ARID1A

AT rich interactive domain 1A (SWI-like)
PDB rendering based on 1ryu.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ryu​
Identifiers
Symbols	ARID1A ; B120; BAF250; BAF250a; BM029; C1orf4; P270; SMARCF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21216
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

AT rich interactive domain 1A (SWI-like), also known as ARID1A, is a human gene.

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Curr. Opin. Genet. Dev. 13 (2): 136–42. PMID 12672490.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Wang W, Xue Y, Zhou S; et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–30. PMID 8804307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang W, Côté J, Xue Y; et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMID 8895581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi T, Chen BK, Qiu Y; et al. (1998). "Molecular cloning and expression of a novel human cDNA containing CAG repeats". Gene. 204 (1–2): 71–7. PMID 9434167.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dallas PB, Cheney IW, Liao DW; et al. (1998). "p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes". Mol. Cell. Biol. 18 (6): 3596–603. PMID 9584200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi T, Furihata M, Heng HH; et al. (1998). "Chromosomal mapping and expression of the human B120 gene". Gene. 213 (1–2): 189–93. PMID 9630625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dallas PB, Pacchione S, Wilsker D; et al. (2000). "The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity". Mol. Cell. Biol. 20 (9): 3137–46. PMID 10757798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nie Z, Xue Y, Yang D; et al. (2000). "A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex". Mol. Cell. Biol. 20 (23): 8879–88. PMID 11073988.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takeuchi T, Nicole S, Misaki A; et al. (2001). "Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma". Am. J. Pathol. 158 (2): 663–72. PMID 11159203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozmik Z, Machon O, Králová J; et al. (2001). "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex". Genomics. 73 (2): 140–8. doi:10.1006/geno.2001.6477. PMID 11318604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato H, Tjernberg A, Zhang W; et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription". Nature. 414 (6866): 924–8. doi:10.1038/414924a. PMID 11780067.CS1 maint: Multiple names: authors list (link)
• Hurlstone AF, Olave IA, Barker N; et al. (2002). "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein". Biochem. J. 364 (Pt 1): 255–64. PMID 11988099.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue H, Furukawa T, Giannakopoulos S; et al. (2003). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". J. Biol. Chem. 277 (44): 41674–85. doi:10.1074/jbc.M205961200. PMID 12200431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nie Z, Yan Z, Chen EH; et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. PMID 12665591.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitagawa H, Fujiki R, Yoshimura K; et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. PMID 12837248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• ARID1A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.