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{{ | '''Forkhead box protein H1''' is a [[protein]] that in humans is encoded by the ''FOXH1'' [[gene]].<ref name="pmid9702198">{{cite journal | vauthors = Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B | title = Characterization of human FAST-1, a TGF beta and activin signal transducer | journal = Mol Cell | volume = 2 | issue = 1 | pages = 121–7 | date = August 1998 | pmid = 9702198 | pmc = | doi = 10.1016/S1097-2765(00)80120-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FOXH1 forkhead box H1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8928| accessdate = }}</ref> | ||
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== Function == | |||
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.<ref name="entrez" /> | |||
==See also== | == Interactions == | ||
FOXH1 has been shown to [[Protein-protein interaction|interact]] with [[DRAP1]]<ref name=pmid12471260>{{cite journal | vauthors = Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM | title = Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1 | journal = [[Science (journal)|Science]] | volume = 298 | issue = 5600 | pages = 1996–9 | date = December 2002 | pmid = 12471260 | doi = 10.1126/science.1073405 }}</ref> and [[Mothers against decapentaplegic homolog 2]].<ref name=pmid10199400>{{cite journal | vauthors = Wotton D, Lo RS, Lee S, Massagué J | title = A Smad transcriptional corepressor | journal = Cell | volume = 97 | issue = 1 | pages = 29–39 | date = April 1999 | pmid = 10199400 | doi = 10.1016/S0092-8674(00)80712-6 }}</ref><ref name=pmid9858566>{{cite journal | vauthors = Liu B, Dou CL, Prabhu L, Lai E | title = FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 424–30 | date = January 1999 | pmid = 9858566 | pmc = 83900 }}</ref><ref name=pmid9389648>{{cite journal | vauthors = Liu F, Pouponnot C, Massagué J | title = Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes | journal = Genes Dev. | volume = 11 | issue = 23 | pages = 3157–67 | date = December 1997 | pmid = 9389648 | pmc = 316747 | doi = 10.1101/gad.11.23.3157 }}</ref><ref name=pmid10938097>{{cite journal | vauthors = Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E | title = BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6201–11 | date = September 2000 | pmid = 10938097 | pmc = 86095 | doi = 10.1128/MCB.20.17.6201-6211.2000 }}</ref><ref name=pmid9288972>{{cite journal | vauthors = Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M | title = Smad4 and FAST-1 in the assembly of activin-responsive factor | journal = [[Nature (journal)|Nature]] | volume = 389 | issue = 6646 | pages = 85–9 | date = September 1997 | pmid = 9288972 | doi = 10.1038/38008 }}</ref> | |||
== See also == | |||
* [[FOX proteins]] | * [[FOX proteins]] | ||
==References== | == References == | ||
{{reflist | {{reflist}} | ||
==Further reading== | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M | title = Smad4 and FAST-1 in the assembly of activin-responsive factor | journal = Nature | volume = 389 | issue = 6646 | pages = 85–9 | year = 1997 | pmid = 9288972 | doi = 10.1038/38008 }} | |||
* {{cite journal | vauthors = Liu F, Pouponnot C, Massagué J | title = Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes | journal = Genes Dev. | volume = 11 | issue = 23 | pages = 3157–67 | year = 1998 | pmid = 9389648 | pmc = 316747 | doi = 10.1101/gad.11.23.3157 }} | |||
*{{cite journal | * {{cite journal | vauthors = Liu B, Dou CL, Prabhu L, Lai E | title = FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals | journal = Mol. Cell. Biol. | volume = 19 | issue = 1 | pages = 424–30 | year = 1999 | pmid = 9858566 | pmc = 83900 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E | title = BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6201–11 | year = 2000 | pmid = 10938097 | pmc = 86095 | doi = 10.1128/MCB.20.17.6201-6211.2000 }} | ||
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }} | |||
*{{cite journal | * {{cite journal | vauthors = Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A | title = c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 11 | pages = 6198–203 | year = 2001 | pmid = 11371641 | pmc = 33445 | doi = 10.1073/pnas.101579798 }} | ||
*{{cite journal | * {{cite journal | vauthors = Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM | title = Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1 | journal = Science | volume = 298 | issue = 5600 | pages = 1996–9 | year = 2003 | pmid = 12471260 | doi = 10.1126/science.1073405 }} | ||
