RAR-related orphan receptor gamma

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RAR-related orphan receptor C
Identifiers
Symbols RORC ; MGC129539; NR1F3; RORG; RZRG; TOR
External IDs Template:OMIM5 Template:MGI HomoloGene: 21051
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

RAR-related orphan receptor gamma (ROR-γ) is a member of the nuclear receptor family of transcription factors. ROR-γ is encoded by the RORC gene (RAR-related orphan receptor C).[1]

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RORC RAR-related orphan receptor C".

Further reading

  • Winoto A, Littman DR (2002). "Nuclear hormone receptors in T lymphocytes". Cell. 109 Suppl: S57–66. PMID 11983153.
  • Huang Z, Xie H, Wang R, Sun Z (2007). "Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity". Expert Opin. Ther. Targets. 11 (6): 737–43. doi:10.1517/14728222.11.6.737. PMID 17504012.
  • Hirose T, Smith RJ, Jetten AM (1995). "ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 205 (3): 1976–83. doi:10.1006/bbrc.1994.2902. PMID 7811290.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Medvedev A, Chistokhina A, Hirose T, Jetten AM (1998). "Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene". Genomics. 46 (1): 93–102. doi:10.1006/geno.1997.4980. PMID 9403063.
  • Villey I, de Chasseval R, de Villartay JP (2000). "RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter". Eur. J. Immunol. 29 (12): 4072–80. PMID 10602018.
  • Sun Z, Unutmaz D, Zou YR; et al. (2000). "Requirement for RORgamma in thymocyte survival and lymphoid organ development". Science. 288 (5475): 2369–73. PMID 10875923.
  • Kurebayashi S, Ueda E, Sakaue M; et al. (2000). "Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10132–7. PMID 10963675.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Wang H, Chu W, Das SK; et al. (2004). "Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes". Mol. Genet. Metab. 79 (3): 176–82. PMID 12855222.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
  • Weaver CT, Murphy KM (2007). "T-cell subsets: the more the merrier". Curr. Biol. 17 (2): R61–3. doi:10.1016/j.cub.2006.12.015. PMID 17240331.

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