RAR-related orphan receptor beta: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''RAR-related orphan receptor beta''' ('''ROR-beta'''), also known as '''NR1F2''' (nuclear receptor subfamily 1, group F, member 2) is a [[nuclear receptor]] that in humans is encoded by the ''RORB'' gene.<ref name="pmid7926749">{{cite journal | vauthors = Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G | title = Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors | journal = Genes Dev. | volume = 8 | issue = 5 | pages = 538–53  | date = March 1994 | pmid = 7926749 | doi = 10.1101/gad.8.5.538 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RORB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1k4w.
| PDB = {{PDB2|1k4w}}, {{PDB2|1n4h}}, {{PDB2|1nq7}}
| Name = RAR-related orphan receptor B
| HGNCid = 10259
| Symbol = RORB
| AltSymbols =; NR1F2; ROR-BETA; RZRB; bA133M9.1
| OMIM = 601972
| ECnumber = 
| Homologene = 38250
| MGIid = 1343464
| GeneAtlas_image1 = PBB_GE_RORB_206443_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0042462 |text = eye photoreceptor cell development}} {{GNF_GO|id=GO:0043193 |text = positive regulation of gene-specific transcription}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6096
    | Hs_Ensembl = ENSG00000198963
    | Hs_RefseqProtein = NP_008845
    | Hs_RefseqmRNA = NM_006914
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 76302072
    | Hs_GenLoc_end = 76491937
    | Hs_Uniprot = Q92753
    | Mm_EntrezGene = 225998
    | Mm_Ensembl = ENSMUSG00000036192
    | Mm_RefseqmRNA = NM_001043354
    | Mm_RefseqProtein = NP_001036819
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 19004903
    | Mm_GenLoc_end = 19055146
    | Mm_Uniprot = Q8R1B8
  }}
}}
'''RAR-related orphan receptor beta''' ('''ROR-beta'''), also known as '''NR1F2''' (nuclear receptor subfamily 1, group F, member 2) is a [[nuclear receptor]] encoded by the {{gene|RORB}} gene.


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to [[hormone response element]]s upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with [[NME1|NM23-2]], a [[nucleoside-diphosphate kinase]] involved in organogenesis and differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: RORB RAR-related orphan receptor B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6096| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: RORB RAR-related orphan receptor B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6096| accessdate = }}</ref>
}}


==References==
In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.<ref name="pmid21799210">{{cite journal | vauthors = Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD | title = RORβ induces barrel-like neuronal clusters in the developing neocortex | journal = Cereb. Cortex | volume = 22 | issue = 5 | pages = 996–1006  | date = May 2012 | pmid = 21799210 | pmc = 3328343 | doi = 10.1093/cercor/bhr182 }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
RAR-related orphan receptor beta has been shown to [[Protein-protein interaction|interact]] with [[NME1]].<ref name="pmid8858107">{{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7  | date = October 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}</ref>
 
