Rev-ErbA
| nuclear receptor subfamily 1, group D, member 1 | |
|---|---|
| Identifiers | |
| Symbol | NR1D1 |
| Alt. symbols | ear-1, hRev, Rev-ErbAalpha, THRA1 |
| Entrez | 9572 |
| HUGO | 7962 |
| OMIM | 602408 |
| RefSeq | NM_021724 |
| UniProt | P20393 |
| Other data | |
| Locus | Chr. 17 q11.2 |
| nuclear receptor subfamily 1, group D, member 2 | |
|---|---|
| Identifiers | |
| Symbol | NR1D2 |
| Alt. symbols | BD73, RVR, EAR-1r, HZF2, Hs.37288 |
| Entrez | 9975 |
| HUGO | 7963 |
| OMIM | 602304 |
| RefSeq | XM_001130839 |
| UniProt | Q14995 |
| Other data | |
| Locus | Chr. 3 p24.1 |
The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).[1][2]
The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.[1]
The rev-Erb-α protein is a key regulatory component of the circadian clock.[3][4] In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.[5]
Ligands
- SR9009 (aka Stenabolic) is listed as an agonist
References
- ↑ 1.0 1.1 Lazar MA, Jones KE, Chin WW (1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA Cell Biol. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
- ↑ Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Mol. Endocrinol. 8 (8): 996–1005. doi:10.1210/me.8.8.996. PMID 7997240.
- ↑ Yin L, Wang J, Klein PS, Lazar MA (2006). "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock". Science. 311 (5763): 1002–5. doi:10.1126/science.1121613. PMID 16484495.
- ↑ Wang J, Yin L, Lazar MA (2006). "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1". J. Biol. Chem. 281 (45): 33842–8. doi:10.1074/jbc.M607873200. PMID 16968709.
- ↑ Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S (2006). "Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis". Arthritis Rheum. 54 (11): 3513–22. doi:10.1002/art.22170. PMID 17075855.
External links
- HZF-2alpha at the US National Library of Medicine Medical Subject Headings (MeSH)
- HZF-2beta at the US National Library of Medicine Medical Subject Headings (MeSH)
- NR1D1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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