Dearth LR, DeWille J |title=Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11246-55 |year= 2003 |pmid= 12554732 |doi= 10.1074/jbc.M207930200 }}
* {{cite journal | vauthors = Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW | title = CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control | journal = Journal of Cellular Biochemistry | volume = 93 | issue = 4 | pages = 844–56 | date = Nov 2004 | pmid = 15389878 | doi = 10.1002/jcb.20224 }}
*{{cite journal | author=Milde-Langosch K, Löning T, Bamberger AM |title=Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins. |journal=Breast Cancer Res. Treat. |volume=79 |issue= 2 |pages= 175-85 |year= 2003 |pmid= 12825852 |doi= }}
*{{cite journal | author=Kovács KA, Steinmann M, Magistretti PJ, ''et al.'' |title=CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36959-65 |year= 2003 |pmid= 12857754 |doi= 10.1074/jbc.M303147200 }}
*{{cite journal | author=Chen YW, Hubal MJ, Hoffman EP, ''et al.'' |title=Molecular responses of human muscle to eccentric exercise. |journal=J. Appl. Physiol. |volume=95 |issue= 6 |pages= 2485-94 |year= 2004 |pmid= 12937035 |doi= 10.1152/japplphysiol.01161.2002 }}
*{{cite journal | author=Li R, Strohmeyer R, Liang Z, ''et al.'' |title=CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. |journal=Neurobiol. Aging |volume=25 |issue= 8 |pages= 991-9 |year= 2004 |pmid= 15212823 |doi= 10.1016/j.neurobiolaging.2003.10.016 }}
*{{cite journal | author=Sivko GS, Sanford DC, Dearth LD, ''et al.'' |title=CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control. |journal=J. Cell. Biochem. |volume=93 |issue= 4 |pages= 844-56 |year= 2005 |pmid= 15389878 |doi= 10.1002/jcb.20224 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{UCSC gene info|CEBPD}}
* {{MeshName|CEBPD+protein,+human}}
* {{MeshName|CEBPD+protein,+human}}


{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g1}}
 
{{DEFAULTSORT:Cebpd}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{Membrane-protein-stub}}

Revision as of 00:34, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]

Function

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]

Functions

CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[4]

One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[5]

Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[6]

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[7]

See also

References

  1. ↑ Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
  2. ↑ Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
  3. ↑ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
  4. ↑ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331.
  5. ↑ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
  6. ↑ Munkácsy, Gyöngyi; Sztupinszki, Zsófia; Herman, Péter; Bán, Bence; Pénzváltó, Zsófia; Szarvas, Nóra; Győrffy, Balázs (2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy - Nucleic Acids. 5. doi:10.1038/mtna.2016.66. ISSN 2162-2531. PMC 5056990. PMID 28131298.
  7. ↑ Choy L, Derynck R (Mar 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–19. doi:10.1074/jbc.M212259200. PMID 12524424.

Further reading

  • Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
  • Kinoshita S, Akira S, Kishimoto T (Feb 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
  • Nagulapalli S, Pongubala JM, Atchison ML (Nov 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–8. PMID 7594592.
  • Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168.
  • Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.
  • Chen PL, Riley DJ, Chen Y, Lee WH (Nov 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.
  • Xia C, Cheshire JK, Patel H, Woo P (Dec 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
  • Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
  • Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E (Dec 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384.
  • Gao H, Parkin S, Johnson PF, Schwartz RC (Oct 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
  • Dearth LR, DeWille J (Mar 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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