Retinoic acid receptor beta: Difference between revisions

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==Overview==
'''Retinoic acid receptor beta''' ('''RAR-beta'''), also known as '''NR1B2''' (nuclear receptor subfamily 1, group B, member 2) is a [[nuclear receptor]] encoded by the {{gene|RARB}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: RARB retinoic acid receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5915| accessdate = }}</ref>
'''Retinoic acid receptor beta''' ('''RAR-beta'''), also known as '''NR1B2''' (nuclear receptor subfamily 1, group B, member 2) is a [[nuclear receptor]] encoded by the {{gene|RARB}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: RARB retinoic acid receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5915| accessdate = }}</ref>


Revision as of 16:37, 17 June 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Retinoic acid receptor, beta
File:PBB Protein RARB image.jpg
PDB rendering based on 1dsz.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols RARB ; HAP; NR1B2; RRB2
External IDs Template:OMIM5 Template:MGI HomoloGene: 68100
RNA expression pattern
File:PBB GE RARB 205080 at tn.png
File:PBB GE RARB 208530 s at tn.png
File:PBB GE RARB 208412 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Overview

Retinoic acid receptor beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.[1]

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: RARB retinoic acid receptor, beta".

Further reading

  • Dejean A, de Thé H (1990). "Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma". Mol. Biol. Med. 7 (3): 213–22. PMID 2170809.
  • Sun SY (2004). "Retinoic acid receptor beta and colon cancer". Cancer Biol. Ther. 3 (1): 87–8. PMID 14726690.
  • Saba N, Jain S, Khuri F (2004). "Chemoprevention in lung cancer". Current problems in cancer. 28 (5): 287–306. PMID 15375805.
  • Klein O, Grignon Y, Civit T; et al. (2006). "[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors]". Neuro-Chirurgie. 51 (3-4 Pt 1): 147–54. PMID 16389900.
  • Katahira M, Knegtel RM, Boelens R; et al. (1992). "Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements". Biochemistry. 31 (28): 6474–80. PMID 1321662.
  • Berrodin TJ, Marks MS, Ozato K; et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Mol. Endocrinol. 6 (9): 1468–78. PMID 1331778.
  • van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT (1992). "Genomic organization of the human retinoic acid receptor beta 2". Biochem. Biophys. Res. Commun. 188 (2): 695–702. PMID 1332705.
  • Prentice A, Matthews CJ, Thomas EJ, Redfern CP (1992). "The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid". Hum. Reprod. 7 (5): 692–700. PMID 1379266.
  • Shen S, Kruyt FA, den Hertog J; et al. (1992). "Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness". DNA Seq. 2 (2): 111–9. PMID 1663808.
  • de Thé H, Vivanco-Ruiz MM, Tiollais P; et al. (1990). "Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene". Nature. 343 (6254): 177–80. doi:10.1038/343177a0. PMID 2153268.
  • Hoffmann B, Lehmann JM, Zhang XK; et al. (1991). "A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter". Mol. Endocrinol. 4 (11): 1727–36. PMID 2177841.
  • de Thé H, Marchio A, Tiollais P, Dejean A (1988). "A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma". Nature. 330 (6149): 667–70. doi:10.1038/330667a0. PMID 2825037.
  • Brand N, Petkovich M, Krust A; et al. (1988). "Identification of a second human retinoic acid receptor". Nature. 332 (6167): 850–3. doi:10.1038/332850a0. PMID 2833708.
  • Benbrook D, Lernhardt E, Pfahl M (1988). "A new retinoic acid receptor identified from a hepatocellular carcinoma". Nature. 333 (6174): 669–72. doi:10.1038/333669a0. PMID 2836738.
  • Mattei MG, de Thé H, Mattei JF; et al. (1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Hum. Genet. 80 (2): 189–90. PMID 2844650.
  • Dejean A, Bougueleret L, Grzeschik KH, Tiollais P (1986). "Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma". Nature. 322 (6074): 70–2. doi:10.1038/322070a0. PMID 3014347.
  • Si SP, Tsou HC, Lee X, Peacocke M (1995). "Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts". Exp. Cell Res. 219 (1): 243–8. doi:10.1006/excr.1995.1224. PMID 7628539.
  • Houle B, Pelletier M, Wu J; et al. (1994). "Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines". Cancer Res. 54 (2): 365–9. PMID 8275470.
  • Knegtel RM, Katahira M, Schilthuis JG; et al. (1993). "The solution structure of the human retinoic acid receptor-beta DNA-binding domain". J. Biomol. NMR. 3 (1): 1–17. PMID 8383553.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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