*{{cite journal | * {{cite journal | vauthors = Seoane J, Le HV, Shen L, Anderson SA, Massagué J | title = Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation | journal = Cell | volume = 117 | issue = 2 | pages = 211–23 | year = 2004 | pmid = 15084259 | doi = 10.1016/S0092-8674(04)00298-3 }} | ||
*{{cite journal | * {{cite journal | vauthors = von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL | title = Foxh1 is essential for development of the anterior heart field | journal = Dev. Cell | volume = 7 | issue = 3 | pages = 331–45 | year = 2004 | pmid = 15363409 | doi = 10.1016/j.devcel.2004.07.023 }} | ||
*{{cite journal | * {{cite journal | vauthors = Kelemen SF, Eisen HJ, Autieri MV | title = Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells | journal = J. Heart Lung Transplant. | volume = 24 | issue = 3 | pages = 246–50 | year = 2005 | pmid = 15737749 | doi = 10.1016/j.healun.2004.01.015 }} | ||
*{{cite journal | * {{cite journal | vauthors = Cui Q, Lim SK, Zhao B, Hoffmann FM | title = Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP | journal = Oncogene | volume = 24 | issue = 24 | pages = 3864–74 | year = 2005 | pmid = 15750622 | doi = 10.1038/sj.onc.1208556 }} | ||
* {{cite journal | vauthors = Hart AH, Willson TA, Wong M, Parker K, Robb L | title = Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1 | journal = Biochem. Biophys. Res. Commun. | volume = 333 | issue = 4 | pages = 1361–9 | year = 2005 | pmid = 15982639 | doi = 10.1016/j.bbrc.2005.06.044 }} | |||
*{{cite journal | * {{cite journal | vauthors = Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, Yanase T, Zheng H, Lu J, Nawata H | title = Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor | journal = J. Biol. Chem. | volume = 280 | issue = 43 | pages = 36355–63 | year = 2006 | pmid = 16120611 | doi = 10.1074/jbc.M506147200 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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{{NLM content}} | {{NLM content}} | ||
{{Transcription factors}} | {{Transcription factors|g3}} | ||
[[Category: | |||
{{ | [[Category:Forkhead transcription factors]] | ||
{{gene-8-stub}} |
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Species | Human | Mouse | |||||
Entrez |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.[1][2]
Function
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.[2]
Interactions
FOXH1 has been shown to interact with DRAP1[3] and Mothers against decapentaplegic homolog 2.[4][5][6][7][8]
See also
References
- ↑ Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
- ↑ 2.0 2.1 "Entrez Gene: FOXH1 forkhead box H1".
- ↑ Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.
- ↑ Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.
- ↑ Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.
- ↑ Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
- ↑ Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
- ↑ Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.
Further reading
- Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.
- Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
- Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.
- Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. doi:10.1073/pnas.101579798. PMC 33445. PMID 11371641.
- Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.
- Seoane J, Le HV, Shen L, Anderson SA, Massagué J (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell. 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.
- von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL (2004). "Foxh1 is essential for development of the anterior heart field". Dev. Cell. 7 (3): 331–45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.
- Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". J. Heart Lung Transplant. 24 (3): 246–50. doi:10.1016/j.healun.2004.01.015. PMID 15737749.
- Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–74. doi:10.1038/sj.onc.1208556. PMID 15750622.
- Hart AH, Willson TA, Wong M, Parker K, Robb L (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.
- Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, Yanase T, Zheng H, Lu J, Nawata H (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". J. Biol. Chem. 280 (43): 36355–63. doi:10.1074/jbc.M506147200. PMID 16120611.
External links
- FOXH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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