== See also ==
* [[RAR-related orphan receptor]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Beeson WM, Perry TW, Zurcher TD | title = Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle | journal = J. Anim. Sci. | volume = 45 | issue = 1 | pages = 160–5 | year = 1977 | pmid = 885817 | doi =  }}
| citations =
* {{cite journal | vauthors = Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-André M | title = RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers | journal = Mol. Endocrinol. | volume = 8 | issue = 6 | pages = 757–70 | year = 1994 | pmid = 7935491 | doi = 10.1210/me.8.6.757 }}
*{{cite journal | author=Beeson WM, Perry TW, Zurcher TD |title=Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle. |journal=J. Anim. Sci. |volume=45 |issue= 1 |pages= 160-5 |year= 1977 |pmid= 885817 |doi=  }}
* {{cite journal | vauthors = Greiner EF, Kirfel J, Greschik H, Dörflinger U, Becker P, Mercep A, Schüle R | title = Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10105–10 | year = 1996 | pmid = 8816759 | pmc = 38344 | doi = 10.1073/pnas.93.19.10105 }}
*{{cite journal | author=Giguère V, Tini M, Flock G, ''et al.'' |title=Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. |journal=Genes Dev. |volume=8 |issue= 5 |pages= 538-53 |year= 1994 |pmid= 7926749 |doi=  }}
* {{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7 | year = 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}
*{{cite journal  | author=Carlberg C, Hooft van Huijsduijnen R, Staple JK, ''et al.'' |title=RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. |journal=Mol. Endocrinol. |volume=8 |issue= 6 |pages= 757-70 |year= 1994 |pmid= 7935491 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Greiner EF, Kirfel J, Greschik H, ''et al.'' |title=Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10105-10 |year= 1996 |pmid= 8816759 |doi= }}
* {{cite journal | vauthors = Park HT, Baek SY, Kim BS, Kim JB, Kim JJ | title = Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat | journal = Neurosci. Lett. | volume = 217 | issue = 1 | pages = 17–20 | year = 1996 | pmid = 8905729 | doi = 10.1016/S0304-3940(96)13060-3 }}
*{{cite journal | author=Paravicini G, Steinmayr M, André E, Becker-André M |title=The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 1 |pages= 82-7 |year= 1996 |pmid= 8858107 |doi= 10.1006/bbrc.1996.1471 }}
* {{cite journal | vauthors = André E, Conquet F, Steinmayr M, Stratton SC, Porciatti V, Becker-André M | title = Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice | journal = EMBO J. | volume = 17 | issue = 14 | pages = 3867–77 | year = 1998 | pmid = 9670004 | pmc = 1170722 | doi = 10.1093/emboj/17.14.3867 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Greiner EF, Kirfel J, Greschik H, Huang D, Becker P, Kapfhammer JP, Schüle R | title = Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 13 | pages = 7160–5 | year = 2000 | pmid = 10860982 | pmc = 16516 | doi = 10.1073/pnas.97.13.7160 }}
*{{cite journal | author=Park HT, Baek SY, Kim BS, ''et al.'' |title=Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat. |journal=Neurosci. Lett. |volume=217 |issue= 1 |pages= 17-20 |year= 1997 |pmid= 8905729 |doi= }}
* {{cite journal | vauthors = Gawlas K, Stunnenberg HG | title = Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1) | journal = Biochim. Biophys. Acta | volume = 1494 | issue = 3 | pages = 236–41 | year = 2000 | pmid = 11121580 | doi = 10.1016/s0167-4781(00)00237-2 }}
*{{cite journal | author=André E, Conquet F, Steinmayr M, ''et al.'' |title=Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. |journal=EMBO J. |volume=17 |issue= 14 |pages= 3867-77 |year= 1998 |pmid= 9670004 |doi= 10.1093/emboj/17.14.3867 }}
* {{cite journal | vauthors = Gawlas K, Stunnenberg HG | title = Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells | journal = Nucleic Acids Res. | volume = 29 | issue = 16 | pages = 3424–32 | year = 2001 | pmid = 11504880 | pmc = 55847 | doi = 10.1093/nar/29.16.3424 }}
*{{cite journal | author=Greiner EF, Kirfel J, Greschik H, ''et al.'' |title=Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7160-5 |year= 2000 |pmid= 10860982 |doi= }}
* {{cite journal | vauthors = Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schüle R, Moras D, Renaud JP | title = X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation | journal = EMBO J. | volume = 20 | issue = 21 | pages = 5822–31 | year = 2001 | pmid = 11689423 | pmc = 125710 | doi = 10.1093/emboj/20.21.5822 }}
*{{cite journal | author=Gawlas K, Stunnenberg HG |title=Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1). |journal=Biochim. Biophys. Acta |volume=1494 |issue= 3 |pages= 236-41 |year= 2001 |pmid= 11121580 |doi= }}
* {{cite journal | vauthors = Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H | title = Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus | journal = Neurosci. Lett. | volume = 320 | issue = 1-2 | pages = 13–6 | year = 2002 | pmid = 11849752 | doi = 10.1016/S0304-3940(02)00011-3 }}
*{{cite journal | author=Gawlas K, Stunnenberg HG |title=Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. |journal=Nucleic Acids Res. |volume=29 |issue= 16 |pages= 3424-32 |year= 2001 |pmid= 11504880 |doi= }}
* {{cite journal | vauthors = Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R | title = All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta | journal = Nat. Struct. Biol. | volume = 10 | issue = 10 | pages = 820–5 | year = 2003 | pmid = 12958591 | doi = 10.1038/nsb979 }}
*{{cite journal | author=Stehlin C, Wurtz JM, Steinmetz A, ''et al.'' |title=X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5822-31 |year= 2001 |pmid= 11689423 |doi= 10.1093/emboj/20.21.5822 }}
*{{cite journal | author=Sumi Y, Yagita K, Yamaguchi S, ''et al.'' |title=Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus. |journal=Neurosci. Lett. |volume=320 |issue= 1-2 |pages= 13-6 |year= 2002 |pmid= 11849752 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Stehlin-Gaon C, Willmann D, Zeyer D, ''et al.'' |title=All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. |journal=Nat. Struct. Biol. |volume=10 |issue= 10 |pages= 820-5 |year= 2003 |pmid= 12958591 |doi= 10.1038/nsb979 }}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{Transcription factors}}
* {{MeshName|orphan+nuclear+receptor+ROR-beta}}
 
{{PDB Gallery|geneid=6096}}
{{Transcription factors|g2}}
{{Nuclear receptor ligands}}
 
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-9-stub}}

Latest revision as of 08:55, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.[1]

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.[2]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[3]

Interactions

RAR-related orphan receptor beta has been shown to interact with NME1.[4]

See also

References

  1. ↑ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749.
  2. ↑ "Entrez Gene: RORB RAR-related orphan receptor B".
  3. ↑ Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex. 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210.
  4. ↑ Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.

Further reading

External links


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