USF1

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Upstream transcription factor 1
File:PBB Protein USF1 image.jpg
PDB rendering based on 1an4.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols USF1 ; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF
External IDs Template:OMIM5 Template:MGI HomoloGene: 31426
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Upstream transcription factor 1, also known as USF1, is a human gene.[1]

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: USF1 upstream transcription factor 1".

Further reading

  • Corre S, Galibert MD (2006). "[USF as a key regulatory element of gene expression]". Med Sci (Paris). 22 (1): 62–7. PMID 16386222.
  • Lee JC, Lusis AJ, Pajukanta P (2007). "Familial combined hyperlipidemia: upstream transcription factor 1 and beyond". Curr. Opin. Lipidol. 17 (2): 101–9. doi:10.1097/01.mol.0000217890.54875.13. PMID 16531745.
  • Roy AL, Meisterernst M, Pognonec P, Roeder RG (1992). "Cooperative interaction of an initiator-binding transcription initiation factor and the helix-loop-helix activator USF". Nature. 354 (6350): 245–8. doi:10.1038/354245a0. PMID 1961251.
  • Gregor PD, Sawadogo M, Roeder RG (1991). "The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer". Genes Dev. 4 (10): 1730–40. PMID 2249772.
  • Henrion AA, Martinez A, Mattei MG; et al. (1995). "Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse". Genomics. 25 (1): 36–43. PMID 7774954.
  • Ferré-D'Amaré AR, Pognonec P, Roeder RG, Burley SK (1994). "Structure and function of the b/HLH/Z domain of USF". EMBO J. 13 (1): 180–9. PMID 8306960.
  • Shieh BH, Sparkes RS, Gaynor RB, Lusis AJ (1993). "Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23". Genomics. 16 (1): 266–8. doi:10.1006/geno.1993.1174. PMID 8486371.
  • Viollet B, Lefrançois-Martinez AM, Henrion A; et al. (1996). "Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms". J. Biol. Chem. 271 (3): 1405–15. PMID 8576131.
  • Ghosh AK, Datta PK, Jacob ST (1997). "The dual role of helix-loop--helix-zipper protein USF in ribosomal RNA gene transcription in vivo". Oncogene. 14 (5): 589–94. doi:10.1038/sj.onc.1200866. PMID 9053857.
  • Pognonec P, Boulukos KE, Aperlo C; et al. (1997). "Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity". Oncogene. 14 (17): 2091–8. doi:10.1038/sj.onc.1201046. PMID 9160889.
  • Roy AL, Du H, Gregor PD; et al. (1998). "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". EMBO J. 16 (23): 7091–104. doi:10.1093/emboj/16.23.7091. PMID 9384587.
  • Pajukanta P, Nuotio I, Terwilliger JD; et al. (1998). "Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23". Nat. Genet. 18 (4): 369–73. doi:10.1038/ng0498-369. PMID 9537421.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
  • Bengtsson SH, Madeyski-Bengtson K, Nilsson J, Bjursell G (2002). "Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2". Biochem. J. 365 (Pt 2): 481–8. doi:10.1042/BJ20020223. PMID 11945176.
  • Villavicencio EH, Yoon JW, Frank DJ; et al. (2002). "Cooperative E-box regulation of human GLI1 by TWIST and USF". Genesis. 32 (4): 247–58. PMID 11948912.
  • Coulson JM, Edgson JL, Marshall-Jones ZV; et al. (2003). "Upstream stimulatory factor activates the vasopressin promoter via multiple motifs, including a non-canonical E-box". Biochem. J. 369 (Pt 3): 549–61. doi:10.1042/BJ20021176. PMID 12403649.
  • Salero E, Giménez C, Zafra F (2003). "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene". Biochem. J. 370 (Pt 3): 979–86. doi:10.1042/BJ20021142. PMID 12444925.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Pickwell GV, Shih H, Quattrochi LC (2003). "Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation". Biochem. Pharmacol. 65 (7): 1087–96. PMID 12663044.

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