Rev-ErbA: Difference between revisions

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{{short description|Type of protein}}
{{infobox protein | Name = [[Rev-ErbA alpha|nuclear receptor subfamily 1, group D, member 1]] | caption = | image = | width = | HGNCid = 7962 | Symbol = [[NR1D1]] | AltSymbols = ear-1, hRev, Rev-ErbAalpha, THRA1 | EntrezGene = 9572 | OMIM = 602408 | RefSeq = NM_021724 | UniProt = P20393 | PDB = | ECnumber = | Chromosome = 17 | Arm = q | Band = 11.2 | LocusSupplementaryData = }}
{{infobox protein | Name = [[Rev-ErbA alpha|nuclear receptor subfamily 1, group D, member 1]] | caption = | image = | width = | HGNCid = 7962 | Symbol = [[NR1D1]] | AltSymbols = ear-1, hRev, Rev-ErbAalpha, THRA1 | EntrezGene = 9572 | OMIM = 602408 | RefSeq = NM_021724 | UniProt = P20393 | PDB = | ECnumber = | Chromosome = 17 | Arm = q | Band = 11.2 | LocusSupplementaryData = }}


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The rev-Erb-α protein is a key regulatory component of the circadian clock.<ref name="pmid16484495">{{cite journal | vauthors = Yin L, Wang J, Klein PS, Lazar MA | title = Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock | journal = Science | volume = 311 | issue = 5763 | pages = 1002–5 | year = 2006 | pmid = 16484495 | doi = 10.1126/science.1121613 }}</ref><ref name="pmid16968709">{{cite journal | vauthors = Wang J, Yin L, Lazar MA | title = The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1 | journal = J. Biol. Chem. | volume = 281 | issue = 45 | pages = 33842–8 | year = 2006 | pmid = 16968709 | doi = 10.1074/jbc.M607873200 }}</ref>  In addition, rev-Erb-α appears also to regulate the breakdown of [[cartilage]].<ref name="pmid17075855">{{cite journal | vauthors = Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S | title = Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis | journal = Arthritis Rheum. | volume = 54 | issue = 11 | pages = 3513–22 | year = 2006 | pmid = 17075855 | doi = 10.1002/art.22170 }}</ref>
The rev-Erb-α protein is a key regulatory component of the circadian clock.<ref name="pmid16484495">{{cite journal | vauthors = Yin L, Wang J, Klein PS, Lazar MA | title = Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock | journal = Science | volume = 311 | issue = 5763 | pages = 1002–5 | year = 2006 | pmid = 16484495 | doi = 10.1126/science.1121613 }}</ref><ref name="pmid16968709">{{cite journal | vauthors = Wang J, Yin L, Lazar MA | title = The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1 | journal = J. Biol. Chem. | volume = 281 | issue = 45 | pages = 33842–8 | year = 2006 | pmid = 16968709 | doi = 10.1074/jbc.M607873200 }}</ref>  In addition, rev-Erb-α appears also to regulate the breakdown of [[cartilage]].<ref name="pmid17075855">{{cite journal | vauthors = Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S | title = Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis | journal = Arthritis Rheum. | volume = 54 | issue = 11 | pages = 3513–22 | year = 2006 | pmid = 17075855 | doi = 10.1002/art.22170 }}</ref>
 
==Ligands==
*[[SR9009]] (aka [[Stenabolic]]) is listed as an agonist
== References ==
== References ==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 13:05, 19 October 2018

nuclear receptor subfamily 1, group D, member 1
Identifiers
SymbolNR1D1
Alt. symbolsear-1, hRev, Rev-ErbAalpha, THRA1
Entrez9572
HUGO7962
OMIM602408
RefSeqNM_021724
UniProtP20393
Other data
LocusChr. 17 q11.2
nuclear receptor subfamily 1, group D, member 2
Identifiers
SymbolNR1D2
Alt. symbolsBD73, RVR, EAR-1r, HZF2, Hs.37288
Entrez9975
HUGO7963
OMIM602304
RefSeqXM_001130839
UniProtQ14995
Other data
LocusChr. 3 p24.1

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).[1][2]

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.[1]

The rev-Erb-α protein is a key regulatory component of the circadian clock.[3][4] In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.[5]

Ligands

References

  1. ↑ 1.0 1.1 Lazar MA, Jones KE, Chin WW (1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA Cell Biol. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
  2. ↑ Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Mol. Endocrinol. 8 (8): 996–1005. doi:10.1210/me.8.8.996. PMID 7997240.
  3. ↑ Yin L, Wang J, Klein PS, Lazar MA (2006). "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock". Science. 311 (5763): 1002–5. doi:10.1126/science.1121613. PMID 16484495.
  4. ↑ Wang J, Yin L, Lazar MA (2006). "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1". J. Biol. Chem. 281 (45): 33842–8. doi:10.1074/jbc.M607873200. PMID 16968709.
  5. ↑ Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S (2006). "Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis". Arthritis Rheum. 54 (11): 3513–22. doi:10.1002/art.22170. PMID 17075855.

External links


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