ZNF300: Difference between revisions
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==Clinical relevance== | ==Clinical relevance== | ||
It is associated with Crohn's disease.<ref name="pmid20106866">{{cite journal |vauthors=Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG | title = Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease | journal = Hum. Mol. Genet. | volume = 19 | issue = 9 | pages = 1828–39 |date=May 2010 | pmid = 20106866 | pmc = 2850616 | doi = 10.1093/hmg/ddq041 }}</ref> | It is associated with Crohn's disease.<ref name="pmid20106866">{{cite journal |vauthors=Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG | title = Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease | journal = Hum. Mol. Genet. | volume = 19 | issue = 9 | pages = 1828–39 |date=May 2010 | pmid = 20106866 | pmc = 2850616 | doi = 10.1093/hmg/ddq041 | url = https://dash.harvard.edu/bitstream/handle/1/4706587/2850616.pdf?sequence=1 }}</ref> | ||
==References== | ==References== | ||
Latest revision as of 12:21, 4 November 2018
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Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.[1][2] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.
It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression.[3]
Clinical relevance
It is associated with Crohn's disease.[4]
References
- ↑ Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta. 1676 (2): 203–9. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.
- ↑ "Entrez Gene: zinc finger protein 300".
- ↑ mieg@ncbi.nlm.nih.gov, Danielle Thierry-Mieg and Jean Thierry-Mieg, NCBI/NLM/NIH,. "AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2017-05-20.
- ↑ Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease" (PDF). Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.
Further reading
- Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data". Hum. Genet. 128 (3): 269–80. doi:10.1007/s00439-010-0849-9. PMC 2922446. PMID 20549515.
- Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein". Cell. Mol. Biol. Lett. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMID 18350257.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60". Leuk. Res. 34 (12): 1636–46. doi:10.1016/j.leukres.2010.04.009. PMID 20471086.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site". Cell. Mol. Biol. Lett. 15 (4): 530–40. doi:10.2478/s11658-010-0025-1. PMID 20585888.
- Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis". DNA Seq. 18 (4): 312–5. doi:10.1080/10425170701243393. PMID 17541838.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature. 447 (7145): 661–78. 2007. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.
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