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'''Transcription factor II E''' ('''TF<sub>II</sub>E''') is one of several [[general transcription factor]]s that make up the [[RNA polymerase II]] [[Transcription preinitiation complex|preinitiation complex]].<ref name="isbn0-13-144946-X">{{cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = 636–637 | isbn = 0-13-144946-X | oclc = | doi = }}</ref> It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.<ref name="UniProtKB">{{cite web|url=http://www.uniprot.org/uniprot/P29083|title=UniProtKB - P29083 (T2EA_HUMAN)|website=UniProt|accessdate=2016-10-19}}</ref>
'''Transcription factor II E''' ('''TF<sub>II</sub>E''') is one of several [[general transcription factor]]s that make up the [[RNA polymerase II]] [[Transcription preinitiation complex|preinitiation complex]].<ref name="isbn0-13-144946-X">{{cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = 636–637 | isbn = 0-13-144946-X | oclc = | doi = }}</ref> It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.<ref name="UniProtKB">{{cite web|url=https://www.uniprot.org/uniprot/P29083|title=UniProtKB - P29083 (T2EA_HUMAN)|website=UniProt|accessdate=2016-10-19}}</ref>


TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.<ref name="UniProtKB"/> Transcription factor II E is encoded by the [[GTF2E1]] and [[GTF2E2]] genes.<ref name="pmid1454543">{{cite journal | vauthors = Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M | title = Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences | journal = Nucleic Acids Res. | volume = 20 | issue = 21 | pages = 5838 | year = 1992 | pmid = 1454543 | pmc = 334425 | doi = 10.1093/nar/20.21.5838| issn = }}</ref><ref name="pmid8162052">{{cite journal | vauthors = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = 10.1093/hmg/3.1.61| issn = }}</ref><ref name="pmid1956404">{{cite journal | vauthors = Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG | title = Conserved sequence motifs in the small subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 401–4 | year = 1991 | pmid = 1956404 | doi = 10.1038/354401a0 | issn = }}</ref><ref name="pmid1956403">{{cite journal | vauthors = Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG | title = Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 398–401 |date=December 1991 | pmid = 1956403 | doi = 10.1038/354398a0 | url = | issn = }}</ref>  TFIIE is thought to be involved in [[DNA melting]] at the [[promoter (biology)|promoter]]: it contains a zinc ribbon motif that can bind single stranded DNA.<ref name="pmid11092823">{{cite journal | vauthors = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77}}</ref>
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.<ref name="UniProtKB"/> Transcription factor II E is encoded by the [[GTF2E1]] and [[GTF2E2]] genes.<ref name="pmid1454543">{{cite journal | vauthors = Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M | title = Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences | journal = Nucleic Acids Res. | volume = 20 | issue = 21 | pages = 5838 | year = 1992 | pmid = 1454543 | pmc = 334425 | doi = 10.1093/nar/20.21.5838| issn = }}</ref><ref name="pmid8162052">{{cite journal | vauthors = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = 10.1093/hmg/3.1.61| issn = }}</ref><ref name="pmid1956404">{{cite journal | vauthors = Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG | title = Conserved sequence motifs in the small subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 401–4 | year = 1991 | pmid = 1956404 | doi = 10.1038/354401a0 | issn = }}</ref><ref name="pmid1956403">{{cite journal | vauthors = Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG | title = Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 398–401 |date=December 1991 | pmid = 1956403 | doi = 10.1038/354398a0 | url = | issn = }}</ref>  TFIIE is thought to be involved in [[DNA melting]] at the [[promoter (biology)|promoter]]: it contains a zinc ribbon motif that can bind single stranded DNA.<ref name="pmid11092823">{{cite journal | vauthors = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77}}</ref>

Revision as of 05:21, 23 March 2018

general transcription factor IIE, polypeptide 1, alpha 56kDa
Identifiers
SymbolGTF2E1
Alt. symbolsTF2E1
Entrez2960
HUGO4650
OMIM189962
RefSeqNM_005513
UniProtP29083
Other data
LocusChr. 3 q21-q24
general transcription factor IIE, polypeptide 2, beta 34kDa
Identifiers
SymbolGTF2E2
Alt. symbolsTF2E2
Entrez2961
HUGO4651
OMIM189964
RefSeqNM_002095
UniProtP29084
Other data
LocusChr. 8 p12

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.[2]

TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.[3][4][5][6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[7]

See also

References

  1. ↑ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
  2. ↑ 2.0 2.1 "UniProtKB - P29083 (T2EA_HUMAN)". UniProt. Retrieved 2016-10-19.
  3. ↑ Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M (1992). "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838. doi:10.1093/nar/20.21.5838. PMC 334425. PMID 1454543.
  4. ↑ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
  5. ↑ Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG (1991). "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature. 354 (6352): 401–4. doi:10.1038/354401a0. PMID 1956404.
  6. ↑ Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG (December 1991). "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE". Nature. 354 (6352): 398–401. doi:10.1038/354398a0. PMID 1956403.
  7. ↑ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.

External links


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